scholarly journals Dual-responsive Gemini Micelles for Efficient Delivery of Anticancer Therapeutics

Polymers ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 604 ◽  
Author(s):  
Young Choi ◽  
Eun-sook Choi ◽  
Kwan Mun ◽  
Se Lee ◽  
Sung Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polymeric Micelles ◽  
Therapeutic Effects ◽  
Cancer Therapies ◽  
Drug Delivery Vehicles ◽  
Dual Responsive ◽  
Intracellular Drug Delivery ◽  
Efficient Delivery ◽  
Poly Ethylene ◽  
Oxidation Of Methionine

Polymeric micelles as drug delivery vehicles are popular owing to several advantages. In this study, a gemini amphiphile (gemini mPEG-Cys-PMT) consisting of hydrophilic poly(ethylene glycol) and hydrophobic poly(methionine) with cystine disulfide spacer was synthesized and its micellar properties for thiol- or reactive oxygen species (ROS)-dependent intracellular drug delivery were described. The cleavage of cystine linkage in a redox environment or the oxidation of methionine units in a ROS environment caused the destabilization of micelles. Such redox- or ROS-triggered micellar destabilization led to enhanced release of encapsulated doxorubicin (DOX) to induce cytotoxicity against cancer cells. Further, the therapeutic effects of the DOX-loaded micelles were demonstrated using the KB cell line. This study shows that thiol and ROS dual-responsive gemini micelles are promising platforms for nano-drug delivery in various cancer therapies.

CD47 Functionalization of Nanoparticles as a Poly(ethylene glycol) Alternative: A Novel Approach to Improve Drug Delivery

2021 ◽  
Vol 22 ◽  
Author(s):  
Noushin Rezaei Vandchali ◽  
Fatemeh Moadab ◽  
Eskandar Taghizadeh ◽  
Amir Tajbakhsh ◽  
Seyed Mohammad Gheibi-hayat
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Retention Time ◽  
Blood Circulation ◽  
Regulatory Protein ◽  
Reticuloendothelial System ◽  
Poly Ethylene Glycol ◽  
Drug Delivery Vehicles ◽  
Novel Approach ◽  
Poly Ethylene

Abstract: Bio-degradable nanoparticles (NPs) have several utilizations as the drug delivery vehicles due to their acceptable bio-availability, lower toxicity, potency for encapsulation and controlled release. Moreover, interaction of the NPs with the macrophages of reticuloendothelial system (RES) may decrease NPs efficacy for medical purposes. The surface of NPs is conventionally neutralized with the molecules such as poly(ethylene glycol) (PEG), as one of the most widely applied stealth polymers, in order to restrict the NPs clearance through the RES system. In fact, these molecules exhibit resistance to the RES clearance and proteins adsorption. It is unfortunate that modifying the PEG has some shortcomings like problems in the synthesis as well as correlation to the immune reaction. The CD47 receptor has been well known as a ‘don’t-eat-me’ molecule on the self-cells' surface. Therefore, the receptor will inhibit phagocytosis via binding to its ligand that is known as the signal regulatory protein α (SIRP-α). Moreover, the CD47 receptor, as one of the biomimetic substances, or its derivative peptides have been used recently on the surface of nanoparticles to inhibit phagocytosis and increase the NPs retention time in the blood circulation. Therefore, this review study examined the CD47 receptor and its role in the immune system as well as the use of the CD47 receptor in coating NPs to increase their retention time in the blood circulation.

scholarly journals Stealth Coating of Nanoparticles in Drug-Delivery Systems

Nanomaterials ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 787 ◽  
Author(s):  
See Yee Fam ◽  
Chin Fei Chee ◽  
Chean Yeah Yong ◽  
Kok Lian Ho ◽  
Abdul Razak Mariatulqabtiah ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Blood Circulation ◽  
Delivery Systems ◽  
Mononuclear Phagocyte ◽  
Polymer Chains ◽  
Cancer Therapies ◽  
Drug Actions ◽  
Coating Characteristics ◽  
Systemic Side Effects ◽  
Poly Ethylene

Nanoparticles (NPs) have emerged as a powerful drug-delivery tool for cancer therapies to enhance the specificity of drug actions, while reducing the systemic side effects. Nonetheless, NPs interact massively with the surrounding physiological environments including plasma proteins upon administration into the bloodstream. Consequently, they are rapidly cleared from the blood circulation by the mononuclear phagocyte system (MPS) or complement system, resulting in a premature elimination that will cause the drug release at off-target sites. By grafting a stealth coating layer onto the surface of NPs, the blood circulation half-life of nanomaterials can be improved by escaping the recognition and clearance of the immune system. This review focuses on the basic concept underlying the stealth behavior of NPs by polymer coating, whereby the fundamental surface coating characteristics such as molecular weight, surface chain density as well as conformations of polymer chains are of utmost importance for efficient protection of NPs. In addition, the most commonly used stealth polymers such as poly(ethylene glycol) (PEG), poly(2-oxazoline) (POx), and poly(zwitterions) in developing long-circulating NPs for drug delivery are also thoroughly discussed. The biomimetic strategies, including the cell-membrane camouflaging technique and CD47 functionalization for the development of stealth nano-delivery systems, are highlighted in this review as well.

Mixed-Charged Zwitterionic Polymeric Micelles for Tumor Acidic Environment Responsive Intracellular Drug Delivery

Langmuir ◽  
2018 ◽  
Vol 35 (5) ◽  
pp. 1242-1248 ◽  
Author(s):  
Zhihui Qin ◽  
Tingting Chen ◽  
Wenzhuo Teng ◽  
Qiao Jin ◽  
Jian Ji
Keyword(s):  
Drug Delivery ◽  
Polymeric Micelles ◽  
Acidic Environment ◽  
Intracellular Drug Delivery

Cyclic RGDyK conjugation facilitates intracellular drug delivery of polymeric micelles to integrin-overexpressing tumor cells and neovasculature

2010 ◽  
Vol 19 (1) ◽  
pp. 25-36 ◽  
Author(s):  
Jie Yin ◽  
Zaiquan Li ◽  
Tingyuan Yang ◽  
Jiancheng Wang ◽  
Xuan Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Cells ◽  
Polymeric Micelles ◽  
Intracellular Drug Delivery

ChemInform Abstract: Polymeric Micelles as Drug Delivery Vehicles

ChemInform ◽  
2014 ◽  
Vol 45 (36) ◽  
pp. no-no
Author(s):  
Zaheer Ahmad ◽  
Afzal Shah ◽  
Muhammad Siddiq ◽  
Heinz-Bernhard Kraatz
Keyword(s):  
Drug Delivery ◽  
Polymeric Micelles ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles
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