scholarly journals Strong and Tough Polyion-Complex Hydrogels from Oppositely Charged Polyelectrolytes: A Comparative Study with Polyampholyte Hydrogels

2016 ◽  
Vol 49 (7) ◽  
pp. 2750-2760 ◽  
Author(s):  
Feng Luo ◽  
Tao Lin Sun ◽  
Tasuku Nakajima ◽  
Daniel R. King ◽  
Takayuki Kurokawa ◽  
...  
Keyword(s):  
Comparative Study ◽  
Polyion Complex ◽  
Oppositely Charged

scholarly journals Effect of Mixing Ratio of Oppositely Charged Block Copolymers on Polyion Complex Micelles for In Vivo Application

Polymers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 5
Author(s):  
Noriko Nakamura ◽  
Yuki Mochida ◽  
Kazuko Toh ◽  
Shigeto Fukushima ◽  
Horacio Cabral ◽  
...  
Keyword(s):  
Physicochemical Characteristics ◽  
Charge Ratio ◽  
Structural Variations ◽  
Polyion Complex ◽  
Functional Capabilities ◽  
The Stability ◽  
Biological Performance ◽  
Complex Micelles ◽  
Oppositely Charged

Self-assembled supramolecular structures based on polyion complex (PIC) formation between oppositely charged polymers are attracting much attention for developing drug delivery systems able to endure harsh in vivo environments. As controlling polymer complexation provides an opportunity for engineering the assemblies, an improved understanding of the PIC formation will allow constructing assemblies with enhanced structural and functional capabilities. Here, we focused on the influence of the mixing charge ratio between block aniomers and catiomers on the physicochemical characteristics and in vivo biological performance of the resulting PIC micelles (PIC/m). Our results showed that by changing the mixing charge ratio, the structural state of the core was altered despite the sizes of PIC/m remaining almost the same. These structural variations greatly affected the stability of the PIC/m in the bloodstream after intravenous injection and determined their biodistribution.

Formation of Amphiphilic Polyion Complex Vesicles from Mixtures of Oppositely Charged Block Ionomers

2003 ◽  
Vol 36 (5) ◽  
pp. 1417-1420 ◽  
Author(s):  
Stefan Schrage ◽  
Reinhard Sigel ◽  
Helmut Schlaad
Keyword(s):  
Polyion Complex ◽  
Block Ionomers ◽  
Oppositely Charged

Encapsulation of Myoglobin in PEGylated Polyion Complex Vesicles Made from a Pair of Oppositely Charged Block Ionomers: A Physiologically Available Oxygen Carrier

2007 ◽  
Vol 119 (32) ◽  
pp. 6197-6200 ◽  
Author(s):  
Akihiro Kishimura ◽  
Aya Koide ◽  
Kensuke Osada ◽  
Yuichi Yamasaki ◽  
Kazunori Kataoka
Keyword(s):  
Oxygen Carrier ◽  
Polyion Complex ◽  
Block Ionomers ◽  
Oppositely Charged

scholarly journals Polyion Complex Vesicles with Solvated Phosphobetaine Shells Formed from Oppositely Charged Diblock Copolymers

Polymers ◽  
2017 ◽  
Vol 9 (12) ◽  
pp. 49 ◽  
Author(s):  
Keita Nakai ◽  
Kazuhiko Ishihara ◽  
Michael Kappl ◽  
Syuji Fujii ◽  
Yoshinobu Nakamura ◽  
...  
Keyword(s):  
Diblock Copolymers ◽  
Polyion Complex ◽  
Oppositely Charged

scholarly journals Polyion Complex Micelles for Protein Delivery

2018 ◽  
Vol 71 (10) ◽  
pp. 768 ◽  
Author(s):  
Fan Chen ◽  
Martina H. Stenzel
Keyword(s):  
Protein Delivery ◽  
Hydrolytic Degradation ◽  
Protective Layer ◽  
Drug Market ◽  
The Body ◽  
Interpolyelectrolyte Complex ◽  
Polyion Complex ◽  
Block Ionomer Complexes ◽  
Block Ionomer ◽  
Oppositely Charged

Proteins are ubiquitous in life and next to water, they are the most abundant compounds found in human bodies. Proteins have very specific roles in the body and depending on their function, they are for example classified as enzymes, antibodies or transport proteins. Recently, therapeutic proteins have made an impact in the drug market. However, some proteins can be subject to quick hydrolytic degradation or denaturation depending on the environment and therefore require a protective layer. A range of strategies are available to encapsulate and deliver proteins, but techniques based on polyelectrolyte complex formation stand out owing to their ease of formulation. Depending on their isoelectric point, proteins are charged and can condense with oppositely charged polymers. Using block copolymers with a neutral block and a charged block results in the formation of polyion complex (PIC) micelles when mixed with the oppositely charged protein. The neutral block stabilises the charged protein–polymer core, leading to nanoparticles. The types of micelles are also known under the names interpolyelectrolyte complex, complex coacervate core micelles, and block ionomer complexes. In this article, we discuss the formation of PIC micelles and their stability. Strategies to enhance the stability such as supercharging the protein or crosslinking the PIC micelles are discussed.

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