scholarly journals Selenol-Based Nucleophilic Reaction for the Preparation of Reactive Oxygen Species-Responsive Amphiphilic Diblock Copolymers

Polymers ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 827
Author(s):  
Xiaowei An ◽  
Weihong Lu ◽  
Jian Zhu ◽  
Xiangqiang Pan ◽  
Xiulin Zhu
Keyword(s):  
Reactive Oxygen Species ◽  
Molecular Weight ◽  
Self Assembly ◽  
Diblock Copolymers ◽  
Raft Polymerization ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Amphiphilic Copolymers ◽  
Nucleophilic Reaction ◽  
Amphiphilic Diblock Copolymers

Selenide-containing amphiphilic copolymers have shown significant potential for application in drug release systems. Herein, we present a methodology for the design of a reactive oxygen species-responsive amphiphilic diblock selenide-labeled copolymer. This copolymer with controlled molecular weight and narrow molecular weight distribution was prepared by sequential organoselenium-mediated reversible addition fragmentation chain transfer (Se-RAFT) polymerization and selenol-based nucleophilic reaction. Nuclear magnetic resonance (NMR) and matrix-assisted laser desorption/ionization time-to-flight (MALDI-TOF) techniques were used to characterize its structure. Its corresponding nanomicelles successfully formed through self-assembly from the copolymer itself. Such nanomicelles could rapidly disassemble under oxidative conditions due to the fragmentation of the Se–C bond. Therefore, this type of nanomicelle based on selenide-labeled amphiphilic copolymers potentially provides a new platform for drug delivery.

A reactive oxygen species (ROS)-responsive low molecular weight gel co-loaded with doxorubicin and Zn(ii) phthalocyanine tetrasulfonic acid for combined chemo-photodynamic therapy

2017 ◽  
Vol 5 (46) ◽  
pp. 9157-9164 ◽  
Author(s):  
Long Xu ◽  
Mingying Zhao ◽  
Yidi Yang ◽  
Yan Liang ◽  
Changzhen Sun ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Molecular Weight ◽  
Photodynamic Therapy ◽  
Anticancer Drug ◽  
Reactive Oxygen ◽  
Low Molecular Weight ◽  
Oxygen Species

A ROS-responsive low molecular weight hydrogel was fabricated and loaded with an anticancer drug and a photosensitizer for efficient chemo-photodynamic therapy.

Uniform zinc thioporphyrazine nanosphere by self-assembly and the photocatalytic performance

2018 ◽  
Vol 22 (09n10) ◽  
pp. 868-876 ◽  
Author(s):  
Changjun Yang ◽  
Lanchang Gao ◽  
Bingguang Zhang ◽  
Zehui Zhang ◽  
Kejian Deng
Keyword(s):  
Reactive Oxygen Species ◽  
Self Assembly ◽  
Photocatalytic Performance ◽  
Aqueous Media ◽  
Reactive Oxygen ◽  
Polymerization Reaction ◽  
Oxygen Species ◽  
Paramagnetic Resonance ◽  
Novel Strategy ◽  
Means Of Transmission

A novel strategy for the synthesis of zinc thioporphyrazine nanospheres is presented. The uniform spheres were fabricated through a polymerization reaction without using any template or emulsifier, which result from the covalent links between zinc tetra(2,3-bis(pentenylthio)porphyrazine (ZnPz) possessing eight long flexible chains in periphery and each with one terminal olefin group. A possible mechanism to explain the self-assembly of ZnPz nanospheres was also illuminated through monitoring nanosphere formation by means of transmission electron microscopy (TEM). More importantly, ZnPz nanospheres can effectively activate dioxygen in aqueous media under simulated sunlight irradiation, and showed significantly improved photocatalytic activity for the degradation of Rhodamine B (RhB) as compared to monomeric ZnPz. Furthermore, the reactive oxygen species derived from ZnPz nanospheres under light irradiation were determined by electron paramagnetic resonance (EPR) technology, indicating that singlet oxygen ([Formula: see text]O[Formula: see text] and hydroxyl radical (•OH) are the major reactive oxygen species. The facile synthetic methodology and the enhanced photocatalytic performance of the ZnPz nanospheres endow this novel material with the potential of being an efficient biomimetic photocatalyst for wastewater treatment.

Amphiphilic diblock copolymers based on sucrose methacrylate: RAFT polymerization and self-assembly

2018 ◽  
Vol 266 ◽  
pp. 628-639 ◽  
Author(s):  
Raphael Henrique Marques Marcilli ◽  
Ana Paula Rodrigues Camilo ◽  
Cesar Liberato Petzhold ◽  
Maria Isabel Felisberti
Keyword(s):  
Self Assembly ◽  
Diblock Copolymers ◽  
Raft Polymerization ◽  
Amphiphilic Diblock Copolymers

Influence of surface chemistry on the formation of a protein corona on nanodiamonds

2019 ◽  
Vol 7 (21) ◽  
pp. 3383-3389 ◽  
Author(s):  
Alfonso E. Garcia-Bennett ◽  
Arun Everest-Dass ◽  
Irene Moroni ◽  
Ishan Das Rastogi ◽  
Lindsay M. Parker ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Molecular Weight ◽  
Surface Chemistry ◽  
Cell Viability ◽  
Reactive Oxygen ◽  
Protein Corona ◽  
Low Molecular Weight ◽  
Oxygen Species ◽  
Low Molecular Weight Proteins

The protein corona of nanodiamonds is dominated by low molecular weight proteins and is largely independent of surface chemistry. The pre-incubation of nanodiamonds in serum and the formation of a protein corona decrease the production of reactive oxygen species, increasing the cell viability of macrophages.

scholarly journals Preparation of well-defined 2D-lenticular aggregates by self-assembly of PNIPAM-b-PVDF amphiphilic diblock copolymers in solution

2021 ◽  
Author(s):  
Enrique Folgado ◽  
Matthias Mayor ◽  
Didier Cot ◽  
Michel Ramonda ◽  
Franck Godiard ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Self Assembly ◽  
Diblock Copolymers ◽  
Dimethyl Carbonate ◽  
Raft Polymerization ◽  
Amphiphilic Block Copolymers ◽  
Amphiphilic Diblock Copolymers

PNIPAM-b-PVDF amphiphilic block copolymers were synthesized via RAFT polymerization in dimethyl carbonate. These block copolymers were able to self-assemble into various morphologies such as spherical, crumpled, lamellar and lenticular 2D aggregates.

scholarly journals Reactive Oxygen Species-Responsive Adaptable Self-Assembly of Peptides toward Advanced Biomaterials

2020 ◽  
Vol 3 (9) ◽  
pp. 5529-5551
Author(s):  
Binbin Hu ◽  
Zhengwen Lian ◽  
Zhifei Zhou ◽  
Linqi Shi ◽  
Zhilin Yu
Keyword(s):  
Reactive Oxygen Species ◽  
Self Assembly ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Advanced Biomaterials
Sign in / Sign up

Export Citation Format

Share Document