scholarly journals Polysaccharides as Stabilizers for Polymeric Microcarriers Fabrication

Polymers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 3045
Author(s):  
Tatiana S. Demina ◽  
Liubov A. Kilyashova ◽  
Tatiana N. Popyrina ◽  
Eugenia A. Svidchenko ◽  
Sankar Bhuniya ◽  
...  
Keyword(s):  
Chemical Structure ◽  
Total Yield ◽  
Solvent Evaporation ◽  
Prolonged Release ◽  
Water Emulsion ◽  
Polymeric Microparticles ◽  
One Step ◽  
Evaporation Technique ◽  
Oil Water ◽  
Emulsifying Ability

Biodegradable polymeric microparticles are widely used in drug delivery systems with prolonged-release profiles and/or cell microcarriers. Their fabrication via the oil/water emulsion solvent evaporation technique has normally required emulsifiers in the aqueous phase. The present work aims to evaluate the effectiveness of various polysaccharides, such as chitosan, hyaluronic acid, cellulose, arabinogalactan, guar and their derivatives, as an alternative to synthetic surfactants for polylactide microparticle stabilization during their fabrication. Targeted modification of the biopolymer’s chemical structure was also tested as a tool to enhance polysaccharides’ emulsifying ability. The transformation of biomacromolecules into a form of nanoparticle via bottom-up or top-down methods and their subsequent application for microparticle fabrication via the Pickering emulsion solvent evaporation technique was useful as a one-step approach towards the preparation of core/shell microparticles. The effect of polysaccharides’ chemical structure and the form of their application on the polylactide microparticles’ total yield, size distribution and morphology was evaluated. The application of polysaccharides has great potential in terms of the development of green chemistry and the biocompatibility of the formed microparticles, which is especially important in biomedicine application.

scholarly journals Preparation of Poly(L,L-Lactide) Microparticles via Pickering Emulsions Using Chitin Nanocrystals

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
T. S. Demina ◽  
Yu. S. Sotnikova ◽  
A. V. Istomin ◽  
Ch. Grandfils ◽  
T. A. Akopova ◽  
...  
Keyword(s):  
Chemical Structure ◽  
Total Yield ◽  
Crab Shell ◽  
Pickering Emulsions ◽  
Water Emulsion ◽  
Force Microscopy ◽  
Aspect Ratios ◽  
Atomic Force ◽  
Evaporation Technique ◽  
Oil Water

The aim of the present study was to investigate an ability of chitin nanocrystals to be used as stabilizing components for fabrication of poly(L,L-lactide) microparticles via the Pickering oil/water emulsion solvent evaporation technique. The anisometric chitin nanocrystals were extracted from two different samples of crab shell chitin via acetic hydrolysis and analyzed using atomic force microscopy, dynamic light scattering, and FTIR spectroscopy. The extracted nanocrystals showed no difference in the chemical structure but possessed different morphology and aspect ratios as a function of raw chitin used. The effect of chitin nanocrystals characteristics and concentration in the aqueous phase on the total yield, size distribution, and shape and surface morphology of the prepared polylactide microparticles was evaluated.

Controlled release of amoxicillin from PMMA and poly(butylsuccinate) microspheres

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Encapsulation Efficiency ◽  
Release Kinetics ◽  
Tween 80 ◽  
Water Emulsion ◽  
Polymeric Systems ◽  
Evaporation Technique ◽  
Polybutylene Succinate ◽  
Oil Water

This work focus on the study and the elaboration of microspheres based on amoxicillin (AMO), those microspheres were prepared through the oil/water emulsion evaporation technique. Polybutylene succinate (PBS) and Poly(methylmethacrylate) (PMMA) polymeric matrix were used with Tween 80 (T80) and Polyvinyl alcohol (PVA) as emulsifiers. These polymeric systems were analyzed by SEM, FTIR and optical microscopy. The conditions of the microspheres forming were varied and the preparation was performed by changing different parameters such as: the nature of the polymer, the stirring speed, organic solvent, surfactant nature, and concentration, which allows the study of their effect on encapsulation efficiency and drug release kinetics. These parameters affect strongly the size of microspheres, the drug content and the drug release, the latter is settled in an artificially reconstituted media of pH = 1.2 transcribed from the stomachal medium.

scholarly journals Biodegradable Cell Microcarriers Based on Chitosan/Polyester Graft-Copolymers

Molecules ◽  
2020 ◽  
Vol 25 (8) ◽  
pp. 1949
Author(s):  
Tatiana S. Demina ◽  
Maria G. Drozdova ◽  
Chantal Sevrin ◽  
Philippe Compère ◽  
Tatiana A. Akopova ◽  
...  
Keyword(s):  
Total Yield ◽  
Volume Ratio ◽  
Core Material ◽  
Cell Cultivation ◽  
Water Solvent ◽  
Evaporation Technique ◽  
Oil Water ◽  
Cultivation In Vitro ◽  
Kinetics Of

Self-stabilizing biodegradable microcarriers were produced via an oil/water solvent evaporation technique using amphiphilic chitosan-g-polyester copolymers as a core material in oil phase without the addition of any emulsifier in aqueous phase. The total yield of the copolymer-based microparticles reached up to 79 wt. %, which is comparable to a yield achievable using traditional emulsifiers. The kinetics of microparticle self-stabilization, monitored during their process, were correlated to the migration of hydrophilic copolymer’s moieties to the oil/water interface. With a favorable surface/volume ratio and the presence of bioadhesive natural fragments anchored to their surface, the performance of these novel microcarriers has been highlighted by evaluating cell morphology and proliferation within a week of cell cultivation in vitro.

One-step solid-oil-water emulsion for sustained bioactive ranibizumab release

2018 ◽  
Vol 15 (12) ◽  
pp. 1143-1156 ◽  
Author(s):  
Hui Yee Chua ◽  
Yuan Siang Lui ◽  
Ramya Bhuthalingam ◽  
Rupesh Agrawal ◽  
Tina Wong ◽  
...  
Keyword(s):  
Water Emulsion ◽  
One Step ◽  
Oil Water

Improved antifouling property of PVDF membranes by incorporating an amphiphilic block-like copolymer for oil/water emulsion separation

RSC Advances ◽  
2015 ◽  
Vol 5 (27) ◽  
pp. 21349-21359 ◽  
Author(s):  
Yuan Liu ◽  
Yanlei Su ◽  
Yafei Li ◽  
Xueting Zhao ◽  
Zhongyi Jiang
Keyword(s):  
Surface Segregation ◽  
Water Emulsion ◽  
Membrane Surfaces ◽  
Antifouling Property ◽  
Emulsion Separation ◽  
One Step ◽  
Oil Water

Amphiphilic membrane surfaces were constructed in one step by surface segregation and the membranes exhibited a superior antifouling property.

New Technology for Oil/Water Emulsion Treatment: Phases I and II

1998 ◽  
Author(s):  
S. Venkatesh ◽  
C. Watson ◽  
C. D. Wolbach ◽  
L. R. Waterland
Keyword(s):  
New Technology ◽  
Water Emulsion ◽  
Oil Water
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