scholarly journals Shape Memory Polymer Foams Synthesized Using Glycerol and Hexanetriol for Enhanced Degradation Resistance

Polymers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2290
Author(s):  
Sayyeda Marziya Hasan ◽  
Grace K. Fletcher ◽  
Mary Beth Browning Monroe ◽  
Mark A. Wierzbicki ◽  
Landon D. Nash ◽  
...  
Keyword(s):  
Shape Memory ◽  
Shape Memory Polymer ◽  
Polymer System ◽  
Vascular Occlusion ◽  
Superior Performance ◽  
Polymer Foams ◽  
Polymer Foam ◽  
Shape Memory Behavior ◽  
Wide Range

Shape memory polymer foams have been used in a wide range of medical applications, including, but not limited to, vessel occlusion and aneurysm treatment. This unique polymer system has been proven to shape-fill a void, which makes it useful for occlusion applications. While the shape memory polymer foam has superior performance and healing outcomes compared to its leading competitors, some device applications may benefit from longer material degradation times, or degradation-resistant formulations with increased fibrous encapsulation. In this study, biostable shape memory polymer foams were synthesized, and their physical and chemical properties were characterized as an initial evaluation of feasibility for vascular occlusion applications. After characterizing their shape memory behavior in an aqueous environment, degradation of this polymer system was studied in vitro using accelerated oxidative and hydrolytic solutions. Results indicated that the foams did not lose mass under oxidative or hydrolytic conditions, and they maintained high shape recovery in aqueous in vitro models. These degradation-resistant systems have potential for use in vascular occlusion and other wound healing applications that benefit from permanent, space-filling shape memory behavior.

scholarly journals In vitro performance of a shape memory polymer foam-coated coil embolization device

2017 ◽  
Vol 49 ◽  
pp. 56-62 ◽  
Author(s):  
Anthony J. Boyle ◽  
Mark A. Wierzbicki ◽  
Scott Herting ◽  
Andrew C. Weems ◽  
Adam Nathan ◽  
...  
Keyword(s):  
Shape Memory ◽  
Coil Embolization ◽  
Shape Memory Polymer ◽  
Polymer Foam ◽  
Shape Memory Polymer Foam ◽  
In Vitro Performance

Characterization of shape memory polymer foam hemostats in in vitro hemorrhagic wound models

2020 ◽  
Author(s):  
Nakira Christmas ◽  
Anand Utpal Vakil ◽  
Christopher J. Hatch ◽  
Shi Dong ◽  
David Fikhman ◽  
...  
Keyword(s):  
Shape Memory ◽  
Shape Memory Polymer ◽  
Polymer Foam ◽  
Shape Memory Polymer Foam

scholarly journals Biostable Shape Memory Polymer Foams for Smart Biomaterial Applications

Polymers ◽  
2021 ◽  
Vol 13 (23) ◽  
pp. 4084
Author(s):  
Anand Utpal Vakil ◽  
Natalie Marie Petryk ◽  
Ellen Shepherd ◽  
Mary Beth B. Monroe
Keyword(s):  
Shape Memory ◽  
Shape Memory Polymer ◽  
Time Frame ◽  
Biological Properties ◽  
Polyurethane Foams ◽  
Physical Chemical ◽  
Degradation Rates ◽  
Wide Range ◽  
Key Parameter

Polyurethane foams provide a wide range of applications as a biomaterial system due to the ability to tune their physical, chemical, and biological properties to meet the requirements of the intended applications. Another key parameter that determines the usability of this biomaterial is its degradability under body conditions. Several current approaches focus on slowing the degradation rate for applications that require the implant to be present for a longer time frame (over 100 days). Here, biostable shape memory polymer (SMP) foams were synthesized with added ether-containing monomers to tune the degradation rates. The physical, thermal and shape memory properties of these foams were characterized along with their cytocompatibility and blood interactions. Degradation profiles were assessed in vitro in oxidative (3% H2O2; real-time) and hydrolytic media (0.1 M NaOH; accelerated) at 37 °C. The resulting foams had tunable degradation rates, with up 15% mass remaining after 108 days, and controlled erosion profiles. These easy-to-use, shape-filling SMP foams have the potential for various biomaterial applications where longer-term stability without the need for implant removal is desired.

scholarly journals Enhanced X-ray Visibility of Shape Memory Polymer Foam Using Iodine Motifs and Tantalum Microparticles

2021 ◽  
Vol 5 (1) ◽  
pp. 14
Author(s):  
Lindy K. Jang ◽  
Landon D. Nash ◽  
Grace K. Fletcher ◽  
Thomas Cheung ◽  
Andrew Soewito ◽  
...  
Keyword(s):  
Shape Memory ◽  
Shape Memory Polymer ◽  
High Surface ◽  
High Surface Area ◽  
Polymer Foam ◽  
Brain Aneurysm ◽  
X Ray ◽  
Safe Delivery ◽  
Aneurysm Embolization

Shape memory polymer (SMP) foams are porous materials with high surface area and large volumetric expansion capabilities that are well suited for endovascular occlusion applications, including brain aneurysm embolization. However, many polyurethane SMP foams are inherently radiolucent when X-ray visibility is required to ensure the safe delivery of the foam to the targeted aneurysm site using fluoroscopy. Here, highly radio-dense tantalum microparticles were added to a previously reported triiodobenzene-containing SMP foam (ATIPA foam) premix to fabricate ATIPA foam-tantalum composites (AT_T). The AT_T foams showed comparable glass transition temperatures, faster expansion profiles, increased X-ray visibility, good cytocompatibility, and faster oxidative degradation compared to the control ATIPA foam without tantalum. The mechanical properties were improved up to 4 vol% tantalum and the X-ray visibility was most appropriate for the 2 vol% (AT_2%T) and 4 vol% (AT_4%T) tantalum foams. E-beam sterilization did not impair the critical properties of the ATIPA foams. Overall, AT_2%T was the optimal foam composition for neurovascular prototypes due to its high oxidative stability in vitro compared to previous low-density SMP foams. The AT_T foams are very promising materials with high toughness and sufficient X-ray visibility for use as neurovascular embolization devices.

scholarly journals Reticulation of low density shape memory polymer foam with an in vivo demonstration of vascular occlusion

2014 ◽  
Vol 40 ◽  
pp. 102-114 ◽  
Author(s):  
Jennifer N. Rodriguez ◽  
Matthew W. Miller ◽  
Anthony Boyle ◽  
John Horn ◽  
Cheng-Kang Yang ◽  
...  
Keyword(s):  
Shape Memory ◽  
Shape Memory Polymer ◽  
Vascular Occlusion ◽  
Low Density ◽  
Polymer Foam ◽  
Shape Memory Polymer Foam

Controlling the Physical Properties of Random Network Based Shape Memory Polymer Foams

2010 ◽  
Vol 1274 ◽  
Author(s):  
Pooja Singhal ◽  
Thomas S Wilson ◽  
Duncan J Maitland
Keyword(s):  
Shape Memory ◽  
Random Network ◽  
Shape Memory Polymer ◽  
Shape Memory Polymers ◽  
Low Density ◽  
Polymer Foams ◽  
Glass Transitions ◽  
Shape Memory Behavior ◽  
Monomer Composition ◽  
Implanted Devices

AbstractShape memory polymers (SMPs) are increasingly being considered for use in minimally invasive medical devices. For safe deployment of implanted devices it is important to be able to precisely control the actuation temperature of the device. In this study we report the effect of varying monomer composition on the glass transitions/actuation temperatures (Tg) of novel low density shape memory foams. The foams were based on hexamethylenediisocyanate (HDI), triethanolamine (TEA) and tetrakis (2-hydroxyl propyl) ethylenediamine (HPED), and were produced via a combination of chemical and physical blowing process. The process for post-foaming cleaning was also varied. Foams were characterized by DSC, DMA, and for shape memory. No clear trends were observed for foam samples without cleaning, and this was attributed to process chemicals acting as plasticizers. In foams cleaned via washing and/or sonication, the Tg was observed to decrease for compositions that were higher in the TEA content. Also, no change in shape memory behavior was observed for varying compositions. This work demonstrates the ability to tailor actuation transition temperature while maintaining shape memory behavior for low density foams suitable for aneurysm treatment.

Shape Memory Polymer Foam With Tunable Properties for Treatment of Intracranial Aneurysm

2020 ◽  
Author(s):  
Sergio A. Pineda-Castillo ◽  
Jishan Luo ◽  
Bradley N. Bohnstedt ◽  
Chung-Hao Lee ◽  
Yingtao Liu
Keyword(s):  
Shape Memory ◽  
Intracranial Aneurysms ◽  
Shape Memory Polymer ◽  
Specific Treatment ◽  
Mass Effect ◽  
Patient Specific ◽  
Polymer Foam ◽  
Composite Foams ◽  
Incomplete Occlusion

Abstract Intracranial aneurysms have the potential to be fatal; when detected, they must be treated promptly by surgical clipping or by endovascular methods. The latter, while having better long-term overall survival than the former, fail to provide complete occlusion of the aneurysm lumen, creating risks for therapy-related adverse events, such as embolic device migration or recanalization. Polyurethane shape memory polymers (SMPs) have the potential to provide patient-specific treatment to reduce rates of incomplete occlusion and mass effect. In this study, SMP matrices are infiltrated with carbon nanotubes (CNTs) to induce electrical conductivity and provide a precise triggering method for deployment of the embolic device. Through thermomechanical characterization of the composite, it was determined that CNTs play a significant role in resistivity of the SMP foam and its ultimate shape recovery properties. Cyclic mechanical testing allowed to determine that CNTs might induce polymeric matrix damage, creating the need for new approaches to CNT infiltration. The studied composite foams were able to occlude an in vitro idealized aneurysm phantom model, which allowed to conclude that the proposed CNT-infiltrated SMP foams exhibit potential as biomedical devices for endovascular therapy of intracranial aneurysms.

A Novel Versatile Process for the Production of Polymer Foams

1998 ◽  
Vol 550 ◽  
Author(s):  
V.P. Shastri ◽  
I. Martin ◽  
R. Langer
Keyword(s):  
Water Soluble ◽  
Wound Dressings ◽  
High Porosity ◽  
Polymer Foams ◽  
Polymer Foam ◽  
Water Soluble Polymers ◽  
Soluble Polymers ◽  
Great Utility ◽  
Wide Range ◽  
Short Time

AbstractPorous polymeric media are used in several applications such as solid supports for separations and catalysis, as well as biomedical applications such as vascular grafts and wound dressings. We have developed a novel versatile process to produce polymeric cellular solids. This process which is based on a phase extraction-co-polymer precipitation is applicable to a wide range of polymer systems including water soluble polymers. It is capable of yielding polymer foams of high porosity (> 90%) and excellent mechanical characteristics in a very short time (less than 2 hours) without limitations in foam thickness. Polymer foam with such characteristics have great utility in tissue engineering applications. We have successfully explored polymer foams of biocompatible polymers produced by the presented approach for bone and cartilage engineering using bone marrow stromal cells.

scholarly journals Cover Feature: Multifunctional Shape-Memory Polymer Foams with Bio-inspired Antimicrobials (ChemPhysChem 16/2018)

ChemPhysChem ◽  
2018 ◽  
Vol 19 (16) ◽  
pp. 1936-1936
Author(s):  
Mary Beth Browning Monroe ◽  
Alexandra D. Easley ◽  
Katie Grant ◽  
Grace K. Fletcher ◽  
Calla Boyer ◽  
...  
Keyword(s):  
Shape Memory ◽  
Shape Memory Polymer ◽  
Polymer Foams
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