scholarly journals Spirocerca lupi Proteomics and Its Role in Cancer Development: An Overview of Spirocercosis-Induced Sarcomas and Revision of Helminth-Induced Carcinomas

Pathogens ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 124
Author(s):  
Catalina Porras-Silesky ◽  
María José Mejías-Alpízar ◽  
Javier Mora ◽  
Gad Baneth ◽  
Alicia Rojas
Keyword(s):  
Clonorchis Sinensis ◽  
Taenia Solium ◽  
Clinical Manifestations ◽  
Protein Composition ◽  
Strongyloides Stercoralis ◽  
Spirocerca Lupi ◽  
Trichuris Muris ◽  
Parasitic Helminths ◽  
Secretory Products ◽  
Parasitic Worms

Spirocerca lupi is a parasitic nematode of canids that induces a myriad of clinical manifestations in its host and, in 25% of infections, leads to the formation of sarcomas. The description of the protein composition of the excretory and secretory products (Sl-ESP) of S. lupi has shed light on its possible interactions with the host environment, including migration within the host and mechanisms of immunomodulation. Despite this, the process by which S. lupi induces cancer in the dog remains poorly understood, and some hypotheses have arisen regarding these possible mechanisms. In this review, we discuss the role of specific ESP from the carcinogenic helminths Clonorchis sinensis, Opisthorchis viverrini and Schistosoma haematobium in inducing chronic inflammation and cancer in their host’s tissues. The parasitic worms Taenia solium, Echinococcus granulosus, Heterakis gallinarum, Trichuris muris and Strongyloides stercoralis, which have less-characterized mechanisms of cancer induction, are also analyzed. Based on the pathological findings in spirocercosis and the mechanisms by which other parasitic helminths induce cancer, we propose that the sustained inflammatory response in the dog´s tissues produced in response to the release of Sl-ESP homologous to those of other carcinogenic worms may lead to the malignant process in infected dogs.

INTESTINAL PARASITE INFECTION IN HUE UNIVERSITY HOSPITAL IN 2013-2014 BY DIRECT EXAMINATION AND IMMUNOLOGICAL DIAGNOSTICS

2016 ◽  
pp. 105-111
Author(s):  
Nu Phuong Anh Ton ◽  
Thi Minh Chau Ngo
Keyword(s):  
Intestinal Parasite ◽  
Intestinal Parasites ◽  
Clonorchis Sinensis ◽  
Taenia Solium ◽  
University Hospital ◽  
High Rate ◽  
Intestinal Helminth ◽  
Direct Examination ◽  
Life Condition ◽  
Parasite Infections

Introduction: Intestinalparasite infections still are very common in tropical country such as Vietnam. Therefore evaluation of the prevalence of them should be done. Materials and methods: A crosssectional descriptivestudy were carried out to use the wet mount direct examination, Kato and ELISA technique for evaluation the rate of intestinal parasite infections, interviewed them to reveal their life’s hygenic condition, knowledge and risk behaviour of intestinal parasite infections in 640 patients attending to the in Hue University of hospital. Result: The rate of soiltransmitted intestinal helminth were lower than the foodborne infection of cestode and trematode such as: Taenia solium/saginata 3.64%, Clonorchis sinensis 2.73%. The rate of positive antibody of rare intestinal parasite were Fasciola gigantica 40.68%, E. histolytica/dispar 43.75%, Toxocara canis 32.43%, Gnasthostoma spinigerum 37.5%, Taenia solium 51.43%, Strongyloidesstercoralis 16.67%. Most of people has hygenic life condition with hygenic water available. The popular knowledge of intestinal parasite diseases of transmission, pathology, prevention and treatment were concentrate on oiltransmittedintestinal helminth.There were high rate of platyhelminths infectious behaviourssuch as: eating raw water plant 75.6%, eating raw beef 80.6%, eating raw pork 72.2%, eating raw fish 11.8%, bare foot 34.2%. Conclusions: The result of our study showed that the higher rate of foodborne cestode and trematode than soiltransmittedhelminth correspond tothe hygenic life condition, the knowledge of the diseases and risk behavior of intestinal parasites infection. Key words: Helminth, cestode, trematode

scholarly journals Um estudo sôbre a eosinofilia nas helmintoses

1968 ◽  
Vol 2 (4) ◽  
pp. 169-214 ◽  
Author(s):  
Ruy Gomes de Moraes
Keyword(s):  
Schistosoma Mansoni ◽  
Ascaris Lumbricoides ◽  
Rio De Janeiro ◽  
Taenia Solium ◽  
Strongyloides Stercoralis ◽  
Trichuris Trichiura ◽  
Enterobius Vermicularis ◽  
Hymenolepis Nana ◽  
Necator Americanus ◽  
Ancylostoma Duodenale

1 - Foram examinadas as fezes de 2.666 indivíduos, operários e funcionários de duas Emprésas industriais, situadas, uma na cidade do Rio de Janeiro e outra no Estado do Rio (Brasil); 2 - Dos 2.666 indivíduos, 1941 (72.80%) estavam parasitados por um ou mais helmintos e 725 (27,20%) tinham seus exames de fezes negativos; 3 - De cada um dos 2.666 indivíduos foi feito um hemograma completo, tendo sido aproveitada a taxa de eosinófilos que, em associação com os exames de fezes, constituiu o objeto principal dêste trabalho. 4 - Na Tabela A observa-se o número de vêzes em que cada um dos vermes foi observado e seus respectivos percentuais. Embora não seja um trabalho de epidemiologia, verifica-se que 46,81% são infestados pelo Trichuris trichiura; 23,85% pelo Strongyloides stercoralis; 22,46% pelo Necator americanus e/ou Ancylostoma duodenale; 20,51% pelo Ascaris lumbricóides; 1,65% pelo Schistosoma mansoni; 0.67% pelo Enterobius vermicularis; 0,26% por Taenia solium ou T. saginata e 0,11% por Hymenolepis nana; 5 - Os exames de fezes foram feitos pelos métodos de Faust (ou de Ritchie), de Willis, de Baermann e de sedimentação; 6 - A eosinofilia anotada foi a relativa ou em seu percentual, sendo considerada hipereosinofilia uma taxa de eosinófilos igual ou superior a 5% (Eo > 5%); 7 - Foram abordados de modo conciso os fatores que provocam oscilações na eosinofilia normal tais como a idade, a raça, as horas do nictêmero, os fatores físicos, o sexo, os fatores químicos e outros; 8 - Tratou-se de modo mais extenso das diferenças entre as hipereosinofilias parasitárias e não parasitárias, tendo sido focalizada a dinâmica da eosinofilia traduzida na curva de Lavier. 9 - A distribuição dos 2.666 casos foi feita pelos diferentes graus de eosinofilia, tendo sido levantados gráficos e traçadas curvas sôbre a distribuição de cada helminto e de suas associações. 10 - Por ser necessário à explanação do assunto, foi criado o "índice eosinofilico", o qual corresponde à relação entre o número de casos de um determinado grupo com Eo > 5% e Eo < 5%. Para o total de casos positivos, ao "índice eosinofílico" denominamos "índice eosinofílico médio" em para o total dos negativos "índice eosinofílico residual"; 11 - Estabelecendo-se o "índice eosinofílico", pode-se ajuizar a capacidade eosinofilogênica de cada helminto isoladamente, bem como a de suas associações; 12 - Atenção especial foi dada aos problemas da existência da hipereosinofilia nos casos com exames coprológicos negativos para helmintos, tendo-se passado em revista vários dos aspectos biológicos que o assunto comporta; 13 - Outra questão de grande importância clínica explanada neste trabalho é a do encontro de casos de parasitismo por vermes, sem hipereosinofilia. O autor, baseado em seus dados e em outros colhidos na literatura sôbre o assunto, discute a fisiopatologia da eosinopoiese nas helmintoses e ojerece uma interpretação para êste fato ainda não defintivamente esclarecido.

scholarly journals Recent Progress in the Development of Liver Fluke and Blood Fluke Vaccines

Vaccines ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 553 ◽  
Author(s):  
Donald P. McManus
Keyword(s):  
Vaccine Development ◽  
Neglected Tropical Diseases ◽  
Clonorchis Sinensis ◽  
Economic Losses ◽  
Helminth Parasites ◽  
Blood Fluke ◽  
Parasitic Helminths ◽  
The Status ◽  
Liver Flukes ◽  
Fasciola Spp

Liver flukes (Fasciola spp., Opisthorchis spp., Clonorchis sinensis) and blood flukes (Schistosoma spp.) are parasitic helminths causing neglected tropical diseases that result in substantial morbidity afflicting millions globally. Affecting the world’s poorest people, fasciolosis, opisthorchiasis, clonorchiasis and schistosomiasis cause severe disability; hinder growth, productivity and cognitive development; and can end in death. Children are often disproportionately affected. F. hepatica and F. gigantica are also the most important trematode flukes parasitising ruminants and cause substantial economic losses annually. Mass drug administration (MDA) programs for the control of these liver and blood fluke infections are in place in a number of countries but treatment coverage is often low, re-infection rates are high and drug compliance and effectiveness can vary. Furthermore, the spectre of drug resistance is ever-present, so MDA is not effective or sustainable long term. Vaccination would provide an invaluable tool to achieve lasting control leading to elimination. This review summarises the status currently of vaccine development, identifies some of the major scientific targets for progression and briefly discusses future innovations that may provide effective protective immunity against these helminth parasites and the diseases they cause.

scholarly journals Різноманіття паразитів м’ясоїдних тварин на території м. Дніпропетровськ

2011 ◽  
Vol 2 (2) ◽  
pp. 3-7 ◽  
Author(s):  
О. О. Boyko ◽  
L. I. Faly ◽  
V. V. Brygadyrenko
Keyword(s):  
Toxoplasma Gondii ◽  
Strongyloides Stercoralis ◽  
Toxocara Canis ◽  
Spirocerca Lupi ◽  
Dipylidium Caninum ◽  
Trichuris Vulpis

In Dnipropetrovsk sity (Ukraine, Dnipropetrovsk region) in carnivorous animals 10 species of parasites (helminths and coccidia) were found: Uncinaria sp., Ancylostoma sp., Dictyocaulus immitis (Nematoda, Strongylata), Strongyloides stercoralis (Nematoda, Rhabditata), Spirocerca lupi (Nematoda, Spirurata), Toxocara canis (Nematoda, Ascaridata), Trichuris vulpis (Nematoda, Trichurata), Dipylidium caninum (Cestoda, Hymenolepidata), Cystoisospora sp. and Toxoplasma gondii (Sporozoa, Coccidia). In soil S. stercoralisand Uncinaria sp. weredominanted. In most carnivorous animals registered in L. Globa park and T. Shevchenko park the S. stercoralisand Uncinaria sp., Cystoisosporasp. and T. gondii were found.

scholarly journals The making of oncology: The tales of false carcinogenic worms

2017 ◽  
Vol 17 (1) ◽  
pp. 33-52
Author(s):  
K. Lalchhandama
Keyword(s):  
Stomach Cancer ◽  
History Of Science ◽  
Nobel Prize ◽  
Schistosoma Haematobium ◽  
Clonorchis Sinensis ◽  
Opisthorchis Viverrini ◽  
Health Concern ◽  
Carcinogenic Agent ◽  
History Of ◽  
Parasitic Worms

Cancer is a disease of antiquity. The Ancient Greeks were familiar with onkos (from which we have the term oncology)—tumour of all sorts. Hippocrates coined karkinos and karkinoma, our source of the words cancer and carcinoma. Of a plethora of carcinogens, parasitic worms (helminths) constitute a considerable health concern. Three trematodes, Clonorchis sinensis, Opisthorchis viverrini, and Schistosoma haematobium are now officially classified carcinogens. But the discovery of helminths as cancer-causing agents took wrong turns and marks an inglorious chapter in the history of science. The carcinogenicity of worms, vindicating Rudolf Virchow’s reiztheorie (irritation theory) of cancer origin, was glorified in the scientific forefront by Johannes Fibiger in the 1910s. Discovery of a new nematode, which he proudly named Spiroptera carcinoma, and his subsequent demonstration that the parasite could induce stomach cancer in rats, earned Fibiger a retrospective Nobel Prize in Physiology or Medicine in 1926, and a lasting fame. But not in an appealing way. His achievement did not withstand the test of time. S. carcinoma was annulled as an invalid taxon in zoology—supplanted by Gongylonema neoplasticum—and eventually was branded as a non-carcinogenic agent.

scholarly journals Parasitic Contamination of Common Vegetables Sold in Lusaka, Zambia

2021 ◽  
Author(s):  
S.S. Nyirenda ◽  
K.M. Bukowa ◽  
W.R. Banda ◽  
J. Mbewe ◽  
F. Hamankolo ◽  
...  
Keyword(s):  
Intestinal Parasites ◽  
Clonorchis Sinensis ◽  
Parasitic Infection ◽  
Strongyloides Stercoralis ◽  
Parasitic Infections ◽  
Contamination Rate ◽  
Vegetable Samples ◽  
Potential Source ◽  
Fresh Vegetables ◽  
Diphyllobothrium Latum

Background: Consumption of raw or unhygienically prepared vegetables is a potential source of parasitic infection. This study aimed to establish the prevalence and types of intestinal parasites on the freshly sold vegetables at the market. Methods: Totally, 95 vegetable samples were randomly procured from vendors at Lusaka City market (Zambia). The samples were examined for parasitic contamination using floatation and sedimentation methods. Data were analyzed using Epi Info version 7.2.4.0. Results: The overall parasitic contamination of fresh vegetables was 35.8% (34 out of 95). The highest parasitic contamination rate was found in Chinese cabbage with 7.4% (7 out of 95), followed by rape with 6.3% (6 out of 95), chilli with 5.3% (5 out of 95), pigweed with 5.3% (5 out of 95), pumpkin leaves with 5.3% (5 out of 95), tomatoes with 4.2% (4 out of 95), and cabbage with 2.1% (2 out of 95). There was a significant (p=0.001) statistically difference between the type of vegetables and the presence of the parasites. The identified helminths had different prevalence rates, including Taenia spp. with 9.5%, Trichuris trichuria with 5.3%, Ascaris lumbricoides with 3.2%, Clonorchis sinensis with 2.1%, Diphyllobothrium latum with 2.1%, Paragonimus westermani with 2.1%, and Strongyloides stercoralis with 2.1%. Also, Giardia lamblia with 24.2% and Balantidium coli with 4.2% were the protozoan parasites identified. Conclusion: This study showed that some vegetables sold at the Lusaka City market (Zambia) were a potential source of parasitic infections for local consumers. G. lamblia was the most prevalent parasite found in the vegetable samples. 

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