scholarly journals Comparative Safety Profiles of Sedatives Commonly Used in Clinical Practice: A 10-Year Nationwide Pharmacovigilance Study in Korea

2021 ◽  
Vol 14 (8) ◽  
pp. 783
Author(s):  
Yeo-Jin Choi ◽  
Seung-Won Yang ◽  
Won-Gun Kwack ◽  
Jun-Kyu Lee ◽  
Tae-Hee Lee ◽  
...  
Keyword(s):  
Heart Rate ◽  
Adverse Event Reporting System ◽  
Adverse Event Reporting ◽  
World Health ◽  
Gastrointestinal Disorders ◽  
Reporting Odds Ratio ◽  
Cross Sectional ◽  
Factors Associated ◽  
Concurrent Use ◽  
Health Organization

This study aims to compare the prevalence and seriousness of adverse events (AEs) among sedatives used in critically ill patients or patients undergoing invasive procedures and to identify factors associated with serious AEs. Retrospective cross-sectional analysis of sedative-related AEs voluntarily reported to the Korea Adverse Event Reporting System from 2008 to 2017 was performed. All AEs were grouped using preferred terms and System Organ Classes per the World Health Organization—Adverse Reaction Terminology. Logistic regression was performed to identify factors associated with serious events. Among 95,188 AEs, including 3132 (3.3%) serious events, the most common etiologic sedative was fentanyl (58.8%), followed by pethidine (25.9%). Gastrointestinal disorders (54.2%) were the most frequent AEs. The most common serious AE was heart rate/rhythm disorders (33.1%). Serious AEs were significantly associated with male sex; pediatrics; etiologic sedative with etomidate at the highest risk, followed by dexmedetomidine, ketamine, and propofol; polypharmacy; combined sedative use; and concurrent use of corticosteroids, aspirin, neuromuscular blockers, and antihistamines (reporting odds ratio > 1, p < 0.001 for all). Sedative-induced AEs are most frequently reported with fentanyl, primarily manifesting as gastrointestinal disorders. Etomidate is associated with the highest risk of serious AEs, with the most common serious events being heart rate/rhythm disorders.

scholarly journals Fatal Events Associated with Adverse Drug Reactions in the Korean National Pharmacovigilance Database

2021 ◽  
Vol 12 (1) ◽  
pp. 5
Author(s):  
Hyeong-Geun Jo ◽  
Kyeoul Jeong ◽  
Ji-Young Ryu ◽  
Soyun Park ◽  
Yun-Seok Choi ◽  
...  
Keyword(s):  
Contrast Media ◽  
Adverse Drug Reactions ◽  
Adverse Event Reporting System ◽  
Adverse Event Reporting ◽  
World Health ◽  
Reporting Odds Ratio ◽  
Global Public Health ◽  
Drug Reactions ◽  
Cross Sectional ◽  
Relative Paucity

Adverse drug reactions (ADRs) pose a global public health threat, substantially contributing to death. Due to the relative paucity of clinical evidence regarding fatal ADRs, this study was performed to characterize the epidemiology of fatal ADRs in Korea. This was a retrospective, cross-sectional analysis of ADR cases reported to the Korea Adverse Event Reporting System from 2010 to 2019. All ADRs were coded using the World Health Organization-Adverse Reaction Terminology system and classified as either fatal or non-fatal events. Logistic regression was performed to identify factors associated with fatal events. Among 289,756 ADR records, 629 fatal events (0.2%) occurred. The most common causative agent of fatal ADRs was antibacterials (20.3%), followed by antimycobacterials (5.4%), analgesics (4.0%), and contrast media (1.9%). Among antimicrobials, vancomycin was most frequently implicated without significantly increasing the risk of fatal events. The risk for fatal ADRs was significantly increased with male sex; advanced age; polypharmacy; piperacillin/β-lactamase inhibitor; cefotetan; ceftriaxone; combination antimycobacterial therapy consisting of rifampicin, isoniazid, pyrazinamide, and ethambutol; morphine; and iopromide (reporting odds ratio > 1, p < 0.05 for all). Although fatal ADRs are uncommon (<1%) in Korea, they are primarily caused by commonly used medications including antibiotics, analgesics, and contrast media.

scholarly journals “Yes, I’m interested in taking PrEP!”: PrEP interest among women respondents to the European community-based survey “Flash! PrEP in Europe”

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0246037
Author(s):  
Rosemary M. Delabre ◽  
Adeline Bernier ◽  
Flor Sánchez ◽  
Antoine Vilotitch ◽  
Sophocles Chanos ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
World Health ◽  
Community Based ◽  
Cross Sectional ◽  
Logistic Regression Models ◽  
Factors Associated ◽  
Final Multivariable Model ◽  
Cdc Guidelines ◽  
Health Organization ◽  
Exposure Prophylaxis

The World Health Organization recommends pre-exposure prophylaxis (PrEP) for all populations at substantial risk of HIV infection, including women. However, data regarding PrEP interest among women is lacking, particularly in Europe. Factors associated with interest in using PrEP were assessed among women respondents to the Flash! PrEP in Europe (FPIE) survey. This community-based cross-sectional study, conducted in 12 European countries, aimed to assess PrEP knowledge and interest. “High objective risk” (HOR) was assessed using established risk criteria following EACS and CDC guidelines. Factors associated with interest in using PrEP were assessed in univariable and multivariable logistic regression models. Among 678 women, 12.5% (n = 85) were considered at HOR, 46.8% (n = 317) indicated prior PrEP knowledge and 18.0% (n = 122) reported interest in using PrEP. Among women at HOR, 40.0% (n = 34) were interested in PrEP. Factors significantly associated with PrEP interest in the final multivariable model were: younger age (18–29 years) (aOR 1.91[95CI: 1.07; 3.41]), bad self-perceived financial status (1.84[1.09; 3.11]), migrant status (south to north) (2.87[1.05; 7.89]), single or dating relationship status (1.93[1.23; 3.03]), sexual abuse history (1.86[1.17; 2.97]), “rather high”/ “high” self-perceived HIV risk (3.21[1.32; 7.81]), and HOR (2.49[1.42; 4.35]). These results show that women at HOR and those who perceived themselves to be at high risk are interested in using PrEP. There is a critical need for targeted information and improved access to PrEP to increase uptake of this HIV prevention tool to meet PrEP interest among women.

scholarly journals Correlates of Hypertension among Persons with HIV at Livingstone Central Hospital: CHAP study

2021 ◽  
Author(s):  
Sody Mweetwa Munsaka ◽  
Annet Kirabo ◽  
Benson M. Hamooya ◽  
Musalula Sinkala ◽  
John R. Koethe ◽  
...  
Keyword(s):  
Low Cost ◽  
Heart Association ◽  
Cross Sectional Study ◽  
World Health ◽  
Cross Sectional ◽  
Factors Associated ◽  
Salt Consumption ◽  
New Guidelines ◽  
Definition Of ◽  
Health Organization

Abstract Background: Persons with HIV (PWH) are more likely to develop hypertension and cardiovascular disease than the HIV-negative population. The new hypertension guidelines by the American Heart Association (AHA) and the American College of Cardiology (ACC) lowered the definition of hypertension from a systolic and diastolic blood pressure (BP) of ≥140/90mmHg to ≥130/80, respectively. This study was aimed at determining the prevalence and factors associated with hypertension in PWH using the new hypertension diagnostic criteria.Methods: This was a cross-sectional study. We recruited 226 antiretroviral treated PWH attending routine visits. Socio-demographic, health, and clinical data including BP readings were collected. Interviewer-structured questionnaires adapted from the World Health Organization Stepwise approach to Surveillance (WHO STEPs) and the international physical activity questionnaire (IPAQ) were used to collect data. Statistical evaluations were employed to elucidate relationships between hypertension and all response variables.Results: The prevalence of hypertension using the old and new guidelines was 16% and 42%, respectively. Factors significantly associated with increased and reduced odds for developing hypertension after adjustments in multivariate logistic regression were age, body mass index (BMI), employment status, fasting blood sugar (FBS) and table salt consumption, respectively (p<0.05 for all). Using the new AHA/ACC criteria for hypertension shifted the prevalence from 16% (old criteria) to 42%.Conclusion: The major risk factors associated with hypertension in PWH were increasing age, BMI and FBS. We recommend inclusion of FBS in routine measurements in PWH. The AHA/ACC new guidelines should be re-enforced in low-cost settings to increase the treatment of hypertension among PWH.

scholarly journals Post-Cesarean Section Maternal Health Outcome and its Determinants in Tigray Regional State, North Ethiopia.

2019 ◽  
Author(s):  
Mebrahtu Abay ◽  
Welay Gebremariam ◽  
Mirkuzie Woldie Kurie ◽  
Haileselassie Berhane ◽  
Abraham Mengstu
Keyword(s):  
Cesarean Section ◽  
Cross Sectional Study ◽  
Maternal Outcome ◽  
Health Facilities ◽  
World Health ◽  
Cross Sectional ◽  
Factors Associated ◽  
Regional State ◽  
Health Organization ◽  
Referral Status

Abstract Back ground Cesarean section rate is increasing worldwide. However, the World Health Organization has declared that there is insufficient information on maternal outcome following cesarean section for decision making.Objective The aim of this study was to assess post cesarean section maternal outcome and its associated factors availing evidence for practice and policy.Methods Institution based cross-sectional study was conducted among 357 mothers who underwent cesarean section in six selected public general hospitals of Tigray regional State, Ethiopia. Mothers were followed for the duration of post-operative period until they became safe for discharge. The maternal outcomes were categorized into either adverse or good outcomes depending on whether mothers develop any cesarean section related morbidity or not. Logistic regression model was constructed to determine the AOR and 95% CI of independent factors associated with maternal outcome following cesarean section.Results The proportion of adverse maternal outcome was 19.3% with 95% CI of (15.7% -23.8%). Route of anesthesia administration (AOR = 0.296, 95% CI: 0.126 - 0.695) and referral status (AOR = 0.371, 95%CI: 0.214 - 0.641) were statistically significant factors associated with maternal outcome following cesarean section.Conclusion There was high proportion of adverse maternal outcome. General anesthesia and referral from lower health facilities were associated with higher risk of post-CS adverse maternal outcome. Equipping lower level health facilities with the human and material capacity for timely detection of CS indications and provision of cesarean section services could decrease the number of referrals and subsequent delays that lead to adverse maternal outcome.

scholarly journals Prevalence of vaccine hesitancy and its associated factors in an urban area of West Bengal, India

2020 ◽  
Vol 7 (9) ◽  
pp. 3443
Author(s):  
Rajib Sikder ◽  
Dipankar Mukherjee ◽  
Ujjwal Pattanayak ◽  
Kunal Kanti Majumdar ◽  
Subha Sankha Kundu ◽  
...  
Keyword(s):  
West Bengal ◽  
Simple Random Sampling ◽  
Cross Sectional Study ◽  
Childhood Vaccination ◽  
World Health ◽  
Vaccine Hesitancy ◽  
Cross Sectional ◽  
Factors Associated ◽  
Care Givers ◽  
Health Organization

Background: Vaccine hesitancy is delay in acceptance or refusal of vaccines despite availability of vaccine services. This study was conducted to find out the prevalence and factors associated and contributing to vaccine hesitancy for childhood vaccinations in Rajpur-Sonarpur municipalty of south 24 parganas, India.Methods: A cross‑sectional study was done among 352 children aged 0-59 months. Hesitancy to all childhood vaccination including the birth doses were observed. By simple random sampling ward no 8 was selected among the 37 wards of Rajpur-Sonarpur municipalty. All the vaccination center of ward no 8 on various vaccination days were covered from July 2019- December 2019. Data were collected at these vaccination centers by interviewing parents /associates of the children. Validated version of vaccine hesitancy survey questionnaire by the World Health Organization was used.Results: Vaccine hesitancy was present among 103 (29%) parents/relatives /associates of children. Delay was more common for measles and the booster doses of other vaccines. Reluctance to vaccinate was the most common reason (26.2%) for vaccine hesitancy. About 15(15.4%) parents reported to be unaware or confused of when to vaccinate their children. Improper counselling by health care givers, illness or irritability of the child were other causes.Conclusions: To avoid delay in vaccination weekly vaccination days were recommended. Community level campaigning and home visit of those eligible children to generate awareness about vaccination and to avoid reluctance in parents/associates of children were suggested.

scholarly journals Faktor risiko yang berhubungan dengan nyeri ekstremitas inferior pada guru sekolah dasar di Kecamatan Tuminting

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Elvin A. Herlambang ◽  
Vanda D. Doda ◽  
Helina I. S. Wungouw
Keyword(s):  
Risk Factors ◽  
World Health Organization ◽  
Musculoskeletal Disorders ◽  
Significant Risk ◽  
World Health ◽  
Common Disease ◽  
Cross Sectional ◽  
Factors Associated ◽  
Inferior Extremity ◽  
Health Organization

Abstract: Musculoskeletal disorders (MSDs) is a major cause of work-related illness and become a cost burden for individuals, industry and society in many countries and as has been acknowledged by the United Nations and the World Health Organization (WHO). One of the common disease of MSDs is inferior ekstremity pain. The purpose of this study is to determine the risk factors associated with the onset of MSDs, especially in the inferior ekstremity. This study was a cross sectional study with surveys of 282 respondents who are of primary school teachers in Tuminting. This study found that respondents experiencing inferior extremity pain as much as 94% while never experiencing inferior extremity pain as much as 6%. Significant risk factors associated with inferior extremity pain are gender and psychosocial factors that respondents felt over the last few years his work increasingly demanding (p <0.05). This result support the teoritical framework that individual factor and psikosocial factor associate with workrelated MSDs.Keywords: Inferior ekstremity pain, Risk factors, Musculoskeletal Disorders (MSDs)Abstrak: Musculoskeletal disorders (MSDs) merupakan penyebab utama terjadinya sakit yang berhubungan dengan pekerjaan, dan menjadi beban biaya bagi individu, industri dan masyarakat di banyak negara dan telah diakui oleh United Nation dan World Health Organization (WHO). Salah satu keluhan dari MSDs adalah nyeri pada ektremitas inferior. Oleh karena itu penelitian ini bermaksud untuk mengetahui faktor risiko apa saja yang berhubungan dengan timbulnya MSDs khususnya yang terjadi pada ekstremitas inferior. Penelitian ini merupakan penelitian cross sectional dengan survei lapangan terhadap 282 responden yang merupakan guru sekolah dasar di kecamatan Tuminting. Hasil penelitian ini menunjukan responden yang mengalami nyeri ekstremitas inferior sebanyak 94% sedangkan yang tidak pernah mengalami nyeri ekstremitas inferior sebanyak 6%. Faktor risiko yang berhubungan signifikan dengan nyeri ekstremitas inferior adalah jenis kelamin dan faktor psikososial dimana responden merasakan selama beberapa tahun terakhir pekerjaannya semakin lama semakin banyak (p< 0,05). Hasil penelitian ini yaitu faktor individu dengan faktor psikososial berhubungan dengan MSDs yang disebabkan oleh kerja.Kata kunci: Nyeri ekstremitas inferior, Faktor risiko, Musculoskeletal Disorders (MSDs)

Factors Associated With Extended Breastfeeding in India

2016 ◽  
Vol 33 (1) ◽  
pp. 140-148 ◽  
Author(s):  
Arpit R. Mehta ◽  
Sigamani Panneer ◽  
Suparna Ghosh-Jerath ◽  
Elizabeth F. Racine
Keyword(s):  
Median Duration ◽  
Rural Areas ◽  
Health Effect ◽  
World Health ◽  
Breastfeeding Duration ◽  
Cross Sectional ◽  
Factors Associated ◽  
Nationally Representative ◽  
Health Organization ◽  
Duration Of Breastfeeding

Background: Extended breastfeeding duration is common in India. Extended breastfeeding protects the infant from infectious disease and promotes child spacing. In the 1990s, the median breastfeeding duration in India was 24 months. Research aim: This study aimed to investigate the median duration of breastfeeding in India and to identify the factors associated with extended breastfeeding to 24 months as recommended by the World Health Organization. Methods: This cross-sectional data analysis used nationally representative data from the 2011–2012 Indian Human Development Survey II. The outcome in this study was extended breastfeeding defined as breastfeeding to 24 months or more. Multivariate logistic regression was used to identify the factors associated with extended breastfeeding. Results: The median duration of breastfeeding was 12 months; approximately 25% of women breastfed 24 months or more. Women were at greater odds of breastfeeding 24 months or more if the infant was a boy compared with a girl, if the women lived in a rural area compared with an urban area, if the women were married at a young age (< 17 vs. 20 years or older at marriage), and if the delivery was assisted by a friend or relative compared with a doctor. Conclusion: The median duration of breastfeeding has decreased by 50% from 1992–1993 to 2011–2012. The women who continue to breastfeed 24 months or more tend to be more traditional (i.e., living in rural areas, marrying young, and having family/friends as birth attendants). Further research to study the health effect of decreased breastfeeding duration is warranted.

Breastmilk Substitutes Marketing Violations and Associated Factors in Rio de Janeiro, Brazil

2020 ◽  
pp. 089033442097840
Author(s):  
Maria Inês Couto de Oliveira ◽  
Cristiano Siqueira Boccolini ◽  
Enilce de Oliveira Fonseca Sally
Keyword(s):  
Rio De Janeiro ◽  
Cross Sectional Study ◽  
World Health ◽  
Retail Stores ◽  
Department Stores ◽  
Chain Store ◽  
Cross Sectional ◽  
Factors Associated ◽  
A Chain ◽  
Health Organization

Background Aiming to protect breastfeeding, the World Health Organization released the International Code of Marketing of Breastmilk Substitutes in 1981, which was adopted by the vast majority of the 118 member countries, including Brazil. The Brazilian Code regulates the marketing of infant formulas, baby bottles, teats, pacifiers, milk, and processed complementary food. Research aims (1) To determine if retail stores had violated the Brazilian Code and (2) to analyze factors associated with these violations. Methods This cross-sectional study included all drugstores, supermarkets, and department stores in the Southern Zone of Rio de Janeiro City, Brazil. Trained health professionals observed retail stores for marketed products and violations of the Brazilian Code and then interviewed their managers. Factors associated with the retail stores violating the Brazilian Code (outcome) were analyzed, employing a logistic regression model with 95% Confidence Interval. Results Of the retail stores ( N = 349) evaluated, 62.8% violated the Brazilian Code, ranging from 1 to 37 violations per retail store. The most common promotion strategies were price discounts and special displays. Retail stores being part of a chain store (aOR = 4.59) and their manager receiving visits from industry business representatives (aOR = 2.14) were associated with the presence of violations. Conclusions The prevalence of Brazilian Code violations was high, especially in chain stores. The association between regular visits by industry representatives and violations suggests an indirect influence of manufacturers on the promotion of human milk substitutes. We recommend strengthening compliance with the Brazilian Code through calling on governmental surveillance agencies and civil society mobilization.

Demographic Factors Associated with Acceptance of COVID-19 Vaccination: An Online Survey-Based Study from Hyderabad Sindh

BioSight ◽  
2021 ◽  
Vol 2 (1) ◽  
pp. 18-23
Author(s):  
Tayyaba Kazi ◽  
Talha Arain ◽  
Saima Naz Shaikh ◽  
Ayaz Ali Samo ◽  
Nimra Masood Baig ◽  
...  
Keyword(s):  
Online Survey ◽  
Demographic Factors ◽  
Cross Sectional Study ◽  
World Health ◽  
Sectional Study ◽  
Low Literacy ◽  
Cross Sectional ◽  
Factors Associated ◽  
Other Information ◽  
Health Organization

Background: COVID19 is a major threat to global health. World health organization has proposed use of vaccines against COVID19 to end the pandemic. Due to low literacy rate in many developing countries and disinformation, the population is reluctant for COVID19 vaccination. To explore the demographic factors associated with acceptance of COVID19 vaccination, we set up an online cross-sectional study. Methods: The online survey-based cross-sectional study was conducted to understand the demographic factors of residents of Hyderabad city associated with vaccine acceptance. The questionnaire was divided into sections to get sociodemographic characters and other information related with willingness of vaccination. This questionnaire was sent to 300 people from which 205 people participated. Results: The result showed that 28.8% of the participants were not sure to get vaccination of COVID-19, while 41.5% participants were willing to get vaccine if available; rest of the people (29.8%) were not willing be vaccinated at all. The main reason behind this denial was due to belief on conspiracies against COVID-19 vaccine. Many participants either denied (42%) for any disinformation or were not sure (12%) on this account. Conclusion: The study was based on demographic factors of residents of Hyderabad associated with acceptance of COVID-19 vaccine. Among the studied population only 41.5% showed willingness to get vaccinated which indicate the necessity to effectively educate the population about COVID-19 vaccines.

scholarly journals Prevalence and factors associated with alcohol use among pregnant adolescents

2013 ◽  
Vol 21 (1) ◽  
pp. 433-441 ◽  
Author(s):  
Lorena Uchôa Portela Veloso ◽  
Claudete Ferreira de Souza Monteiro
Keyword(s):  
Alcohol Consumption ◽  
Alcohol Use ◽  
Cross Sectional Study ◽  
World Health ◽  
Pregnant Adolescents ◽  
Chi Square ◽  
Cross Sectional ◽  
Factors Associated ◽  
Increased Risk ◽  
Health Organization

AIM: to identify alcohol use and the associated factors in pregnant adolescents of the municipality of Teresina-PI. METHOD: this is cross-sectional study with 256 pregnant adolescents whose data were obtained through questionnaires covering socioeconomic, pregnancy and alcohol consumption characteristics and through the application of the Alcohol Use Disorders Identification Test, an instrument developed by the World Health Organization for screening for the excessive use of alcohol. Descriptive statistical analysis was performed using the chi-square test and odds ratio. RESULTS: the study indicates a prevalence of 32.4% for alcohol use during pregnancy in adolescents. Of these, 36.1% had scores consistent with risky use. The factors associated with an increased risk of alcohol use during pregnancy are: not having a partner, living on less than 1 minimum wage, not being religious, performing up to 3 prenatal consultations, having suffered violence and alcohol use in previous pregnancies. CONCLUSION: a high prevalence of alcohol consumption by pregnant adolescents and various risk factors involved in this process were identified. These data reflect the need for the use, by nurses, of screening technologies for alcohol consumption during pregnancy and health promotion strategies among groups of adolescents.

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