scholarly journals Demineralized Dentin Matrix Particle-Based Bio-Ink for Patient-Specific Shaped 3D Dental Tissue Regeneration

Polymers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1294
Author(s):  
Jonghyeuk Han ◽  
Wonwoo Jeong ◽  
Min-Kyeong Kim ◽  
Sang-Hyeon Nam ◽  
Eui-Kyun Park ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Three Dimensional ◽  
Patient Specific ◽  
Excellent Performance ◽  
Dental Tissue ◽  
Cell Compatibility ◽  
Dental Tissues ◽  
Dentin Matrix ◽  
Demineralized Dentin Matrix ◽  
Demineralized Dentin

Demineralized dentin matrix (DDM)-based materials have been actively developed and are well-known for their excellent performance in dental tissue regeneration. However, DDM-based bio-ink suitable for fabrication of engineered dental tissues that are patient-specific in terms of shape and size, has not yet been developed. In this study, we developed a DDM particle-based bio-ink (DDMp bio-ink) with enhanced three-dimensional (3D) printability. The bio-ink was prepared by mixing DDM particles and a fibrinogen–gelatin mixture homogeneously. The effects of DDMp concentration on the 3D printability of the bio-ink and dental cell compatibility were investigated. As the DDMp concentration increased, the viscosity and shear thinning behavior of the bio-ink improved gradually, which led to the improvement of the ink’s 3D printability. The higher the DDMp content, the better were the printing resolution and stacking ability of the 3D printing. The printable minimum line width of 10% w/v DDMp bio-ink was approximately 252 μm, whereas the fibrinogen–gelatin mixture was approximately 363 μm. The ink’s cytocompatibility test with dental pulp stem cells (DPSCs) exhibited greater than 95% cell viability. In addition, as the DDMp concentration increased, odontogenic differentiation of DPSCs was significantly enhanced. Finally, we demonstrated that cellular constructs with 3D patient-specific shapes and clinically relevant sizes could be fabricated through co-printing of polycaprolactone and DPSC-laden DDMp bio-ink.

scholarly journals Liposomal Delivery of Demineralized Dentin Matrix for Dental Tissue Regeneration

2018 ◽  
Vol 24 (13-14) ◽  
pp. 1057-1065 ◽  
Author(s):  
Genevieve E. Melling ◽  
John S. Colombo ◽  
Steven J. Avery ◽  
Wayne Nishio Ayre ◽  
Samuel L. Evans ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Dental Tissue ◽  
Dentin Matrix ◽  
Demineralized Dentin Matrix ◽  
Liposomal Delivery ◽  
Demineralized Dentin

Demineralized dentin matrix composite collagen material for bone tissue regeneration

2013 ◽  
Vol 24 (13) ◽  
pp. 1519-1528 ◽  
Author(s):  
Jianan Li ◽  
Juan Yang ◽  
Xiaozhong Zhong ◽  
Fengrong He ◽  
Xiongwen Wu ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Matrix Composite ◽  
Tissue Regeneration ◽  
Bone Tissue Regeneration ◽  
Dentin Matrix ◽  
Demineralized Dentin Matrix ◽  
Demineralized Dentin

scholarly journals Dentin-Derived-Barrier Membrane in Guided Bone Regeneration: A Case Report

Materials ◽  
2021 ◽  
Vol 14 (9) ◽  
pp. 2166
Author(s):  
Jeong-Kui Ku ◽  
In-Woong Um ◽  
Mi-Kyoung Jun ◽  
Il-hyung Kim
Keyword(s):  
Case Report ◽  
Bone Regeneration ◽  
Guided Bone Regeneration ◽  
Successful Outcome ◽  
Collagen Membrane ◽  
Type I ◽  
Barrier Membrane ◽  
Dentin Matrix ◽  
Demineralized Dentin Matrix ◽  
Demineralized Dentin

An autogenous, demineralized, dentin matrix is a well-known osteo-inductive bone substitute that is mostly composed of type I collagen and is widely used in implant dentistry. This single case report describes a successful outcome in guided bone regeneration and dental implantation with a novel human-derived collagen membrane. The authors fabricated a dentin-derived-barrier membrane from a block-type autogenous demineralized dentin matrix to overcome the mechanical instability of the collagen membrane. The dentin-derived-barrier acted as an osteo-inductive collagen membrane with mechanical and clot stabilities, and it replaced the osteo-genetic function of the periosteum. Further research involving large numbers of patients should be conducted to evaluate bone forming capacity in comparison with other collagen membranes.

scholarly journals Volumetric, Radiographic, and Histologic Analyses of Demineralized Dentin Matrix Combined with Recombinant Human Bone Morphogenetic Protein-2 for Ridge Preservation: A Prospective Randomized Controlled Trial in Comparison with Xenograft

2018 ◽  
Vol 8 (8) ◽  
pp. 1288 ◽  
Author(s):  
Gyu-Un Jung ◽  
Tae-Hyun Jeon ◽  
Mong-Hun Kang ◽  
In-Woong Um ◽  
In-Seok Song ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Bone Morphogenetic Protein 2 ◽  
Ridge Preservation ◽  
Tissue Volume ◽  
Morphogenetic Protein ◽  
Human Bone Morphogenetic Protein ◽  
Dentin Matrix ◽  
Demineralized Dentin Matrix ◽  
Recombinant Human Bone ◽  
Demineralized Dentin

The aim of this study was to evaluate the clinical, volumetric, radiographic, and histologic aspects of autogenous demineralized dentin matrix (DDM) combined with recombinant human bone morphogenetic protein-2 (rhBMP-2) used for ridge preservation, compared to those of deproteinized bovine bone with collagen (DBBC). Following atraumatic extraction, the socket was filled with DBBC, DDM, or rhBMP-2/DDM. Scanned images of dental casts and cone beam computed tomographs (CBCT) were superimposed for the calculation of soft and hard tissue volume alteration. Preoperative and postoperative measurements of the height and width of the alveolar ridge were compared using CBCT images. After 4 months, bone specimens were harvested for histomorphometric assessment. Loss of hard and soft tissue volume occurred at 4 months after extraction and ridge preservation in all groups. No volumetric differences were detected among the three groups before and 4 months after ridge preservation. The reduction in the horizontal width at 5 mm was higher in the DBBC compared to the DDM. Histologically, approximately 40% newly formed bone was founded in rhBMP-2/DDM group. The autogenous dentin matrix used to fill the socket was as beneficial for ridge preservation as conventional xenografts. The combination of rhBMP-2 with dentin matrix also demonstrated appreciable volumetric stability and higher new bone formation compared to DDM alone and DBBC.

scholarly journals Autogenous Demineralized Dentin Matrix Graft for Socket Preservation

2021 ◽  
Vol 5 (4) ◽  
pp. 214-218
Author(s):  
Mahadeepa Kar ◽  
Ashish Gupta ◽  
N Srinath ◽  
Umashankar DN ◽  
Mahesh Kumar ◽  
...  
Keyword(s):  
Socket Preservation ◽  
Dentin Matrix ◽  
Demineralized Dentin Matrix ◽  
Demineralized Dentin

Full Regeneration of Maxillary Alveolar Bone Using Autogenous Partially Demineralized Dentin Matrix and Particulate Cancellous Bone and Marrow for Implant-Supported Full Arch Rehabilitation

2020 ◽  
Vol 46 (2) ◽  
pp. 122-127 ◽  
Author(s):  
Mayumi Umebayashi ◽  
Seigo Ohba ◽  
Tadafumi Kurogi ◽  
Sawako Noda ◽  
Izumi Asahina
Keyword(s):  
Cancellous Bone ◽  
Alveolar Bone ◽  
Graft Material ◽  
Oral Rehabilitation ◽  
Wide Range ◽  
Old Japanese ◽  
Sinus Floor Augmentation ◽  
Dentin Matrix ◽  
Demineralized Dentin Matrix ◽  
Demineralized Dentin

Autogenous partially demineralized dentin matrix (APDDM) has been reportedly used as a superior bone graft material. A 52-year-old Japanese man who exhibited severe periodontitis was referred for oral rehabilitation. He underwent wide-range anterior maxillary alveolar bone and bilateral sinus floor augmentation by grafting of a mixture of APDDM and particulate cancellous bone and marrow (PCBM); subsequently, he underwent implant-supported full arch rehabilitation. He has been followed up for 4 years after placement of the final restoration without any complications, and his physiological bone volume has been maintained. APDDM constitutes an alternative treatment that may increase the volume of graft material and might prevent rapid resorption of PCBM, because APDDM served as a scaffold for osteoblasts from PCBM. When possible, it may be useful to apply APDDM as a graft material with PCBM for large-volume alveolar bone regeneration.

Effects of acid-etching on the tensile properties of demineralized dentin matrix

1998 ◽  
Vol 14 (3) ◽  
pp. 222-228 ◽  
Author(s):  
Yi Zhang ◽  
Kelli Agee ◽  
Jacques Nör ◽  
Ricardo Carvalho ◽  
Bhupinder Sachar ◽  
...  
Keyword(s):  
Tensile Properties ◽  
Acid Etching ◽  
Dentin Matrix ◽  
Demineralized Dentin Matrix ◽  
Demineralized Dentin
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