scholarly journals Recent Progress on Near-Infrared Photoacoustic Imaging: Imaging Modality and Organic Semiconducting Agents

Polymers ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 1693 ◽  
Author(s):  
Doyoung Jung ◽  
Suhyeon Park ◽  
Changho Lee ◽  
Hyungwoo Kim
Keyword(s):  
Recent Progress ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Imaging Modality ◽  
Point Of Care ◽  
Tissue Imaging ◽  
Nir Imaging ◽  
Precise Diagnosis ◽  
Deep Tissue Imaging ◽  
Review Reports

Over the past few decades, the photoacoustic (PA) effect has been widely investigated, opening up diverse applications, such as photoacoustic spectroscopy, estimation of chemical energies, or point-of-care detection. Notably, photoacoustic imaging (PAI) has also been developed and has recently received considerable attention in bio-related or clinical imaging fields, as it now facilitates an imaging platform in the near-infrared (NIR) region by taking advantage of the significant advancement of exogenous imaging agents. The NIR PAI platform now paves the way for high-resolution, deep-tissue imaging, which is imperative for contemporary theragnosis, a combination of precise diagnosis and well-timed therapy. This review reports the recent progress on NIR PAI modality, as well as semiconducting contrast agents, and outlines the trend in current NIR imaging and provides further direction for the prospective development of PAI systems.

scholarly journals NIR-to-NIR Imaging: Extended Excitation Up to 2.2 μm Using Harmonic Nanoparticles with a Tunable hIGh EneRgy (TIGER) Widefield Microscope

Nanomaterials ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 3193
Author(s):  
Laura Vittadello ◽  
Jan Klenen ◽  
Karsten Koempe ◽  
Laura Kocsor ◽  
Zsuzsanna Szaller ◽  
...  
Keyword(s):  
Harmonic Generation ◽  
Near Infrared ◽  
Second Harmonic ◽  
Difference Frequency Generation ◽  
High Energy ◽  
Tissue Imaging ◽  
Sum Frequency ◽  
Nir Imaging ◽  
Deep Tissue Imaging ◽  
Frequency Generation

Near-infrared (NIR) marker-based imaging is of growing importance for deep tissue imaging and is based on a considerable reduction of optical losses at large wavelengths. We aim to extend the range of NIR excitation wavelengths particularly to values beyond 1.6 μm in order to profit from the low loss biological windows NIR-III and NIR-IV. We address this task by studying NIR-excitation to NIR-emission conversion and imaging in the range of 1200 up to 2400 nm at the example of harmonic Mg-doped lithium niobate nanoparticles (i) using a nonlinear diffuse femtosecond-pulse reflectometer and (ii) a Tunable hIGh EneRgy (TIGER) widefield microscope. We successfully demonstrate the existence of appropriate excitation/emission configurations in this spectral region taking harmonic generation into account. Moreover, NIR-imaging using the most striking configurations NIR-III to NIR-I, based on second harmonic generation (SHG), and NIR-IV to NIR-I, based on third harmonic generation (THG), is demonstrated with excitation wavelengths from 1.6–1.8 μm and from 2.1–2.2 μm, respectively. The advantages of the approach and the potential to additionally extend the emission range up to 2400 nm, making use of sum frequency generation (SFG) and difference frequency generation (DFG), are discussed.

Two-Dimensional Near-Infrared and Shortwave Infrared Molecular Aggregates: Taking Kasha’s Model to the Next Dimension

2019 ◽  
Author(s):  
Arundhati Deshmukh ◽  
Danielle Koppel ◽  
Chern Chuang ◽  
Danielle Cadena ◽  
Jianshu Cao ◽  
...  
Keyword(s):  
Near Infrared ◽  
Photophysical Properties ◽  
Satellite Telemetry ◽  
Transition Dipole Moment ◽  
Short Wave ◽  
Tissue Imaging ◽  
Transition Dipole ◽  
Deep Tissue Imaging ◽  
Excitonic States ◽  
Shortwave Infrared

Technologies which utilize near-infrared (700 – 1000 nm) and short-wave infrared (1000 – 2000 nm) electromagnetic radiation have applications in deep-tissue imaging, telecommunications and satellite telemetry due to low scattering and decreased background signal in this spectral region. However, there are few molecular species, which absorb efficiently beyond 1000 nm. Transition dipole moment coupling (e.g. J-aggregation) allows for redshifted excitonic states and provides a pathway to highly absorptive electronic states in the infrared. We present aggregates of two cyanine dyes whose absorption peaks redshift dramatically upon aggregation in water from ~ 800 nm to 1000 nm and 1050 nm with sheet-like morphologies and high molar absorptivities (e ~ 10<sup>5 </sup>M<sup>-1</sup>cm<sup>-1</sup>). To describe this phenomenology, we extend Kasha’s model for J- and H-aggregation to describe the excitonic states of <i> 2-dimensional aggregates</i> whose slip is controlled by steric hindrance in the assembled structure. A consequence of the increased dimensionality is the phenomenon of an <i>intermediate </i>“I-aggregate”, one which redshifts yet displays spectral signatures of band-edge dark states akin to an H-aggregate. We distinguish between H-, I- and J-aggregates by showing the relative position of the bright (absorptive) state within the density of states using temperature dependent spectroscopy. Our results can be used to better design chromophores with predictable and tunable aggregation with new photophysical properties.

Responsive optical probes for deep-tissue imaging: Photoacoustics and second near-infrared fluorescence

2021 ◽  
Vol 173 ◽  
pp. 141-163
Author(s):  
Fei Ding ◽  
Jing Feng ◽  
Xueli Zhang ◽  
Jielin Sun ◽  
Chunhai Fan ◽  
...  
Keyword(s):  
Near Infrared ◽  
Tissue Imaging ◽  
Deep Tissue ◽  
Optical Probes ◽  
Near Infrared Fluorescence ◽  
Deep Tissue Imaging

scholarly journals Near-infrared probe-based confocal microendoscope for deep-tissue imaging

2018 ◽  
Vol 9 (10) ◽  
pp. 5011 ◽  
Author(s):  
Jiafu Wang ◽  
Hua Li ◽  
Geng Tian ◽  
Yong Deng ◽  
Qian Liu ◽  
...  
Keyword(s):  
Near Infrared ◽  
Tissue Imaging ◽  
Deep Tissue ◽  
Deep Tissue Imaging

scholarly journals A Review of Endogenous and Exogenous Contrast Agents Used in Photoacoustic Tomography with Different Sensing Configurations

Sensors ◽  
2020 ◽  
Vol 20 (19) ◽  
pp. 5595 ◽  
Author(s):  
Victor T.C. Tsang ◽  
Xiufeng Li ◽  
Terence T.W. Wong
Keyword(s):  
Contrast Agents ◽  
Biomedical Imaging ◽  
Imaging Modality ◽  
Biological Tissues ◽  
Tissue Imaging ◽  
Imaging Tool ◽  
Endogenous Contrast ◽  
Deep Tissue Imaging ◽  
Molecular Specificity ◽  
System Configurations

Optical-based sensing approaches have long been an indispensable way to detect molecules in biological tissues for various biomedical research and applications. The advancement in optical microscopy is one of the main drivers for discoveries and innovations in both life science and biomedical imaging. However, the shallow imaging depth due to the use of ballistic photons fundamentally limits optical imaging approaches’ translational potential to a clinical setting. Photoacoustic (PA) tomography (PAT) is a rapidly growing hybrid imaging modality that is capable of acoustically detecting optical contrast. PAT uniquely enjoys high-resolution deep-tissue imaging owing to the utilization of diffused photons. The exploration of endogenous contrast agents and the development of exogenous contrast agents further improve the molecular specificity for PAT. PAT’s versatile design and non-invasive nature have proven its great potential as a biomedical imaging tool for a multitude of biomedical applications. In this review, representative endogenous and exogenous PA contrast agents will be introduced alongside common PAT system configurations, including the latest advances of all-optical acoustic sensing techniques.

Recent Progress in Near-infrared Photoacoustic Imaging

2021 ◽  
pp. 113478
Author(s):  
Jinya Du ◽  
Shuangshuang Yang ◽  
Yuchun Qiao ◽  
Huiting Lu ◽  
Haifeng Dong
Keyword(s):  
Recent Progress ◽  
Near Infrared ◽  
Photoacoustic Imaging

scholarly journals Imaging of red-shifted photons from bioluminescent tumours using fluorescence by unbound excitation from luminescence

2018 ◽  
Author(s):  
Fabiane Sônego ◽  
Sophie Bouccara ◽  
Thomas Pons ◽  
Nicolas Lequeux ◽  
Anne Danckaert ◽  
...  
Keyword(s):  
Cell Line ◽  
Near Infrared ◽  
Tumour Size ◽  
Visible Spectrum ◽  
Tissue Imaging ◽  
Tumour Detection ◽  
Signal Sensitivity ◽  
Bioluminescence Signal ◽  
Deep Tissue Imaging

AbstractEarly detection of tumours is today a major challenge and requires sensitive imaging methodologies coupled with new efficient probes. Bioluminescence imaging has been widely used in the field of oncology and several cancer cell lines have been genetically modified to provide bioluminescence signals. However, photons that are emitted by the majority of commonly used luciferases are usually in the blue part of the visible spectrum, where tissue absorption is still very high, making deep tissue imaging non-optimal and calling for optimised optical imaging methodologies. We have previously shown that red-shifting of bioluminescence signal by Fluorescence Unbound Excitation from Luminescence (FUEL) is a mean to increase bioluminescence signal sensitivity detection in vivo. Here, we applied FUEL to tumour detection in two different subcutaneous tumour models: the auto-luminescent human embryonic kidney (HEK293) cell line and the murine B16-F10 melanoma cell line previously transfected with the plasmid Luc2. Tumour size and bioluminescence were measured over time and tumour vascularization characterized. We then locally injected near infrared emitting Quantum Dots (NIR QDs)in the tumour site and observed a red-shifting of bioluminescence signal by (FUEL) indicating that FUEL could be used to allow deeper tumour detection.

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