Phyto and hydrothermal synthesis of Fe3O4@ZnO core-shell nanoparticles using Azadirachta indica and its cytotoxicity studies

2018 ◽  
Vol 449 ◽  
pp. 584-590 ◽  
Author(s):  
V. Madhubala ◽  
T. Kalaivani
Keyword(s):  
Hydrothermal Synthesis ◽  
Azadirachta Indica ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Cytotoxicity Studies ◽  
Core Shell Nanoparticles

scholarly journals Gemcitabine-Loaded Magnetically Responsive Poly(ε-caprolactone) Nanoparticles against Breast Cancer

Polymers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 2790
Author(s):  
Gracia García-García ◽  
Fátima Fernández-Álvarez ◽  
Laura Cabeza ◽  
Ángel V. Delgado ◽  
Consolación Melguizo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Loading ◽  
Production Performance ◽  
Solid Matrix ◽  
Complete Analysis ◽  
Core Shell ◽  
Hysteresis Cycle ◽  
Shell Nanoparticles ◽  
Cytotoxicity Studies ◽  
Core Shell Nanoparticles

A reproducible and efficient interfacial polymer disposition method has been used to formulate magnetite/poly(ε-caprolactone) (core/shell) nanoparticles (average size ≈ 125 nm, production performance ≈ 90%). To demonstrate that the iron oxide nuclei were satisfactorily embedded within the polymeric solid matrix, a complete analysis of these nanocomposites by, e.g., electron microscopy visualizations, energy dispersive X-ray spectroscopy, Fourier-transform infrared spectroscopy, electrophoresis, and contact angle goniometry was conducted. The magnetic responsive behaviour of these nanoparticles was quantitatively characterized by the hysteresis cycle and qualitatively investigated by visualization of the colloid under exposure to a 0.4 T magnet. Gemcitabine entrapment into the polymeric shell reported adequate drug loading values (≈11%), and a biphasic and pH-responsive drug release profile (≈four-fold faster Gemcitabine release at pH 5.0 compared to pH 7.4). Cytotoxicity studies in MCF-7 human breast cancer cells proved that the half maximal inhibitory concentration of Gem-loaded nanocomposites was ≈two-fold less than that of the free drug. Therefore, these core/shell nanoparticles could have great possibilities as a magnetically targeted Gemcitabine delivery system for breast cancer treatment.

scholarly journals Brinzolamide loaded core-shell nanoparticles for enhanced coronial penetration in the treatment of glaucoma

2020 ◽  
Vol 18 ◽  
pp. 228080002094271
Author(s):  
Jing Song ◽  
Ziping Zhang
Keyword(s):  
Glycolic Acid ◽  
Neurodegenerative Disorder ◽  
Treatment Strategies ◽  
Entrapment Efficiency ◽  
Single Step ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Cytotoxicity Studies ◽  
Electrospray Process ◽  
Core Shell Nanoparticles

A neurodegenerative disorder, glaucoma is a leading cause of blindness in the world. The conventional treatment strategies do not allow the significant penetration of the drug in the cornea. Therefore, we prepare a brinzolamide (Brz) loaded core-shell nanoparticles (NPs) to enhance the coronial penetration of the drug and thus treating the glaucoma. The shell of the NPs was composed of phosphatidylserine (PS; 1,2-diacyl-sn-glycero-3-phospho-L-serine), whereas the core of the NPs contains the Brz encapsulated in brinzolamide–phosphatidylserine–polymer poly-(DL-lactic acid-co-glycolic acid)–phosphatidylserine (Brz-PS-PLGA). The synthesis of Brz-PS-PLGA was achieved by using a coaxial electrospray process (CEP), which allows the preparation of the particles in a single step. The size of Brz-PS-PLGA with PS shell and brinzolamide–poly (lactic-co-glycolic) acid (Brz-PLGA) without shell was 571 ± 27.02 nm and 456 ± 19.17 nm, respectively. The charges on the surface of Brz-PS-PLGA and Brz-PLGA were (-) 27.45 ± 2.98 mV and (-) 19.47 ± 2.83 mV. The transmission electron microscopy images clearly reveal the PS shell as a light black layer over the dark black PLGA core. The CEP allows the high encapsulation of Brz in Brz-PS-PLGA where percentage of entrapment efficiency for Brz-PS-PLGA was 88.13 ± 6.43%. The release study conducted in a simulated tear fluid revealed the sustained release patterns of Brz from Brz-PS-PLGA and these were nontoxic to the cells as revealed by the cytotoxicity studies. Further, the Brz-PS-PLGA enhanced the coronial penetration of Brz and was capable of significantly reducing the intraocular pressure (IOP) after administration to the rabbit eye in comparison to the Brz-PLGA and free Brz. The results clearly suggest that the PS coating significantly enhances the capability of the particles in reducing IOP.

Hydrothermal synthesis of Ag@MSiO2@Ag three core–shell nanoparticles and their sensitive and stable SERS properties

Nanoscale ◽  
2016 ◽  
Vol 8 (9) ◽  
pp. 4908-4914 ◽  
Author(s):  
Tao Jiang ◽  
Xiaolong Wang ◽  
Jun Zhou ◽  
Dong Chen ◽  
Ziqi Zhao
Keyword(s):  
Hydrothermal Synthesis ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles

Preparation and Electrocatalytic Performance of Thin-shell Ni/Pt Core-shell Nanoparticles

2012 ◽  
Vol 27 (1) ◽  
pp. 95-101
Author(s):  
Shi-Bin LIU ◽  
Chun-Ying YANG ◽  
Zhong-Lin ZHANG ◽  
Dong-Hong DUAN ◽  
Xiao-Gang HAO ◽  
...  
Keyword(s):  
Thin Shell ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Electrocatalytic Performance ◽  
Core Shell Nanoparticles

Pluronic-Based Core/Shell Nanoparticles for Drug Delivery and Diagnosis

2013 ◽  
Vol 20 (28) ◽  
pp. 3488-3499 ◽  
Author(s):  
Yon Jung ◽  
Hwanbum Lee ◽  
Jae Kim ◽  
Eun Koo ◽  
Keun Oh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles

Colorimetric and SERS dual-mode sensing of mercury (II) based on controllable etching of Au@Ag core/shell nanoparticles

2021 ◽  
Vol 330 ◽  
pp. 129364
Author(s):  
Jinhua Wang ◽  
Jiamin Wu ◽  
Yuping Zhang ◽  
Xia Zhou ◽  
Ziwei Hu ◽  
...  
Keyword(s):  
Core Shell ◽  
Dual Mode ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles
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