scholarly journals Positive Association Between 25-Hydroxyvitamin D and C-Reactive Protein is Confounded by Hormonal Contraceptive Use

2013 ◽  
Vol 22 (5) ◽  
pp. 417-425 ◽  
Author(s):  
Bibiana García-Bailo ◽  
Andrea R. Josse ◽  
Joseph Jamnik ◽  
Alaa Badawi ◽  
Ahmed El-Sohemy
Keyword(s):  
Contraceptive Use ◽  
Positive Association ◽  
Hormonal Contraceptive ◽  
C Reactive Protein ◽  
Hydroxyvitamin D ◽  
Reactive Protein ◽  
25 Hydroxyvitamin D

scholarly journals Hormonal Contraceptive Use Is Associated With Higher Total but Unaltered Free 25-Hydroxyvitamin D Serum Concentrations

2018 ◽  
Vol 103 (6) ◽  
pp. 2385-2391 ◽  
Author(s):  
Stefan Pilz ◽  
Rima Obeid ◽  
Verena Schwetz ◽  
Christian Trummer ◽  
Marlene Pandis ◽  
...  
Keyword(s):  
Contraceptive Use ◽  
Hormonal Contraceptive ◽  
Serum Concentrations ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

Biological and Neuroimaging Markers as Predictors of 5-Year Incident Frailty in Older Adults: A Secondary Analysis of the MAPT Study

2020 ◽  
Author(s):  
Wan-Hsuan Lu ◽  
Philipe de Souto Barreto ◽  
Yves Rolland ◽  
Ali Bouyahia ◽  
Clara Fischer ◽  
...  
Keyword(s):  
Older Adults ◽  
Gray Matter ◽  
Hippocampal Volume ◽  
Community Dwelling ◽  
Low Grade ◽  
Omega 3 ◽  
C Reactive Protein ◽  
Hydroxyvitamin D ◽  
Reactive Protein ◽  
25 Hydroxyvitamin D

Abstract Background This study aims to investigate the predictive value of biological and neuroimaging markers to determine incident frailty among older people for a period of 5 years. Methods We included 1394 adults aged 70 years and older from the Multidomain Alzheimer Preventive Trial, who were not frail at baseline (according to Fried’s criteria) and who had at least 1 post-baseline measurement of frailty. Participants who progressed to frailty during the 5-year follow-up were categorized as “incident frailty” and those who remained non-frail were categorized as “without frailty.” The differences of baseline biochemical factors (25-hydroxyvitamin D, homocysteine, omega-3 index, C-reactive protein), other biological markers (Apolipoprotein E genotypes, amyloid-β deposits), and neuroimaging data (gray matter volume, hippocampal volume, white matter hyperintensities) were compared between groups. Cox proportional hazard model was used to evaluate the associations between biomarkers and incident frailty. Results A total of 195 participants (14.0%) became frail over 5 years. Although 25-hydroxyvitamin D deficiency, homocysteine levels, low-grade inflammation (persistently increased C-reactive protein 3–10 mg/L), gray matter, and hippocampal volume were significantly associated with incident frailty in unadjusted models, these associations disappeared after adjustment for age, sex, and other confounders. Omega-3 index was the sole marker that presented a trend of association with incident frailty (hazard ratio: 0.92; 95% confidence interval: 0.83–1.01; p = .082). Conclusions This study failed to identify biomarkers able to predict frailty incidence in community-dwelling older adults for a period of 5 years. Further longitudinal research with multiple measurements of biomarkers and frailty is needed to evaluate the long-term relationships between changes in biomarkers levels and frailty evolution.

scholarly journals Deficiency of 25-Hydroxyvitamin D and Dyslipidemia in Indian Subjects

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Jaydip Ray Chaudhuri ◽  
K. Rukmini Mridula ◽  
Alluri Anamika ◽  
Demudu Babu Boddu ◽  
Pradeep Kumar Misra ◽  
...  
Keyword(s):  
Vitamin D ◽  
Alkaline Phosphatase ◽  
Vitamin D Deficiency ◽  
Serum Glucose ◽  
C Reactive Protein ◽  
Hydroxyvitamin D ◽  
Reactive Protein ◽  
Calcium Phosphorus ◽  
25 Hydroxyvitamin D ◽  
Chemiluminescent Microparticle Immunoassay

Background. Vitamin D deficiency is widespread throughout the world. Several reports have incriminated vitamin D deficiency as the cause of rickets, osteomalacia, and other chronic diseases. Recent studies have suggested a possible link between deficiency of 25-hydroxyvitamin D and dyslipidemia.Aim. To investigate the association between 25-hydroxyvitamin D deficiency and dyslipidemia in Indian subjects.Methodology. We recruited 150 asymptomatic consecutive subjects from patients’ attendees at the Departments of Neurology and Medicine in Yashoda Hospital, Hyderabad, India. Study period was from October 2011 to March 2012. All subjects underwent 25-hydroxyvitamin D assay by chemiluminescent microparticle immunoassay, fasting blood sugar and lipid profile, calcium, phosphorus, alkaline phosphatase, and C-reactive protein (CRP).Results. Out of 150 subjects, men were 82 (54.6%), and mean age was 49.4 (±15.6) years. Among risk factors, hypertension was noted in 63/150 (42%), 25-hydroxyvitamin D deficiency in 59/150 (39.3%), diabetes in 45/150 (30%), dyslipidemia in 60 (40%), smoking in 35/150 (23.3%), and alcoholism in 27/150 (18%). Deficiency of 25-hydroxyvitamin D was significantly associated with dyslipidemia (P=0.0001), mean serum glucose (P=0.0002) mean CRP (P=0.04), and mean alkaline phosphatase (P=0.01). Multivariate analysis showed that 25-hydroxyvitamin D deficiency was independently associated with dyslipidemia (odds ratio: 1.9; 95% CI : 1.1–3.5).Conclusions. We found that deficiency of 25-hydroxyvitamin D was independently associated with dyslipidemia in Indian subjects.

Maternal serum 25-hydroxyvitamin D and C-reactive protein levels in pregnancies complicated with threatened preterm labour

2016 ◽  
Vol 32 (9) ◽  
pp. 777-781 ◽  
Author(s):  
Natalia Fischer-Suárez ◽  
Ana M. Fernández-Alonso ◽  
Alejandra Herrera-Muñoz ◽  
Peter Chedraui ◽  
Faustino R. Pérez-López
Keyword(s):  
Preterm Labour ◽  
Maternal Serum ◽  
C Reactive Protein ◽  
Hydroxyvitamin D ◽  
Protein Levels ◽  
Reactive Protein ◽  
25 Hydroxyvitamin D

scholarly journals Plasma 25-Hydroxyvitamin D Concentrations and Serum and Salivary C-Reactive Protein in the Osteoporosis and Periodontal Disease Study

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1148
Author(s):  
Sarah E. Twardowski ◽  
Jean Wactawski-Wende ◽  
Kathleen M. Hovey ◽  
Christopher A. Andrews ◽  
Hailey R. Banack ◽  
...  
Keyword(s):  
Vitamin D ◽  
Periodontal Disease ◽  
Postmenopausal Women ◽  
Inverse Association ◽  
Vitamin D Status ◽  
C Reactive Protein ◽  
Hydroxyvitamin D ◽  
Reactive Protein ◽  
25 Hydroxyvitamin D ◽  
Serum Crp

Vitamin D has been hypothesized to play an important role in preventing the development and progression of periodontal disease, but the underlying immune modulatory mechanisms remain understudied. We examined the cross-sectional association between biomarkers of vitamin D status and C-reactive protein (CRP) among postmenopausal women aged 53–81 years. Linear regression was used to examine the association between plasma 25-hydroxyvitamin D (25[OH]D) concentrations, a biomarker of vitamin D status, and both salivary and serum CRP concentrations in 567 women from the Buffalo Osteoporosis and Periodontal Disease (OsteoPerio) Study (1997–2000). CRP concentrations were measured with multiplex arrays and transformed for normality using the natural log. Concentrations above and below the limit of detection were included in analysis as right- and left-censored observations. An inverse association was observed between 25(OH)D and salivary CRP in a model adjusted for age, smoking status, frequency of tooth brushing and flossing, and hormone therapy use (−7.56% difference in salivary CRP concentrations per 10 nmol/L increase in 25(OH)D, 95% CI: −12.78 to −2.03). Further adjustment for percent body fat attenuated this association (−2.48%, 95% CI: −7.88 to 3.24). No significant associations were found between 25(OH)D and serum CRP. Plasma vitamin D concentrations were not associated with salivary or serum CRP concentrations in this cohort of postmenopausal women.

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