scholarly journals Polysaccharide-Based Micro- and Nanosized Drug Delivery Systems for Potential Application in the Pediatric Dentistry

Polymers ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 3342
Author(s):  
Plamen Katsarov ◽  
Maria Shindova ◽  
Paolina Lukova ◽  
Ani Belcheva ◽  
Cédric Delattre ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Potential Application ◽  
Drug Carriers ◽  
Pediatric Dentistry ◽  
Oral Diseases ◽  
Innovative Strategies ◽  
Polymeric Drug ◽  
Low Toxicity ◽  
Successful Technique ◽  
Forming Characteristics

The intensive development of micro- and nanotechnologies in recent years has offered a wide horizon of new possibilities for drug delivery in dentistry. The use of polymeric drug carriers turned out to be a very successful technique for formulating micro- and nanoparticles with controlled or targeted drug release in the oral cavity. Such innovative strategies have the potential to provide an improved therapeutic approach to prevention and treatment of various oral diseases not only for adults, but also in the pediatric dental practice. Due to their biocompatibility, biotolerance and biodegradability, naturally occurring polysaccharides like chitosan, alginate, pectin, dextran, starch, etc., are among the most preferred materials for preparation of micro- and nano-devices for drug delivery, offering simple particle-forming characteristics and easily tunable properties of the formulated structures. Their low immunogenicity and low toxicity provide an advantage over most synthetic polymers for the development of pediatric formulations. This review is focused on micro- and nanoscale polysaccharide biomaterials as dental drug carriers, with an emphasis on their potential application in pediatric dentistry.

Advances in Oral Chitosan Based Nano Delivery System for colon Targeted Drug Delivery in Inflammatory Bowel Disease

2021 ◽  
pp. 3769-3774
Author(s):  
Ganesh Narayan Sharma ◽  
Ch. Praveen Kumar ◽  
Birendra Shrivastava ◽  
B. Kumar
Keyword(s):  
Drug Delivery ◽  
Oral Absorption ◽  
Drug Carriers ◽  
Multiple Features ◽  
Delivery Vector ◽  
Macromolecular Drugs ◽  
Natural Polysaccharide ◽  
Low Toxicity ◽  
Inflammatory Bowel ◽  
Derivatives Of

Nanomaterials can be used as drug carriers with multiple features, including target delivery triggered by environmental, pH, thermal responses, enhanced biocompatibility, and the ability to cross the blood-brain barrier. Chitosan (CS) is a natural polysaccharide largely obtained from marine crustaceans. It provides drug delivery vector for therapeutic CS and diagnostic CS, owing to its biocompatibility, biodegradability, low toxicity, and structural variability. Derivatives of CS such as quaternized CS, thiolated CS and carboxylated CS have enhanced its effectiveness in oral absorption of macromolecular drugs. This review discusses different forms of nanomaterials generated from CS and its derivatives for controlled drug delivery.

The Essential Properties of Nanoemulsions

2022 ◽  
pp. 1-23
Author(s):  
Mohamed Akif S. ◽  
Jahangir Ahmed ◽  
Karthikeyan Ramalingam
Keyword(s):  
Drug Delivery ◽  
Thermodynamic Stability ◽  
Antineoplastic Agents ◽  
Drug Carriers ◽  
Primary Objective ◽  
Drug Formulation ◽  
Immiscible Liquids ◽  
Essential Properties ◽  
Low Toxicity

Nanoemulsions are a submicron with colloidal particulate systems ranging from 10 to 1,000 nm in size. Nanoemulsions hold enormous scope in the field of cosmetics, diagnostics, food, and paint. Moreover, nanoemulsions are ubiquitously regarded as superior drug carriers for the infusion of lipophilic cytotoxic antineoplastic agents on a particular target criterion. Nanoemulsions are prepared from two immiscible liquids that are mixed by employing surfactants and co-surfactants. It also encompasses some significant benefits like biocompatibility, non-immunogenicity, low toxicity, drug entrapment, nanoscale size, large surface area, long-term and restrained release, uncomplicated mode of formulation, as well as thermodynamic stability. Nanoemulsion drug delivery can address the major challenge of effective drug formulation due to its instability and poor solubility in the vehicle. The primary objective of this chapter is to provide a quick overview of various physico-properties of nanoemulsion, with a special emphasis on its various applications in various fields.

scholarly journals Chitosan-Based Nanomaterials for Drug Delivery

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2661 ◽  
Author(s):  
Jianghua Li ◽  
Chao Cai ◽  
Jiarui Li ◽  
Jun Li ◽  
Jia Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Efficacy ◽  
Controlled Drug Delivery ◽  
Drug Carriers ◽  
Multiple Features ◽  
Target Delivery ◽  
Delivery Vector ◽  
Marine Crustaceans ◽  
Natural Polysaccharide ◽  
Low Toxicity

This review discusses different forms of nanomaterials generated from chitosan and its derivatives for controlled drug delivery. Nanomaterials are drug carriers with multiple features, including target delivery triggered by environmental, pH, thermal responses, enhanced biocompatibility, and the ability to cross the blood-brain barrier. Chitosan (CS), a natural polysaccharide largely obtained from marine crustaceans, is a promising drug delivery vector for therapeutics and diagnostics, owing to its biocompatibility, biodegradability, low toxicity, and structural variability. This review describes various approaches to obtain novel CS derivatives, including their distinct advantages, as well as different forms of nanomaterials recently developed from CS. The advanced applications of CS-based nanomaterials are presented here in terms of their specific functions. Recent studies have proven that nanotechnology combined with CS and its derivatives could potentially circumvent obstacles in the transport of drugs thereby improving the drug efficacy. CS-based nanomaterials have been shown to be highly effective in targeted drug therapy.

Poly(phenyleneethynylene) nanoparticles: preparation, living cell imaging and potential application as drug carriers

2015 ◽  
Vol 3 (17) ◽  
pp. 3564-3572 ◽  
Author(s):  
Tong Chen ◽  
Wanfu Xu ◽  
Zehai Huang ◽  
Hongmei Peng ◽  
Zhiyong Ke ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Potential Application ◽  
Living Cell ◽  
Cell Imaging ◽  
Drug Carriers ◽  
Therapeutic Delivery ◽  
Self Assembled ◽  
Living Cell Imaging

Novel PPE nanoparticles self-assembled from amphiphilic poly(phenyleneethynylenes) would be a promising drug delivery system for therapeutic delivery and/or bioimaging.

scholarly journals Protein nano-cages: Novel carriers for optimized targeted remedy

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 1541 ◽  
Author(s):  
Negar Etehad Roudi ◽  
Neda Saraygord-Afshari ◽  
Maryam Hemmaty
Keyword(s):  
Drug Delivery ◽  
Targeted Delivery ◽  
Large Scale ◽  
Drug Carriers ◽  
The Body ◽  
Nano Particles ◽  
Diagnostic Tools ◽  
Multiple Protein ◽  
Low Toxicity ◽  
Novel Protein

Since 1980, when the idea of drug-delivery was proposed, various drug-carriers have been developed, including DNA, proteins, liposomes and several other polymer cages, consisting of many well established natural and synthetic nano-particles. All these drug-carriers can self-assemble in the body and can be manipulated for safer delivery into target tissues. By definition, nano-scale drug delivery systems encompass any structure (either cage or particle) in the form of solid colloids, which range in size from 10 nm to 100 nm. Today, optimization of these nano drug-vehicles is a topic in many research centers. Researchers are trying to improve the carrier’s solubility and their loading capacity and also wish to increase the half-life of drug delivery cargos in target tissues. Efforts in recent years have led to the introduction of novel protein nano-cages composed of multiple protein subunits, which self-assemble within a superfine and precise format. Science their introduction these promising structure have shown many unique characteristics, including low toxicity, bio-system compatibility, minor immunogenicity, high solubility, and a relatively easy production in large scale. Herein, we review and discuss the recently developed protein nano-carriers that are used as drug cargos for targeted delivery and/or diagnostic tools.

Advances in Nanoparticles as Anticancer Drug Delivery Vector: Need of this Century

2020 ◽  
Vol 26 (15) ◽  
pp. 1637-1649 ◽  
Author(s):  
Imran Ali ◽  
Sofi D. Mukhtar ◽  
Heyam S. Ali ◽  
Marcus T. Scotti ◽  
Luciana Scotti
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Medical Science ◽  
Drug Carriers ◽  
Anticancer Drug Delivery ◽  
Ph Values ◽  
Delivery Vector ◽  
Future Challenges ◽  
Smart Drug ◽  
Smart Drug Delivery

Background: Nanotechnology has contributed a great deal to the field of medical science. Smart drugdelivery vectors, combined with stimuli-based characteristics, are becoming increasingly important. The use of external and internal stimulating factors can have enormous benefits and increase the targeting efficiency of nanotechnology platforms. The pH values of tumor vascular tissues are acidic in nature, allowing the improved targeting of anticancer drug payloads using drug-delivery vectors. Nanopolymers are smart drug-delivery vectors that have recently been developed and recommended for use by scientists because of their potential targeting capabilities, non-toxicity and biocompatibility, and make them ideal nanocarriers for personalized drug delivery. Method: The present review article provides an overview of current advances in the use of nanoparticles (NPs) as anticancer drug-delivery vectors. Results: This article reviews the molecular basis for the use of NPs in medicine, including personalized medicine, personalized therapy, emerging vistas in anticancer therapy, nanopolymer targeting, passive and active targeting transports, pH-responsive drug carriers, biological barriers, computer-aided drug design, future challenges and perspectives, biodegradability and safety. Conclusions: This article will benefit academia, researchers, clinicians, and government authorities by providing a basis for further research advancements.

Sign in / Sign up

Export Citation Format

Share Document