scholarly journals Contamination Sources and Transmission Routes for Campylobacter on (Mixed) Broiler Farms in Belgium, and Comparison of the Gut Microbiota of Flocks Colonized and Uncolonized with Campylobacter

Pathogens ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 66
Author(s):  
Karolien Hertogs ◽  
Annelies Haegeman ◽  
Dries Schaumont ◽  
Philippe Gelaude ◽  
Lieven De Zutter ◽  
...  
Keyword(s):  
Risk Factor ◽  
Gut Microbiota ◽  
Epidemiological Study ◽  
Molecular Typing ◽  
Production Cycle ◽  
Poultry House ◽  
Promising Tool ◽  
Poultry Farms ◽  
Production Cycles ◽  
Broiler House

Biosecurity seems to be the most promising tool for Campylobacter control on poultry farms. A longitudinal molecular epidemiological study was performed during two production cycles, in which the broilers, the poultry house, and the environment of 10 (mixed) broiler farms were monitored weekly. Cecal droppings from the second production cycle were also used for 16S metabarcoding to study the differences in the microbiota of colonized and uncolonized flocks. Results showed that 3 out of 10 farms were positive for Campylobacter in the first production cycle, and 4 out of 10 were positive in the second. Broilers became colonized at the earliest when they were four weeks old. The majority of the flocks (57%) became colonized after partial depopulation. Before colonization of the flocks, Campylobacter was rarely detected in the environment, but it was frequently isolated from cattle and swine. Although these animals appeared to be consistent carriers of Campylobacter, molecular typing revealed that they were not the source of flock colonization. In accordance with previous reports, this study suggests that partial depopulation appears to be an important risk factor for Campylobacter introduction into the broiler house. Metabarcoding indicated that two Campylobacter-free flocks carried high relative abundances of Megamonas in their ceca, suggesting potential competition with Campylobacter.

scholarly journals Epidemiology ofCampylobacterspp. at two Dutch broiler farms

1995 ◽  
Vol 114 (3) ◽  
pp. 413-421 ◽  
Author(s):  
W. F. Jacobs-Reitsma ◽  
A. W. Van de Giessen ◽  
N. M. Bolder ◽  
R. W. A. W. Mulder
Keyword(s):  
Horizontal Transmission ◽  
Conclusive Evidence ◽  
Production Cycle ◽  
Epidemiological Factors ◽  
Broiler Flock ◽  
Water Feed ◽  
Production Cycles ◽  
Darkling Beetles ◽  
Fresh Litter ◽  
Broiler House

SUMMARYBroiler flocks on two Dutch poultry farms were screened weekly for the presence of Campylobacter in fresh caecal droppings during eight consecutive production cycles. Hatchery and fresh litter samples were taken at the start of each new cycle. Water, feed, insects, and faeces of domestic animals, present on the farms were also included in the sampling. Penner seretyping of isolates was used to identify epidemiological factors that contribute to Campylobacter colonization in the broiler flocks. Generally, broiler flocks became colonized with Campylobacter at about 3–4 weeks of age with isolation percentages of 100%, and stayed colonized up to slaughter. A similar pattern of serotypes was found within the various broiler houses on one farm during one production cycle. New flocks generally showed also a new pattern of serotypes. Most serotypes isolated from the laying hens, pigs, sheep and cattle were different from those isolated from the broilers at the same time. Campylobacter serotypes from darkling beetles inside the broiler houses were identical to the ones isolated from the broilers. No Campylobacter was isolated from any of the hatchery, water, feed or fresh litter samples. Conclusive evidence of transmission routes was not found, but results certainly point towards horizontal transmission from the environment. Horizontal transmission from one broiler flock to the next one via a persistent contamination within the broiler house, as well as vertical transmission from breeder flocks via the hatchery to progeny, did not seem to be very likely.

Regulatory effect of volatile compounds in fermented alcoholic beverages on gut microbiota and serum metabolism in mouse model

2021 ◽  
Author(s):  
Mei Ji ◽  
Cheng Fang ◽  
Wei Jia ◽  
Hai Du ◽  
Yan Xu
Keyword(s):  
Risk Factor ◽  
Liver Disease ◽  
Mouse Model ◽  
Gut Microbiota ◽  
Volatile Compounds ◽  
Alcoholic Liver Disease ◽  
Alcoholic Beverages ◽  
Regulatory Effect ◽  
Main Risk Factor

Ethanol (EtOH) is the main risk factor for alcoholic liver disease. However, fermented alcoholic beverages contain not only ethanol but also various volatile compounds. Currently, effects of volatile compounds in...

Hypertriglyceridemia, an Underestimated Cardiovascular Risk Factor: An Epidemiological Study of the Rome Area

2017 ◽  
Vol 24 (4) ◽  
pp. 401-404 ◽  
Author(s):  
Roberto Volpe ◽  
◽  
Giulio Nati ◽  
Alberto Chiriatti ◽  
Massimo Sabatini ◽  
...  
Keyword(s):  
Risk Factor ◽  
Cardiovascular Risk ◽  
Epidemiological Study ◽  
Cardiovascular Risk Factor

scholarly journals Mechanically Ventilated Broiler Sheds: a Possible Source of Aerosolized Salmonella, Campylobacter, and Escherichia coli

2009 ◽  
Vol 75 (23) ◽  
pp. 7417-7425 ◽  
Author(s):  
H. N. Chinivasagam ◽  
T. Tran ◽  
L. Maddock ◽  
A. Gale ◽  
P. J. Blackall
Keyword(s):  
Escherichia Coli ◽  
Most Probable Number ◽  
Production Cycle ◽  
Airborne Bacteria ◽  
Probable Number ◽  
Mechanically Ventilated ◽  
The Public ◽  
E Coli ◽  
Poultry Farms ◽  
Low Levels

ABSTRACT This study assessed the levels of two key pathogens, Salmonella and Campylobacter, along with the indicator organism Escherichia coli in aerosols within and outside poultry sheds. The study ranged over a 3-year period on four poultry farms and consisted of six trials across the boiler production cycle of around 55 days. Weekly testing of litter and aerosols was carried out through the cycle. A key point that emerged is that the levels of airborne bacteria are linked to the levels of these bacteria in litter. This hypothesis was demonstrated by E. coli. The typical levels of E. coli in litter were ∼108 CFU g−1 and, as a consequence, were in the range of 102 to 104 CFU m−3 in aerosols, both inside and outside the shed. The external levels were always lower than the internal levels. Salmonella was only present intermittently in litter and at lower levels (103 to 105 most probable number [MPN] g−1) and consequently present only intermittently and at low levels in air inside (range of 0.65 to 4.4 MPN m−3) and once outside (2.3 MPN m−3). The Salmonella serovars isolated in litter were generally also isolated from aerosols and dust, with the Salmonella serovars Chester and Sofia being the dominant serovars across these interfaces. Campylobacter was detected late in the production cycle, in litter at levels of around 107 MPN g−1. Campylobacter was detected only once inside the shed and then at low levels of 2.2 MPN m−3. Thus, the public health risk from these organisms in poultry environments via the aerosol pathway is minimal.

scholarly journals Effect of microclimate on the airborne dust and endotoxin concentration in a broiler house

2008 ◽  
Vol 53 (No. 2) ◽  
pp. 83-89 ◽  
Author(s):  
M. Vučemilo ◽  
K. Matković ◽  
B. Vinković ◽  
J. Macan ◽  
V.M. Varnai ◽  
...  
Keyword(s):  
Relative Humidity ◽  
Measured Temperature ◽  
Air Concentration ◽  
Airflow Velocity ◽  
Poultry House ◽  
Airborne Dust ◽  
Endotoxin Concentration ◽  
Fattening Period ◽  
Broiler House ◽  
Poultry Farming

Poultry farming is considered to be a notable source of bioaerosols. They can be a risk factor from the aspect of some diseases and for the environment. A study was conducted to assess the effect of microclimate on the level of airborne dust and endotoxins in an intensive broiler fattening facility. The content of airborne dust, endotoxins, air temperature, relative humidity, airflow velocity, ammonia and carbon dioxide were determined. The study was conducted in a poultry house accommodating 22 000 broilers of Ross-308 breed. The measured temperature in the broiler house ranged from 22.02°C to 31.05°C, relative humidity from 49.55% to 65.45%, and airflow velocity from 0.07 m/s to 0.09 m/s. The air concentration of dust ranged from 2.0 mg/m<sup>3</sup> at the end of fattening period to 4.9 mg/m<sup>3</sup> in the mid-fattening period, and endotoxins from 6.21 EU/m<sup>3</sup> in the second study week to 99.40 EU/m<sup>3</sup> at the end of fattening period. The air concentration of ammonia ranged from 5.17 ppm at the beginning to 25.49 ppm at the end of fattening period. Air concentrations of dust and endotoxins recorded in this poultry house varied during the fattening period and depended on relative humidity and temperature as demonstrated by multiple regression at the level of <I>P</I> ≤ 0.05.

scholarly journals Epidemiologica and factors risk of stroke in Kemerovo

2008 ◽  
Vol 7 (5-1) ◽  
pp. 170-174
Author(s):  
A. V. Kovalenko ◽  
O. A. Gileva
Keyword(s):  
Risk Factor ◽  
Arterial Hypertension ◽  
Epidemiological Study ◽  
Stroke Risk ◽  
Cerebrovascular Disorders ◽  
Stroke Risk Factor ◽  
Cardiac Pathology ◽  
Prospective Epidemiological Study ◽  
Close Relatives

The paper presents the results of the first prospective epidemiological study of stroke in Kemerovo. The stroke was primary in 77,1% patients, the second one was in 22,9% patients. The frequency of the development of stroke increased with the years. The most prevalent risk factor was arterial hypertension which was recorded in 91,6% patients. Cardiac pathology as a stroke risk factor ranked second (61,7%). Cerebrovascular disorders in close relatives were registered in 55,5% patients. One-month lethality was 41,1%.

scholarly journals Multi-omics analysis reveals the influence of genetic and environmental risk factors on developing gut microbiota in infants at risk of celiac disease

Microbiome ◽  
2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Maureen M. Leonard ◽  
◽  
Hiren Karathia ◽  
Meritxell Pujolassos ◽  
Jacopo Troisi ◽  
...  
Keyword(s):  
Risk Factors ◽  
At Risk ◽  
Risk Factor ◽  
Celiac Disease ◽  
Cesarean Section ◽  
Gut Microbiota ◽  
Environmental Risk ◽  
Environmental Risk Factors ◽  
Environmental Risk Factor ◽  
Cesarean Section Delivery

Abstract Background Celiac disease (CD) is an autoimmune digestive disorder that occurs in genetically susceptible individuals in response to ingesting gluten, a protein found in wheat, rye, and barley. Research shows that genetic predisposition and exposure to gluten are necessary but not sufficient to trigger the development of CD. This suggests that exposure to other environmental stimuli early in life, e.g., cesarean section delivery and exposure to antibiotics or formula feeding, may also play a key role in CD pathogenesis through yet unknown mechanisms. Here, we use multi-omics analysis to investigate how genetic and early environmental risk factors alter the development of the gut microbiota in infants at risk of CD. Results Toward this end, we selected 31 infants from a large-scale prospective birth cohort study of infants with a first-degree relative with CD. We then performed rigorous multivariate association, cross-sectional, and longitudinal analyses using metagenomic and metabolomic data collected at birth, 3 months and 6 months of age to explore the impact of genetic predisposition and environmental risk factors on the gut microbiota composition, function, and metabolome prior to the introduction of trigger (gluten). These analyses revealed several microbial species, functional pathways, and metabolites that are associated with each genetic and environmental risk factor or that are differentially abundant between environmentally exposed and non-exposed infants or between time points. Among our significant findings, we found that cesarean section delivery is associated with a decreased abundance of Bacteroides vulgatus and Bacteroides dorei and of folate biosynthesis pathway and with an increased abundance of hydroxyphenylacetic acid, alterations that are implicated in immune system dysfunction and inflammatory conditions. Additionally, longitudinal analysis revealed that, in infants not exposed to any environmental risk factor, the abundances of Bacteroides uniformis and of metabolite 3-3-hydroxyphenylproprionic acid increase over time, while those for lipoic acid and methane metabolism pathways decrease, patterns that are linked to beneficial immunomodulatory and anti-inflammatory effects. Conclusions Overall, our study provides unprecedented insights into major taxonomic and functional shifts in the developing gut microbiota of infants at risk of CD linking genetic and environmental risk factors to detrimental immunomodulatory and inflammatory effects.

Recent trends in pig production: the importance of intake

1989 ◽  
Vol 13 ◽  
pp. 1-5 ◽  
Author(s):  
J. E. Riley
Keyword(s):  
Food Intake ◽  
Growth Traits ◽  
Meat Production ◽  
Production Cycle ◽  
Limiting Factor ◽  
New Production ◽  
Fat Reserves ◽  
Production Cycles ◽  
The Individual ◽  
The Uk

AbstractThe UK pig industry has shown an ability to respond quickly to changing market requirements and improving efficiency of pig meat production. Rapid genetic improvement in breeding stock, particularly in carcass quality and growth traits, together with the adoption of new production strategies, have been the main factors. These changes have had major implications for the way pigs are fed at all stages of the production cycles. Market forces have resulted in a pig population with reduced fat reserves and low appetite. Food intake is a limiting factor at several stages of the production cycle including post weaning, in the case of early-weaned piglets, and the management of young lactating sows. Knowledge of the daily nutrient requirements of the individual animal far exceeds the ability to ensure that those requirements are satisfied by feeding systems in commercial use. Manipulation of food intake to achieve optimum profit is the weakest link in the UK producers' knowledge.

scholarly journals Migraine and cardiovascular disease

2011 ◽  
Vol 69 (1) ◽  
pp. 122-129 ◽  
Author(s):  
Marcelo E. Bigal
Keyword(s):  
Myocardial Infarction ◽  
Cardiovascular Disease ◽  
Risk Factor ◽  
Diagnostic Criteria ◽  
Epidemiological Study ◽  
Cardiovascular Mortality ◽  
Coronary Revascularization ◽  
Meta Analysis ◽  
Established Risk Factor ◽  
The Brain

Migraine, especially migraine with aura is an established risk factor for ischemic lesions of the brain. Recent evidence has also linked migraine with and without aura to a broader range of ischemic vascular disorders including angina, myocardial infarction, coronary revascularization, claudication and cardiovascular mortality. The topic is therefore of considerable interest. Accordingly, herein we review the association between migraine and cardiovascular disease. We start by briefly presenting diagnostic criteria for migraine and revising its pathophysiology. We follow by summarizing the evidence on the topic. We then briefly present the results of a recent meta-analysis. We close by highlighting results of a large epidemiological study conducted after the publication of the meta-analysis.

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