Conjugation of Arginine-Glycine-Aspartic Acid Peptides to Poly(ethylene oxide)-b-poly(ε-caprolactone) Micelles for Enhanced Intracellular Drug Delivery to Metastatic Tumor Cells

2007 ◽  
Vol 8 (3) ◽  
pp. 874-884 ◽  
Author(s):  
Xiao-Bing Xiong ◽  
Abdullah Mahmud ◽  
Hasan Uludaǧ ◽  
Afsaneh Lavasanifar
Keyword(s):  
Drug Delivery ◽  
Ethylene Oxide ◽  
Tumor Cells ◽  
Aspartic Acid ◽  
Metastatic Tumor ◽  
Intracellular Drug Delivery ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene ◽  
Arginine Glycine Aspartic Acid

scholarly journals Poloxamer Hydrogels for Biomedical Applications

Pharmaceutics ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 671 ◽  
Author(s):  
Eleonora Russo ◽  
Carla Villa
Keyword(s):  
Drug Delivery ◽  
Ethylene Oxide ◽  
Propylene Oxide ◽  
Biomedical Application ◽  
Aqueous Environment ◽  
Molecular Weights ◽  
Long Time ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene ◽  
Concentration Threshold

This review article focuses on thermoresponsive hydrogels consisting of poloxamers which are of high interest for biomedical application especially in drug delivery for ophthalmic, injectable, transdermal, and vaginal administration. These hydrogels remain fluid at room temperature but become more viscous gel once they are exposed to body temperature. In this way, the gelling system remains at the topical level for a long time and the drug release is controlled and prolonged. Poloxamers are synthetic triblock copolymers of poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (PEO-PPO-PEO), also commercially known as Pluronics®, Synperonics® or Lutrol®. The different poloxamers cover a range of liquids, pastes, and solids, with molecular weights and ethylene oxide–propylene oxide weight ratios varying from 1100 to 14,000 and 1:9 to 8:2, respectively. Concentrated aqueous solutions of poloxamers form thermoreversible gels. In recent years this type of gel has arouse interest for tissue engineering. Finally, the use of poloxamers as biosurfactants is evaluated since they are able to form micelles in an aqueous environment above a concentration threshold known as critical micelle concentration (CMC). This property is exploited for drug delivery and different therapeutic applications.

Biodegradable copolymers based on poly(ethylene oxide), polylactide and polydepsipeptide sequences with functional groups

e-Polymers ◽  
2001 ◽  
Vol 1 (1) ◽  
Author(s):  
Yakai Feng ◽  
Doris Klee ◽  
Hartwig Höcker
Keyword(s):  
Block Copolymers ◽  
Ethylene Oxide ◽  
Aspartic Acid ◽  
Functional Groups ◽  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Biodegradable Copolymers ◽  
Protective Groups ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

AbstractFor the purpose of increasing the hydrophilicity of polylactide, new block copolymers with protected functional groups, poly(lactide-co-(S)-b-benzyl aspartate)-poly(ethylene oxide)-poly(lactide-co-(S)- b-benzyl aspartate), were synthesized via ring-opening polymerization of D,L-lactide and (3S, 6R,S)-3- [(benzyloxycarbonyl)methyl]-6-methylmorpholine-2,5-dione in the presence of hydroxyltelechelic poly(ethylene oxide) (PEO) as an initiator at 140 °C for 24 h. The benzyl protective groups of the block copolymers were completely removed to give poly(lactide-co-(S)-aspartic acid)-PEO-poly(lactide-co-(S)-aspartic acid), (poly(DLLA-co-Asp)-b-PEO-b-poly(DLLA-co-Asp)). This shows lower crystallization and melting temperature compared with the polymers before deprotection. Poly(DLLA-co-Asp)-b-PEO-b-poly(DLLA-co-Asp) with 55.6 wt.-% of PEO is more hydrophilic, shows higher water absorption and is degraded faster than with 39.5 wt.-% of PEO.

Synthesis and unimolecular micelles of amphiphilic copolymer with dendritic poly(l-lactide) core and poly(ethylene oxide) shell for drug delivery

RSC Advances ◽  
2015 ◽  
Vol 5 (122) ◽  
pp. 100816-100823 ◽  
Author(s):  
Xiaoshan Fan ◽  
Zhiguo Hu ◽  
Guowei Wang
Keyword(s):  
Drug Delivery ◽  
Ethylene Oxide ◽  
Amphiphilic Copolymer ◽  
Oxide Shell ◽  
Third Generation ◽  
Carboxylic Groups ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

A novel type of amphiphilic copolymer POSS-(G3-PLLA-b-PEO-COOH)8 with a hydrophobic third-generation dendritic PLLA core and a functionalized hydrophilic PEO shell with surface carboxylic groups was synthesized as a carrier for drug delivery.

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