scholarly journals Acrylic Bone Cement Incorporated with Low Chitosan Loadings

Polymers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1617 ◽  
Author(s):  
Mayra Eliana Valencia Zapata ◽  
José Herminsul Mina Hernandez ◽  
Carlos David Grande Tovar
Keyword(s):  
Bone Cement ◽  
Weight Bearing ◽  
Setting Time ◽  
Acrylic Bone Cement ◽  
Residual Monomer ◽  
Water Contact ◽  
Bending Modulus ◽  
Wide Range ◽  
Monomer Content

Despite the potential of acrylic bone cement (ABC) loaded with chitosan (CS) for orthopedic applications, there are only a few in vitro studies of this composite with CS loading ≤ 15 wt.% evaluated in bioactivity tests in simulated body fluid (SBF) for duration > 30 days. The purpose of the present work was to address this shortcoming of the literature. In addition to bioactivity, a wide range of cement properties were determined for composites with CS loading ranging from 0 to 20 wt.%. These properties included maximum exotherm temperature (Tmax), setting time (tset), water contact angle, residual monomer content, flexural strength, bending modulus, glass transition temperature, and water uptake. For cement with CS loading ≥ 15 wt.%, there was an increase in bioactivity, increase in biocompatibility, decrease in Tmax, increase in tset, all of which are desirable trends, but increase in residual monomer content and decrease in each of the mechanical properties, with each of these trends, were undesirable. Thus, a composite with CS loading of 15 wt.% should be further characterized to explore its suitability for use in low-weight-bearing applications, such as bone void filler and balloon kyphoplasty.

Effect of test frequency on the in vitro fatigue life of acrylic bone cement

Biomaterials ◽  
2003 ◽  
Vol 24 (6) ◽  
pp. 1111-1117 ◽  
Author(s):  
Gladius Lewis ◽  
Si Janna ◽  
Michael Carroll
Keyword(s):  
Fatigue Life ◽  
Bone Cement ◽  
Acrylic Bone Cement ◽  
Test Frequency

scholarly journals Diffusion of antibiotics from acrylic bone-cement in vitro

1977 ◽  
Vol 59-B (2) ◽  
pp. 197-199 ◽  
Author(s):  
J Hill ◽  
L Klenerman ◽  
S Trustey ◽  
R Blowers
Keyword(s):  
Bone Cement ◽  
Acrylic Bone Cement

scholarly journals In vitro study of elution kinetics and bio-activity of meropenem-loaded acrylic bone cement

2012 ◽  
Vol 13 (3) ◽  
pp. 131-136 ◽  
Author(s):  
Sumant Samuel ◽  
Binu S. Mathew ◽  
Balaji Veeraraghavan ◽  
Denise H. Fleming ◽  
Samuel B. Chittaranjan ◽  
...  
Keyword(s):  
Bone Cement ◽  
In Vitro Study ◽  
Vitro Study ◽  
Acrylic Bone Cement

scholarly journals Enhanced osteointegration of poly(methylmethacrylate) bone cements by incorporating strontium-containing borate bioactive glass

2017 ◽  
Vol 14 (131) ◽  
pp. 20161057 ◽  
Author(s):  
Xu Cui ◽  
Chengcheng Huang ◽  
Meng Zhang ◽  
Changshun Ruan ◽  
Songlin Peng ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Bone Cement ◽  
Setting Time ◽  
Composite Cement ◽  
Collagen Secretion ◽  
Pmma Bone Cement ◽  
Borate Bioactive Glass ◽  
Composite Cements ◽  
Pmma Cement

Although poly(methylmethacrylate) (PMMA) cements are widely used in orthopaedics, they have numerous drawbacks. This study aimed to improve their bioactivity and osseointegration by incorporating strontium-containing borate bioactive glass (SrBG) as the reinforcement phase and bioactive filler of PMMA cement. The prepared SrBG/PMMA composite cements showed significantly decreased polymerization temperature when compared with PMMA and retained properties of appropriate setting time and high mechanical strength. The bioactivity of SrBG/PMMA composite cements was confirmed in vitro , evidenced by ion release (Ca, P, B and Sr) from SrBG particles. The cellular responses of MC3T3-E1 cells in vitro demonstrated that SrBG incorporation could promote adhesion, migration, proliferation and collagen secretion of cells. Furthermore, our in vivo investigation revealed that SrBG/PMMA composite cements presented better osseointegration than PMMA bone cement. SrBG in the composite cement could stimulate new-bone formation around the interface between the composite cement and host bone at eight and 12 weeks post-implantation, whereas PMMA bone cement only stimulated development of an intervening connective tissue layer. Consequently, the SrBG/PMMA composite cement may be a better alternative to PMMA cement in clinical applications and has promising orthopaedic applications by minimal invasive surgery.

Radiopaque acrylic bone cement with bromine-containing acrylic monomer. II

e-Polymers ◽  
2009 ◽  
Vol 9 (1) ◽  
Author(s):  
Marius Ciprian Rusu ◽  
Ionut Cameliu Ichim ◽  
Marcel Popa ◽  
Daniela Rusu ◽  
Mihai Rusu
Keyword(s):  
Thermal Stability ◽  
Compressive Strength ◽  
Glass Transition ◽  
Thermal Properties ◽  
Transition Temperature ◽  
Bone Cement ◽  
Setting Time ◽  
Maximum Temperature ◽  
Acrylic Bone Cement ◽  
Compression Tests

AbstractBromine-containing methacrylate, 2-(2-bromoisobutyryloxy) ethyl methacrylate (BIEM), had been used in the formulation of acrylic radiopaque cements. The effect of this monomer incorporated into the liquid phase of acrylic bone cement (ABC), on the curing parameters, thermal properties, water absorption, density, compression tests and radiopacity was studied. A decrease of maximum temperature and an increase of the setting time were observed with the addition of the brominecontaining monomer in the radiolucent cement composition. Adding BIEM in radiolucent ABCs composition results in the decrease of glass transition temperature and increase in its thermal stability. The ABCs modified with bromine-containing comonomer are characterized by polymerization shrinkage lower than the radiolucent cement. Addition of bromine-containing comonomer in radiolucent ABC composition determines the increase of compressive strength. The ABCs modified with brominecontaining comonomer proved to be radiopaque.

Incorporation of large amounts of gentamicin sulphate into acrylic bone cement: Effect on handling and mechanical properties, antibiotic release, and biofilm formation

2008 ◽  
Vol 222 (3) ◽  
pp. 355-365 ◽  
Author(s):  
N J Dunne ◽  
J Hill ◽  
P McAfee ◽  
R Kirkpatrick ◽  
S Patrick ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Methyl Methacrylate ◽  
Bone Cement ◽  
Revision Surgery ◽  
Biofilm Formation ◽  
Acrylic Bone Cement ◽  
Cement Powder ◽  
Gentamicin Sulphate ◽  
Staphylococcus Spp

Bacterial infection remains a significant complication following total joint replacement. If infection is suspected when revision surgery is being performed, a large dose of antibiotic, usually gentamicin sulphate, is often blended with the acrylic bone cement powder in an attempt to reduce the risk of recurrent infection. In this in-vitro study the effect of small and large doses of gentamicin sulphate on the handling and mechanical properties of the cement, gentamicin release from the cement, and in-vitro biofilm formation by clinical Staphylococcus spp. isolates on the cement was determined. An increase in gentamicin loading of 1, 2, 3, or 4 g, in a cement powder mass of 40 g, resulted in a significant decrease in the compressive and four-point bending strength, but a significant increase in the amount of gentamicin released over a 72 h period. When overt infection was modelled, using Staphylococcus spp. clinical isolates at an inoculum of 1×107 colony-forming units/ml, an increase in the amount of gentamicin (1, 2, 3, or 4 g) added to 40 g of poly(methyl methacrylate) cement resulted in an initial decrease in bacterial colonization but this beneficial effect was no longer apparent by 72 h, with the bacterial strains forming biofilms on the cements despite the release of high levels of gentamicin. The findings suggest that orthopaedic surgeons should carefully consider the clinical consequences of blending large doses (1 g or more per 40 g of poly(methyl methacrylate)) of gentamicin into Palacos® R bone cement for use in revision surgery as the increased gentamicin loading does not prevent bacterial biofilm formation and the effect on the mechanical properties could be important to the longevity of the prosthetic joint.

scholarly journals Investigation of Biological Activity, Open Porosity and Water Absorption of Ternary Polymeric Blend (Polymethylmethacrylate / Starch) used for Bone Scaffold

2019 ◽  
Vol 42 (2) ◽  
pp. 82-89
Author(s):  
Sihama I. Salih ◽  
Sally A. Al-Saedi
Keyword(s):  
Biological Activity ◽  
Water Absorption ◽  
Bone Cement ◽  
Open Porosity ◽  
Weight Fraction ◽  
Bone Scaffold ◽  
Acrylic Bone Cement ◽  
Weight Percentage ◽  
Gram Positive Bacteria

In this study a fabrication of three groups of biological system for bone scaffold, which consist of first group samples (Acrylic bone cement: % X poly methyl meth acrylate ), second group samples (poly methyl meth acrylate: % X Acrylic bone cement), with selected weight percentages of second material are (5, 10,15 and 20 % wt.) and third group, (Acrylic bone cement: 15 % poly methyl meth acrylate : % X starch) with selected weight percentage ratios of starch are (2, 4 and 6 %wt.). In vitro biological activity and water absorption have been studied. The results clarified that the in vitro biological activity test showed that all fabricated samples have no biological influence on the gram positive bacteria Bacillus subtilis and gram negative bacteria Escherichia coli . The results show that the first group of polymer blend have low open porosity and water uptake capacity than a second group. The increasing in starch weight fraction for the third group led to increasing in open porosity and water absorption..

Sign in / Sign up

Export Citation Format

Share Document