scholarly journals Polyion Complex Vesicles with Solvated Phosphobetaine Shells Formed from Oppositely Charged Diblock Copolymers

Polymers ◽  
2017 ◽  
Vol 9 (12) ◽  
pp. 49 ◽  
Author(s):  
Keita Nakai ◽  
Kazuhiko Ishihara ◽  
Michael Kappl ◽  
Syuji Fujii ◽  
Yoshinobu Nakamura ◽  
...  
Polymers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 5
Author(s):  
Noriko Nakamura ◽  
Yuki Mochida ◽  
Kazuko Toh ◽  
Shigeto Fukushima ◽  
Horacio Cabral ◽  
...  

Self-assembled supramolecular structures based on polyion complex (PIC) formation between oppositely charged polymers are attracting much attention for developing drug delivery systems able to endure harsh in vivo environments. As controlling polymer complexation provides an opportunity for engineering the assemblies, an improved understanding of the PIC formation will allow constructing assemblies with enhanced structural and functional capabilities. Here, we focused on the influence of the mixing charge ratio between block aniomers and catiomers on the physicochemical characteristics and in vivo biological performance of the resulting PIC micelles (PIC/m). Our results showed that by changing the mixing charge ratio, the structural state of the core was altered despite the sizes of PIC/m remaining almost the same. These structural variations greatly affected the stability of the PIC/m in the bloodstream after intravenous injection and determined their biodistribution.


2003 ◽  
Vol 36 (5) ◽  
pp. 1417-1420 ◽  
Author(s):  
Stefan Schrage ◽  
Reinhard Sigel ◽  
Helmut Schlaad

2002 ◽  
Vol 58 (6) ◽  
pp. 912-918 ◽  
Author(s):  
P Hervé ◽  
M Destarac ◽  
J.-F Berret ◽  
J Lal ◽  
J Oberdisse ◽  
...  

2007 ◽  
Vol 119 (32) ◽  
pp. 6197-6200 ◽  
Author(s):  
Akihiro Kishimura ◽  
Aya Koide ◽  
Kensuke Osada ◽  
Yuichi Yamasaki ◽  
Kazunori Kataoka

2016 ◽  
Vol 49 (7) ◽  
pp. 2750-2760 ◽  
Author(s):  
Feng Luo ◽  
Tao Lin Sun ◽  
Tasuku Nakajima ◽  
Daniel R. King ◽  
Takayuki Kurokawa ◽  
...  

2010 ◽  
Vol 43 (4) ◽  
pp. 1992-2001 ◽  
Author(s):  
Serena De Santis ◽  
Rita Diana Ladogana ◽  
Marco Diociaiuti ◽  
Giancarlo Masci

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