In vitro evaluation of antibiotic release from and bacteria growth inhibition by antibiotic-loaded acrylic bone cement spacers

2005 ◽  
Vol 72B (2) ◽  
pp. 373-378 ◽  
Author(s):  
Konstantinos Anagnostakos ◽  
Jens Kelm ◽  
Thilo Regitz ◽  
Eduard Schmitt ◽  
Werner Jung
Keyword(s):  
Growth Inhibition ◽  
Bone Cement ◽  
Acrylic Bone Cement ◽  
In Vitro Evaluation ◽  
Bacteria Growth ◽  
Antibiotic Release

scholarly journals Influence of Antibiotic-Loaded Acrylic Bone Cement Composition on Drug Release Behavior and Mechanism

Polymers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 2240
Author(s):  
I-Cheng Chen ◽  
Chen-Ying Su ◽  
Wei-Han Nien ◽  
Tzu-Tien Huang ◽  
Chang-Hung Huang ◽  
...  
Keyword(s):  
Infection Control ◽  
Bone Cement ◽  
Joint Replacement ◽  
Total Joint Replacement ◽  
Joint Infection ◽  
Acrylic Bone Cement ◽  
Joint Replacement Surgery ◽  
Replacement Surgery ◽  
Antibiotic Release

Periprosthetic joint infection (PJI) is a devastating complication after total joint replacement with considerable morbidity and large economic burdens. Antibiotic-Loaded Bone Cement (ALBC) has been developed as a valuable tool for local administration and is becoming one of the most effective methods for the prevention and treatment of orthopedic infections. Controlling antibiotic release from ALBC is critical to achieve effective infection control, however, the antibiotic elution rates are generally low, and the mechanisms are poorly understood. Thus, the present study aims to investigate the effects of the basic acrylic bone cement components, including liquid/powder (monomer-to-polymer) ratios, radiopacifier, initiator, and doses of antibiotics on the porosity, antibiotic elution rates and mechanical properties of polymethylmethacrylate (PMMA) based ALBC. The obtained results from the in vitro studies suggested that a reduction in the liquid/powder ratio and an increase in the radiopacifier ratio and gentamicin doses led to increased porosity and release of antibiotic, while the initiator ratio exerted no effect on elution rates. In conclusion, we hope that by varying the composition of ALBC, we could considerably enhance the antibiotic elution rates by increasing porosity, while maintaining an adequate mechanical strength of the bone cements. This finding might provide insights into controlling antibiotic release from ALBC to achieve effective infection control after total joint replacement surgery.

scholarly journals In vitro evaluation of bacteria growth inhibition by E. coli, S. aureus, E. faecalis

2016 ◽  
Vol 4 ◽  
Author(s):  
Pluta Klaudia ◽  
Malina Dagmara ◽  
Tyliszczak Bozena ◽  
Sobczak-Kupiec Agnieszka
Keyword(s):  
Growth Inhibition ◽  
In Vitro Evaluation ◽  
Bacteria Growth ◽  
E Coli

Effect of test frequency on the in vitro fatigue life of acrylic bone cement

Biomaterials ◽  
2003 ◽  
Vol 24 (6) ◽  
pp. 1111-1117 ◽  
Author(s):  
Gladius Lewis ◽  
Si Janna ◽  
Michael Carroll
Keyword(s):  
Fatigue Life ◽  
Bone Cement ◽  
Acrylic Bone Cement ◽  
Test Frequency

Mechanical Strength and In Vitro Antibiotic Release Profile of Antibiotic-Loaded Calcium Phosphate Bone Cement

2013 ◽  
Vol 24 (4) ◽  
pp. 1447-1450 ◽  
Author(s):  
Yoshiaki Sakamoto ◽  
Hiroko Ochiai ◽  
Ikuko Ohsugi ◽  
Yoshikazu Inoue ◽  
Yohko Yoshimura ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Mechanical Strength ◽  
Bone Cement ◽  
Release Profile ◽  
Calcium Phosphate Bone Cement ◽  
Antibiotic Release

scholarly journals Diffusion of antibiotics from acrylic bone-cement in vitro

1977 ◽  
Vol 59-B (2) ◽  
pp. 197-199 ◽  
Author(s):  
J Hill ◽  
L Klenerman ◽  
S Trustey ◽  
R Blowers
Keyword(s):  
Bone Cement ◽  
Acrylic Bone Cement

scholarly journals In vitro study of elution kinetics and bio-activity of meropenem-loaded acrylic bone cement

2012 ◽  
Vol 13 (3) ◽  
pp. 131-136 ◽  
Author(s):  
Sumant Samuel ◽  
Binu S. Mathew ◽  
Balaji Veeraraghavan ◽  
Denise H. Fleming ◽  
Samuel B. Chittaranjan ◽  
...  
Keyword(s):  
Bone Cement ◽  
In Vitro Study ◽  
Vitro Study ◽  
Acrylic Bone Cement
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