scholarly journals Hydrogel Contact Lens for Extended Delivery of Ophthalmic Drugs

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Xiaohong Hu ◽  
Lingyun Hao ◽  
Huaiqing Wang ◽  
Xiaoli Yang ◽  
Guojun Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Contact Lens ◽  
Contact Lenses ◽  
Drug Carriers ◽  
Soft Contact ◽  
Soft Contact Lenses ◽  
Advantages And Disadvantages ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug ◽  
Polymeric Hydrogels

Soft contact lenses can improve the bioavailability and prolong the residence time of drugs and, therefore, are ideal drug carriers for ophthalmic drug delivery. Hydrogels are the leading materials of soft contact lenses because of their biocompatibility and transparent characteristic. In order to increase the amount of load drug and to control their release at the expected intervals, many strategies are developed to modify the conventional contact lens as well as the novel hydrogel contact lenses that include (i) polymeric hydrogels with controlled hydrophilic/hydrophobic copolymer ratio; (ii) hydrogels for inclusion of drugs in a colloidal structure dispersed in the contact lenses; (iii) ligand-containing hydrogels; (iv) molecularly imprinted polymeric hydrogels; (v) hydrogel with the surface containing multilayer structure for drugs loading and releasing. The advantages and disadvantages of these strategies in modifying or designing hydrogel contact lenses for extended ophthalmic drug delivery are analyzed in this paper.

The Effect of Photoinitiator Concentration on the Physicochemical Properties of Hydrogel Contact Lenses

2014 ◽  
Vol 679 ◽  
pp. 118-127 ◽  
Author(s):  
Deirdre M. McElroy ◽  
Luke M. Geever ◽  
Clement L. Higginbotham ◽  
Sinead M. Devery
Keyword(s):  
Drug Delivery ◽  
Physicochemical Properties ◽  
Contact Lens ◽  
Contact Lenses ◽  
Delivery Systems ◽  
Eye Drops ◽  
Soft Contact ◽  
Soft Contact Lenses ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug

Hydrogel soft contact lenses have been investigated as delivery systems for ophthalmic drug products in response to the need for more efficient ophthalmic drug delivery systems. Ocular drugs delivered via eye drops have a low residence time in the eye resulting in as low as 5% bioavailability of the therapeutic agent. This study investigates the effect of varying concentrations of the photoinitiator diphenyl (2,4,6-trimethylbenzoyl)-phosphine oxide (TPO) on the physicochemical properties of hydrogel soft contact lenses for ophthalmic drug delivery purposes. Contact lens samples were synthesised via photopolymerisation with a range of initiator concentration. Gel fraction and swelling results indicated that increasing the photoinitiator concentration increased the efficiency of the gel network and reduced the water content of contact lens samples. Fourier transform infra-red spectroscopy (FTIR) analysis was employed to confirm polymerisation of the lenses and also indicated the presence of residual photoinitiator in lenses with higher TPO concentrations.

scholarly journals Improvements in Topical Ocular Drug Delivery Systems: Hydrogels and Contact Lenses

2015 ◽  
Vol 18 (5) ◽  
pp. 683 ◽  
Author(s):  
Andreza Maria Ribeiro ◽  
Ana Figueiras ◽  
Francisco Veiga
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Contact Lenses ◽  
Delivery Systems ◽  
Ocular Drug Delivery ◽  
Ocular Tissue ◽  
Soft Contact Lenses ◽  
Ophthalmic Drug Delivery ◽  
New Therapeutic Approaches ◽  
Ophthalmic Drug

Conventional ophthalmic systems present very low corneal systemic bioavailability due to the nasolacrimal drainage and the difficulty to deliver the drug in the posterior segment of ocular tissue. For these reasons, recent advances have focused on the development of new ophthalmic drug delivery systems. This review provides an insight into the various constraints associated with ocular drug delivery, summarizes recent findings in soft contact lenses (SCL) and the applications of novel pharmaceutical systems for ocular drug delivery. Among the new therapeutic approaches in ophthalmology, SCL are novel continuous-delivery systems, providing high and sustained levels of drugs to the cornea. The tendency of research in ophthalmic drug delivery systems development are directed towards a combination of several technologies (bio-inspired and molecular imprinting techniques) and materials (cyclodextrins, surfactants, specific monomers). There is a tendency to develop systems which not only prolong the contact time of the vehicle at the ocular surface, but also at the same time slow down the clearance of the drug. Different materials can be applied during the development of contact lenses and can be combined with natural inspired strategies of drug immobilization and release, providing successful tools for ocular drug delivery systems. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

Polymeric hydrogels for novel contact lens-based ophthalmic drug delivery systems: A review

2008 ◽  
Vol 31 (2) ◽  
pp. 57-64 ◽  
Author(s):  
Li Xinming ◽  
Cui Yingde ◽  
Andrew W. Lloyd ◽  
Sergey V. Mikhalovsky ◽  
Susan R. Sandeman ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Contact Lens ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug ◽  
Polymeric Hydrogels

scholarly journals Soft Contact Lenses as Drug Delivery Systems: A Review

Molecules ◽  
2021 ◽  
Vol 26 (18) ◽  
pp. 5577
Author(s):  
Iwona Rykowska ◽  
Iwona Nowak ◽  
Rafał Nowak
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Contact Lenses ◽  
Delivery Systems ◽  
Interdisciplinary Studies ◽  
Eye Drops ◽  
Innovative Drug ◽  
Soft Contact ◽  
Soft Contact Lenses ◽  
Advantages And Disadvantages

This review describes the role of contact lenses as an innovative drug delivery system in treating eye diseases. Current ophthalmic drug delivery systems are inadequate, particularly eye drops, which allow about 95% of the active substance to be lost through tear drainage. According to the literature, many interdisciplinary studies have been carried out on the ability of contact lenses to increase the penetration of topical therapeutic agents. Contact lenses limit drug loss by releasing the medicine into two layers of tears on either side of the contact lens, eventually extending the time of contact with the ocular surface. Thanks to weighted soft contact lenses, a continuous release of the drug over an extended period is possible. This article reviewed the various techniques to deliver medications through contact lenses, examining their advantages and disadvantages. In addition, the potential of drug delivery systems based on contact lenses has been extensively studied.

Cosmetics and Contact Lenses: Influence on Safety

The Eye ◽  
2021 ◽  
Vol 23 (3) ◽  
pp. 59-63
Author(s):  
S. V. Zimovets ◽  
A. Ya. Sverdlik
Keyword(s):  
Contact Lens ◽  
Contact Lenses ◽  
Cosmetic Products ◽  
Soft Contact ◽  
Dry Eyes ◽  
Soft Contact Lenses

The article describes the effect of decorative cosmetics on the material of soft contact lenses and studies specific features that can be observed in SCL wearers who use cosmetics extensively. Examples of complications associated with the use of various cosmetic products that may occur in contact lens wearers are given. Conclusion: in cases when patients have complaints about discomfort and dry eyes, doctors should pay attention to the amount of decorative cosmetics used as well as study the effect it can have on the surface of the contact lenses.

Polymeric hydrogels for soft contact lenses

1992 ◽  
Vol 26 (9) ◽  
pp. 1253-1257 ◽  
Author(s):  
J. Singh ◽  
K. Agrawal ◽  
A. R. Ray ◽  
J. P. Singhal ◽  
H. Singh ◽  
...  
Keyword(s):  
Contact Lenses ◽  
Soft Contact ◽  
Soft Contact Lenses ◽  
Polymeric Hydrogels

scholarly journals The impact of wearing single vision soft contact lenses on the peripheral refractive error

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 2803
Author(s):  
Kareem Allinjawi ◽  
Sharanjeet-Kaur Sharanjeet-Kaur ◽  
Saadah Mohamed Akhir ◽  
Haliza Abdul Mutalib
Keyword(s):  
Visual Field ◽  
Open Field ◽  
Refractive Error ◽  
Contact Lens ◽  
Contact Lenses ◽  
Soft Contact ◽  
Soft Contact Lenses ◽  
Single Vision ◽  
The Right ◽  
The Impact

Aim: The purpose of this study was to determine the changes in the relative peripheral refractive error produced by soft single vision contact lenses in myopic schoolchildren. Methods: 27 myopic schoolchildren aged between 13 to 15 years were included in this study. The measurements of central and peripheral refraction were made only on the right eye using a Grand-Seiko WR-5100K open-field autorefractometer without contact lens (WL), and with wearing single vision contact lens (SVCL). Refractive power was measured at center and horizontal eccentricity between 35° temporal to 35° nasal visual field (in 5° steps). Results: SVCL showed an increase in peripheral hyperopic defocus at the nasal and temporal visual field compare with baseline, but this change was not statistically significant (p=0.129). Conclusion: Wearing single vision soft contact lenses increases the relative peripheral hyperopic defocus in myopic schoolchildren.

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