Poly(phenyleneethynylene) nanoparticles: preparation, living cell imaging and potential application as drug carriers

2015 ◽  
Vol 3 (17) ◽  
pp. 3564-3572 ◽  
Author(s):  
Tong Chen ◽  
Wanfu Xu ◽  
Zehai Huang ◽  
Hongmei Peng ◽  
Zhiyong Ke ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Potential Application ◽  
Living Cell ◽  
Cell Imaging ◽  
Drug Carriers ◽  
Therapeutic Delivery ◽  
Self Assembled ◽  
Living Cell Imaging

Novel PPE nanoparticles self-assembled from amphiphilic poly(phenyleneethynylenes) would be a promising drug delivery system for therapeutic delivery and/or bioimaging.

scholarly journals A self-assembled RNA-triple helix hydrogel drug delivery system targeting triple-negative breast cancer

2020 ◽  
Vol 8 (16) ◽  
pp. 3527-3533 ◽  
Author(s):  
Lairong Ding ◽  
Junwei Li ◽  
Changrong Wu ◽  
Feng Yan ◽  
Xuemei Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Triple Negative Breast Cancer ◽  
Triple Helix ◽  
Triple Negative ◽  
Breast Cancers ◽  
Self Assembled ◽  
Rna Triple Helix

A novel RNA-triple-helix hydrogel for treatment of triple negative breast cancers (TNBCs) by incorporating RNA-triple-helix and siRNA duplexes of CXCR4 into the same RNA nanoparticles was developed, without the synthetic polycationic reagents.

scholarly journals Self-assembled pH-responsive supramolecular hydrogel for hydrophobic drug delivery

RSC Advances ◽  
2018 ◽  
Vol 8 (55) ◽  
pp. 31581-31587 ◽  
Author(s):  
Lin Wang ◽  
Xuefeng Shi ◽  
Jian Zhang ◽  
Yuejun Zhu ◽  
Jinben Wang
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Delivery System ◽  
Hydrophobic Drug ◽  
Ph Responsive ◽  
Supramolecular Hydrogel ◽  
Self Assembled

Supramolecular hydrogel, AGC16/NTS, was used to encapsulate hydrophobic drug curcumin (Cur), constructing a pH-responsive drug delivery system; the uptake of released Cur by cancer cells also occurred.

scholarly journals A Versatile Polymer Micelle Drug Delivery System for Encapsulation and In Vivo Stabilization of Hydrophobic Anticancer Drugs

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Jonathan Rios-Doria ◽  
Adam Carie ◽  
Tara Costich ◽  
Brian Burke ◽  
Habib Skaff ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Biological Fluids ◽  
Drug Carriers ◽  
Chemotherapeutic Drugs ◽  
Polymer Micelle ◽  
Drug Stabilization

Chemotherapeutic drugs are widely used for the treatment of cancer; however, use of these drugs is often associated with patient toxicity and poor tumor delivery. Micellar drug carriers offer a promising approach for formulating and achieving improved delivery of hydrophobic chemotherapeutic drugs; however, conventional micelles do not have long-term stability in complex biological environments such as plasma. To address this problem, a novel triblock copolymer has been developed to encapsulate several different hydrophobic drugs into stable polymer micelles. These micelles have been engineered to be stable at low concentrations even in complex biological fluids, and to release cargo in response to low pH environments, such as in the tumor microenvironment or in tumor cell endosomes. The particle sizes of drugs encapsulated ranged between 30–80 nm, with no relationship to the hydrophobicity of the drug. Stabilization of the micelles below the critical micelle concentration was demonstrated using a pH-reversible crosslinking mechanism, with proof-of-concept demonstrated in both in vitro and in vivo models. Described herein is polymer micelle drug delivery system that enables encapsulation and stabilization of a wide variety of chemotherapeutic drugs in a single platform.

Highly uniform self-assembled microspheres from single macromolecule self-recognition for enhanced cancer immunotherapy

2020 ◽  
Vol 56 (64) ◽  
pp. 9190-9193
Author(s):  
Xin Shen ◽  
Zhenxia Zhou ◽  
Dongmei Qi ◽  
Yanchao Li ◽  
Zhiying Zeng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Immunotherapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Local Drug Delivery ◽  
Self Recognition ◽  
Self Assembled ◽  
Local Drug Delivery System ◽  
Highly Uniform ◽  
Single Macromolecule

Self-assembled highly uniform microspheres has been developed as a local drug delivery system for effective synergistic immunotherapy.

Pharmaceutically Active Ionic Liquid Self-Assembled Vesicles for the Application as an Efficient Drug Delivery System

ChemPhysChem ◽  
2013 ◽  
Vol 14 (15) ◽  
pp. 3454-3457 ◽  
Author(s):  
Longlong Zhang ◽  
Jing Liu ◽  
Tingting Tian ◽  
Ya Gao ◽  
Xiaoqing Ji ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ionic Liquid ◽  
Drug Delivery System ◽  
Delivery System ◽  
Self Assembled

The “click-on-tube” approach for the production of efficient drug carriers based on oxidized multi-walled carbon nanotubes

2016 ◽  
Vol 4 (21) ◽  
pp. 3823-3831 ◽  
Author(s):  
Stefano Fedeli ◽  
Alberto Brandi ◽  
Lorenzo Venturini ◽  
Paola Chiarugi ◽  
Elisa Giannoni ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Carbon Nanotube ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Carriers ◽  
Multi Walled Carbon Nanotube ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes ◽  
Straightforward Approach

An efficient drug delivery system through a straightforward approach to multi-walled carbon nanotube decoration.

Ultrasonic Measurement and Control of Microrobotic Drug Delivery System

1992 ◽  
Vol 4 (3) ◽  
pp. 218-222
Author(s):  
Ken Ishihara ◽  
◽  
Toshiyuki Furukawa
Keyword(s):  
Drug Delivery ◽  
Blood Flow ◽  
Drug Delivery System ◽  
Delivery System ◽  
Imaging System ◽  
Drug Carriers ◽  
Ultrasonic Measurement ◽  
Resonant Ultrasound ◽  
And Control ◽  
Measurement And Control

We attempt a microrobotic drug delivery system (DDS) in which drug carriers of air-filled microcapsules are recognized with echography and are controlled using resonant ultrasound. We have confirmed the physical possibility of resonance design for drug carriers depending on the shell structure of the microcapsule. In addition, we have developed a novel echographic imaging system to locate microrobots precisely. Path lines of microrobots in blood flow could be clearly visualized.

Sign in / Sign up

Export Citation Format

Share Document