scholarly journals Cordyceps militaris Extract Protects Human Dermal Fibroblasts against Oxidative Stress-Induced Apoptosis and Premature Senescence

Nutrients ◽  
2014 ◽  
Vol 6 (9) ◽  
pp. 3711-3726 ◽  
Author(s):  
Jun Park ◽  
Jong Lee ◽  
Ki Lee ◽  
Suk-Jin Ha ◽  
Eock Hong
Keyword(s):  
Oxidative Stress ◽  
Cordyceps Militaris ◽  
Dermal Fibroblasts ◽  
Premature Senescence ◽  
Human Dermal Fibroblasts ◽  
Induced Apoptosis

scholarly journals Inonotus obliquus Extracts Decreased Expression of MMP1 mRNA via JNK-AP-1 Axis

Cosmetics ◽  
2020 ◽  
Vol 7 (2) ◽  
pp. 36
Author(s):  
Young Joo Kim ◽  
Hwa Jun Cha
Keyword(s):  
Oxidative Stress ◽  
Matrix Metalloproteinases ◽  
Mrna Expression ◽  
Transcriptional Activity ◽  
Dermal Fibroblasts ◽  
Human Dermal Fibroblasts ◽  
Inonotus Obliquus ◽  
The Family ◽  
Normal Human ◽  
Normal Human Dermal Fibroblasts

Inonotus obliquus, which is parasitic on birch and other trees, is a fungus in the family Hymenochaetaceae. In this study, we investigated whether Inonotus obliquus extracts used in traditional medicine were decreased in the expression of matrix metalloproteinases-1 (MMP-1) in the normal human dermal fibroblasts. As shown in our results, extracts of Inonotus obliquus decreased MMP1 expression in oxidative stress-exposed normal human dermal fibroblasts. Additionally, Inonotus obliquus extracts decreased AP-1 transcriptional activity and phospho-JNK in oxidative stress-exposed normal human dermal fibroblasts. Oxidative stress mediated the elevation of MMP1 mRNA expression and was well regulated by the JNK-AP-1 axis. Therefore, the results suggest that Inonotus obliquus extracts decreased MMP1 mRNA expression by regulating JNK-AP-1 axis. Additionally, Inonotus obliquus extracts have the potential to reduce collagen destruction and the formation of wrinkles and to be used as a cosmetic ingredient.

Guava (Psidium guajava L. cv. Red Suprema) Crude Extract Protect Human Dermal Fibroblasts against Cytotoxic Damage Mediated by Oxidative Stress

2018 ◽  
Vol 73 (1) ◽  
pp. 18-24 ◽  
Author(s):  
José M. Alvarez-Suarez ◽  
Francesca Giampieri ◽  
Massimiliano Gasparrini ◽  
Luca Mazzoni ◽  
Tamara Y. Forbes-Hernández ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Crude Extract ◽  
Psidium Guajava ◽  
Dermal Fibroblasts ◽  
Human Dermal Fibroblasts

Retinol, at concentrations greater than the physiological limit, induces oxidative stress and apoptosis in human dermal fibroblasts

2004 ◽  
Vol 13 (1) ◽  
pp. 45-54 ◽  
Author(s):  
Amparo Gimeno ◽  
Rosa Zaragoza ◽  
Inma Vivo-Sese ◽  
Juan R. Vina ◽  
Vicente J. Miralles
Keyword(s):  
Oxidative Stress ◽  
Dermal Fibroblasts ◽  
Human Dermal Fibroblasts ◽  
Physiological Limit

scholarly journals Glycosyl flavones from Humulus japonicus suppress MMP-1 production via decreasing oxidative stress in UVB irradiated human dermal fibroblasts

BMB Reports ◽  
2020 ◽  
Vol 53 (7) ◽  
pp. 379-384
Author(s):  
Eui Jeong Nam ◽  
Gyhye Yoo ◽  
Joo Young Lee ◽  
Myungsuk Kim ◽  
Changho Jhin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dermal Fibroblasts ◽  
Human Dermal Fibroblasts ◽  
Humulus Japonicus

scholarly journals Pechiche (Vitex cymosa Berteo ex Speng), a Nontraditional Fruit from Ecuador, is a Dietary Source of Phenolic Acids and Nutrient Minerals, in Addition to Efficiently Counteracting the Oxidative-Induced Damage in Human Dermal Fibroblasts

Antioxidants ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 109
Author(s):  
Mabel Guevara ◽  
Luis A. Valdés-Silverio ◽  
María G. Granda-Albuja ◽  
Gabriel Iturralde ◽  
Tatiana Jaramillo-Vivanco ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Enzymes ◽  
Oxidative Damage ◽  
Phenolic Acids ◽  
Glutathione Transferase ◽  
Dermal Fibroblasts ◽  
Human Dermal Fibroblasts ◽  
Atp Levels ◽  
Intracellular Ros ◽  
Phosphorus And Potassium

Pechiche fruits (Vitex cymosa Berteo ex Speng) from Ecuador were studied to determine their phenolic acid profile, nutrient minerals and capacity to protect primary human dermal fibroblasts (HDFa) against oxidative-induced damage. Up to five phenolic acids were identified, with homovanillic acid as the main one. Vitamin C, β-carotene and lutein were also determined. Phosphorus and potassium were the main macrominerals, while iron was the principal micromineral. HDFa were preincubated with a crude pechiche extract (PCext) and then subjected to oxidative stress. The activity of five antioxidant enzymes, intracellular reactive oxygen species (ROS) and ATP levels and lipid peroxidation and protein oxidation were used as markers of oxidative damage. Preincubation with PCext for 24 h allowed for the significant reduction of intracellular ROS levels, improved the intracellular ATP levels and protected lipids and proteins against oxidative damage (p < 0.05). Additionally, preincubation with PCext was also able to significantly (p < 0.05) improve the activity of the antioxidant enzymes catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase and glutathione transferase, compared to the stressed group without pretreatment. The results obtained in this study suggest the potential of pechiche as a source of bioactive compounds, as well as its beneficial effect against oxidative stress.

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