Acute NMDA receptor antagonism impairs working memory performance but not attention in rats—Implications for the NMDAr hypofunction theory of schizophrenia.

2020 ◽  
Vol 134 (4) ◽  
pp. 323-331
Author(s):  
Jaime Lee ◽  
Maarten van den Buuse ◽  
Jess Nithianantharajah ◽  
Nigel C. Jones
Keyword(s):  
Working Memory ◽  
Nmda Receptor ◽  
Memory Performance ◽  
Receptor Antagonism

Estrogen and NMDA receptor antagonism: effects upon reference and working memory

1999 ◽  
Vol 381 (2-3) ◽  
pp. 93-99 ◽  
Author(s):  
Iain A Wilson ◽  
Jukka Puoliväli ◽  
Taneli Heikkinen ◽  
Paavo Riekkinen
Keyword(s):  
Working Memory ◽  
Nmda Receptor ◽  
Receptor Antagonism

S159. NMDA Receptor Antagonism Effects on Delayed Spatial Working Memory and Distraction in Comparison With Schizophrenia

2019 ◽  
Vol 85 (10) ◽  
pp. S358
Author(s):  
Flora Moujaes ◽  
Katrin Preller ◽  
Franz Vollenweider ◽  
Charles Schleifer ◽  
Jie Lisa Ji ◽  
...  
Keyword(s):  
Working Memory ◽  
Nmda Receptor ◽  
Spatial Working Memory ◽  
Receptor Antagonism

scholarly journals Dynamic brain network reconfiguration as a potential schizophrenia genetic risk mechanism modulated by NMDA receptor function

2016 ◽  
Vol 113 (44) ◽  
pp. 12568-12573 ◽  
Author(s):  
Urs Braun ◽  
Axel Schäfer ◽  
Danielle S. Bassett ◽  
Franziska Rausch ◽  
Janina I. Schweiger ◽  
...  
Keyword(s):  
Neural Networks ◽  
Working Memory ◽  
Nmda Receptor ◽  
Genetic Risk ◽  
Brain Networks ◽  
Dynamic Network ◽  
Dynamic Reconfiguration ◽  
Healthy Controls ◽  
Receptor Antagonism ◽  
Network Flexibility

Schizophrenia is increasingly recognized as a disorder of distributed neural dynamics, but the molecular and genetic contributions are poorly understood. Recent work highlights a role for altered N-methyl-d-aspartate (NMDA) receptor signaling and related impairments in the excitation–inhibitory balance and synchrony of large-scale neural networks. Here, we combined a pharmacological intervention with novel techniques from dynamic network neuroscience applied to functional magnetic resonance imaging (fMRI) to identify alterations in the dynamic reconfiguration of brain networks related to schizophrenia genetic risk and NMDA receptor hypofunction. We quantified “network flexibility,” a measure of the dynamic reconfiguration of the community structure of time-variant brain networks during working memory performance. Comparing 28 patients with schizophrenia, 37 unaffected first-degree relatives, and 139 healthy controls, we detected significant differences in network flexibility [F(2,196) = 6.541, P = 0.002] in a pattern consistent with the assumed genetic risk load of the groups (highest for patients, intermediate for relatives, and lowest for controls). In an observer-blinded, placebo-controlled, randomized, cross-over pharmacological challenge study in 37 healthy controls, we further detected a significant increase in network flexibility as a result of NMDA receptor antagonism with 120 mg dextromethorphan [F(1,34) = 5.291, P = 0.028]. Our results identify a potential dynamic network intermediate phenotype related to the genetic liability for schizophrenia that manifests as altered reconfiguration of brain networks during working memory. The phenotype appears to be influenced by NMDA receptor antagonism, consistent with a critical role for glutamate in the temporal coordination of neural networks and the pathophysiology of schizophrenia.

Short- and long-term memory tasks predict working memory performance, and vice versa.

2019 ◽  
Vol 73 (2) ◽  
pp. 79-93 ◽  
Author(s):  
Ian Neath ◽  
Jean Saint-Aubin ◽  
Tamra J. Bireta ◽  
Andrew J. Gabel ◽  
Chelsea G. Hudson ◽  
...  
Keyword(s):  
Working Memory ◽  
Memory Performance ◽  
Long Term Memory ◽  
Term Memory ◽  
Short And Long Term

How Does Caffeine Impact Working Memory Performance in Extraverts and Introverts?

2012 ◽  
Author(s):  
Jaclyn Jansen ◽  
Gabriella Dimotsantos ◽  
Marian E. Berryhill
Keyword(s):  
Working Memory ◽  
Memory Performance

Retrospective prioritization of multiple items during working memory storage

2019 ◽  
Author(s):  
Ashley DiPuma ◽  
Kelly Rivera ◽  
Edward Ester
Keyword(s):  
Working Memory ◽  
Memory Performance ◽  
Memory Item ◽  
Neutral Condition ◽  
Memory Storage ◽  
Single Item ◽  
Incorrect Item ◽  
Memory Precision ◽  
Neutral Conditions ◽  
Directing Attention

Working memory (WM) performance can be improved by an informative cue presented during storage. This effect, termed a retro-cue benefit, can be used to explore mechanisms of attentional prioritization in WM. Directing attention to a single item stored in memory is known to increase memory precision while decreasing the likelihood of incorrect item reports and random guesses, but it is unclear whether similar benefits manifest when participants direct attention to multiple items stored in memory. We tested this possibility by quantifying memory performance when participants were cued to prioritize one or two items stored in working memory. Consistent with prior work, cueing participants to prioritize a single memory item yielded higher recall precision, fewer swap errors, and fewer guesses relative to a neutral cue condition. Conversely, cueing participants to prioritize two memory items yielded fewer swap errors relative to a neutral condition, but no differences in recall precision or guess rates. Although swap rates were less likely during the cue-two vs. neutral conditions, planned comparisons revealed that when participants made swap errors during cue-two trials they were far more likely to confuse two prioritized stimuli than they were to confuse a prioritized stimulus vs. a non-prioritized stimulus. Our results suggest that it is possible to prioritize multiple items stored in memory, with the caveat that doing so may increase the probability of confusing prioritized items.

Mindfulness Training as Cognitive Training in High-Demand Cohorts: An Initial Study in Elite Military Servicemembers

2018 ◽  
Author(s):  
Anthony Paul Zanesco ◽  
Ekaterina Denkova ◽  
Scott L. Rogers ◽  
William K. MacNulty ◽  
Amishi P. Jha
Keyword(s):  
Working Memory ◽  
Cognitive Training ◽  
Short Form ◽  
Memory Performance ◽  
Memory Task ◽  
Selection Criterion ◽  
Initial Study ◽  
Mindfulness Training ◽  
Training Tool ◽  
Cognitive Failures

Cognitive ability is a key selection criterion for entry into many elite professions. Herein, we investigate whether mindfulness training (MT) can enhance cognitive performance in elite military forces. The cognitive effects of a short-form 8-hour MT program contextualized for military cohorts, referred to as Mindfulness-Based Attention Training (MBAT), were assessed. Servicemembers received either a 2-week (n = 40) or 4-week (n = 36) version of MBAT, or no training (NTC, n = 44). Sustained attention and working memory task performance along with self-reported cognitive failures were assessed at study onset (T1) and 8-weeks later (T2). In contrast to both the NTC and 2-week MT groups, the 4-week MT group significantly improved over time on attention and working memory outcome measures. Among the 4-week more so than the 2-week MBAT participants, working memory performance improvements were correlated with their amount of out-of-class MT practice. In addition to these group-wise effects, all participants receiving MBAT decreased in their self-reported cognitive failures from T1 to T2. Importantly, none of these improvements were related to self-reported task motivation. Together, these results suggest that short-form MT, when delivered over a 4-week delivery schedule, may be an effective cognitive training tool in elite military cohorts.

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