scholarly journals A Comparison of Retinyl Palmitate and Red Palm Oil β-Carotene as Strategies to Address Vitamin A Deficiency

Nutrients ◽  
2013 ◽  
Vol 5 (8) ◽  
pp. 3257-3271 ◽  
Author(s):  
Ellie Souganidis ◽  
Arnaud Laillou ◽  
Magali Leyvraz ◽  
Regina Moench-Pfanner
2000 ◽  
Vol 51 (sup1) ◽  
pp. s43-s50 ◽  
Author(s):  
M. E. van Stuijvenberg ◽  
M. Faber ◽  
M. A. Dhansay ◽  
C. J. Lombard ◽  
N. Vorster ◽  
...  

1994 ◽  
Vol 15 (2) ◽  
pp. 1-6 ◽  
Author(s):  
C. Rukmini

Red palm oil (RPO), besides providing calorie density to the diet, is also the richest natural source of β-carotene, a precursor of vitamin A and an antioxidant that destroys singlet oxygen and free radicals. Chemical analysis of the fatty acid composition of RPO indicates that it has 50% saturated, 40% mono-unsaturated, and 10% polyunsaturated fatty acids. RPO contains 550 mg/g of total carotenoids, of which 375 mg/g represent β-carotene. It also contains 1,000 mg/g of tocopherols and tocotrienols. Nutritional values in rats fed 10% RPO in a 10% casein diet were comparable to those fed 10% ground nut oil (GNO) or 10% RBDPO (refined, bleached, deodorized palm oil). Rats fed RPO or RBDPO had significantly lower plasma cholesterol concentrations than those fed GNO. Significant inhibition of micro-somal 3-hydroxy-3-methylglutaryl coenzyme A reductase activity was observed in the RPO and RBDPO groups, indicating reduced synthesis of endogenous cholesterol. Toxicological studies also indicate that RPO is safe for human consumption. Indian school children fed supplementary snacks prepared with RPO for 60 days had significant increases in serum retinol levels as well as an increased liver retinol store, suggesting the ready bioavailability of β-carotene.


2019 ◽  
Vol 2 (3) ◽  
pp. 108-119
Author(s):  
Krisna Malau ◽  
◽  
Nuri Andarwulan ◽  
Drajat Martianto ◽  
Desty Gitapratiwi ◽  
...  

1992 ◽  
Vol 68 (2) ◽  
pp. 529-540 ◽  
Author(s):  
Cécile Carlier ◽  
Michel Etchepare ◽  
Jean-François Ceccon ◽  
Marie-Sophie Mourey ◽  
Olivier Amédée-Manesme

Administration of large oral doses of retinyl palmitate has become the most widely practised vitamin A deficiency prevention strategy in developing countries. We conducted a follow-up study among 220 Senegalese children aged 2–7 years suffering from moderate undernutrition to determine the efficacy of vitamin A treatment on their vitamin A status assessed by biochemical and cytological (impression cytology with transfer) methods. The first examination (T = 0 m[onth]) was carried out during April 1989, before the mango (Mangifera indica L,) harvest. The second examination (T = 2 m) was carried out 2 months after vitamin A treatment during June 1989 when ripe mangoes become widely available. Conjunctival cells of the eyes of the children with or without ocular inflammation were responsive to vitamin A administration (P < 0.01). There was a significant increase (P < 0.001) in mean serum retinol and β-carotene levels between T = 0 m and T = 2 m. Mean serum retinol-binding protein (RBP) and transthyretin (TTR) levels did not differ significantly (P > 0.05) at T = 0 m and T = 2 m. Despite the intake of vitamin A, 54% of the children who had abnormal cytology at T = 0 m remained abnormal at T = 2 m. This was due to inadequate levels of TTR and RBP, presumably due to the cereal diet eaten by the Senegalese population. Children with abnormal eye cytology had lower serum retinol levels than those with normal eyes at T = 0 m, and β-carotene values did not correlate with eye cytological abnormalities at T = 0 m. Children with normal cytology had higher serum retinol and also β-carotene levels than those with abnormal cytology after massive oral doses of vitamin A and consumption of mangoes at T = 2 m. Retinyl palmitate may, therefore, only lead to partial cytological improvement due to a lack of retinol-carrier proteins but dietary β-carotene may also be involved


2017 ◽  
Vol 57 (6) ◽  
pp. 1079 ◽  
Author(s):  
A. J. Parker ◽  
J. P. Goopy ◽  
M. J. Callaghan ◽  
J. J. Vermunt ◽  
R. de Nys

Serum and liver retinol concentrations and blood β-carotene concentrations were studied in 30 Bos indicus heifers rendered deficient of vitamin A over 180 days and then given treatments of access to algae-based lick blocks (n = 10), injectable retinyl palmitate and molasses-based lick blocks (n = 10), or a negative control given access to molasses-based lick blocks only (n = 10). All heifers became deficient in blood and liver vitamin A, as well as blood β-carotene by 180 days. There was no treatment effect on bodyweight (P = 0.347). However, a highly significant effect of time (P = 0.001) was detected where all heifers achieved an average daily gain of 0.74 kg/day throughout the depletion phase of the study but lost 0.150 kg/day during the repletion phase. The concentrations of serum and liver retinol and blood β-carotene were not different between treatment groups (P = 0.362, P = 0.535 and P = 0.839) during the depletion or repletion phases of the study. All heifers continued to be rendered deficient in the concentrations of serum and liver retinol and blood β-carotene throughout the experiment demonstrating a highly significant effect of time (P = 0.001). Injectable retinyl palmitate (818 100 IU retinol) or access to algal lick blocks (4180 IU retinol) did not elevate blood or liver retinol concentrations in heifers rendered deficient of vitamin A. It is speculated that the protein-deficient diet fed to the heifers had an adverse effect on the blood retinol transport proteins.


1967 ◽  
Vol 3 (4) ◽  
pp. 287-293 ◽  
Author(s):  
T. B. Miller ◽  
L. E. Iduma

SummaryThe importance of carotene supplements in the feeding of White Fulani Zebu cattle has been studied in three experiments. The live weight gains of heifers, with and without carotene on two planes of nutrition, showed 0·2 lb/head/day gain on the ‘high’ plane, but the ‘low’ plane group did not respond to carotene supplement. The association between cottonseed feeding and vitamin A deficiency, studied by comparing the rates of depletion of heifer calves on cottonseed supplements and on a sorghum/groundnut mixture, indicated that cottonseed can enhance the rate of carotene/vitamin A depletion in the liver. Carotene supplements equivalent to 2 oz red palm oil, to cows before and after calving failed to improve the vitamin A potency of milk. The total daily secretion of carotene and vitamin A in the milk was insufficient to maintain adequate liver stores in a suckled calf.


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