scholarly journals The Effect of Serum 25-Hydroxyvitamin D Concentrations on Elevated Serum C-Reactive Protein Concentrations in Normal Weight, Overweight and Obese Participants of a Preventive Health Program

Nutrients ◽  
2016 ◽  
Vol 8 (11) ◽  
pp. 696 ◽  
Author(s):  
Silmara Mastroeni ◽  
Lalani Munasinghe ◽  
Truong-Minh Pham ◽  
Sarah Loehr ◽  
John Ekwaru ◽  
...  
Keyword(s):  
Health Program ◽  
Elevated Serum ◽  
Normal Weight ◽  
Preventive Health ◽  
C Reactive Protein ◽  
Hydroxyvitamin D ◽  
Reactive Protein ◽  
25 Hydroxyvitamin D

Biological and Neuroimaging Markers as Predictors of 5-Year Incident Frailty in Older Adults: A Secondary Analysis of the MAPT Study

2020 ◽  
Author(s):  
Wan-Hsuan Lu ◽  
Philipe de Souto Barreto ◽  
Yves Rolland ◽  
Ali Bouyahia ◽  
Clara Fischer ◽  
...  
Keyword(s):  
Older Adults ◽  
Gray Matter ◽  
Hippocampal Volume ◽  
Community Dwelling ◽  
Low Grade ◽  
Omega 3 ◽  
C Reactive Protein ◽  
Hydroxyvitamin D ◽  
Reactive Protein ◽  
25 Hydroxyvitamin D

Abstract Background This study aims to investigate the predictive value of biological and neuroimaging markers to determine incident frailty among older people for a period of 5 years. Methods We included 1394 adults aged 70 years and older from the Multidomain Alzheimer Preventive Trial, who were not frail at baseline (according to Fried’s criteria) and who had at least 1 post-baseline measurement of frailty. Participants who progressed to frailty during the 5-year follow-up were categorized as “incident frailty” and those who remained non-frail were categorized as “without frailty.” The differences of baseline biochemical factors (25-hydroxyvitamin D, homocysteine, omega-3 index, C-reactive protein), other biological markers (Apolipoprotein E genotypes, amyloid-β deposits), and neuroimaging data (gray matter volume, hippocampal volume, white matter hyperintensities) were compared between groups. Cox proportional hazard model was used to evaluate the associations between biomarkers and incident frailty. Results A total of 195 participants (14.0%) became frail over 5 years. Although 25-hydroxyvitamin D deficiency, homocysteine levels, low-grade inflammation (persistently increased C-reactive protein 3–10 mg/L), gray matter, and hippocampal volume were significantly associated with incident frailty in unadjusted models, these associations disappeared after adjustment for age, sex, and other confounders. Omega-3 index was the sole marker that presented a trend of association with incident frailty (hazard ratio: 0.92; 95% confidence interval: 0.83–1.01; p = .082). Conclusions This study failed to identify biomarkers able to predict frailty incidence in community-dwelling older adults for a period of 5 years. Further longitudinal research with multiple measurements of biomarkers and frailty is needed to evaluate the long-term relationships between changes in biomarkers levels and frailty evolution.

scholarly journals Positive Association Between 25-Hydroxyvitamin D and C-Reactive Protein is Confounded by Hormonal Contraceptive Use

2013 ◽  
Vol 22 (5) ◽  
pp. 417-425 ◽  
Author(s):  
Bibiana García-Bailo ◽  
Andrea R. Josse ◽  
Joseph Jamnik ◽  
Alaa Badawi ◽  
Ahmed El-Sohemy
Keyword(s):  
Contraceptive Use ◽  
Positive Association ◽  
Hormonal Contraceptive ◽  
C Reactive Protein ◽  
Hydroxyvitamin D ◽  
Reactive Protein ◽  
25 Hydroxyvitamin D

scholarly journals Deficiency of 25-Hydroxyvitamin D and Dyslipidemia in Indian Subjects

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Jaydip Ray Chaudhuri ◽  
K. Rukmini Mridula ◽  
Alluri Anamika ◽  
Demudu Babu Boddu ◽  
Pradeep Kumar Misra ◽  
...  
Keyword(s):  
Vitamin D ◽  
Alkaline Phosphatase ◽  
Vitamin D Deficiency ◽  
Serum Glucose ◽  
C Reactive Protein ◽  
Hydroxyvitamin D ◽  
Reactive Protein ◽  
Calcium Phosphorus ◽  
25 Hydroxyvitamin D ◽  
Chemiluminescent Microparticle Immunoassay

Background. Vitamin D deficiency is widespread throughout the world. Several reports have incriminated vitamin D deficiency as the cause of rickets, osteomalacia, and other chronic diseases. Recent studies have suggested a possible link between deficiency of 25-hydroxyvitamin D and dyslipidemia.Aim. To investigate the association between 25-hydroxyvitamin D deficiency and dyslipidemia in Indian subjects.Methodology. We recruited 150 asymptomatic consecutive subjects from patients’ attendees at the Departments of Neurology and Medicine in Yashoda Hospital, Hyderabad, India. Study period was from October 2011 to March 2012. All subjects underwent 25-hydroxyvitamin D assay by chemiluminescent microparticle immunoassay, fasting blood sugar and lipid profile, calcium, phosphorus, alkaline phosphatase, and C-reactive protein (CRP).Results. Out of 150 subjects, men were 82 (54.6%), and mean age was 49.4 (±15.6) years. Among risk factors, hypertension was noted in 63/150 (42%), 25-hydroxyvitamin D deficiency in 59/150 (39.3%), diabetes in 45/150 (30%), dyslipidemia in 60 (40%), smoking in 35/150 (23.3%), and alcoholism in 27/150 (18%). Deficiency of 25-hydroxyvitamin D was significantly associated with dyslipidemia (P=0.0001), mean serum glucose (P=0.0002) mean CRP (P=0.04), and mean alkaline phosphatase (P=0.01). Multivariate analysis showed that 25-hydroxyvitamin D deficiency was independently associated with dyslipidemia (odds ratio: 1.9; 95% CI : 1.1–3.5).Conclusions. We found that deficiency of 25-hydroxyvitamin D was independently associated with dyslipidemia in Indian subjects.

Maternal serum 25-hydroxyvitamin D and C-reactive protein levels in pregnancies complicated with threatened preterm labour

2016 ◽  
Vol 32 (9) ◽  
pp. 777-781 ◽  
Author(s):  
Natalia Fischer-Suárez ◽  
Ana M. Fernández-Alonso ◽  
Alejandra Herrera-Muñoz ◽  
Peter Chedraui ◽  
Faustino R. Pérez-López
Keyword(s):  
Preterm Labour ◽  
Maternal Serum ◽  
C Reactive Protein ◽  
Hydroxyvitamin D ◽  
Protein Levels ◽  
Reactive Protein ◽  
25 Hydroxyvitamin D

scholarly journals The Effect of Serum 25-Hydroxyvitamin D on Elevated Homocysteine Concentrations in Participants of a Preventive Health Program

PLoS ONE ◽  
2016 ◽  
Vol 11 (8) ◽  
pp. e0161368 ◽  
Author(s):  
Truong-Minh Pham ◽  
John Paul Ekwaru ◽  
Silmara S. Mastroeni ◽  
Marco F. Mastroeni ◽  
Sarah A. Loehr ◽  
...  
Keyword(s):  
Health Program ◽  
Preventive Health ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

Association between serum 25-hydroxyvitamin D concentrations and mortality among adults with prediabetes

2021 ◽  
Author(s):  
Qi Lu ◽  
Zhenzhen Wan ◽  
Jingyu Guo ◽  
Liegang Liu ◽  
An Pan ◽  
...  
Keyword(s):  
Lower Risk ◽  
Elevated Serum ◽  
Density Lipoprotein ◽  
Mortality Data ◽  
Hydroxyvitamin D ◽  
Reactive Protein ◽  
All Cause Mortality ◽  
25 Hydroxyvitamin D ◽  
Sufficient Vitamin ◽  
Cvd Mortality

Abstract Objectives To investigate the association of circulating 25-hydroxyvitamin D [25(OH)D] levels with mortality among adults with prediabetes. Methods This retrospective cohort study included 15195 adults with prediabetes (aged ≥20 years) from the National Health and Nutrition Examination Survey (NHANES) III and NHANES 2001-2014. Mortality from all causes, cardiovascular disease (CVD), and cancer was linked to National Death Index mortality data. Results The median (interquartile range) concentration of serum 25(OH)D was 60.5 (45.3, 77.4) nmol/L, and only 23.1% had sufficient vitamin D (≥75 nmol/L). Elevated serum 25(OH)D concentrations were significantly associated with lower levels of insulin, HOMA-IR, triglyceride, and C-reactive protein, and higher levels of high-density lipoprotein at baseline (all Ptrend<0.05). During a median follow up of 10.7 years, 3765 deaths (including 1080 CVD deaths and 863 cancer deaths) were identified. Compared with participants with 25(OH)D <30 nmol/L, the multivariate-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for participants with 25(OH)D ≥75 nmol/L were 0.66 (0.53, 0.82) for all-cause mortality (Ptrend<0.001), 0.66 (0.48, 0.89) for CVD mortality (Ptrend=0.001), and 0.82 (0.49, 1.35) for cancer mortality (Ptrend=0.32). For per unit increment in ln-transformed 25(OH)D, there was a 27% lower risk of all-cause mortality and a 34% lower risk of CVD mortality (both P<0.01). Conclusions These findings suggested that higher serum 25(OH)D concentrations were associated with lower all-cause and CVD mortality among individuals with prediabetes.

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