scholarly journals Simulation of Food Folate Digestion and Bioavailability of an Oxidation Product of 5-Methyltetrahydrofolate

Nutrients ◽  
2017 ◽  
Vol 9 (9) ◽  
pp. 969 ◽  
Author(s):  
Christiane Ringling ◽  
Michael Rychlik
Keyword(s):  
Oxidation Product ◽  
Food Folate

Oxidation mechanism of carcinogenic bis-azo dyestuff Trypan Blue

1982 ◽  
Vol 47 (10) ◽  
pp. 2746-2748 ◽  
Author(s):  
Miroslav Matrka ◽  
Jana Pípalová
Keyword(s):  
Acid Medium ◽  
Quantitative Evaluation ◽  
Oxidation Product ◽  
Trypan Blue ◽  
Oxidation Mechanism ◽  
Azo Coupling ◽  
Arenediazonium Salt

Oxidation of Trypan Blue with cerium(IV) ion in acid medium gives arenediazonium cation similar to the oxidation product of N,N-dimethyl-4-aminoazobenzene. Quantitative evaluation of the arenediazonium salt formed has been carried out spectrophotometrically after previous C-azo coupling with 2-naphthol.

Oxidation scheme of symmetrically disulphonated naphthidines with cerium(IV) sulphate

1981 ◽  
Vol 46 (3) ◽  
pp. 561-572 ◽  
Author(s):  
Karel Komers
Keyword(s):  
Sulphuric Acid ◽  
Rate Constants ◽  
Oxidation Product ◽  
Side Reaction ◽  
Reaction Scheme ◽  
Second Order ◽  
Intermediate Products ◽  
Stable Intermediate ◽  
Starting Compound ◽  
Oxidation Agent

The author derived theoretical dependences of preasymptotic slopes of the currentless E-t curves (potential of an indicator redox electrode against time) on the number of equivalents, n, of added oxidation agent, assuming a reaction scheme of two consecutive concurrent second-order reactions involving the formation of intermediate products ( a side reaction of the starting compound with the final oxidation product leading to an adduct, which undergoes consecutive bimolecular oxidations leading again to the final product). The dependences enable to determine the type of the relatively stable intermediate products and the ratios of the rate constants. The theory was applied to the oxidation of four symmetrically disulphonated naphthidines with cerium(IV) sulphate in aqueous sulphuric acid and the results were substantiated spectrophotometrically

scholarly journals AN OXIDATION PRODUCT OF CREATINE

1918 ◽  
Vol 35 (2) ◽  
pp. 277-280
Author(s):  
Louis Baumann ◽  
Thorsten Ingvaldsen
Keyword(s):  
Oxidation Product

scholarly journals Detoxification of the tricyclic antidepressant opipramol and its analog – IS-noh by UGT enzymes before and after activation by phase I enzymes in rat liver microsomes

2021 ◽  
Author(s):  
Anna Mieszkowska ◽  
Koleta Hemine ◽  
Anna Skwierawska ◽  
Ewa Augustin ◽  
Zofia Mazerska
Keyword(s):  
Phase I ◽  
Rat Liver ◽  
Phase Ii ◽  
Oxidation Product ◽  
Liver Microsomes ◽  
Correct Selection ◽  
Rat Liver Microsomes ◽  
Recombinant Enzymes ◽  
Data Set ◽  
Phase I Enzymes

AbstractThe present studies were carried out to evaluate the simultaneous one-pot metabolism of opipramol (IS-opi) and analog (IS-noh) by phase I and phase II enzymes present in rat liver microsomes (RLM) as an alternative to separate testing with recombinant enzymes. This approach allows for more time-saving and cost-effective screening of the metabolism of newly discovered drugs. We also considered that the lack of results for phase II, including UGT, often creates problems in correct selection of valuable compounds. Moreover, microsomes data set is richer in the contest and provides medical scientist to determine also the susceptibility of drugs to undergo phase I and then phase II. In the present work, we have shown that IS-noh was metabolized in vitro by phase I enzymes to the oxidation product, which was next transformed with UGTs to glucuronide. The results showed also that the previously known oxidation product of opipramol was changed to previously no reported glucuronidation product by UDP-glucuronosyltransferases. In addition, unlike IS-noh, opipramol did not prove to be the substrate for UGTs. Therefore, tricyclic antidepressants depending on the structure can trigger a different response after contact with UGT enzymes. Some will metabolize directly with UGTs, others only after activation by phase I enzymes.

scholarly journals A CRYSTALLINE, ACTIVE OXIDATION PRODUCT OF α-CHYMOTRYPSIN

1951 ◽  
Vol 189 (2) ◽  
pp. 671-682 ◽  
Author(s):  
Eugene F. Jansen ◽  
A. Laurence Curl ◽  
A.K. Balls
Keyword(s):  
Oxidation Product ◽  
Active Oxidation

Total Synthesis and Detection of the Bilirubin Oxidation Product (Z)-2-(3-Ethenyl-4-methyl-5-oxo-1,5-dihydro-2H-pyrrol-2-ylidene)ethanamide (Z-BOX A)

2013 ◽  
Vol 15 (17) ◽  
pp. 4608-4611 ◽  
Author(s):  
Maurice Klopfleisch ◽  
Raphael A. Seidel ◽  
Helmar Görls ◽  
Hannes Richter ◽  
Rainer Beckert ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Oxidation Product

Food Folate Assay with Protease, α-Amylase, and Folate Conjugase Treatments

1997 ◽  
Vol 45 (1) ◽  
pp. 135-139 ◽  
Author(s):  
Tsunenobu Tamura ◽  
Yasuharu Mizuno ◽  
Kelley E. Johnston ◽  
Robert A. Jacob
Keyword(s):  
Food Folate
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