scholarly journals Temporal Changes of Human Breast Milk Lipids of Chinese Mothers

Nutrients ◽  
2016 ◽  
Vol 8 (11) ◽  
pp. 715 ◽  
Author(s):  
Francesca Giuffrida ◽  
Cristina Cruz-Hernandez ◽  
Emmanuelle Bertschy ◽  
Patric Fontannaz ◽  
Isabelle Masserey Elmelegy ◽  
...  
Keyword(s):  
Breast Milk ◽  
Temporal Changes ◽  
Human Breast Milk ◽  
Human Breast ◽  
Chinese Mothers ◽  
Milk Lipids

scholarly journals Effect of 9,12-Octadecadiynoic Acid on Neurobehavioral Development in Caenorhabditis elegans

2021 ◽  
Vol 22 (16) ◽  
pp. 8917
Author(s):  
Tun-Chieh Chen ◽  
How-Ran Chao ◽  
Ching-Ying Wu ◽  
Yun-Ru Lai ◽  
Chu-Huang Chen ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Breast Milk ◽  
Biological Function ◽  
Behavioral Development ◽  
Human Breast Milk ◽  
Related Gene ◽  
Human Breast ◽  
Neurobehavioral Development ◽  
Foraging Ability ◽  
Milk Lipids

Human breast milk lipids have major beneficial effects: they promote infant early brain development, growth and health. To identify the relationship between human breast milk lipids and infant neurodevelopment, multivariate analyses that combined lipidomics and psychological Bayley-III scales evaluation were utilized. We identified that 9,12-octadecadiynoic acid has a significantly positive correlation with infant adaptive behavioral development, which is a crucial neurodevelopment to manage risk from environmental stress. To further clarify the biological function of 9,12-octadecadiynoic acid in regulating neurodevelopment, Caenorhabditis elegans (C. elegans) was used as a model to investigate the effect of 9,12-octadecadiynoic acid on neurobehavioral development. Supplementation with 9,12-octadecadiynoic acid from the L1 to L4 stage in larvae affected locomotive behaviors and foraging ability that were not socially interactive, implying that 9,12-octadecadiynoic acid is involved in regulating the serotonergic neuronal ability. We found that supplementary 0.1 μM 9,12-octadecadiynoic acid accelerated the locomotive ability and foraging ability via increasing the expression of serotonin transporter mod-1. Antioxidant defense genes, sod-1, sod-3 and cyp-35A2 are involved in 9,12-octadecadiynoic acid-induced motor neuronal activity. Nevertheless, supplementary 9,12-octadecadiynoic acid at concentrations above 1 μM significantly attenuated locomotive behaviors, foraging ability, serotonin synthesis, serotonin-related gene expressions and stress-related gene expression, resulting in the decreased longevity of worms in the experiment. In conclusion, our study demonstrates the biological function of 9,12-octadecadiynoic acid in governing adaptive behavioral development.

Replicating the Self-assembly of Human Breast Milk Lipids During Digestion with Emulsions of Cow Milk Fat Mixed with Canola Oil

2021 ◽  
Author(s):  
Andrew Clulow ◽  
Adrian Hawley ◽  
Malinda Salim ◽  
Syaza Binte Abu Bakar ◽  
Cameron Nowell ◽  
...  
Keyword(s):  
Breast Milk ◽  
Self Assembly ◽  
Canola Oil ◽  
Milk Fat ◽  
The Self ◽  
Cow Milk ◽  
Human Breast Milk ◽  
Human Breast ◽  
Milk Lipids

Lactational changes in concentration and distribution of ganglioside molecular species in human breast milk from Chinese mothers

Lipids ◽  
2015 ◽  
Vol 50 (11) ◽  
pp. 1145-1154 ◽  
Author(s):  
Lin Ma ◽  
Xihong Liu ◽  
Alastair K. H. MacGibbon ◽  
Angela Rowan ◽  
Paul McJarrow ◽  
...  
Keyword(s):  
Breast Milk ◽  
Molecular Species ◽  
Human Breast Milk ◽  
Human Breast ◽  
Chinese Mothers

scholarly journals Distinct Changes Occur in the Human Breast Milk Microbiome Between Early and Established Lactation in Breastfeeding Guatemalan Mothers

2021 ◽  
Vol 12 ◽  
Author(s):  
Emmanuel Gonzalez ◽  
Nicholas J. B. Brereton ◽  
Chen Li ◽  
Lilian Lopez Leyva ◽  
Noel W. Solomons ◽  
...  
Keyword(s):  
Breast Milk ◽  
Post Partum ◽  
Temporal Changes ◽  
Human Populations ◽  
Human Breast Milk ◽  
Early Lactation ◽  
Human Breast ◽  
Differential Abundance ◽  
Lactation Stage ◽  
Differential Abundance Analysis

Human breast milk contains a diverse community of bacteria, but as breast milk microbiome studies have largely focused on mothers from high income countries where few women breastfeed to 6 months, the temporal changes in the breast milk microbiome that occur during later lactation stages have not been explored. For this cross-sectional study, microbiota from breast milk samples of Mam-Mayan mothers living in eight remote rural communities in the Western Highlands of Guatemala were analyzed. All mothers delivered vaginally and breastfed their infants for 6 months. Breast milk from 76 unrelated mothers was used to compare two lactation stages, either “early” (6–46 days post-partum, n = 33) or “late” (109–184 days post-partum, n = 43). Breast milk microbial communities were assessed using 16S ribosomal RNA gene sequencing and lactation stages were compared using DESeq2 differential abundance analysis. A total of 1,505 OTUs were identified, including 287 which could be annotated as putative species. Among several maternal factors, lactation stage explained microbiome variance and inertia in ordination with the most significance (p < 0.001). Differential abundance analysis identified 137 OTUs as significantly higher in either early or late lactation. These included a general shift from Staphylococcus and Streptococcus species in early lactation to Sphingobium and Pseudomonas species in late lactation. Species enriched in early lactation included putative commensal bacteria known to colonize the infant oral and intestinal tracts whereas species enriched in late lactation had a uniform functional trait associated with aromatic compound degradation. Differentially abundant species also included several species which have not previously been reported within breast milk, such as Janthinobacterium agaricidamnosum, Novosphingobium clariflavum, Ottowia beijingensis, and Flavobacterium cucumis. These discoveries describe temporal changes to the breast milk microbiome of healthy Guatemalan mothers from early to late lactation. Collectively, these findings illustrate how studying under-represented human populations might advance our understanding of factors that modulate the human milk microbiome in low and middle income countries (LMIC).

Organohalogen compounds in human breast milk from Republic of Buryatia, Russia

2007 ◽  
Vol 146 (1) ◽  
pp. 225-232 ◽  
Author(s):  
Oyuna V. Tsydenova ◽  
Agus Sudaryanto ◽  
Natsuko Kajiwara ◽  
Tatsuya Kunisue ◽  
Valeriy B. Batoev ◽  
...  
Keyword(s):  
Breast Milk ◽  
Human Breast Milk ◽  
Human Breast ◽  
Organohalogen Compounds
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