scholarly journals An Investigation into Mechanical Properties and Printability of Potential Substrates for Inkjet Printing of Orodispersible Films

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 468
Author(s):  
Erna Turković ◽  
Ivana Vasiljević ◽  
Milica Drašković ◽  
Nataša Obradović ◽  
Dragana Vasiljević ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Inkjet Printing ◽  
Load Capacity ◽  
Drug Dissolution ◽  
Mechanical Resistance ◽  
Disintegration Time ◽  
Drug Load ◽  
Orodispersible Films ◽  
Novel Approach ◽  
Substrate Properties

Inkjet printing is novel approach in drug manufacturing that enables dispensing precise volumes of ink onto substrates. Optimal substrate properties including suitable mechanical characteristic are recognized as crucial to achieve desired dosage form performance upon administration. Identification of relevant quality attributes and their quantification is subject of intensive scientific research. The aim of this work was to explore applicability of different materials as printing substrates and explore contribution of the investigated substrate properties to its printability. Substrates were characterized with regards to uniformity, porosity, disintegration time, mechanical properties and drug dissolution. Experimentally obtained values were mathematically transformed and the obtained results were presented as relevant radar charts. It was shown that structurally different substrates may be employed for orodispersible films inkjet printing. Main disadvantage of single-polymer films was low drug load, and their printability was dependent on film flexibility and mechanical strength. Structured orodispersible film templates exhibited favorable mechanical properties and drug load capacity. Wafer edible sheets were characterized with high mechanical resistance and brittleness which somewhat diminished printability, but did not hinder high drug load. Obtained results provide insight into application of different materials as printing substrates and contribute to understanding of substrate properties which can affect printability.

scholarly journals The Impact of the Preparation Method on the Properties of Orodispersible Films with Aripiprazole: Electrospinning vs. Casting and 3D Printing Methods

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1122
Author(s):  
Ewelina Łyszczarz ◽  
Witold Brniak ◽  
Joanna Szafraniec-Szczęsny ◽  
Tomasz Mariusz Majka ◽  
Dorota Majda ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
3D Printing ◽  
Microscopic Analysis ◽  
Storage Condition ◽  
Stability Studies ◽  
Disintegration Time ◽  
Manufacturing Method ◽  
Orodispersible Films ◽  
Swallowing Problems ◽  
The Impact

Orodispersible films (ODFs) address the needs of pediatric and geriatric patients and people with swallowing difficulties due to fast disintegration in the mouth. Typically, they are obtained using the solvent casting method, but other techniques such as 3D printing and electrospinning have already been investigated. The decision on the manufacturing method is of crucial importance because it affects film properties. This study aimed to compare electrospun ODFs containing aripiprazole and polyvinyl alcohol with films prepared using casting and 3D printing methods. Characterization of films included DSC and XRD analysis, microscopic analysis, the assessment of mechanical parameters, disintegration, and dissolution tests. Simplified stability studies were performed after one month of storage. All prepared films met acceptance criteria for mechanical properties. Electrospun ODFs disintegrated in 1.0 s, which was much less than in the case of other films. Stability studies have shown the sensitivity of electrospun films to the storage condition resulting in partial recrystallization of ARP. These changes negatively affected the dissolution rate, but mechanical properties and disintegration time remained at a desirable level. The results demonstrated that electrospun fibers are promising solutions that can be used in the future for the treatment of patients with swallowing problems.

scholarly journals Characterization of Hydrophilic Polymers as a Syringe Extrusion 3D Printing Material for Orodispersible Film

Polymers ◽  
2021 ◽  
Vol 13 (20) ◽  
pp. 3454
Author(s):  
Pattaraporn Panraksa ◽  
Sheng Qi ◽  
Suruk Udomsom ◽  
Pratchaya Tipduangta ◽  
Pornchai Rachtanapun ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
3D Printing ◽  
Hydroxypropyl Methylcellulose ◽  
Three Dimensional ◽  
Pharmaceutical Products ◽  
Hydrophilic Polymers ◽  
Sodium Carboxymethylcellulose ◽  
Disintegration Time ◽  
Orodispersible Films ◽  
3D Printed

The application of hydrophilic polymers in designing and three-dimensional (3D) printing of pharmaceutical products in various dosage forms has recently been paid much attention. Use of hydrophilic polymers and syringe extrusion 3D printing technology in the fabrication of orodispersible films (ODFs) might hold great potential in rapid drug delivery, personalized medicine, and manufacturing time savings. In this study, the feasibility of 3D-printed ODFs fabrication through a syringe extrusion 3D printing technique and using five different hydrophilic polymers (e.g., hydroxypropyl methylcellulose E15, hydroxypropyl methylcellulose E50, high methoxyl pectin, sodium carboxymethylcellulose, and hydroxyethylcellulose) as film-forming polymers and printing materials has been investigated. Rheology properties and printability of printing gels and physicochemical and mechanical properties of 3D-printed ODFs were evaluated. Amongst the investigated hydrophilic polymers, sodium carboxymethylcellulose at a concentration of 5% w/v (SCMC-5) showed promising results with a good printing resolution and accurate dimensions of the 3D-printed ODFs. In addition, SCMC-5 3D-printed ODFs exhibited the fastest disintegration time within 3 s due to high wettability, roughness and porosity on the surface. However, the results of the mechanical properties study showed that SCMC-5 3D printed ODFs were rigid and brittle, thus requiring special packaging to prevent them from any damage before practical use.

scholarly journals Development and Evaluation of Fluoxetine Fast Dissolving Films: An Alternative for Noncompliance in Pediatric Patients

Processes ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 778
Author(s):  
Emőke-Margit Rédai ◽  
Paula Antonoaea ◽  
Nicoleta Todoran ◽  
Robert Alexandru Vlad ◽  
Magdalena Bîrsan ◽  
...  
Keyword(s):  
Pediatric Patients ◽  
Hydroxypropyl Methylcellulose ◽  
Pharmaceutical Formulations ◽  
Release Kinetic ◽  
Disintegration Time ◽  
Casting Technique ◽  
First Order ◽  
Orodispersible Films ◽  
Folding Endurance

The most used pharmaceutical formulations for children are syrups, suppositories, soft chewable capsules, and mini-tablets. Administrating them might create an administration discomfort. This study aimed to develop and evaluate orodispersible films (ODFs) for pediatric patients in which the fluoxetine (FX) is formulated in the polymeric matrix. Six FX fast dissolving films (10 mg FX/ODF), FX1, FX2, FX3, FX4, FX5, and FX6, were prepared by solvent casting technique. In the composition of the ODFs, the concentration of the hydroxypropyl methylcellulose and the concentration of the propylene glycol were varied. Each formulation of fluoxetine ODF was evaluated by determining the tensile strength, folding endurance, disintegration, behavior in the controlled humidity and temperature conditions, and adhesiveness. All the obtained results were compared with the results obtained for six ODFs prepared without FX. The disintegration time of the FX ODFs was of maximum 88 s for FX2. Via the in vitro releasing study of the FX from the ODFs it was noticed that FX1 and FX2 allow a better release of the drug 99.98 ± 3.81% and 97.67 ± 3.85% being released within 15 min. From the obtained results it was also confirmed that FX ODFs were found to follow first-order release kinetic.

scholarly journals Construction of hollow polydopamine nanoparticle based drug sustainable release system and its application in bone regeneration

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Lu Wang ◽  
Shuwei Liu ◽  
Chunxia Ren ◽  
Siyuan Xiang ◽  
Daowei Li ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Defect ◽  
Load Capacity ◽  
Good Prospect ◽  
Alizarin Red ◽  
Drug Load ◽  
Load Rate ◽  
Low Toxicity

AbstractNanomaterial-based drug sustainable release systems have been tentatively applied to bone regeneration. They, however, still face disadvantages of high toxicity, low biocompatibility, and low drug-load capacity. In view of the low toxicity and high biocompatibility of polymer nanomaterials and the excellent load capacity of hollow nanomaterials with high specific surface area, we evaluated the hollow polydopamine nanoparticles (HPDA NPs), in order to find an optimal system to effectively deliver the osteogenic drugs to improve treatment of bone defect. Data demonstrated that the HPDA NPs synthesized herein could efficiently load four types of osteogenic drugs and the drugs can effectively release from the HPDA NPs for a relatively longer time in vitro and in vivo with low toxicity and high biocompatibility. Results of qRT-PCR, ALP, and alizarin red S staining showed that drugs released from the HPDA NPs could promote osteogenic differentiation and proliferation of rat bone marrow mesenchymal stem cells (rBMSCs) in vitro. Image data from micro-CT and H&E staining showed that all four osteogenic drugs released from the HPDA NPs effectively promoted bone regeneration in the defect of tooth extraction fossa in vivo, especially tacrolimus. These results suggest that the HPDA NPs, the biodegradable hollow polymer nanoparticles with high drug load rate and sustainable release ability, have good prospect to treat the bone defect in future clinical practice.

scholarly journals DESIGN, OPTIMIZATION AND EVALUATION OF CETRIZINE DIHYDROCHLORIDE FAST DISSOLVING FILMS EMPLOYING STARCH TARTRATE–A NOVEL SUPERDISINTEGRANT

2019 ◽  
pp. 75-86
Author(s):  
R. SANTOSH KUMAR ◽  
ANNU KUMARI ◽  
B. KUSUMA LATHA ◽  
PRUDHVI RAJ
Keyword(s):  
Tensile Strength ◽  
Drug Dissolution ◽  
In Vitro Dissolution ◽  
Content Uniformity ◽  
Scanning Calorimetry ◽  
Disintegration Time ◽  
Folding Endurance ◽  
Contour Plots ◽  
The Individual

Objective: The aim of the current research is optimization, preparation and evaluation of starch tartrate (novel super disintegrant) and preparation of fast dissolving oral films of cetirizine dihydrochloride by employing starch tartrate. Methods: To check the drug excipient compatibility studies of the selected drug (Cetrizine dihydrochloride) and the prepared excipient i. e starch tartrate, different studies like FTIR (Fourier-transform infrared spectroscopy), DSC (Differential scanning calorimetry) and thin-layer chromatography (TLC) were carried out to find out whether there is any interaction between cetirizine dihydrochloride and starch tartrate. The solvent casting method was used for the preparation of fast dissolving films. The prepared films were then evaluated for thickness, folding endurance, content uniformity, tensile strength, percent elongation, in vitro disintegration time and in-vitro dissolution studies. Response surface plots and contour plots were also plotted to know the individual and combined effect of starch tartrate (A), croscarmellose sodium (B) and crospovidone (C) on disintegration time and drug dissolution efficiency in 10 min (dependent variables). Results: Films of all the formulations are of good quality, smooth and elegant by appearance. Drug content (100±5%), thickness (0.059 mm to 0.061 mm), the weight of films varies from 51.33 to 58.06 mg, folding endurance (52 to 67 times), tensile strength (10.25 to 12.08 N/mm2). Fast dissolving films were found to disintegrate between 34 to 69 sec. Percent dissolved in 5 min were found to be more in F1 formulation which confirms that starch tartrate was effective at 1%. Conclusion: From the research conducted, it was proved that starch tartrate can be used in the formulation of fast dissolving films of cetirizine dihydrochloride. The disintegration time of the films was increased with increase in concentration of super disintegrant.

scholarly journals 3DP Printing of Oral Solid Formulations: A Systematic Review

Pharmaceutics ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 358 ◽  
Author(s):  
Chiara R. M. Brambilla ◽  
Ogochukwu Lilian Okafor-Muo ◽  
Hany Hassanin ◽  
Amr ElShaer
Keyword(s):  
Systematic Review ◽  
Data Extraction ◽  
New Technology ◽  
Three Dimensional ◽  
Extraction Process ◽  
Carcinogenic Risk ◽  
Drug Dissolution ◽  
Dissolution Profile ◽  
Disintegration Time ◽  
Advantages And Disadvantages

Three-dimensional (3D) printing is a recent technology, which gives the possibility to manufacture personalised dosage forms and it has a broad range of applications. One of the most developed, it is the manufacture of oral solid dosage and the four 3DP techniques which have been more used for their manufacture are FDM, inkjet 3DP, SLA and SLS. This systematic review is carried out to statistically analyze the current 3DP techniques employed in manufacturing oral solid formulations and assess the recent trends of this new technology. The work has been organised into four steps, (1) screening of the articles, definition of the inclusion and exclusion criteria and classification of the articles in the two main groups (included/excluded); (2) quantification and characterisation of the included articles; (3) evaluation of the validity of data and data extraction process; (4) data analysis, discussion, and conclusion to define which technique offers the best properties to be applied in the manufacture of oral solid formulations. It has been observed that with SLS 3DP technique, all the characterisation tests required by the BP (drug content, drug dissolution profile, hardness, friability, disintegration time and uniformity of weight) have been performed in the majority of articles, except for the friability test. However, it is not possible to define which of the four 3DP techniques is the most suitable for the manufacture of oral solid formulations, because the selection is affected by different parameters, such as the type of formulation, the physical-mechanical properties to achieve. Moreover, each technique has its specific advantages and disadvantages, such as for FDM the biggest challenge is the degradation of the drug, due to high printing temperature process or for SLA is the toxicity of the carcinogenic risk of the photopolymerising material.

scholarly journals Comparative Study of High-Performance Concrete Characteristics and Loading Test of Pretensioned Experimental Beams

Crystals ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 427
Author(s):  
Pavlina Mateckova ◽  
Vlastimil Bilek ◽  
Oldrich Sucharda
Keyword(s):  
Mechanical Properties ◽  
High Performance ◽  
High Performance Concrete ◽  
Raw Materials ◽  
Load Capacity ◽  
Materials Testing ◽  
Loading Test ◽  
Conventional Concrete ◽  
Concrete Mechanical Properties ◽  
Normal Strength

High-performance concrete (HPC) is subjected to wide attention in current research. Many research tasks are focused on laboratory testing of concrete mechanical properties with specific raw materials, where a mixture is prepared in a relatively small amount in ideal conditions. The wider utilization of HPC is connected, among other things, with its utilization in the construction industry. The paper presents two variants of HPC which were developed by modification of ordinary concrete used by a precast company for pretensioned bridge beams. The presented variants were produced in industrial conditions using common raw materials. Testing and comparison of basic mechanical properties are complemented with specialized tests of the resistance to chloride penetration. Tentative expenses for normal strength concrete (NSC) and HPC are compared. The research program was accomplished with a loading test of model experimental pretensioned beams with a length of 7 m made of ordinarily used concrete and one variant of HPC. The aim of the loading test was to determine the load–deformation diagrams and verify the design code load capacity calculation method. Overall, the article summarizes the possible benefits of using HPC compared to conventional concrete.

scholarly journals Diffuse approximation for identification of the mechanical properties of microcapsules

2020 ◽  
pp. 108128652097760
Author(s):  
Carlos Quesada ◽  
Claire Dupont ◽  
Pierre Villon ◽  
Anne-Virginie Salsac
Keyword(s):  
Mechanical Properties ◽  
Active Material ◽  
Liquid Core ◽  
Constitutive Law ◽  
Data Driven ◽  
Membrane Properties ◽  
Mechanical Resistance ◽  
Data Set ◽  
Diffuse Approximation ◽  
Capsule Size

A novel data-driven real-time procedure based on diffuse approximation is proposed to characterize the mechanical behavior of liquid-core microcapsules from their deformed shape and identify the mechanical properties of the submicron-thick membrane that protects the inner core through inverse analysis. The method first involves experimentally acquiring the deformed shape that a given microcapsule takes at steady state when it flows through a microfluidic microchannel of comparable cross-sectional size. From the mid-plane capsule profile, we deduce two characteristic geometric quantities that uniquely characterize the shape taken by the microcapsule under external hydrodynamic stresses. To identify the values of the unknown rigidity of the membrane and of the size of the capsule, we compare the geometric quantities with the values predicted numerically using a fluid-structure-interaction model by solving the three-dimensional capsule-flow interactions. The complete numerical data set is obtained off-line by systematically varying the governing parameters of the problem, i.e. the capsule-to-tube confinement ratio, and the capillary number, which is the ratio of the viscous to elastic forces. We show that diffuse approximation efficiently estimates the unknown mechanical resistance of the capsule membrane. We validate the data-driven procedure by applying it to the geometric and mechanical characterization of ovalbumin microcapsules (diameter of the order of a few tens of microns). As soon as the capsule is sufficiently deformed to exhibit a parachute shape at the rear, the capsule size and surface shear modulus are determined with an accuracy of 0.2% and 2.7%, respectively, as compared with 2–3% and 25% without it, in the best cases (Hu et al. Characterizing the membrane properties of capsules flowing in a square-section microfluidic channel: Effects of the membrane constitutive law. Phys Rev E 2013; 87(6): 063008). Diffuse approximation thus allows the capsule size and membrane elastic resistance to be provided quasi-instantly with very high precision. This opens interesting perspectives for industrial applications that require tight control of the capsule mechanical properties in order to secure their behavior when they transport active material.

scholarly journals Automatic Evaluation of the Mechanical Properties of Steels Maraging using Digital Image Processing Techniques

2020 ◽  
Author(s):  
Angélica Alves Viana ◽  
Savio Lopes Rabelo ◽  
José Daniel de Alencar Santos ◽  
Venceslau Xavier de Lima Filho ◽  
Douglas De Araújo Rodrigues ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Fracture Toughness ◽  
Maraging Steel ◽  
Raw Material ◽  
High Fracture Toughness ◽  
Mechanical Resistance ◽  
High Fracture ◽  
Traditional System ◽  
Transformation Methods ◽  
Processing Techniques

Some strategic sectors of the economy require that the raw material of their machines and equipment have mechanical properties that satisfy their use. Maraging steel is a material of great concern since it is necessary to have a high mechanical resistance associated with high fracture toughness. The traditional tests to determine the fracture toughness of this material before use in applications are the Charpy and KIC tests. However, this process is characterized by being exhaustive and requiring specialized and trained professionals. Thus, to reverse this situation, this work proposes a new approach to determine the mechanical properties of maraging steel. For this, initially, the method removes any artifacts present in the image resulting from the mode of acquisition. In sequence, this works tested the method Extended Minimum Transformation (EMT) and mathematical morphology to find these markers of the regions of the dimples. Then, the Adaptive Thresholding, Optimal Global Thresholdusing the Otsu Method and Watershed transformation methods were used to segment the dimples. In the end, the diameter of the dimples and the toughness of the material were calculated. Tests are carried out and compared with the result obtained by specialists using the traditional system to evaluate the proposed approach. The results obtained were satisfactory for the application because the proposed approach presented speed and precision to the conventional methods.

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