scholarly journals Stimuli-Responsive Polypeptides for Biomedical Applications

Polymers ◽  
2018 ◽  
Vol 10 (8) ◽  
pp. 830 ◽  
Author(s):  
DaeYong Lee ◽  
N. Rejinold ◽  
Seong Jeong ◽  
Yeu-Chun Kim
Keyword(s):  
Physical Properties ◽  
Adenosine Triphosphate ◽  
Biomedical Applications ◽  
Stimuli Responsive ◽  
The Past ◽  
Bioactive Properties ◽  
Recent Advances ◽  
Ph Reduction ◽  
Biomedical Fields

Stimuli-responsive polypeptides have gained attention because desirable bioactive properties can be easily imparted to them while keeping their biocompatibility and biodegradability intact. In this review, we summarize the most recent advances in various stimuli-responsive polypeptides (pH, reduction, oxidation, glucose, adenosine triphosphate (ATP), and enzyme) over the past five years. Various synthetic strategies exploited for advanced polypeptide-based materials are introduced, and their applicability in biomedical fields is discussed. The recent polypeptides imparted with new stimuli-responsiveness and their novel chemical and physical properties are explained in this review.

scholarly journals Stimuli-responsive nanobubbles for biomedical applications

2021 ◽  
Author(s):  
Ranhua Xiong ◽  
Ronald X. Xu ◽  
Chaobo Huang ◽  
Stefaan De Smedt ◽  
Kevin Braeckmans
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Stimuli Responsive ◽  
Recent Advances ◽  
Tumor Tissues ◽  
Bio Imaging

This review presents an overview of the recent advances in the development of stimuli-responsive nanobubbles and their novel biomedical applications including bio-imaging, drug delivery and ablation of tumor tissues.

scholarly journals Recent Advances in Zwitterionic Hydrogels: Preparation, Property, and Biomedical Application

Gels ◽  
2022 ◽  
Vol 8 (1) ◽  
pp. 46
Author(s):  
Sihang Liu ◽  
Jingyi Tang ◽  
Fangqin Ji ◽  
Weifeng Lin ◽  
Shengfu Chen
Keyword(s):  
Immune System ◽  
Polyethylene Glycol ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Synthetic Polymers ◽  
Human Environment ◽  
The Past ◽  
Recent Advances ◽  
Nonspecific Protein Adsorption ◽  
Anionic Groups

Nonspecific protein adsorption impedes the sustainability of materials in biologically related applications. Such adsorption activates the immune system by quick identification of allogeneic materials and triggers a rejection, resulting in the rapid failure of implant materials and drugs. Antifouling materials have been rapidly developed in the past 20 years, from natural polysaccharides (such as dextran) to synthetic polymers (such as polyethylene glycol, PEG). However, recent studies have shown that traditional antifouling materials, including PEG, still fail to overcome the challenges of a complex human environment. Zwitterionic materials are a class of materials that contain both cationic and anionic groups, with their overall charge being neutral. Compared with PEG materials, zwitterionic materials have much stronger hydration, which is considered the most important factor for antifouling. Among zwitterionic materials, zwitterionic hydrogels have excellent structural stability and controllable regulation capabilities for various biomedical scenarios. Here, we first describe the mechanism and structure of zwitterionic materials. Following the preparation and property of zwitterionic hydrogels, recent advances in zwitterionic hydrogels in various biomedical applications are reviewed.

scholarly journals A glimpse of biodegradable polymers and their biomedical applications

e-Polymers ◽  
2019 ◽  
Vol 19 (1) ◽  
pp. 385-410 ◽  
Author(s):  
Tejas V. Shah ◽  
Dilip V. Vasava
Keyword(s):  
Tissue Engineering ◽  
Physical Properties ◽  
Biodegradable Polymers ◽  
Medical Devices ◽  
Biomedical Applications ◽  
Recent Literature ◽  
Drug Carrier ◽  
Physiochemical Properties ◽  
The Past ◽  
Stimuli Response

AbstractOver the past two decades, biodegradable polymers (BPs) have been widely used in biomedical applications such as drug carrier, gene delivery, tissue engineering, diagnosis, medical devices, and antibacterial/antifouling biomaterials. This can be attributed to numerous factors such as chemical, mechanical and physiochemical properties of BPs, their improved processibility, functionality and sensitivity towards stimuli. The present review intended to highlight main results of research on advances and improvements in terms of synthesis, physical properties, stimuli response, and/or applicability of biodegradable plastics (BPs) during last two decades, and its biomedical applications. Recent literature relevant to this study has been cited and their developing trends and challenges of BPs have also been discussed.

scholarly journals Recent Advances in Epsilon-Poly-L-Lysine and L-Lysine-Based Dendrimer Synthesis, Modification, and Biomedical Applications

2021 ◽  
Vol 9 ◽  
Author(s):  
Sijin Chen ◽  
Shuting Huang ◽  
Yan Li ◽  
Chuncai Zhou
Keyword(s):  
Biomedical Applications ◽  
Scale Production ◽  
Facile Synthesis ◽  
Gene Therapies ◽  
Design And Synthesis ◽  
Recent Advances ◽  
Or Gene ◽  
Advanced Development ◽  
Biomedical Fields ◽  
Bio Synthesis

With the advantages in biocompatibility, antimicrobial ability, and comparative facile synthesis technology, poly-L-lysine (PLL) has received considerable attention in recent years. Different arrangement forms and structures of the backbone endow lysine-based polymers with versatile applications, especially for ε-poly-L-lysine (EPL) and lysine-based dendrimer (LBD) compounds. This review summarized the advanced development of the synthesis and modification strategies of EPL and LBD, focus on the modification of bio-synthesis and artificial synthesis, respectively. Meanwhile, biomedical fields, where EPL and LBD are mainly utilized, such as agents, adjuvants, or carriers to anti-pathogen or used in tumor or gene therapies, are also introduced. With the deeper of knowledge of pharmacodynamics and pharmacokinetics of the drug system, the design and synthesis of these drugs can be further optimized. Furthermore, the performances of combination with other advanced methodologies and technologies demonstrated that challenges, such as scale production and high expenses, will not hinder the prospective future of lysine-based polymers.

Recent advances towards the fabrication and biomedical applications of responsive polymeric assemblies and nanoparticle hybrid superstructures

2015 ◽  
Vol 44 (9) ◽  
pp. 3904-3922 ◽  
Author(s):  
Xianglong Hu ◽  
Shiyong Liu
Keyword(s):  
Biomedical Applications ◽  
Stimuli Responsive ◽  
Recent Advances ◽  
Recent Developments ◽  
Polymeric Assemblies ◽  
Microstructural Control

We highlight recent developments, microstructural control, and biomedical applications of stimuli-responsive polymeric assemblies and responsive hybrid superstructures.

scholarly journals Trends in Metal-Based Composite Biomaterials for Hard Tissue Applications

JOM ◽  
2021 ◽  
Author(s):  
Gargi Shankar Nayak ◽  
Adele Carradò ◽  
Patrick Masson ◽  
Geneviève Pourroy ◽  
Flavien Mouillard ◽  
...  
Keyword(s):  
Composite Materials ◽  
Physical Properties ◽  
Biomedical Applications ◽  
Biodegradable Implants ◽  
Hard Tissue ◽  
The Past ◽  
Research Areas ◽  
Mechanical And Physical Properties ◽  
The World ◽  
Pros And Cons

AbstractThe world of biomaterials has been continuously evolving. Where in the past only mono-material implants were used, the growth in technology and collaboration between researchers from different sectors has led to a tremendous improvement in implant industry. Nowadays, composite materials are one of the leading research areas for biomedical applications. When we look toward hard tissue applications, metal-based composites seem to be desirable candidates. Metals provide the mechanical and physical properties needed for load-bearing applications, which when merged with beneficial properties of bioceramics/polymers can help in the creation of remarkable bioactive as well biodegradable implants. Keeping this in mind, this review will focus on various production routes of metal-based composite materials for hard tissue applications. Where possible, the pros and cons of the techniques have been provided.

Nanotechnology-based photodynamic therapy

2013 ◽  
Vol 17 (01n02) ◽  
pp. 16-26 ◽  
Author(s):  
Hee-Jae Yoon ◽  
Woo-Dong Jang
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Combination Therapy ◽  
Biomedical Applications ◽  
Recent Advances ◽  
Recent Trends ◽  
Selective Delivery ◽  
Great Merit ◽  
Multifunctional Platform ◽  
Biomedical Fields

According to recent advances in nanotechnology, various nano-sized formulations have been designed for the application in biomedical fields, including diagnosis, drug delivery, and therapeutics. The nanotechnology-based formulations have a great merit in the design of multifunctional platform for the biomedical applications. Therefore, recent trends in nanotechnology are moving onto the combination of nanotechnology and conventional therapeutic. Typically, photodynamic therapy (PDT) is one of promising techniques for the combination with nanotechnology owing to its less invasiveness. In this paper, we are going to briefly review recent advances in nanotechnology-based PDT, including selective delivery and excitation of photosensitizers, combination therapy, and multifunctional PDT.

scholarly journals Advanced Nanomaterials in Multimodal Imaging: Design, Functionalization, and Biomedical Applications

2010 ◽  
Vol 2010 ◽  
pp. 1-15 ◽  
Author(s):  
Zhe Liu ◽  
Fabian Kiessling ◽  
Jessica Gätjens
Keyword(s):  
Drug Delivery ◽  
Molecular Imaging ◽  
Contrast Agents ◽  
Multimodal Imaging ◽  
Biomedical Applications ◽  
State Of The Art ◽  
The Past ◽  
Recent Advances ◽  
Imaging Probes ◽  
New Generation

The biomedical applications of nanoparticles in molecular imaging, drug delivery, and therapy give rise to the term “nanomedicine” and have led to ever-growing developments in the past decades. New generation of imaging probes (or contrast agents) and state of the art of various strategies for efficient multimodal molecular imaging have drawn much attention and led to successful preclinical uses. In this context, we intend to elucidate the fundamentals and review recent advances as well as to provide an outlook perspective in these fields.

scholarly journals Hydrogel-Based Technologies for the Diagnosis of Skin Pathology

Technologies ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 47
Author(s):  
Christian Wiraja ◽  
Xiaoyu Ning ◽  
Mingyue Cui ◽  
Chenjie Xu
Keyword(s):  
Biomedical Applications ◽  
Polymer Networks ◽  
Therapeutic Agents ◽  
Cross Linking ◽  
Stimuli Responsive ◽  
On Demand ◽  
The Past ◽  
Skin Conditions ◽  
Chemical Cross Linking ◽  
Physical Entanglement

Hydrogels, swellable hydrophilic polymer networks fabricated through chemical cross-linking or physical entanglement are increasingly utilized in various biomedical applications over the past few decades. Hydrogel-based microparticles, dressings and microneedle patches have been explored to achieve safe, sustained and on-demand therapeutic purposes toward numerous skin pathologies, through incorporation of stimuli-responsive moieties and therapeutic agents. More recently, these platforms are expanded to fulfill the diagnostic and monitoring role. Herein, the development of hydrogel technology to achieve diagnosis and monitoring of pathological skin conditions are highlighted, with proteins, nucleic acids, metabolites, and reactive species employed as target biomarkers, among others. The scope of this review includes the characteristics of hydrogel materials, its fabrication procedures, examples of diagnostic studies, as well as discussion pertaining clinical translation of hydrogel systems.

Stimuli responsive nanomaterials for controlled release applications

2012 ◽  
Vol 1 (6) ◽  
pp. 493-513 ◽  
Author(s):  
Song Li ◽  
Wengang Li ◽  
Niveen M. Khashab
Keyword(s):  
Controlled Release ◽  
Biomedical Applications ◽  
Great Promise ◽  
Stimuli Responsive ◽  
Specific Time ◽  
Triggered Release ◽  
The Past ◽  
Scientists And Engineers ◽  
Targeted Release

AbstractThe controlled release of therapeutics has been one of the major challenges for scientists and engineers during the past three decades. Coupled with excellent biocompatibility profiles, various nanomaterials have showed great promise for biomedical applications. Stimuli-responsive nanomaterials guarantee the controlled release of cargo to a given location, at a specific time, and with an accurate amount. In this review, we have combined the major stimuli that are currently used to achieve the ultimate goal of controlled and targeted release by “smart” nanomaterials. The most heavily explored strategies include (1) pH, (2) enzymes, (3) redox, (4) magnetic, and (5) light-triggered release.

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