scholarly journals Fat Taste Sensitivity Is Associated with Short-Term and Habitual Fat Intake

Nutrients ◽  
2017 ◽  
Vol 9 (7) ◽  
pp. 781 ◽  
Author(s):  
Andrew Costanzo ◽  
Liliana Orellana ◽  
Caryl Nowson ◽  
Konsta Duesing ◽  
Russell Keast
Keyword(s):  
Taste Sensitivity ◽  
Fat Intake ◽  
Short Term ◽  
Fat Taste

scholarly journals Bitter Taste Sensitivity Is Determined by TAS2R38 Haplotype, Associated with Saturated Fat Intake and Is Lower in Overweight and Obese Compared to Normal Weight UK adults

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1271-1271
Author(s):  
Leta Pilic ◽  
Catherine Anna-Marie Graham ◽  
Nisrin Hares ◽  
Megan Brown ◽  
Jonathan Kean ◽  
...  
Keyword(s):  
Dietary Fat ◽  
Bitter Taste ◽  
Saturated Fat ◽  
Normal Weight ◽  
Taste Perception ◽  
Taste Sensitivity ◽  
Lower Sensitivity ◽  
Fat Intake ◽  
Fat Taste ◽  
Total Fat

Abstract Objectives Taste perception (sensitivity) may be determined by genetic variations in taste receptors and it affects food intake. Lower fat taste sensitivity is associated with higher dietary fat intake and body mass index (BMI). Recently, associations between bitter and fat taste sensitivity have been reported whereby bitter taste perception may be involved in textural perception of dietary fat. However, it is not clear if lower sensitivity to bitter taste would lead to an actual higher fat intake. Our objectives were to explore the associations between haplotypes in the bitter taste receptor TAS2R38, bitter taste sensitivity and fat intake and if bitter taste sensitivity is lower in individuals with higher BMI. Methods Ethical approval was obtained from the St Mary's and Oxford Brookes University Ethics Committee. Eighty-eight healthy Caucasian participants (44% male and 56% female; mean BMI 24.9 ± 4.8 kg/m2 and mean age 35 ± 14 years) completed this cross-sectional study. Height and weight were measured and genotyping performed for rs713598, rs1726866, rs10246939 genetic variants in the TAS2R38. Haplotypes were determined with Haploview software. Participants rated the intensity of a phenylthiocarbamide (PTC) impregnated strip on the general Labelled Magnitude Scale (gLMS) to determine bitter taste sensitivity and were classified as bitter tasters and non-tasters. Dietary fat intake was calculated from the EPIC-Norfolk Food Frequency Questionnaire and expressed as % total energy intake. Results TAS2R38 haplotypes were associated with bitter taster status (P < 0.005). PTC ratings of intensity were negatively correlated with % saturated fat (SFA) intake (rs = −0.256, P = 0.016). %SFA and %total fat (rs = 0.656, P < 0.005) and %total fat and energy intake (kcal) (rs = 0.225, P = 0.035) were positively correlated. Normal weight participants rated PTC strips as more intense compared to overweight and obese participants (mean rank 53 vs. 41, P = 0.033). Conclusions Bitter taste perception is determined by genetics and lower sensitivity to this taste is associated with higher intake of SFA. Lower bitter taste sensitivity in overweight/obese participants suggests that impaired bitter taste may be associated with an overall unhealthier and more energy dense dietary pattern. Funding Sources St Mary's and Oxford Brookes University.

scholarly journals Effect of dietary fat intake and genetics on fat taste sensitivity: a co-twin randomized controlled trial

2018 ◽  
Vol 107 (5) ◽  
pp. 683-694 ◽  
Author(s):  
Andrew Costanzo ◽  
Caryl Nowson ◽  
Liliana Orellana ◽  
Dieuwerke Bolhuis ◽  
Konsta Duesing ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Dietary Fat ◽  
Controlled Trial ◽  
Taste Sensitivity ◽  
Fat Intake ◽  
Randomized Controlled ◽  
Dietary Fat Intake ◽  
Fat Taste

scholarly journals Reproducibility of 24-h post-exercise changes in energy intake in overweight and obese women using current methodology

2011 ◽  
Vol 108 (2) ◽  
pp. 191-194 ◽  
Author(s):  
Gemma L. Brown ◽  
Michael E. Lean ◽  
Catherine R. Hankey
Keyword(s):  
Energy Intake ◽  
Exercise Intervention ◽  
Statistical Significance ◽  
Intraclass Correlation ◽  
Large Degree ◽  
Exercise Session ◽  
Fat Intake ◽  
Obese Women ◽  
Short Term ◽  
Post Exercise

Direct observation(s) of energy intake (EI) via buffet meals served in the laboratory are often carried out within short-term exercise intervention studies. The reproducibility of values obtained has not been assessed either under resting control conditions or post-exercise, in overweight and obese females. A total of fourteen sedentary, pre-menopausal females (BMI 30·0 (sd5·1) kg/m2) completed four trials; two exercise and two control. Each trial lasted 24 h spanning over 2 d; conducted from afternoon on day 1 and morning on day 2. An exercise session to expend 1·65 MJ was completed on day 1 of exercise trials, and three buffet meals were served during each trial. Reproducibility of post-exercise changes in energy and macronutrient intakes was assessed at each individual buffet meal by intraclass correlation coefficient (ri). Only therivalues for post-exercise changes in energy (ri0·44 (95 % CI − 0·03, 0·77),P = 0·03) and fat intake (ri0·51 (95 % CI 0·04, 0·81),P = 0·02) at the lunch buffet meal achieved statistical significance; however, theserivalues were weak and had large associated 95 % CI, which indicates a large degree of variability associated with these measurements. Energy and macronutrient intakes at the breakfast and evening buffet meals were not reproducible. This study concludes that the frequently used laboratory-based buffet meal method of assessing EI does not produce reliable, reproducible post-exercise changes in EI in overweight and obese women.

scholarly journals Expression of the candidate fat taste receptors in human fungiform papillae and the association with fat taste function

2018 ◽  
Vol 120 (1) ◽  
pp. 64-73 ◽  
Author(s):  
Dongli Liu ◽  
Andrew Costanzo ◽  
Margaret D. M. Evans ◽  
Nicholas S. Archer ◽  
Caryl Nowson ◽  
...  
Keyword(s):  
Ion Channels ◽  
Western Blotting ◽  
Correlation Study ◽  
Taste Buds ◽  
Expression Level ◽  
Taste Receptors ◽  
Fat Intake ◽  
Fungiform Papillae ◽  
Qrt Pcr ◽  
Fat Taste

AbstractSignificant experimental evidence supports fat as a taste modality; however, the associated peripheral mechanisms are not well established. Several candidate taste receptors have been identified, but their expression pattern and potential functions in human fungiform papillae remain unknown. The aim of this study is to identify the fat taste candidate receptors and ion channels that were expressed in human fungiform taste buds and their association with oral sensory of fatty acids. For the expression analysis, quantitative RT-PCR (qRT-PCR) from RNA extracted from human fungiform papillae samples was used to determine the expression of candidate fatty acid receptors and ion channels. Western blotting analysis was used to confirm the presence of the proteins in fungiform papillae. Immunohistochemistry analysis was used to localise the expressed receptors or ion channels in the taste buds of fungiform papillae. The correlation study was analysed between the expression level of the expressed fat taste receptors or ion channels indicated by qRT-PCR and fat taste threshold, liking of fatty food and fat intake. As a result, qRT-PCR and western blotting indicated that mRNA and protein of CD36, FFAR4, FFAR2, GPR84 and delayed rectifying K+ channels are expressed in human fungiform taste buds. The expression level of CD36 was associated with the liking difference score (R −0·567, β=−0·04, P=0·04) between high-fat and low-fat food and FFAR2 was associated with total fat intake (ρ=−0·535, β=−0·01, P=0·003) and saturated fat intake (ρ=−0·641, β=−0·02, P=0·008).

Bariatric Surgery Leads to Short‐Term Effects on Sweet Taste Sensitivity and Hedonic Evaluation of Fatty Food Stimuli

Obesity ◽  
2019 ◽  
Vol 27 (11) ◽  
pp. 1796-1804 ◽  
Author(s):  
Mette S. Nielsen ◽  
Ida Ninett S.K. Andersen ◽  
Belinda Lange ◽  
Christian Ritz ◽  
Carel W. le Roux ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Sweet Taste ◽  
Taste Sensitivity ◽  
Short Term ◽  
Fatty Food ◽  
Hedonic Evaluation ◽  
Short Term Effects

Passive Overconsumption Fat Intake and Short-Term Energy Balance

1997 ◽  
Vol 827 (1 Lipids and Sy) ◽  
pp. 392-407 ◽  
Author(s):  
JOHN E. BLUNDELL ◽  
JENNIE I. MACDIARMID
Keyword(s):  
Energy Balance ◽  
Fat Intake ◽  
Short Term ◽  
Term Energy

scholarly journals Comparison between the timing of the occurrence of taste sensitivity changes and short-term memory decline due to aging in SAMP1 mice

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0248673
Author(s):  
Masataka Narukawa ◽  
Suzuka Takahashi ◽  
Aya Kamiyoshihara ◽  
Kentaro Matsumiya ◽  
Takumi Misaka
Keyword(s):  
Spontaneous Alternation ◽  
Short Term Memory ◽  
Long Term Potentiation ◽  
Taste Sensitivity ◽  
Alternation Behavior ◽  
Spontaneous Alternation Behavior ◽  
Short Term ◽  
Term Memory ◽  
Age Related ◽  
Old Mice

Several studies have suggested that cognitive impairment affects taste sensitivity. However, the mechanism behind this is still unclear. In this study, we focused on short-term memory. Using senescence-accelerated mouse prone 1 (SAMP1) mice, we compared whether the effects of aging are observed earlier in taste sensitivity or short-term memory. We used 8-week-old mice as the young group, and 70- and 80-week-old mice as aged groups. Taste sensitivity was evaluated using a 48-hour two-bottle preference test, and short-term memory was evaluated using the Y-maze test. SAMP1 mice showed apparently changes in taste sensitivity at 70-weeks-old. However, the influence of aging on spontaneous alternation behavior, which is indicative of short-term memory alterations, was not observed in 70-week-old mice. At 80-weeks-old, the influence of aging was observed, and spontaneous alternation behavior was significantly decreased. This suggests that age-dependent changes in taste sensitivity occur prior to short-term memory function decline. In addition, there was no significant influence of aging on the mRNA expression of long-term potentiation-related genes in the hippocampus of 80-week-old mice. Therefore, the age-related decline of short-term memory may not affect taste sensitivity.

Genetic variation in CD36 is associated with dietary intake in Korean males

2020 ◽  
pp. 1-10
Author(s):  
Jeong-Hwa Choi
Keyword(s):  
Genetic Variation ◽  
Dietary Intake ◽  
Vegetable Intake ◽  
Vegetable Consumption ◽  
Cellular Membrane ◽  
Dietary Behaviour ◽  
Taste Intensity ◽  
Fat Intake ◽  
Cruciferous Vegetable ◽  
Fat Taste

Abstract Fat is one of the six types of taste. Perceived taste intensity could affect the preference for a food and whether or not it is consumed. Cluster of differentiation 36 (CD36) translocates fatty acids on the cellular membrane and is involved in the oral fat-sensing mechanism. Therefore, genetic variation rs1761667 in CD36 is known to be associated with the perception of fat taste and, hence, its dietary intake. This study examined whether CD36 rs1527479 T>C, a proxy of rs1761667, is associated with fat intake and related dietary behaviour in Koreans. Using the data of the Ansan/Ansung Study, a part of the Korean Genome Epidemiology Study, the association of rs1527479 with the intake of macronutrients, including fat and selected foods, and fat-related dietary behaviours were investigated in 3194 males and 3425 females grouped by their degree of obesity. The findings suggested that rs1527479 did not have a meaningful effect on the intake of fat or other macronutrients or on the selection of food among non-obese females and males. However, in males with obesity, the genetic variation showed a significant association with vegetable intake. Obese males with the mutant CC genotype had substantially lower cruciferous vegetable consumption (adjusted P = 0·0015) than individuals with the TT and CT genotypes. Rs1527479 had no significant effect on the frequency of consuming fried foods or commonly used types of seasoning and cooking oils. In conclusion, CD36 genetic variation was associated with the intake of cruciferous vegetables but not fat intake in obese Korean males.

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