scholarly journals Gemcitabine-Loaded Magnetically Responsive Poly(ε-caprolactone) Nanoparticles against Breast Cancer

Polymers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 2790
Author(s):  
Gracia García-García ◽  
Fátima Fernández-Álvarez ◽  
Laura Cabeza ◽  
Ángel V. Delgado ◽  
Consolación Melguizo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Loading ◽  
Production Performance ◽  
Solid Matrix ◽  
Complete Analysis ◽  
Core Shell ◽  
Hysteresis Cycle ◽  
Shell Nanoparticles ◽  
Cytotoxicity Studies ◽  
Core Shell Nanoparticles

A reproducible and efficient interfacial polymer disposition method has been used to formulate magnetite/poly(ε-caprolactone) (core/shell) nanoparticles (average size ≈ 125 nm, production performance ≈ 90%). To demonstrate that the iron oxide nuclei were satisfactorily embedded within the polymeric solid matrix, a complete analysis of these nanocomposites by, e.g., electron microscopy visualizations, energy dispersive X-ray spectroscopy, Fourier-transform infrared spectroscopy, electrophoresis, and contact angle goniometry was conducted. The magnetic responsive behaviour of these nanoparticles was quantitatively characterized by the hysteresis cycle and qualitatively investigated by visualization of the colloid under exposure to a 0.4 T magnet. Gemcitabine entrapment into the polymeric shell reported adequate drug loading values (≈11%), and a biphasic and pH-responsive drug release profile (≈four-fold faster Gemcitabine release at pH 5.0 compared to pH 7.4). Cytotoxicity studies in MCF-7 human breast cancer cells proved that the half maximal inhibitory concentration of Gem-loaded nanocomposites was ≈two-fold less than that of the free drug. Therefore, these core/shell nanoparticles could have great possibilities as a magnetically targeted Gemcitabine delivery system for breast cancer treatment.

scholarly journals Controllable Engineering and Functionalizing Nanoparticles with Specific Targeting Capability

2021 ◽  
Author(s):  
Zhanchen Guo ◽  
Rongrong Xing ◽  
Zhen Liu
Keyword(s):  
Breast Cancer ◽  
Biomedical Applications ◽  
High Specificity ◽  
Superparamagnetic Nanoparticles ◽  
Breast Cancer Cell Lines ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Specific Targeting ◽  
Dual Functional ◽  
Core Shell Nanoparticles

Abstract Due to unique properties, nanoparticles been widely used in important biomedical applications such as imaging, drug delivery and disease therapy. Targeting toward specific proteins is essential for the effective utilization of nanoparticles. However, current targeting strategies mainly rely on surface modification with bio-ligands, which often not only fail to provide desired properties but also remain challenging. Here we report an unprecedented approach, called reverse microemulsion-confined epitope-oriented surface imprinting and cladding (ROSIC), for facile, versatile and controllable engineering coreless and core/shell nanoparticles with tunable monodispersed size as well as specific targeting capability towards proteins and peptides. Via engineering coreless imprinted and cladded silica nanoparticles, the effectiveness and superiority over conventional imprinting of the proposed approach was first verified. The prepared nanoparticles exhibited both high specificity and high affinity. Using quantum dots (QDs), superparamagnetic nanoparticles, silver nanoparticles and upconverting nanoparticles as a representative set of core substrates, a variety of dual-functional single-core/shell nanoparticles were then successfully prepared. Finally, selective fluorescence imaging of triple negative breast cancer cells over other breast cancer cell lines using QD-cored nanoparticles was achieved, which well demonstrated the potential of the prepared core/shell nanoparticles in biomedical applications. Thus, this approach opened a new avenue to engineering and functionalization of advanced nanoparticles with targeting capability, holding great prospects in biomedical applications.

Synergistic inhibition of breast cancer by co-delivery of VEGF siRNA and paclitaxel via vapreotide-modified core–shell nanoparticles

Biomaterials ◽  
2014 ◽  
Vol 35 (18) ◽  
pp. 5028-5038 ◽  
Author(s):  
Qiang Feng ◽  
Min-Zhi Yu ◽  
Jian-Cheng Wang ◽  
Wen-Jie Hou ◽  
Ling-Yan Gao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Synergistic Inhibition ◽  
Core Shell Nanoparticles

scholarly journals Brinzolamide loaded core-shell nanoparticles for enhanced coronial penetration in the treatment of glaucoma

2020 ◽  
Vol 18 ◽  
pp. 228080002094271
Author(s):  
Jing Song ◽  
Ziping Zhang
Keyword(s):  
Glycolic Acid ◽  
Neurodegenerative Disorder ◽  
Treatment Strategies ◽  
Entrapment Efficiency ◽  
Single Step ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Cytotoxicity Studies ◽  
Electrospray Process ◽  
Core Shell Nanoparticles

A neurodegenerative disorder, glaucoma is a leading cause of blindness in the world. The conventional treatment strategies do not allow the significant penetration of the drug in the cornea. Therefore, we prepare a brinzolamide (Brz) loaded core-shell nanoparticles (NPs) to enhance the coronial penetration of the drug and thus treating the glaucoma. The shell of the NPs was composed of phosphatidylserine (PS; 1,2-diacyl-sn-glycero-3-phospho-L-serine), whereas the core of the NPs contains the Brz encapsulated in brinzolamide–phosphatidylserine–polymer poly-(DL-lactic acid-co-glycolic acid)–phosphatidylserine (Brz-PS-PLGA). The synthesis of Brz-PS-PLGA was achieved by using a coaxial electrospray process (CEP), which allows the preparation of the particles in a single step. The size of Brz-PS-PLGA with PS shell and brinzolamide–poly (lactic-co-glycolic) acid (Brz-PLGA) without shell was 571 ± 27.02 nm and 456 ± 19.17 nm, respectively. The charges on the surface of Brz-PS-PLGA and Brz-PLGA were (-) 27.45 ± 2.98 mV and (-) 19.47 ± 2.83 mV. The transmission electron microscopy images clearly reveal the PS shell as a light black layer over the dark black PLGA core. The CEP allows the high encapsulation of Brz in Brz-PS-PLGA where percentage of entrapment efficiency for Brz-PS-PLGA was 88.13 ± 6.43%. The release study conducted in a simulated tear fluid revealed the sustained release patterns of Brz from Brz-PS-PLGA and these were nontoxic to the cells as revealed by the cytotoxicity studies. Further, the Brz-PS-PLGA enhanced the coronial penetration of Brz and was capable of significantly reducing the intraocular pressure (IOP) after administration to the rabbit eye in comparison to the Brz-PLGA and free Brz. The results clearly suggest that the PS coating significantly enhances the capability of the particles in reducing IOP.

scholarly journals Functional responsive superparamagnetic core/shell nanoparticles and their drug release properties

RSC Advances ◽  
2017 ◽  
Vol 7 (42) ◽  
pp. 26243-26249 ◽  
Author(s):  
Zied Ferjaoui ◽  
Raphaël Schneider ◽  
Abdelaziz Meftah ◽  
Eric Gaffet ◽  
Halima Alem
Keyword(s):  
Folic Acid ◽  
Iron Oxide ◽  
Drug Release ◽  
Drug Loading ◽  
Superparamagnetic Iron Oxide ◽  
Cancer Drug ◽  
Oxide Nanoparticles ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles

Folic acid functionalized responsive core/shell superparamagnetic iron oxide nanoparticles were successfully synthesized for further application in cancer therapy. Their cancer drug loading and release performances were demonstrated.

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