scholarly journals Rhizoma Dioscoreae Extract Protects against Alveolar Bone Loss in Ovariectomized Rats via microRNAs Regulation

Nutrients ◽  
2015 ◽  
Vol 7 (2) ◽  
pp. 1333-1351 ◽  
Author(s):  
Zhiguo Zhang ◽  
Changheng Song ◽  
Fangzhen Zhang ◽  
Lihua Xiang ◽  
Yanjing Chen ◽  
...  
Keyword(s):  
Bone Loss ◽  
Alveolar Bone ◽  
Alveolar Bone Loss ◽  
Ovariectomized Rats

scholarly journals The Protective Effect of Rhizoma Dioscoreae Extract against Alveolar Bone Loss in Ovariectomized Rats via Regulating Wnt and p38 MAPK Signaling

Nutrients ◽  
2014 ◽  
Vol 6 (12) ◽  
pp. 5853-5870 ◽  
Author(s):  
Zhiguo Zhang ◽  
Lihua Xiang ◽  
Dong Bai ◽  
Wenlai Wang ◽  
Yan Li ◽  
...  
Keyword(s):  
Bone Loss ◽  
Protective Effect ◽  
P38 Mapk ◽  
Alveolar Bone ◽  
Mapk Signaling ◽  
Alveolar Bone Loss ◽  
Ovariectomized Rats

scholarly journals Protective effect of Rhizoma Dioscoreae extract against alveolar bone loss in ovariectomized rats via regulation of IL-6/STAT3 signaling

2017 ◽  
Vol 40 (5) ◽  
pp. 1602-1610
Author(s):  
Zhi-Guo Zhang ◽  
Yan-Jing Chen ◽  
Li-Hua Xiang ◽  
Jing-Hua Pan ◽  
Zhen Wang ◽  
...  
Keyword(s):  
Bone Loss ◽  
Protective Effect ◽  
Alveolar Bone ◽  
Alveolar Bone Loss ◽  
Ovariectomized Rats ◽  
Stat3 Signaling

FSH Aggravates Periodontitis-related Bone Loss in Ovariectomized Rats

2010 ◽  
Vol 89 (4) ◽  
pp. 366-371 ◽  
Author(s):  
S. Liu ◽  
Y. Cheng ◽  
M. Fan ◽  
D. Chen ◽  
Z. Bian
Keyword(s):  
Bone Resorption ◽  
Bone Loss ◽  
Clinical Features ◽  
Alveolar Bone ◽  
Follicle Stimulating Hormone ◽  
Alveolar Bone Loss ◽  
Ovariectomized Rats ◽  
Fsh Receptor ◽  
Histochemical Tests ◽  
Experimental Periodontitis

Alveolar bone loss is one of the prominent pathologic and clinical features of periodontitis. Recently, the direct effect of follicle-stimulating hormone (FSH) on bone resorption has been demonstrated. However, the effect of FSH on alveolar bone loss remains unknown. This study tested the hypothesis that FSH would exacerbate periodontitis-related alveolar bone loss. Experimental periodontitis was induced in ovariectomized rats, and the rats were treated with extrinsic FSH or its inhibitor, leuprorelin. After mandibles were collected, we performed morphological examinations to evaluate bone loss, enzyme histochemical tests for osteoclasts, and immunohistochemical examinations for FSH receptor (FSHR). The results showed that FSH significantly increased alveolar bone resorption compared with non-FSH-treated ovariectomized rats (P < 0.05), and the number of FSHR-positive cells was positively correlated with alveolar bone loss area (r = 0.682, P < 0.01). Our results suggested that FSH can aggravate alveolar bone loss by FSHR, independent of estrogen.

scholarly journals Estrogen deficiency and periodontal condition in rats: a radiographic and macroscopic study

2006 ◽  
Vol 17 (3) ◽  
pp. 201-207 ◽  
Author(s):  
Ana Lia Anbinder ◽  
Marcela de Almeida Prado ◽  
Marianne Spalding ◽  
Ivan Balducci ◽  
Yasmin Rodarte Carvalho ◽  
...  
Keyword(s):  
Risk Factor ◽  
Bone Loss ◽  
Periodontal Disease ◽  
Alveolar Bone ◽  
Alveolar Bone Loss ◽  
Estrogen Deficiency ◽  
Female Rats ◽  
Ovariectomized Rats ◽  
Furcation Involvement ◽  
The Impact

The purpose of this study was to evaluate the impact of ovariectomy-induced estrogen deficiency as a risk factor of periodontal disease in rats. Forty 90-day old female rats were either ovariectomized (OVX; n=20) or sham operated (SHAM; n=20). After 30 days, periodontitis was induced by placement of a cotton ligature around the upper second molars of 10 OVX and 10 SHAM animals. All animals were sacrificed 5 weeks later. Body weight was assessed before all surgical procedures. The left hemimaxillas were removed and the percentage of periodontal bone support was determined radiographically and buccal alveolar bone loss was determined macroscopically using an image-analysis software. Furcation involvement was also evaluated. Data were analyzed statistically by ANOVA at 5% significance level. Within the evaluated period, the ovariectomized rats gained more weight than the sham-operated animals (p<0.001). The animals in which periodontitis was induced had less bone support, greater alveolar bone loss and furcation involvement than those without ligature (p<0.001). However, there was no difference between ovariectomized and sham-operated animals (p>0.05). Based on the findings of this study, estrogen deficiency could not be considered as a risk factor for periodontal disease.

scholarly journals The Influence of Ficus deltoidea in Preserving Alveolar Bone in Ovariectomized Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-15
Author(s):  
N. I. Omar ◽  
B. Baharin ◽  
S. F. Lau ◽  
N. Ibrahim ◽  
N. Mohd ◽  
...  
Keyword(s):  
Body Weight ◽  
Bone Loss ◽  
Alveolar Bone ◽  
Alveolar Bone Loss ◽  
Bone Diseases ◽  
Ovariectomized Rats ◽  
Control Group ◽  
Trabecular Thickness ◽  
Ficus Deltoidea ◽  
Morphometric Assessment

Ficus deltoidea has been shown to possess antioxidant properties that could prevent the development of chronic inflammatory bone diseases. In this study, the efficacy of F. deltoidea in preventing alveolar bone resorption in osteoporotic rats induced by ovariectomy (OVX) was investigated. Twenty-four female Wistar rats were divided into four groups (n = 6) consisting of sham-operated (SO), ovariectomized control (OVXN), ovariectomized treated with estrogen (OVXP), and ovariectomized treated with F. deltoidea extract (OVXF). At the beginning of the study, two nonovariectomized, healthy rats were sacrificed to serve as baseline (BL). Treatment of the rats commenced two weeks after ovariectomy—the OVXP rats that served as positive control received Premarin® (64.5 μg/kg body weight), while OVXF rats were given F. deltoidea (800 mg/kg body weight); both agents were administered orally for two months. The negative control group of rats (OVXN) and the SO group received deionized water, also administered via oral gavage. At necropsy, morphometric assessment of the interradicular bone of the first molar was carried out using a micro-CT scanner, while quantification of osteoclasts and osteoblasts was performed histologically. The results showed that no statistically significant differences among the groups p > 0.05 for bone morphometric assessment. However, trabecular thickness in the OVXF group was similar to BL, while trabecular separation and alveolar bone loss height were lower than those of the OVXN group. Histologically, the OVXF group demonstrated a significantly lower number of osteoclasts and a higher number of osteoblasts compared with OVXN ( p = 0.008 and p = 0.019 , respectively; p < 0.05 ). In conclusion, F. deltoidea has the capacity to prevent alveolar bone loss in ovariectomy-induced osteoporosis rats by potentially preserving trabecular bone microarchitecture and to decrease osteoclast and increase osteoblast cell count.

scholarly journals Green tea extract rich in epigallocatechin gallate impairs alveolar bone loss in ovariectomized rats with experimental periodontal disease

2020 ◽  
Vol 101 (6) ◽  
pp. 277-288
Author(s):  
Paula Katherine Vargas‐Sanchez ◽  
Dimitrius Leonardo Pitol ◽  
Luiz Gustavo Sousa ◽  
Márcio Mateus Beloti ◽  
Adalberto Luiz Rosa ◽  
...  
Keyword(s):  
Bone Loss ◽  
Periodontal Disease ◽  
Green Tea ◽  
Alveolar Bone ◽  
Epigallocatechin Gallate ◽  
Alveolar Bone Loss ◽  
Green Tea Extract ◽  
Ovariectomized Rats ◽  
Tea Extract ◽  
Experimental Periodontal Disease
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