scholarly journals Optimization of Mesoporous Silica Nanoparticles through Statistical Design of Experiment and the Application for the Anticancer Drug

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 184
Author(s):  
Min-Ki Kim ◽  
Do-Hyung Ki ◽  
Young-Guk Na ◽  
Hae-Soo Lee ◽  
Jong-Suep Baek ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Physicochemical Properties ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Release Profile ◽  
Synthesis Process ◽  
Release Mechanism ◽  
Ammonium Bromide ◽  
Cytotoxicity Test

The synthesis process or composition of mesoporous silica nanoparticles (MSNs) affects the physicochemical properties. Using these properties, MSNs were synthesized through the Box–Behnken design (BBD) among statistical experimental methods. The effect of the amounts of synthetic reagents, hexadecyl triethyl ammonium bromide (CTAB), tetraethyl orthosilicate (TEOS), and 2 N sodium hydroxide (NaOH), was studied using the reaction surface design. Surface area, particle size, and zeta potential were set as response values. The physicochemical properties of the optimized MSNs were evaluated, and the effect as a drug delivery system was evaluated by loading doxorubicin hydrochloride (DOX). Nano-sized MSNs were successfully prepared with 0.617 g of CTAB, 8.417 mL of TEOS, and 2.726 mL of 2 N NaOH and showed excellent physicochemical properties. The optimized MSNs showed negligible toxicity in MCF-7 cells. The drug release profile from DOX-loaded MSNs (MSN@DOX) showed an increased rate of release with decreasing pH of the medium, with the release profile sustained for 48 h. In the cytotoxicity test, the sustained drug release mechanism of MSN@DOX was confirmed. This study proposed a new statistical approach to the synthesis of MSNs.

scholarly journals DESIGN, CHARACTERIZATION AND EVALUATION OF CURCUMIN-LOADED MESOPOROUS SILICA NANOPARTICLES BASED TOPICAL DRUG DELIVERY SYSTEM FOR TREATMENT OF WRINKLES

2021 ◽  
Vol 10 (3) ◽  
pp. 2904-2915
Author(s):  
Shivendra Pratap Singh
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Research Work ◽  
In Vitro Release ◽  
Ammonium Bromide ◽  
Topical Drug Delivery ◽  
Treatment Of Wrinkles

The objective of research work was to development and evaluation of curcumin-loaded mesoporous silica nanoparticles (MSN), based topical dosage form for the treatment of facial wrinkles. Curcumin was selected as a hydrophobic model drug since it has been reported as potent anti-oxidizing and as an anti-wrinkle agent. Hence curcumin drug was selected as anti-wrinkle agent for the treatment of wrinkles. The MSN were prepared with tetraethyl ortho silicate and cetyltrimethyl ammonium bromide (as surfactant). The prepared MSN were characterized by using particle size analysis, scanning electron microscope, Xrd, FTIR and porosimetry. The MSN was found to be biocompatible chemically & thermally stable nanoparticles. The curcumin extract was loaded into MSN and incorporated into cream. In-vitro release study of curcumin-loaded MSN system was compared with marketed formulation and was found the curcumin-loaded mesoporous silica nanoparticles (MSN) showed good antioxidant activity and batter % cumulative drug release. The % cumulative drug release of curcumin-loaded MSN was found to be 88% at pH 5.5 and 85% at pH 7.4 respectively. Revealed that after incorporation of curcumin into MSN, the drug release rate was found increased. The properties of curcumin-loaded MSN strongly advocate its good feature for delivery of anti-wrinkles drug. The prepared curcumin-loaded MSN seem to have potential carrier for use as a topical drug delivery.

scholarly journals AuNP and ssDNA capped mesoporous silica nanoparticles for laser controlled drug release

RSC Advances ◽  
2019 ◽  
Vol 9 (60) ◽  
pp. 34958-34962 ◽  
Author(s):  
Lu Zhou ◽  
Guojie Liu ◽  
Yang Wang ◽  
Jianling Liu ◽  
Yajie Zhang ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Release

Gold nanoparticles were linked to the surface of mesoporous silica through a polyA oligonucleotide and infrared stimulation controlled drug release.

DNA-capped Fe3O4/SiO2 magnetic mesoporous silica nanoparticles for potential controlled drug release and hyperthermia

RSC Advances ◽  
2015 ◽  
Vol 5 (29) ◽  
pp. 22365-22372 ◽  
Author(s):  
Yufang Zhu ◽  
Cuilian Tao
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Potential Temperature ◽  
Controlled Drug Release ◽  
Magnetic Hyperthermia ◽  
Temperature Controlled ◽  
Magnetic Mesoporous Silica

DNA-capped Fe3O4/SiO2 magnetic mesoporous silica (MMS) nanoparticles were developed for potential temperature controlled drug release and magnetic hyperthermia.

scholarly journals Photoacoustic ratiometric assessment of mitoxantrone release from theranostic ICG-conjugated mesoporous silica nanoparticles

Nanoscale ◽  
2019 ◽  
Vol 11 (39) ◽  
pp. 18031-18036 ◽  
Author(s):  
Giuseppe Ferrauto ◽  
Fabio Carniato ◽  
Enza Di Gregorio ◽  
Mauro Botta ◽  
Lorenzo Tei
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Chemotherapeutic Drug

A nanosystem based on mesoporous silica functionalized with ICG and the chemotherapeutic drug mitoxantrone has been exploited to introduce an innovative photoacoustic ratiometric approach for the assessment of drug release both in vitro and in vivo.

scholarly journals Bioresponsive Mesoporous Silica Nanoparticles for Triggered Drug Release

2011 ◽  
Vol 133 (49) ◽  
pp. 19582-19585 ◽  
Author(s):  
Neetu Singh ◽  
Amrita Karambelkar ◽  
Luo Gu ◽  
Kevin Lin ◽  
Jordan S. Miller ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Triggered Drug Release

scholarly journals Titania coating of mesoporous silica nanoparticles for improved biocompatibility and drug release within blood vessels

2018 ◽  
Vol 76 ◽  
pp. 208-216 ◽  
Author(s):  
Asima Farooq ◽  
Ali Shukur ◽  
Cai Astley ◽  
Lubomira Tosheva ◽  
Peter Kelly ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Blood Vessels ◽  
Mesoporous Silica Nanoparticles ◽  
Titania Coating
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