scholarly journals Effect of the Oral Administration of Common Evening Primrose Sprout (Oenothera biennis L.) Extract on Skin Function Improvement in UVB-irradiated Hairless Mice

2021 ◽  
Vol 14 (3) ◽  
pp. 222
Author(s):  
Hoon Kim ◽  
Soon Yeong Park ◽  
Dae Kyun Chung
Keyword(s):  
Oral Administration ◽  
Clinical Signs ◽  
The Body ◽  
Skin Barrier Function ◽  
Uvb Radiation ◽  
Oenothera Biennis ◽  
Hairless Mice ◽  
Evening Primrose ◽  
Starting Point ◽  
Skin Function

Most of the studies on common evening primrose (Oenothera biennis L.) are focused on its oils (isolated from seed, root, and stem tissues). We aimed to investigate the effect of the oral administration of OBS-E on the improvement of skin function in skin-damaged hairless mice exposed to excessive ultraviolet B (UVB) radiation owing to the preliminary in vitro findings regarding the antioxidant, anti-wrinkle, and skin moisturizing activities of OBS-E. OBS-E administration for 14 weeks did not significantly affect the body weight or clinical signs. Significant reductions were observed in wrinkle parameters (area, number, length, and depth, and metalloproteinase levels) in OBS-E-administered mice compared with those in UVB-irradiated control mice. OBS-E significantly increased skin elasticity and hyaluronic acid content, but it significantly decreased transepidermal water loss. Histomorphometrical analysis revealed that OBS-E significantly reduced the epidermal thickness, area of the collagen-occupied region, and number of microfolds and inflammatory and mast cells. These results demonstrate that OBS-E can effectively enhance skin functions in terms of ameliorating wrinkle formation, promoting skin-moisturization, enhancing skin barrier function, and inhibiting inflammatory reactions. The obtained results provide good starting point for the continuation in the process of developing new inner beauty products based on OBS-E.

scholarly journals Oral Intake of Collagen Peptide Attenuates Ultraviolet B Irradiation-Induced Skin Dehydration In Vivo by Regulating Hyaluronic Acid Synthesis

2018 ◽  
Vol 19 (11) ◽  
pp. 3551 ◽  
Author(s):  
Min Kang ◽  
Silvia Yumnam ◽  
Sun Kim
Keyword(s):  
Hyaluronic Acid ◽  
Oral Administration ◽  
Protein Expression ◽  
Ultraviolet B ◽  
Skin Hydration ◽  
Skin Barrier Function ◽  
Hairless Mice ◽  
Uvb Irradiation ◽  
Collagen Peptide

Collagen peptide (CP) has beneficial effects on functions of the skin, such as skin barrier function and skin elasticity, in vivo. However, there are few studies investigating the mechanism underlying the potential effects of CP in skin epidermal moisturization after ultraviolet B (UVB) irradiation. In this study, we examined whether orally-administered CP affects the loss of skin hydration induced by UVB irradiation in hairless mice. SKH-1 hairless mice were orally administered CP at two doses (500 and 1000 mg/kg) for nine weeks, and the dorsal skin was exposed to UVB. The potential effects of CP were evaluated by measuring the transepidermal water loss (TEWL), skin hydration, wrinkle formation, and hyaluronic acid expression in the dorsal mice skin. We found that oral administration of CP increased skin hydration and decreased wrinkle formation compared to the UVB-irradiated group. Treatment of CP increased the mRNA and protein expression of hyaluronic acid synthases (HAS-1 and -2) concomitant with an increased hyaluronic acid production in skin tissue. The expression of hyaluronidase (HYAL-1 and 2) mRNA was downregulated in the CP-treated group. In addition, the protein expression of skin-hydrating factors, filaggrin and involucrin, was upregulated via oral administration of CP. In summary, these results show that oral administration of CP increases hyaluronic acid levels, which decreases during UVB photoaging. Therefore, we suggest that CP can be used as a nutricosmetic ingredient with potential effects on UVB-induced skin dehydration and moisture loss in addition to wrinkle formation.

scholarly journals A Comprehensive Toxicological Assessment of Fulvic Acid

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Chongshan Dai ◽  
Xilong Xiao ◽  
Yonglei Yuan ◽  
Gaurav Sharma ◽  
Shusheng Tang
Keyword(s):  
Oral Administration ◽  
Fulvic Acid ◽  
Clinical Chemistry ◽  
Clinical Signs ◽  
Micronucleus Assay ◽  
The Body ◽  
Feed Consumption ◽  
Control Group ◽  
Toxicological Studies

Fulvic acid (FA), a humic substance, has several nutraceutical properties, including anti-inflammation, antimicrobial, and immune regulation abilities. However, systematic safety assessment remains insufficient. In the present study, a battery of toxicological studies was conducted per internationally accepted standards to investigate the genotoxicity and repeated-dose oral toxicity of FA. Sprague-Dawley (SD) rats or ICR mice were used. Compared to the control group, there were no significant changes (all p > 0.05 ) in all FA treatment groups in the bacterial reverse mutation test, in vitro mammalian chromosome aberration test, in vivo sperm shape abnormality assay, and in vivo mouse micronucleus assay. The acute toxicity test showed that no mortality or toxic effect was observed following oral administration of the maximum dose of 5,000 mg/kg BW/day to mice or rats. A 60-day subchronic study was conducted at 0 (control), 200, 1,000, and 5,000 mg/kg/day. Compared to the control group, there were no significant changes (all p > 0.05 ) in the body weights, feed consumption, clinical signs, hematology, clinical chemistry, organ weights, or histopathology examinations. In conclusion, the no-observed-adverse-effect-level (NOAEL) of FA supplementation from the 60-day study was determined to be 5,000 mg/kg body weight/day, the highest dose tested. Our findings suggest that the oral administration of FA may have higher safety.

scholarly journals Wheat Extract Oil (WEO) Attenuates UVB-Induced Photoaging via Collagen Synthesis in Human Keratinocytes and Hairless Mice

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 300 ◽  
Author(s):  
Dong Ju Son ◽  
Jae Chul Jung ◽  
Yong Min Choi ◽  
Hyeon Yeol Ryu ◽  
Somin Lee ◽  
...  
Keyword(s):  
Oral Administration ◽  
Barrier Function ◽  
Collagen Synthesis ◽  
Skin Barrier ◽  
Human Keratinocytes ◽  
Water Evaporation ◽  
Skin Barrier Function ◽  
Type I ◽  
Skin Damage ◽  
Hairless Mice

The efficacy of wheat extract oil (WEO), standardized to glucosylceramides, for protecting against ultraviolet B (UVB)-induced damage of skin barrier function was assessed using the SHK-1 hairless mouse model and two human skin cell lines, namely, CCD-986sk and HeCaT. The ability of repeated oral administration of 30, 60, and 120 mg of WEO/kg/day for 12 weeks to prevent skin damage of SKH-1 hairless mice induced by UVB irradiation was evaluated. The results demonstrated that UVB-induced water evaporation (transepidermal water loss, TEWL) was significantly decreased by WEO. Similarly, UVB-induced losses in moisture and skin elasticity were improved by WEO supplementation. WEO attenuated the tissue procollagen type I, hyaluronic acid (HA), and ceramide reductions induced by UVB treatment as well. Collagen concentrations in skin tissue were increased in the WEO-treated mice, while UVB-induced epidermal thickening was reduced. In vitro studies using HeCaT human keratinocytes confirmed increased HA and collagen synthesis in response to WEO treatment. This may occur via WEO suppression of matrix metalloproteinase-1 (MMP-1), since its induction by UVB treatment was diminished in treated CCD-986sk cells. Oral administration of WEO improves skin barrier function in UVB-irradiated mice by attenuating damage typically observed in photoaging. This research further clarifies the clinical benefits previously observed by dietary WEO consumption.

scholarly journals Wheat Extract Oil (WEO) Attenuates UVB-Induced Photoaging via Collagen Synthesis in Human Keratinocytes and Hairless Mice

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 387-387
Author(s):  
Barbara Davis ◽  
Dong Ju Son ◽  
Jae Chul Jung ◽  
Yong Min Choi ◽  
Hyeon Yeol Ryu ◽  
...  
Keyword(s):  
Oral Administration ◽  
Barrier Function ◽  
Collagen Synthesis ◽  
Skin Barrier ◽  
Human Keratinocytes ◽  
Water Evaporation ◽  
Skin Barrier Function ◽  
Type I ◽  
Skin Damage ◽  
Hairless Mice

Abstract Objectives The efficacy of wheat extract oil (WEO), standardized to glucosylceramides, for protecting against ultraviolet B (UVB)-induced damage of skin barrier function was assessed using the SHK-1 hairless mouse model and two human skin cell lines, namely, CCD-986sk and HeCaT. Methods The ability for repeated oral administration of 30, 60, and 120 mg of WEO/kg/day for 12 weeks to prevent skin damage of SKH-1 hairless mice induced by UVB irradiation was evaluated. To complement this work, and better understand the mechanism(s) through which this dietary ingredient works, changes in procollagen, hyaluronic acid (HA) and matrix metalloproteinase-1 (MMP-1) levels were assessed in response to UVB treatment in the presence and absence of WEO. Results The results demonstrated that UVB-induced water evaporation (transepidermal water loss, TEWL) was significantly decreased by WEO. Similarly, UVB-induced losses in moisture and skin elasticity were improved by WEO supplementation. WEO attenuated the tissue procollagen type I, HA, and ceramide reductions induced by UVB treatment as well. Collagen concentrations in skin tissue were increased in the WEO-treated mice, while UVB-induced epidermal thickening was reduced. In vitro studies using HeCaT human keratinocytes confirmed increased HA and collagen synthesis in response to WEO treatment. This may occur via WEO suppression of MMP-1, since its induction by UVB treatment was diminished in treated CCD-986sk cells. Conclusions Oral administration of WEO improves skin barrier function in UVB-irradiated mice by attenuating damage typically observed in photoaging. This research further clarifies the clinical benefits previously observed by dietary WEO consumption. Funding Sources Funding for this research was provided by the Life Science Research Institute, Novarex Co., Ltd.

Heritability of seed yield, oil concentration and oil quality among wild biotypes of Ontario evening primrose

1993 ◽  
Vol 73 (4) ◽  
pp. 1067-1070
Author(s):  
J. E. Brandle ◽  
W. A. Court ◽  
R. C. Roy
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Seed Yield ◽  
Oil Content ◽  
Oil Quality ◽  
Research Station ◽  
Oenothera Biennis ◽  
Evening Primrose ◽  
Starting Point

Evening primrose (Oenothera biennis L.) is a wild species native to Eastern-North America that has recently come under cultivation as an oilseed. The oil is primarily used as a treatment for skin disorders. As a starting point for genetic improvement and domestication of this species, it was thought essential to first characterize genetic variability in Ontario evening primrose, so that members of this population may be drawn upon as a resource during cultivar development. Thirty-six wild evening primrose biotypes were evaluated in replicated trials conducted at the Delhi Research Station during 1988–1990. Seed yield, oil content and the concentration of individual fatty acids were measured. Heritability estimates demonstrated the presence of heritable genetic variation for all characters measured except the C16:1 (n–9) fatty acid. Selection for yield, oil content or fatty acid composition amongst the wild bio-types should therefore be effective. Key words: Oenothera biennis, gamma-linolenic acid, GLA, oil, fatty acid composition

scholarly journals Effects of planting beds, nutrient treatment and drought stress on biochemical properties and vegetative traits of common evening primrose (Oenothera biennis L.) seeds

2019 ◽  
pp. 753-760
Author(s):  
Robabeh Asghari
Keyword(s):  
Drought Stress ◽  
Correlation Coefficients ◽  
Growth Period ◽  
Biochemical Properties ◽  
The Body ◽  
Organic Fertilizers ◽  
Oenothera Biennis ◽  
Evening Primrose ◽  
Randomized Design ◽  
Cancer Multiple

Oenothera biennis (Common Evening-Primrose, Evening Star, or Sun Drop) is an ornamental plant with medicinal properties belonging to the Onagraceae-Oenotheraceae family and native to North America. Evening primrose seed oil is used to deal with fat accumulation in the body, diabetes, premenstrual syndrome and other diseases, including eczema, mastalgia, cancer, multiple sclerosis and rheumatism. Recent studies have confirmed the presence of antioxidant activity in the polyphenols in evening primrose seeds. In order to evaluate the effect of different planting beds, organic fertilizers and drought stress, as the evening primrose’s environmental and nutritional factors in growth and phytochemical properties, this experiment was carried out at the department of plant products research greenhouse in 2017. The experiment was performed using a completely randomized design in 4 treatments and with three replications. Seeds were planted in the prepared beds. Seedlings resulted from seeding and germination of seeds were transferred to different planting media. Growth characteristics were studied at the end of the plant growth period and before their flowering, and the ripe seeds after harvesting were used to measure 100 seed weight and biochemical traits. The results were analyzed statistically using one-way ANOVA. Also, simple correlation coefficients were calculated to obtain the ratio of characteristics with each other by Duncan's method.

Revaluations through Dance: Friedrich Nietzsche's Thought in Isadora Duncan's Speech The Dance of the Future

2019 ◽  
Vol 37 (2) ◽  
pp. 206-219
Author(s):  
Meindert E. Peters
Keyword(s):  
Twentieth Century ◽  
The Body ◽  
Eternal Recurrence ◽  
Early Twentieth Century ◽  
Starting Point ◽  
The Future ◽  
The Mind

Friedrich Nietzsche's influence on Isadora Duncan's work, in particular his idea of the Dionysian, has been widely discussed, especially in regard to her later work. What has been left underdeveloped in critical examinations of her work, however, is his influence on her earlier choreographic work, which she defended in a famous speech held in 1903 called The Dance of the Future. While commentators often describe this speech as ‘Nietzschean’, Duncan's autobiography suggests that she only studied Nietzsche's work after this speech. I take this incongruity as a starting point to explore the connections between her speech and Nietzsche's work, in particular his Thus Spoke Zarathustra. I argue that in subject and language Duncan's speech resembles Nietzsche's in important ways. This article will draw attention to the ways in which Duncan takes her cues from Nietzsche in bringing together seemingly conflicting ideas of religion and an overturning of morality; Nietzsche's notion of eternal recurrence and the teleology present in his idea of the Übermensch; and a renegotiation of the body's relation to the mind. In doing so, this article contributes not only to scholarship on Duncan's early work but also to discussions of Nietzsche's reception in the early twentieth century. Moreover, the importance Duncan ascribes to the body in dance and expression also asks for a new understanding of Nietzsche's own way of expressing his philosophy.

REGROWTH AND OVERGROWTH OF THE THYMUS AFTER ATROPHY INDUCED BY THE ORAL ADMINISTRATION OF ADRENOCORTICOSTEROIDS TO HUMAN INFANTS

PEDIATRICS ◽  
1960 ◽  
Vol 26 (5) ◽  
pp. 762-770
Author(s):  
John Caffey ◽  
Robert Silbey
Keyword(s):  
Oral Administration ◽  
Cardiac Catheterization ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Human Infants ◽  
Cardiac Image ◽  
Rapid Regrowth

The oral administration of adrenocorti-costeroids provokes rapid atrophy of the thymus which is followed consistently, after stoppage of the steroid, by rapid regrowth of the thymus and, in some cases, over-growth. Steroid-induced shrinkage of the thymus makes possible visualization of the true cardiac image which is often masked by the overlapping lobes of a large thymus. Such shrinkage may prevent the spurious diagnosis of cardiomegaly, and the use of more elaborate and hazardous methods such as opaque angiocardiography and cardiac catheterization. Steroid shrinkage of the thymus is indicated only in patients who have cardiac signs and symptoms combined with enlarged deformed mediastinums in which the true cardiac image cannot be seen radiographically. Steroid shrinkage is not indicated in patients who have cardiac signs and symptoms combined with small mediastinums, or in patients who have large mediastinums without cardiac signs and symptoms. Steroid shrinkage should not be tried when there are other factors which suggest greater than the probable benefits to be derived from their use. Massive rapid regrowth of the thymus following steroid-inducing atrophy was not associated with clinical signs or symptoms in any of our cases.

Dietary glucosylceramide improves skin barrier function in hairless mice

2006 ◽  
Vol 44 (2) ◽  
pp. 101-107 ◽  
Author(s):  
Kiyomi Tsuji ◽  
Susumu Mitsutake ◽  
Junko Ishikawa ◽  
Yutaka Takagi ◽  
Masashi Akiyama ◽  
...  
Keyword(s):  
Barrier Function ◽  
Skin Barrier ◽  
Skin Barrier Function ◽  
Hairless Mice

scholarly journals Ehlers–Danlos syndrome: how to diagnose and when to perform genetic tests

2014 ◽  
Vol 100 (1) ◽  
pp. 57-61 ◽  
Author(s):  
Glenda Sobey
Keyword(s):  
Genetic Basis ◽  
Correct Diagnosis ◽  
Clinical Signs ◽  
Accurate Diagnosis ◽  
Connective Tissue Disorders ◽  
Internal Organs ◽  
Ehlers Danlos Syndrome ◽  
Starting Point ◽  
Life Threatening ◽  
Danlos Syndrome

The term Ehlers–Danlos syndrome (EDS) encompasses a group of inherited connective tissue disorders. The manifestations of EDS can be seen in skin, joints, blood vessels and internal organs and vary from mild to severe and life threatening. Each subtype is a separate and different condition. The genetic basis of many subtypes has now been elucidated, confirming heterogeneity. An awareness of the different conditions within this group is the starting point towards accurate diagnosis. Accurate elicitation of history and clinical signs is vital in selecting the correct confirmatory investigation. Skin biopsy with electron microscopy can be helpful in the decision process of whether and when to perform genetic testing. Correct diagnosis within the EDSs allows targeted management, family screening and prenatal diagnosis.

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