scholarly journals 3D Bioprinted Nanocellulose-Based Hydrogels for Tissue Engineering Applications: A Brief Review

Polymers ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 898 ◽  
Author(s):  
Sandya S. Athukoralalage ◽  
Rajkamal Balu ◽  
Naba K. Dutta ◽  
Namita Roy Choudhury
Keyword(s):  
Tissue Engineering ◽  
Biomedical Applications ◽  
High Surface ◽  
Cellulose Nanofibers ◽  
High Surface Area ◽  
3D Bioprinting ◽  
Engineering Applications ◽  
Bacterial Nanocellulose ◽  
On Demand ◽  
Cell Support

Nanocellulosic materials, such as cellulose nanocrystals, cellulose nanofibers, and bacterial nanocellulose, that display high surface area, mechanical strength, biodegradability, and tunable surface chemistry have attracted great attention over the last decade for biomedical applications. Simultaneously, 3D printing is revolutionizing the field of biomedical engineering, which enables the fast and on-demand printing of customizable scaffolds, tissues, and organs. Nanocellulosic materials hold tremendous potential for 3D bioprinting due to their printability, their shear thinning behavior, their ability to live cell support and owing to their excellent biocompatibility. The amalgamation of nanocellulose-based feedstocks and 3D bioprinting is therefore of critical interest for the development of advanced functional 3D hydrogels. In this context, this review briefly discusses the most recent key developments and challenges in 3D bioprinting nanocellulose-based hydrogel constructs that have been successfully tested for mammalian cell viability and used in tissue engineering applications.

Nano Hydroxyapatite (Nano-Hap): A Potential Bioceramic For Biomedical Applications

2021 ◽  
Vol 06 ◽  
Author(s):  
Varun Saxena ◽  
Lalit Pandey ◽  
T. S. Srivatsan
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Biomedical Applications ◽  
High Surface ◽  
High Surface Area ◽  
Biological Properties ◽  
Engineering Applications ◽  
Biological Responses ◽  
Size And Morphology

Background: Hydroxyapatite (HAp) is one of the most studied biomimic for biomedical applications. Specially, nano-HAp has been utilized for bone tissue engineering various orthopedic applications. HAp possesses various suitable properties such as bioactivity, biodegradability and cell proliferation efficiency for bone tissue engineering applications. Yet, lacks in self-antibacterial activity, high surface area and target efficiency. Results: In this directioon, researchers have focused on exploring the required surface as well as the inherent properties of HAp at the nanoscale. These properties are largely dependent on the composition, size and morphology of the nano-HAp. Hence, nano-HAp has been found to be an excellent candidate with an attractive combination of properties for selection and use in biomedical applications, those required to enhanced biological responses. Further, depending on the type of application, these factors can be tuned to optimize the performance. Conclusion: In this review article, we focus on the chemical structure of HAp and the routes chosen and used for the synthesis of the nano-HAp. The role of various parameters in controlling synthesis at the nanoscale are presented and briefly discussed. In addition, we provide an overview of the various applications for the pristine and doped nano-HAp with recent examples in areas spanning the following: (i) bone tissue engineering applications, (ii) drug delivery applications, (iii) surface coatings, and (iv) scaffolds. The effect of chemical composition on the mechanical properties, surface properties and biological properties are also highlighted. Nano-HAp is found to be highly proficient for its biomedical applications, especially for bone tissue engineering applications. The nano-sized properties enhances the biological responses. The dopant ions that replaces the Ca ion into the hydroxyapatite (HAp) lattice plays a crucial role in its biomedical applications

scholarly journals Renewable Carbon Nanomaterials: Novel Resources for Dental Tissue Engineering

Nanomaterials ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 2800
Author(s):  
Seyyed Mojtaba Mousavi ◽  
Khadije Yousefi ◽  
Seyyed Alireza Hashemi ◽  
Marzie Afsa ◽  
Sonia BahranI ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Graphene Oxide ◽  
Biomedical Applications ◽  
Carbon Nanomaterials ◽  
High Surface ◽  
Graphene Quantum Dots ◽  
High Surface Area ◽  
Biological Properties ◽  
Dental Tissue ◽  
Dental Tissue Engineering

Dental tissue engineering (TE) is undergoing significant modifications in dental treatments. TE is based on a triad of stem cells, signaling molecules, and scaffolds that must be understood and calibrated with particular attention to specific dental sectors. Renewable and eco-friendly carbon-based nanomaterials (CBMs), including graphene (G), graphene oxide (GO), reduced graphene oxide (rGO), graphene quantum dots (GQD), carbon nanotube (CNT), MXenes and carbide, have extraordinary physical, chemical, and biological properties. In addition to having high surface area and mechanical strength, CBMs have greatly influenced dental and biomedical applications. The current study aims to explore the application of CBMs for dental tissue engineering. CBMs are generally shown to have remarkable properties, due to various functional groups that make them ideal materials for biomedical applications, such as dental tissue engineering.

3D bioprinting of dual-crosslinked nanocellulose hydrogels for tissue engineering applications

2021 ◽  
Author(s):  
Marzieh Monfared ◽  
Damia Mawad ◽  
Jelena Rnjak-Kovacina ◽  
Martina Heide Stenzel
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Biomedical Applications ◽  
Cellulose Nanofibrils ◽  
3D Bioprinting ◽  
Engineering Applications ◽  
The Poor

Hydrogels based on cellulose nanofibrils (CNFs) have been widely used as scaffolds for biomedical applications, however, the poor mechanical properties of CNFs hydrogels limit their use as ink for 3D...

scholarly journals The Advances in Biomedical Applications of Carbon Nanotubes

2019 ◽  
Vol 5 (2) ◽  
pp. 29 ◽  
Author(s):  
Timur Saliev
Keyword(s):  
Carbon Nanotubes ◽  
Biomedical Applications ◽  
High Surface ◽  
High Surface Area ◽  
Ideal Candidate ◽  
Biological Features ◽  
On Demand ◽  
Synthesis Of Carbon Nanotubes ◽  
Nano Size ◽  
Unique Chemical

Unique chemical, physical, and biological features of carbon nanotubes make them an ideal candidate for myriad applications in industry and biomedicine. Carbon nanotubes have excellent electrical and thermal conductivity, high biocompatibility, flexibility, resistance to corrosion, nano-size, and a high surface area, which can be tailored and functionalized on demand. This review discusses the progress and main fields of bio-medical applications of carbon nanotubes based on recently-published reports. It encompasses the synthesis of carbon nanotubes and their application for bio-sensing, cancer treatment, hyperthermia induction, antibacterial therapy, and tissue engineering. Other areas of carbon nanotube applications were out of the scope of this review. Special attention has been paid to the problem of the toxicity of carbon nanotubes.

Recent Advances in the Development of Magnetic Nanoparticles for Biomedical Applications

2021 ◽  
Vol 21 (5) ◽  
pp. 2705-2741
Author(s):  
Maria Monteserín ◽  
Silvia Larumbe ◽  
Alejandro V. Martínez ◽  
Saioa Burgui ◽  
L. Francisco Martín
Keyword(s):  
Magnetic Nanoparticles ◽  
Physicochemical Properties ◽  
Biomedical Applications ◽  
High Surface ◽  
High Surface Area ◽  
Synthetic Methods ◽  
Magnetic Drug Targeting ◽  
Surface Area Ratio ◽  
Biomedical Field

The unique properties of magnetic nanoparticles have led them to be considered materials with significant potential in the biomedical field. Nanometric size, high surface-area ratio, ability to function at molecular level, exceptional magnetic and physicochemical properties, and more importantly, the relatively easy tailoring of all these properties to the specific requirements of the different biomedical applications, are some of the key factors of their success. In this paper, we will provide an overview of the state of the art of different aspects of magnetic nanoparticles, specially focusing on their use in biomedicine. We will explore their magnetic properties, synthetic methods and surface modifications, as well as their most significative physicochemical properties and their impact on the in vivo behaviour of these particles. Furthermore, we will provide a background on different applications of magnetic nanoparticles in biomedicine, such as magnetic drug targeting, magnetic hyperthermia, imaging contrast agents or theranostics. Besides, current limitations and challenges of these materials, as well as their future prospects in the biomedical field will be discussed.

scholarly journals Carbon nanotubes and their polymeric composites: the applications in tissue engineering

2020 ◽  
Vol 5 (1) ◽  
Author(s):  
Boyang Huang
Keyword(s):  
Carbon Nanotubes ◽  
Electrical Conductivity ◽  
Tissue Engineering ◽  
Bone Tissue ◽  
Biomedical Applications ◽  
Chemical Properties ◽  
Polymeric Composites ◽  
Biological Properties ◽  
Engineering Applications ◽  
Toxicity Effects

Abstract Carbon nanotubes (CNTs), with unique graphitic structure, superior mechanical, electrical, optical and biological properties, has attracted more and more interests in biomedical applications, including gene/drug delivery, bioimaging, biosensor and tissue engineering. In this review, we focus on the role of CNTs and their polymeric composites in tissue engineering applications, with emphasis on their usages in the nerve, cardiac and bone tissue regenerations. The intrinsic natures of CNTs including their physical and chemical properties are first introduced, explaining the structure effects on CNTs electrical conductivity and various functionalization of CNTs to improve their hydrophobic characteristics. Biosafety issues of CNTs are also discussed in detail including the potential reasons to induce the toxicity and their potential strategies to minimise the toxicity effects. Several processing strategies including solution-based processing, polymerization, melt-based processing and grafting methods are presented to show the 2D/3D construct formations using the polymeric composite containing CNTs. For the sake of improving mechanical, electrical and biological properties and minimising the potential toxicity effects, recent advances using polymer/CNT composite the tissue engineering applications are displayed and they are mainly used in the neural tissue (to improve electrical conductivity and biological properties), cardiac tissue (to improve electrical, elastic properties and biological properties) and bone tissue (to improve mechanical properties and biological properties). Current limitations of CNTs in the tissue engineering are discussed and the corresponded future prospective are also provided. Overall, this review indicates that CNTs are promising “next-generation” materials for future biomedical applications.

scholarly journals Three-Dimensional Stable Alginate-Nanocellulose Gels for Biomedical Applications: Towards Tunable Mechanical Properties and Cell Growing

Nanomaterials ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 78 ◽  
Author(s):  
Priscila Siqueira ◽  
Éder Siqueira ◽  
Ana Elza De Lima ◽  
Gilberto Siqueira ◽  
Ana Delia Pinzón-Garcia ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Mechanical Properties ◽  
Tissue Engineering ◽  
Wound Healing ◽  
Cellulose Nanocrystals ◽  
Biomedical Applications ◽  
Cellulose Nanofibers ◽  
Oxidized Cellulose ◽  
Freeze Dried ◽  
Alginate Gels

Hydrogels have been studied as promising materials in different biomedical applications such as cell culture in tissue engineering or in wound healing. In this work, we synthesized different nanocellulose-alginate hydrogels containing cellulose nanocrystals, TEMPO-oxidized cellulose nanocrystals (CNCTs), cellulose nanofibers or TEMPO-oxidized cellulose nanofibers (CNFTs). The hydrogels were freeze-dried and named as gels. The nanocelluloses and the gels were characterized by different techniques such as Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), and dynamic mechanical thermal analysis (DMTA), while the biological features were characterized by cytotoxicity and cell growth assays. The addition of CNCTs or CNFTs in alginate gels contributed to the formation of porous structure (diameter of pores in the range between 40 and 150 μm). TEMPO-oxidized cellulose nanofibers have proven to play a crucial role in improving the dimensional stability of the samples when compared to the pure alginate gels, mainly after a thermal post-treatment of these gels containing 50 wt % of CNFT, which significantly increased the Ca2+ crosslinking density in the gel structure. The morphological characteristics, the mechanical properties, and the non-cytotoxic behavior of the CNFT-alginate gels improved bioadhesion, growth, and proliferation of the cells onto the gels. Thus, the alginate-nanocellulose gels might find applications in tissue engineering field, as for instance, in tissue repair or wound healing applications.

scholarly journals A review on advanced nanofiber technology for membrane distillation

2019 ◽  
Vol 14 ◽  
pp. 155892501882490 ◽  
Author(s):  
Fatma Yalcinkaya
Keyword(s):  
Tissue Engineering ◽  
Surface Area ◽  
Wound Dressing ◽  
High Surface ◽  
High Surface Area ◽  
Membrane Distillation ◽  
Operating Parameters ◽  
Polymeric Nanofibers ◽  
Highly Porous ◽  
Comprehensive Study

The importance of the nanofiber webs increases rapidly due to their highly porous structure, narrow pore size, and distribution; specific surface area and compatibility with inorganics. Electrospinning has been introduced as one of the most efficient technique for the fabrication of polymeric nanofibers due to its ability to fabricate nanostructures with unique properties such as a high surface area and porosity. The process and the operating parameters affect the nanofiber fabrication and the application of nanofibers in various fields, such as sensors, tissue engineering, wound dressing, protective clothes, filtration, desalination, and distillation. In this review, a comprehensive study is presented on the parameters of electrospinning system including applications. More emphasis is given to the application of nanofibers in membrane distillation (MD). The research developments and the current situation of the nanofiber webs in MD are also discussed.

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