AS1411 Aptamer and Folic Acid Functionalized pH-Responsive ATRP Fabricated pPEGMA–PCL–pPEGMA Polymeric Nanoparticles for Targeted Drug Delivery in Cancer Therapy

2014 ◽  
Vol 15 (5) ◽  
pp. 1737-1752 ◽  
Author(s):  
Shantanu V. Lale ◽  
Aswathy R. G. ◽  
Athulya Aravind ◽  
D. Sakthi Kumar ◽  
Veena Koul
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Cancer Therapy ◽  
Targeted Drug Delivery ◽  
Polymeric Nanoparticles ◽  
Ph Responsive ◽  
Targeted Drug ◽  
As1411 Aptamer

scholarly journals Folic Acid-Terminated Poly(2-Diethyl Amino Ethyl Methacrylate) Brush-Gated Magnetic Mesoporous Nanoparticles as a Smart Drug Delivery System

Polymers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 59
Author(s):  
Abeer M. Beagan ◽  
Ahlam A. Alghamdi ◽  
Shatha S. Lahmadi ◽  
Majed A. Halwani ◽  
Mohammed S. Almeataq ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Folic Acid ◽  
Drug Delivery System ◽  
Targeted Drug Delivery ◽  
Ph Responsive ◽  
Ethyl Methacrylate ◽  
Mesoporous Nanoparticles ◽  
Targeted Drug ◽  
Mcf 7

Currently, chemotherapy is an important method for the treatment of various cancers. Nevertheless, it has many limitations, such as poor tumour selectivity and multi-drug resistance. It is necessary to improve this treatment method by incorporating a targeted drug delivery system aimed to reduce side effects and drug resistance. The present work aims to develop pH-sensitive nanocarriers containing magnetic mesoporous silica nanoparticles (MMSNs) coated with pH-responsive polymers for tumour-targeted drug delivery via the folate receptor. 2-Diethyl amino ethyl methacrylate (DEAEMA) was successfully grafted on MMSNs via surface initiated ARGET atom transfer radical polymerization (ATRP), with an average particle size of 180 nm. The end groups of poly (2-(diethylamino)ethyl methacrylate) (PDEAEMA) brushes were converted to amines, followed by a covalent bond with folic acid (FA) as a targeting agent. FA conjugated to the nanoparticle surface was confirmed by X-ray photoelectron spectroscopy (XPS). pH-Responsive behavior of PDEAEMA brushes was investigated by Dynamic Light Scattering (DLS). The nanoparticles average diameters ranged from ca. 350 nm in basic media to ca. 650 in acidic solution. Multifunctional pH-sensitive magnetic mesoporous nanoparticles were loaded with an anti-cancer drug (Doxorubicin) to investigate their capacity and long-circulation time. In a cumulative release pattern, doxorubicin (DOX) release from nano-systems was ca. 20% when the particle exposed to acidic media, compared to ca. 5% in basic media. The nano-systems have excellent biocompatibility and are minimally toxic when exposed to MCF-7, and -MCF-7 ADR cells.

TEMPERATURE AND PH RESPONSIVE POLYMERIC NANOPARTICLES FOR TARGETED OXALIPLATIN DELIVERY

INDIAN DRUGS ◽  
2018 ◽  
Vol 55 (11) ◽  
pp. 74-77
Author(s):  
A. S Patil ◽  
◽  
A. P. Gadad
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Targeted Drug Delivery ◽  
Polymeric Nanoparticles ◽  
Ph Responsive ◽  
In Vitro Drug Release ◽  
Dual Responsive ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

In the present study temperature and pH responsive co-polymer chitosan-g-poly(N-isopropylacrylamide) (CS-g-PNIPAAm) was synthesized, characterized and efficiently loaded with oxaliplatin. Nanoparticles were evaluated for their physicochemical properties. The drug loaded nanoparticles showed smooth and spherical morphology with loading efficiency and drug content of about 80.7% and 48.7%, respectively. The in vitro drug release was significantly higher at tumor extracellular pH and temperature when compared to physiological pH and temperature. In conclusion, the developed nanoparticulate system is an effective dual responsive targeted drug delivery system for oxaliplatin with low toxic side effects.

Multifunctional sharp pH-responsive nanoparticles for targeted drug delivery and effective breast cancer therapy

2019 ◽  
Vol 7 (4) ◽  
pp. 576-585 ◽  
Author(s):  
Yandan Yao ◽  
Phei Er Saw ◽  
Yan Nie ◽  
Ping-Pui Wong ◽  
Linjia Jiang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Anticancer Drug ◽  
Targeted Drug Delivery ◽  
Ph Responsive ◽  
Breast Cancer Therapy ◽  
Anticancer Drug Delivery ◽  
Targeted Drug

A new multifunctional pH-responsive NP platform was developed for targeted anticancer drug delivery and effective breast cancer therapy.

scholarly journals Conjugation of a smart polymer to doxorubicin through a pH-responsive bond for targeted drug delivery and improving drug loading on graphene oxide

RSC Advances ◽  
2021 ◽  
Vol 11 (31) ◽  
pp. 18809-18817
Author(s):  
Ali Bina ◽  
Heidar Raissi ◽  
Hassan Hashemzadeh ◽  
Farzaneh Farzad
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Anticancer Drug ◽  
Targeted Drug Delivery ◽  
Polymeric Nanoparticles ◽  
Drug Loading ◽  
Ph Responsive ◽  
Smart Polymer ◽  
Anticancer Drug Delivery ◽  
Targeted Drug

Polymeric nanoparticles have emerged as efficient carriers for anticancer drug delivery because they can improve the solubility of hydrophobic drugs and also can increase the bio-distribution of drugs throughout the bloodstream.

scholarly journals pH-responsive polymeric nanoparticles with tunable sizes for targeted drug delivery

RSC Advances ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 4860-4868 ◽  
Author(s):  
Mengle Kong ◽  
Xinwen Peng ◽  
Hao Cui ◽  
Peiwen Liu ◽  
Bo Pang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Targeted Drug Delivery ◽  
Polymeric Nanoparticles ◽  
Ph Responsive ◽  
Tumor Microenvironments ◽  
Dialdehyde Cellulose ◽  
Targeted Drug

Novel nanoparticles for efficient drug delivery were designed and constructed using polymeric 2,3-dialdehyde cellulose (DAC). The drug DOX was encapsulated into nanoparticles and underwent thoroughly controlled release in acidic tumor microenvironments.

Folic acid functionalized starch encapsulated green synthesized copper oxide nanoparticles for targeted drug delivery in breast cancer therapy

2020 ◽  
Vol 164 ◽  
pp. 2073-2084 ◽  
Author(s):  
Arokia Vijaya Anand Mariadoss ◽  
Kandasamy Saravanakumar ◽  
Anbazhagan Sathiyaseelan ◽  
Karthikkumar Venkatachalam ◽  
Myeong-Hyeon Wang
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Folic Acid ◽  
Cancer Therapy ◽  
Copper Oxide ◽  
Targeted Drug Delivery ◽  
Copper Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Breast Cancer Therapy ◽  
Targeted Drug

Dual Functionalized Janus Nanocomposites for Targeted pH-Responsive Drug Delivery

2014 ◽  
Vol 1625 ◽  
Author(s):  
Feng Wang ◽  
Giovanni Pauletti ◽  
Yilong Wang ◽  
Donglu Shi
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Functional Groups ◽  
Targeted Drug Delivery ◽  
Medical Diagnosis ◽  
Diagnosis And Treatment ◽  
Release Mechanism ◽  
Ph Responsive ◽  
Targeted Drug

ABSTRACTA superparamagnetic Janus nanocomposite (SJNC) of polystyrene/Fe3O4@SiO2 was designed and developed with dual surface bearing functional groups for medical diagnosis and treatment. Folic acid (FA) and doxorubicin (DOX) were conjugated stepwise to the surfaces. SJNCs were found to enable simultaneous cell-targeted drug delivery via pH-responsive release mechanism.

Lipid-based Nanoplatforms in Cancer Therapy: Recent Advances and Applications

2020 ◽  
Vol 20 (4) ◽  
pp. 271-287 ◽  
Author(s):  
Kuldeep Rajpoot
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Adverse Effects ◽  
Targeted Drug Delivery ◽  
Tumor Therapy ◽  
Cancer Therapies ◽  
Medication Delivery ◽  
Lipid Nanocarriers ◽  
Targeted Drug ◽  
Drug Nanocarriers

Though modern available cancer therapies are effective, they possess major adverse effects, causing non-compliance to patients. Furthermore, the majority of the polymeric-based medication platforms are certainly not universally acceptable, due to their several restrictions. With this juxtaposition, lipid-based medication delivery systems have appeared as promising drug nanocarriers to replace the majority of the polymer-based products because they are in a position to reverse polymer as well as, drug-associated restrictions. Furthermore, the amalgamation of the basic principle of nanotechnology in designing lipid nanocarriers, which are the latest form of lipid carriers, has tremendous chemotherapeutic possibilities as tumor-targeted drug-delivery pertaining to tumor therapy. Apart from this, it is reported that nearly 40% of the modern medication entities are lipophilic. Moreover, research continues to be efficient in attaining a significant understanding of the absorption and bioavailability of the developed lipids systems.

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