scholarly journals Bioadhesive Matrix Tablets Loaded with Lipophilic Nanoparticles as Vehicles for Drugs for Periodontitis Treatment: Development and Characterization

Polymers ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 1801 ◽  
Author(s):  
Denise Murgia ◽  
Giuseppe Angellotti ◽  
Fabio D’Agostino ◽  
Viviana De Caro
Keyword(s):  
Periodontal Diseases ◽  
Drug Loading ◽  
Average Particle Size ◽  
Spherical Shape ◽  
Matrix Tablets ◽  
Matrix Tablet ◽  
Average Particle ◽  
Glycyrrhetic Acid ◽  
Nanoparticle Dispersion ◽  
Periodontal Pathogens

Periodontitis treatment is usually focused on the reduction or eradication of periodontal pathogens using antibiotics against anaerobic bacteria, such as metronidazole (MTR). Moreover, recently the correlation between periodontal diseases and overexpression of reactive oxygen species (ROS) led to the introduction of antioxidant biomolecules in therapy. In this work, bioadhesive buccal tablets, consisting of a hydrophilic matrix loaded with metronidazole and lipophilic nanoparticles as a vehicle of curcumin, were developed. Curcumin (CUR)-loaded nanostructured lipid carriers (NLC) were prepared using glycyrrhetic acid, hexadecanol, isopropyl palmitate and Tween®80 as a surfactant. As method, homogenization followed by high-frequency sonication was used. After dialysis, CUR-NLC dispersion was evaluated in terms of drug loading (DL, 2.2% w/w) and drug recovery (DR, 88% w/w). NLC, characterized by dynamic light scattering and scanning electron microscopy (SEM), exhibited a spherical shape, an average particle size of 121.6 nm and PDI and PZ values considered optimal for a colloidal nanoparticle dispersion indicating good stability of the system. Subsequently, a hydrophilic sponge was obtained by lyophilization of a gel based on trehalose, Natrosol and PVP-K90, loaded with CUR-NLC and MTR. By compression of the sponge, matrix tablets were obtained and characterized in term of porosity, swelling index, mucoadhesion and drugs release. The ability of the matrix tablets to release CUR and MTR when applied on buccal mucosa and the aptitude of actives to penetrate and/or permeate the tissue were evaluated. The data demonstrate the ability of NLC to promote the penetration of CUR into the lipophilic domains of the mucosal membrane, while MTR can penetrate and permeate the mucosal tissue, where it can perform a loco-regional antibacterial activity. These results strongly support the possibility of using this novel matrix tablet for delivering MTR together with CUR for topical treatment of periodontal diseases.

scholarly journals Biomimetic Growth of Hydroxyapatite on SiO2 Microspheres to Improve Its Biocompatibility and Gentamicin Loading Capacity

Materials ◽  
2021 ◽  
Vol 14 (22) ◽  
pp. 6941
Author(s):  
Alejandra E. Herrera-Alonso ◽  
María C. Ibarra-Alonso ◽  
Sandra C. Esparza-González ◽  
Sofía Estrada-Flores ◽  
Luis A. García-Cerda ◽  
...  
Keyword(s):  
Drug Loading ◽  
Average Particle Size ◽  
Sodium Dodecyl ◽  
Mechanical Damage ◽  
Spherical Shape ◽  
Average Particle ◽  
Loading Capacity ◽  
Bioactive Materials ◽  
Sio2 Microspheres

The interest in multifunctional biomaterials to be implanted are also able to release drugs that reduce pain and inflammation or prevent a possible infection has increased. Bioactive materials such as silica (SiO2) containing surface silanol groups contribute to the nucleation and growth of hydroxyapatite (HAp) in a physiological environment. Regarding biocompatibility, the spherical shape of particles is the desirable one, since it does not cause mechanical damage to the cell membrane. In this work, the synthesis of SiO2 microspheres was performed by the modified Stöber method and they were used for the biomimetic growth of HAp on their surface. The effect of the type of surfactant (sodium dodecyl sulphate (SDS), cetyltrimethylammonium bromide (CTAB), and polyethylene glycol (PEG)), and heat treatment on the morphology and size of SiO2 particles was investigated. Monodisperse, spherical-shaped SiO2 microparticles with an average particle size of 179 nm, were obtained when using PEG (SiO2-PEG). The biomimetic growth of HAp was performed on this sample to improve its biocompatibility and drug-loading capacity using gentamicin as a model drug. Biomimetic growth of HAp was confirmed by FTIR-ATR, SEM-EDX and TEM techniques. SiO2-PEG/HAp sample had a better biocompatibility in vitro and gentamicin loading capacity than SiO2-PEG sample.

scholarly journals Formulation and evaluation of guar gum based matrix tableted glibenclamide microspheres

2020 ◽  
Vol 11 (2) ◽  
pp. 2445-2457
Author(s):  
Prashant Singh ◽  
Ritu M. Gilgotra
Keyword(s):  
Particle Size ◽  
Drug Release ◽  
Guar Gum ◽  
Average Particle Size ◽  
Entrapment Efficiency ◽  
Matrix Tablets ◽  
Matrix Tablet ◽  
Average Particle ◽  
Drug Entrapment Efficiency

The purpose of this investigation is to establish anti-diabetic activity relationship as well as efficiency of formulated guar gum matrix tablet using microencapsulated glibenclamide (GBLD). This research is an approach to utilize pharmaceutical excipients as an alternative hypoglycemic agent. In order to execute the objective, GBLD microspheres were formulated by emulsion solvent evaporation method using dichloromethane and methanol as solvent system which was transferred drop after drop into encapsulating medium i.e. liquid paraffin light. The formulated microspheres were exposed to various assessment parameters like drug entrapment efficiency, % yield, particle size distribution, and average particle size, the morphology of surface, dissolution study (in vitro) and micromeritics of prepared microspheres. By using these microspheres, matrix tablets were then prepared which were further evaluated for weight variation, thickness, friability, hardness, drug content, stability study, disintegration time, swelling index and dissolution (in vitro) studies were carefully carried out. Betwixt all the formulated microspheres GEM3 was found to best optimized with respect to evaluation parameters. The results obtained were found within the desired ranges where % yield 93.75%, drug entrapment efficiency 95.627% at 12th hour, and the average particle size was observed to be 179.4±0.12 µm. Then, by using the method of direct compression matrix tablets of optimized microspheres GEM3 were prepared and drug release (in vitro) was performed. The obtained results of performed parameters on matrix tableted microspheres were within the acceptable range according to IP guidelines. Out of all formulated matrix tableted microspheres, formulation GMT4 and GMT7 showed an in-vitro % drug release of 95.257 and 94.404 at 12th hour in pH 7.4 phosphate buffer. 

Formulating SLN and NLC as Innovative Drug Delivery Systems for Non-Invasive Routes of Drug Administration

2020 ◽  
Vol 27 (22) ◽  
pp. 3623-3656 ◽  
Author(s):  
Bruno Fonseca-Santos ◽  
Patrícia Bento Silva ◽  
Roberta Balansin Rigon ◽  
Mariana Rillo Sato ◽  
Marlus Chorilli
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Drug Release ◽  
Drug Loading ◽  
Average Particle Size ◽  
Delivery Systems ◽  
Average Particle ◽  
Minor Importance ◽  
Routes Of Administration ◽  
Non Invasive

Colloidal carriers diverge depending on their composition, ability to incorporate drugs and applicability, but the common feature is the small average particle size. Among the carriers with the potential nanostructured drug delivery application there are SLN and NLC. These nanostructured systems consist of complex lipids and highly purified mixtures of glycerides having varying particle size. Also, these systems have shown physical stability, protection capacity of unstable drugs, release control ability, excellent tolerability, possibility of vectorization, and no reported production problems related to large-scale. Several production procedures can be applied to achieve high association efficiency between the bioactive and the carrier, depending on the physicochemical properties of both, as well as on the production procedure applied. The whole set of unique advantages such as enhanced drug loading capacity, prevention of drug expulsion, leads to more flexibility for modulation of drug release and makes Lipid-based nanocarriers (LNCs) versatile delivery system for various routes of administration. The route of administration has a significant impact on the therapeutic outcome of a drug. Thus, the non-invasive routes, which were of minor importance as parts of drug delivery in the past, have assumed added importance drugs, proteins, peptides and biopharmaceuticals drug delivery and these include nasal, buccal, vaginal and transdermal routes. The objective of this paper is to present the state of the art concerning the application of the lipid nanocarriers designated for non-invasive routes of administration. In this manner, this review presents an innovative technological platform to develop nanostructured delivery systems with great versatility of application in non-invasive routes of administration and targeting drug release.

Preparation ZnO nanoparticles with Different Concentration by Laser Ablation in Liquid

2021 ◽  
Vol 39 (1B) ◽  
pp. 197-202
Author(s):  
Ghufran S. Jaber ◽  
Khawla S. Khashan ◽  
Maha J. Abbas
Keyword(s):  
Particle Size ◽  
Laser Ablation ◽  
Laser Pulse ◽  
Laser Energy ◽  
Average Particle Size ◽  
Spherical Shape ◽  
Pulse Number ◽  
Average Particle ◽  
Zno Nps ◽  
Laser Ablation In Liquid

The effects of varying laser pulse numbers on the fabricated of ZnONPs by pulsed laser ablation in deionized water of Zn-metal are investigated. The Nd: YAG laser at energy 600mJ prepared three samples by change the laser pulse number (100, 150, and 200). The results were collected and examined using an electron scanning microscope, XRD – diffraction, and transmission electron microscope. The result revealed the colloidal spherical shape and the homogeneous composition of the ZnO NPs. The nanoparticles resulted in different concentrations and sized distributions by changing the pulse number of a laser. The average particle size and the mass concentration of particle size increase with an increasing number of laser pulses by fixed the laser energy.

Enhanced oral bioavailability of nisoldipine-piperine-loaded poly-lactic-co-glycolic acid nanoparticles

2017 ◽  
Vol 6 (6) ◽  
pp. 517-526 ◽  
Author(s):  
Permender Rathee ◽  
Anjoo Kamboj ◽  
Shabir Sidhu
Keyword(s):  
Oral Bioavailability ◽  
Drug Loading ◽  
Average Particle Size ◽  
Entrapment Efficiency ◽  
Pharmacokinetic Interaction ◽  
Precipitation Method ◽  
Pharmacokinetic Studies ◽  
Average Particle

AbstractBackground:Piperine helps in the improvement of bioavailability through pharmacokinetic interaction by modulating metabolism when administered with other drugs. Nisoldipine is a substrate for cytochrome P4503A4 enzymes. The study was undertaken to assess the influence of piperine on the pharmacokinetics and pharmacodynamics of nisoldipine nanoparticles in rats.Methods:Optimization studies of nanoparticles were performed using Taguchi L9 orthogonal array, and the nanoparticles were formulated by the precipitation method. The influence of piperine and nanoparticles was evaluated by means of in vivo kinetic and dynamic studies by oral administration in rats.Results:The entrapment efficiency, drug loading, ζ potential, and average particle size of optimized nisoldipine-piperine nanoparticles was 89.77±1.06%, 13.6±0.56%, −26.5 mV, and 132±7.21 nm, respectively. The in vitro release in 0.1 n HCl and 6.8 pH phosphate buffer was 96.9±0.48% and 98.3±0.26%, respectively. Pharmacokinetic studies showed a 4.9-fold increase in oral bioavailability and a >28.376±1.32% reduction in systemic blood pressure by using nanoparticles as compared to control (nisoldipine suspension) in Wistar rats.Conclusion:The results revealed that piperine being an inhibitor of cytochrome P4503A4 enzymes enhanced the bioavailability of nisoldipine by 4.9-fold in nanoparticles.

scholarly journals Sodium Alginate Nanoparticles of Isoniazid: Preparation and Evaluation

2019 ◽  
Vol 11 (06) ◽  
Author(s):  
Sumit Kumar ◽  
Dinesh Chandra Bhatt
Keyword(s):  
Particle Size ◽  
Sodium Alginate ◽  
Encapsulation Efficiency ◽  
Drug Loading ◽  
Average Particle Size ◽  
Average Particle ◽  
In Vitro Drug Release ◽  
Ionotropic Gelation ◽  
Preparation And Evaluation

Fabrication and evaluation of the Isoniazid loaded sodium alginate nanoparticles (NPs) was main objective of current investigation. These NPs were engineered using ionotropic gelation technique. The NPs fabricated, were evaluated for average particle size, encapsulation efficiency, drug loading, and FTIR spectroscopy along with in vitro drug release. The particle size, drug loading and encapsulation efficiency of fabricated nanoparticles were ranging from 230.7 to 532.1 nm, 5.88% to 11.37% and 30.29% to 59.70% respectively. Amongst all batches studied formulation F-8 showed the best sustained release of drug at the end of 24 hours.

scholarly journals Effect of the polymeric coating over Fe3O4 particles used for magnetic separation

2010 ◽  
Vol 8 (5) ◽  
pp. 1041-1046 ◽  
Author(s):  
Raúl Reza ◽  
Carlos Martínez Pérez ◽  
Claudia Rodríguez González ◽  
Humberto Romero ◽  
Perla García Casillas
Keyword(s):  
Particle Size ◽  
Magnetite Nanoparticles ◽  
Average Particle Size ◽  
Spherical Shape ◽  
Polymeric Coating ◽  
Average Particle ◽  
Synthesis Conditions ◽  
Aging Conditions ◽  
Magnetite Particles ◽  
Average Size

AbstractIn this work, the synthesis of magnetite nanoparticles by two variant chemical coprecipitation methods that involve reflux and aging conditions was investigated. The influence of the synthesis conditions on particle size, morphology, magnetic properties and protein adsorption were studied. The synthesized magnetite nanoparticles showed a spherical shape with an average particle size directly influenced by the synthesis technique. Particles of average size 27 nm and 200 nm were obtained. When the coprecipitation method was used without reflux and aging, the smallest particles were obtained. Magnetite nanoparticles obtained from both methods exhibited a superparamagnetic behavior and their saturation magnetization was particle size dependent. Values of 67 and 78 emu g−1 were obtained for the 27 nm and 200 nm magnetite particles, respectively. The nanoparticles were coated with silica, aminosilane, and silica-aminosilane shell. The influence of the coating on protein absorption was studied using Bovine Serum Albumin (BSA) protein.

Mechanism of Hydrogen Sulfide Drug-Loaded Nanoparticles Promoting the Repair of Spinal Cord Injury in Rats Through Mammalian Target of Rapamycin/Signal Transducer and Activator of Transcription 3 Signaling Pathway

2021 ◽  
Vol 13 (9) ◽  
pp. 1691-1698
Author(s):  
Hongzhe Liu ◽  
Kai Tong ◽  
Ziyi Zhong ◽  
Gang Wang
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Particle Size ◽  
Dispersion Coefficient ◽  
Drug Loading ◽  
Average Particle Size ◽  
Mammalian Target Of Rapamycin ◽  
Average Particle ◽  
Recovery Effect ◽  
Cord Injury

To explore the effect of hydrogen sulfide (H2S) drug-loaded nanoparticles (H2S-NPs) on the mTOR/STAT3 signaling pathway in rats and its mechanism on repair of spinal cord injury (SCI), a new H2S-NP (G16MPG-ADT) was prepared and synthesized. The rats were selected as the research objects to explore the mechanism of SCI repair. The G16MPG-ADT NPs were evaluated by average particle size (APS), dispersion coefficient (DC), drug loading content (DLC), drug loading efficacy (DLE), in vitro release (IV-R), and acute toxicity (AT). It was found that G16MPG-ADT nanoparticles had a uniform particle size distribution with a unimodal distribution, with an average particle size of 186.5 nm and a dispersion coefficient of 0.129; within the concentration range of 8~56 μg/L, there was a good linear relationship with the peak area; and the release rate of the nanoparticles within 16 h~32 h was higher than 50%. G16MPG-ADT NP injection treatment was performed on rats with SCI. Western blotting (WB) and immunofluorescence staining were adopted to analyze the expression levels of mammalian target of rapamycin (mTOR) and signal transducers and activators of transcription (STAT3) protein and the growth of neurites. It was found that G16MPG-ADT can increase mTOR and STAT3 protein levels and promote nerve growth after SCI. Finally, the Basso, Beattie and Bresnahan locomotor rating (BBB) score was to evaluate the recovery effect of rats after treatment. It was found that the recovery effect was excellent after G16MPG-ADT treatment. In summary, G16MPG-ADT has a good effect on SCI repair in rats and can be promoted in the clinic.

Preparation and Particle Size Characterization of Cu Nanoparticles Prepared by Anodic Arc Plasma

2010 ◽  
Vol 92 ◽  
pp. 163-169
Author(s):  
Hong Xia Qiao ◽  
Zhi Qiang Wei ◽  
Ming Ru Zhou ◽  
Zhong Mao He
Keyword(s):  
Crystal Structure ◽  
Particle Size ◽  
Specific Surface ◽  
Size Distribution ◽  
Surface Area ◽  
Specific Surface Area ◽  
Average Particle Size ◽  
Spherical Shape ◽  
Average Particle ◽  
Uniform Size

Copper nanoparticles were successfully prepared in large scales by means of anodic arc discharging plasma method in inert atmosphere. The particle size, specific surface area, crystal structure and morphology of the samples were characterized by X-ray diffraction (XRD), BET equation, transmission electron microscopy (TEM) and the corresponding selected area electron diffraction (SAED). The experiment results indicate that the crystal structure of the samples is fcc structure as same as that of the bulk materials. The specific surface area is is 11 m2/g, with the particle size distribution ranging from 30 to 90 nm, the average particle size about 67nm obtained from TEM and confirmed from XRD and BET results. The nanoparticles have uniform size, higher purity, narrow size distribution and spherical shape can be prepared by this convenient and effective method.

Characteristics of La0.8Sr0.05Ca0.15CrO3 Interconnect Material for SOFC Synthesized by a Modified Pechini Method, USP, and GNP

2007 ◽  
Vol 124-126 ◽  
pp. 799-802
Author(s):  
Tak Hyoung Lim ◽  
Gil Yong Lee ◽  
Dong Hyun Peck ◽  
Rak Hyun Song ◽  
Dong Ryul Shin
Keyword(s):  
Particle Size ◽  
Perovskite Phase ◽  
Pechini Method ◽  
Average Particle Size ◽  
Spherical Shape ◽  
Average Particle ◽  
Orthorhombic Structure ◽  
Single Perovskite Phase ◽  
Modified Pechini Method ◽  
Interconnect Material

The characteristics of La0.8Sr0.05Ca0.15CrO3 interconnect material synthesized by modified pechini method, USP, and GNP was investigated. The powder synthesized by Pechini method exhibited somewhat aggregated shape. The precursor synthesized by USP had spherical shape and their particle size decreased somewhat after calcining procedure at 1000oC. In the case of GNP, the precursor formed agglomerated particles. The average particle size of powders synthesized by Pechini method, USP, and GNP were 0.4+m, 0.6+m, and below 10nm, respectively. The La0.8Sr0.05Ca0.15CrO3 powder had a single perovskite phase and orthorhombic structure. After sintering at 1400oC and 1500oC, the relative density of samples synthesized by pechini method was approximately 95% and that of samples synthesized by USP was slightly small. However, that of the samples synthesized by GNP was approximately 92%.

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