scholarly journals Vitamin D Supplementation and Mental Health in Multiple Sclerosis Patients: A Systematic Review

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4207
Author(s):  
Dominika Głąbska ◽  
Aleksandra Kołota ◽  
Katarzyna Lachowicz ◽  
Dominika Skolmowska ◽  
Małgorzata Stachoń ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Multiple Sclerosis ◽  
Systematic Review ◽  
Vitamin D ◽  
Depressive Symptoms ◽  
Positive Influence ◽  
Vitamin D Supplementation ◽  
Multiple Sclerosis Patients

Vitamin D has a promising role in multiple sclerosis (MS) management, and it has been found to be beneficial for patients’ mental health, which is reduced in MS patients. The aim of the present study was to conduct a systematic review of the literature to assess the influence of vitamin D supplementation on mental health in MS patients. The systematic review was registered in the PROSPERO database (CRD42020155779) and it was conducted on the basis of the PRISMA guidelines. The search procedure was conducted using PubMed and Web of Science databases and it included studies published up until September 2021. Six studies were included in the systematic review. The risk of bias was analyzed using the Newcastle–Ottawa Scale (NOS). Within the included studies, there were two studies randomized against placebo and four other prospective studies. The studies presented vitamin D interventions randomized against placebo or not randomized, while supplementation was applied for various durations—from 4 weeks to 12 months, or the studies compared patients who applied vitamin D supplementation and those who did not apply it and verified the effect of the supplementation after a number of years. The mental health outcomes that were assessed included quality of life, depression/depressive symptoms, and fatigue as an additional element. The majority of studies supported the positive influence of vitamin D on the mental health of MS patients, including the study characterized as having the highest quality (randomized against placebo with the highest NOS score). All the studies that assessed the quality of life indicated the positive influence of vitamin D while the studies that did not find a positive influence of vitamin D were conducted for depression/depressive symptoms. In spite of the fact that only a small number of studies have been conducted so far, and only two studies were randomized against a placebo, some conclusions may be formulated. The systematic review allowed us to conclude that there may be a positive effect of vitamin D supplementation in MS patients, which was stated in all of the studies analyzing quality of life, as well as in one study analyzing depressive symptoms. Considering that vitamin D deficiency is common in MS patients, and the potential positive influence of supplementation on the quality of life, supplementation should be applied at least in doses that cover the recommended intake.

scholarly journals Influence of Vitamin D Supplementation on Mental Health in Diabetic Patients: A Systematic Review

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 3678
Author(s):  
Dominika Guzek ◽  
Aleksandra Kołota ◽  
Katarzyna Lachowicz ◽  
Dominika Skolmowska ◽  
Małgorzata Stachoń ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Systematic Review ◽  
Vitamin D ◽  
Vitamin D Supplementation ◽  
Diabetic Patients ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

Diabetes is associated with a number of mental health consequences, including enhanced risk of depression and anxiety, as well as decreased quality of life, and vitamin D deficiency is considered to be one of the factors that influence these outcomes in diabetic patients. The aim of the present study was to conduct a systematic review of the literature presenting the data regarding the influence of vitamin D supplementation on mental health in diabetic adults. This study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and registered in the International Prospective Register of Systematic Reviews (PROSPERO) database (Registration number CRD42020155779). A systematic search of the PubMed and Web of Science databases was performed, and the intervention studies published until September 2021 were included in the review. The human studies were included if an adult sample of diabetic individuals received vitamin D supplementation during the intervention and its effect on any mental health aspect was assessed, but studies presenting the influence of combined supplementation of multiple nutrients were excluded. After removing duplicate records, a total of 8,514 publications were screened and assessed independently by two researchers, based on their title, abstract, and full text. Finally, six studies were included in the current systematic review, and the risk of bias was evaluated using the Newcastle–Ottawa Scale (NOS). The included studies analyzed the influence of a specific dose of vitamin D, or different doses of vitamin D, or compared the results of supplementation with a specific dose of vitamin D against the placebo group. The supplementation was performed for at least 12 weeks. The mental health outcomes analyzed in these studies included health-related quality of life, depression, anxiety, stress, and general mental health status of adult diabetic patients. The results of the majority of the studies confirmed the positive influence of vitamin D supplementation on the mental health of diabetic individuals. Those studies that analyzed the influence of vitamin D supplementation on depression and anxiety established the beneficial effect of the vitamin. In some studies, the influence of vitamin D supplementation on the health-related quality of life was not considered unless combined with mindfulness training. However, it must be emphasized that different dosage regimens and intervention periods were followed in the reviewed studies, and only a small number of studies were randomized against placebo, which should be considered as a limitation of the present study. The findings of the conducted systematic review demonstrated the positive influence of vitamin D supplementation on the mental health of diabetic patients, which was proved for anxiety and depression, but in the case of health-related quality of life, the positive effect was observed only when the intervention included mindfulness training. These outcomes suggest that supplementation should be recommended to improve the vitamin D status and the mental health of patients in this group.

scholarly journals Vitamin D Supplementation and Mental Health in Inflammatory Bowel Diseases and Irritable Bowel Syndrome Patients: A Systematic Review

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3662
Author(s):  
Dominika Głąbska ◽  
Aleksandra Kołota ◽  
Katarzyna Lachowicz ◽  
Dominika Skolmowska ◽  
Małgorzata Stachoń ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Systematic Review ◽  
Vitamin D ◽  
Vitamin D Supplementation ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Irritable Bowel ◽  
Positive Effect

Inflammatory bowel diseases (IBDs) and irritable bowel syndrome (IBS) are associated with decreased quality of life and mental health problems. Among various approaches to supportive therapy that aims to improve mental health in affected individuals, vitamin D supplementation is considered to be an effective method which may also be beneficial in alleviating the symptoms during the course of IBDs and IBS. The aim of the present study was to conduct a systematic review of the literature presenting the data regarding the influence of vitamin D supplementation on mental health in adults with inflammatory and functional bowel diseases, including IBDs and IBS. This study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and registered in the International Prospective Register of Systematic Reviews (PROSPERO) database (Registration number CRD42020155779). A systematic search of the PubMed and Web of Science databases was performed, and the intervention studies published until September 2021 were included. The human studies eligible to be included in the review should have described any intervention involving vitamin D as a supplement in a group of adult patients suffering from IBDs and/or IBS and should have assessed any component of mental health, but studies presenting the effects of combined supplementation of multiple nutrients were excluded. After eliminating the duplicates, a total of 8514 records were screened and assessed independently by two researchers. Further evaluation was carried out on the basis of title, abstract, and full text. Finally, 10 studies (four for IBDs and six for IBS) were selected for the current systematic review, and their quality was assessed using the Newcastle–Ottawa Scale (NOS). The studies analyzed the influence of various doses of vitamin D on bowel diseases, compared the results of vitamin D supplementation with placebo, or administered specific doses of vitamin D to obtain the required level in the blood. Supplementation was performed for at least 6 weeks. The analyzed mental health outcomes mainly included disease-specific quality of life/quality of life, anxiety, and depression. The majority of studies (including high-quality ones) confirmed the positive effect of vitamin D supplementation on the mental health of IBD and IBS patients, which was proven by all research works evaluating anxiety and depression and by the majority of research works evaluating quality of life. Although the studies followed different dosage regimens and supplementation protocols, the positive influence of vitamin D on mental health was found to be consistent. The number of studies on patients suffering from ulcerative colitis and the availability of trials randomized against the placebo group was low in the current review, which is considered to be a limitation of the present study and could also reflect the final outcome of the analysis. The conducted systematic review established the positive effect of vitamin D supplementation on the mental health of IBD and IBS patients, but this result requires further investigation, particularly in relation to other mental health outcomes.

scholarly journals Association between Vitamin D Supplementation and Mental Health in Healthy Adults: A Systematic Review

2021 ◽  
Vol 10 (21) ◽  
pp. 5156
Author(s):  
Dominika Guzek ◽  
Aleksandra Kołota ◽  
Katarzyna Lachowicz ◽  
Dominika Skolmowska ◽  
Małgorzata Stachoń ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Systematic Review ◽  
Vitamin D ◽  
Fear Of Falling ◽  
Well Being ◽  
Vitamin D Supplementation ◽  
Healthy Adults ◽  
Food Sources

Vitamin D is considered to be a crucial factor that influences symptoms of depression, negative emotions, and quality of life, but to date, no systematic review has been conducted with regard to its effect on other domains of mental health. The aim of the study was to evaluate the influence of vitamin D supplementation on mental health in healthy adults. The systematic review was registered in the PROSPERO database (CRD42020155779) and performed according to the PRISMA guidelines. The literature search was conducted in PubMed and Web of Science databases and included intervention studies published until October 2019. The human studies were included if the supplementation regimen involved the administration of a specified dosage of vitamin D to an adult sample. A total of 7613 records were screened and assessed independently by two researchers, based on their title, abstract, and full text sequentially. Finally, 14 studies were included, and their risk of bias was assessed using the Newcastle–Ottawa Scale (NOS). The studies were included if they presented the results of various doses of vitamin D, compared the supplementation results with the placebo effect, compared the outcome with no supplementation, or observed effect of specific dose applied. The assessed mental health outcomes mainly included depressive symptoms, or depression, well-being, quality of life, mood, general mental component, and anxiety, but single studies also included other parameters such as distress, impression of improvement, and fear of falling and flourishing. The results of the majority of studies did not confirm a positive influence of vitamin D supplementation. None of the high-quality studies (assessed using NOS), which evaluated outcomes other than depression, supported the hypothesis that vitamin D supplementation effectively ameliorates mental health issues, while they present conflicting evidence for depression. Some studies indicated that supplementation should be combined with physical activity to provide effective results, and that supplementation is less effective than vitamin D supply from food sources. The included studies were conducted in diverse populations and followed various doses and intervals of administration, so the results may be incomparable, which should be considered as a limitation. The conducted systematic review did not provide strong evidence for a positive effect of vitamin D supplementation on mental health in healthy adults.

Predicting improvement of quality of life and mental health over 18-months in multiple sclerosis patients

2021 ◽  
pp. 103093
Author(s):  
Irene Gil-González ◽  
María Ángeles Pérez-San-Gregorio ◽  
Rupert Conrad ◽  
Agustín Martín-Rodríguez
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Multiple Sclerosis ◽  
Multiple Sclerosis Patients

The influence of vitamin D on postpartum relapse and quality of life in pregnant multiple sclerosis patients

2014 ◽  
Vol 22 (3) ◽  
pp. 479-484 ◽  
Author(s):  
T. F. Runia ◽  
R. F. Neuteboom ◽  
C. J. M. de Groot ◽  
Y. B. de Rijke ◽  
R. Q. Hintzen
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Vitamin D ◽  
Multiple Sclerosis Patients

scholarly journals Effect of Home-Based Aerobic Training and Vitamin D Supplementation on Fatigue and Quality of Life in Patients with Multiple Sclerosis During COVID-19 Outbreak

2021 ◽  
Author(s):  
Elahe Bahmani ◽  
Rastegar Hoseini ◽  
Ehsan Amiri
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Vitamin D ◽  
Aerobic Training ◽  
Vitamin D Supplementation ◽  
Control Group ◽  
Significance Level ◽  
Positive Effects ◽  
Home Based

Abstract Background: Multiple sclerosis (MS)is the most common neurological disease that causes disability in the nervous system which reduces the quality of life(QoL). Studies have shown positive effects of therapeutic exercise with supplementation on motor- and cognitive functionandfatigue as well as on QoLin persons with MS. The purpose of this study was to the effect of home-based aerobic training (AT) and vitamin D(Vit D) supplementation on fatigue and QoL in patients with MS during the covid-19 outbreak. Methods: We recruited 40 females (20 - 40 years) with MS(EDSS: 3-5). Then, using simple randomization, the subjects were assigned to four groups including aerobic training (AT; n=9; 50%-75%, 20-40 min/day, 3 days/wk aerobic training), vitamin D supplementation (Vit D; n=9; 50,000 IU one day/week), aerobic training plus vitamin D supplementation (AT + Vit D; n=10), and sedentary control (C; n=10 placebo). The data were analyzed using paired t-test and one-way analysis of variance and Tukey’s post hoc test with SPSS21 at a significance level of P < 0.05.Results: After eight weeks of intervention, fatigue grade markedly reduced in the AT + Vit D, AT, and Vit D groups); However, fatigue increased in the control group. QoLincreased significantly in AT+Vit D, AT, and Vit D compared to C. Also, the results show that the AT+Vit D had significantly higherQoL compared to AT and Vit D. Conclusion:These findings suggest that therapeutic AT and VitD supplementation is very effective in reducing fatigue and consequently improves the QoLin female MS patients.

scholarly journals Quality of Life Among Multiple Sclerosis Patients in Terms of Mental Health

2021 ◽  
Vol 17 (5) ◽  
pp. 62
Author(s):  
Dima Ibrahim Abu Maloh ◽  
Hazem Nouri AlNahar ◽  
Haya Ibrahim Abu Maloh
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Multiple Sclerosis ◽  
Outcome Measurement ◽  
Demographic Data ◽  
Physical Activities ◽  
Data Form ◽  
Significant Difference ◽  
Multiple Sclerosis Patients

This study aimed to identify the mental health quality of life among patients with multiple sclerosis in Jordan. Thus, a descriptive quantitative design was used on a total of (N=100) Multiple Sclerosis patients that were randomly selected by using convenience sampling from the Health Insurance Center in the capital Amman, Jordan. Outcome measurement tools were the demographic data form and the Multiple Sclerosis Quality of Life-54 (MSQOL-54) Scale. The demographic data form consisted of questions about: age in years, gender, stage of multiple scleroses, and physical activities. The Multiple Sclerosis Quality of Life-54 (MSQOL-54) consisted of two domains the physical health composite and the mental health composite. In this study the mental health composite were used by the participants. The results revealed that the QOL- Mental Health Composite among patients with multiple sclerosis was 33.9 + 33.6. Moreover, there was no significant difference in score for male and females p=.874. In addition, there was no significant difference in QOL mental health scores for the age groups p=.165. Finally, there was a significant difference in scores for participants and non-participants in physical activity p=.000. Accordingly, this research concluded that Multiple sclerosis patients&rsquo; have a low quality of life in terms of mental health. In addition, practicing physical activities have a positive effect on the quality of mental health among multiple sclerosis patients.

scholarly journals Comparison of Cognitive Rehabilitation versus Donepezil Therapy on Memory Performance, Attention, Quality of Life, and Depression among Multiple Sclerosis Patients

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Mohammad Mahdi Shahpouri ◽  
Majid Barekatain ◽  
Mahgol Tavakoli ◽  
Omid Mirmosayyeb ◽  
Ali Safaei ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Multiple Sclerosis ◽  
Cognitive Rehabilitation ◽  
Digit Span ◽  
Memory Performance ◽  
Intergroup Comparison ◽  
Multiple Sclerosis Patients ◽  
Memory Questionnaire

Background. Multiple sclerosis (MS) is a demyelinating disease of the central nervous system that affects cognitive performance and leads to depression and decreased quality of life (QOL). The current study aims to assess the effects of cognitive rehabilitation versus donepezil therapy on memory, attention, depression, and QOL in MS patients compared to placebo and control groups. Methods. Eighty MS patients were randomly selected from parallel randomized trials and divided into four groups: A: cognitive rehabilitation (10 sessions of 120 minutes), B: control (no intervention), C: donepezil (10 mg daily), and D: placebo. Patients received the intervention for three months. They were assessed for cognitive status, depression, and QOL prior to the intervention and immediately after that using abbreviated mental test (AMT), prospective and retrospective memory questionnaire (PRMQ), everyday memory questionnaire (EMQ), digit span, MSQOL-54, and second edition Beck depression inventory (BDI). We compared scores between groups after the intervention, as well as the progression of scores in every single group. Results. The cognitive rehabilitation group showed improvement in EMQ, RPMQ, digit span, physical and mental health subscales of MSQOL54, and depression P < 0.05 . We observed the same effect for donepezil except for the digit span test P = 0.15 . Intergroup comparison of scores showed the superiority of cognitive rehabilitation over donepezil in digit span, depression, and mental health scores. Conclusion. Both donepezil and cognitive rehabilitation effectively improve memory performance, attention, depression, and QOL in MS patients. Cognitive rehabilitation is superior altogether. This study is registered with the Iranian registry of clinical trials http://clinicaltrials.gov/ct2/show/IRCT2016042227522N1.

Development of a cross-cultural item bank for measuring quality of life related to mental health in multiple sclerosis patients

2015 ◽  
Vol 24 (9) ◽  
pp. 2261-2271 ◽  
Author(s):  
Pierre Michel ◽  
Pascal Auquier ◽  
Karine Baumstarck ◽  
Jean Pelletier ◽  
Anderson Loundou ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Multiple Sclerosis ◽  
Item Bank ◽  
Cross Cultural ◽  
Multiple Sclerosis Patients

scholarly journals The Role of Iron Metabolism in Fatigue, Depression, and Quality of Life in Multiple Sclerosis Patients

2020 ◽  
Vol 17 (18) ◽  
pp. 6818
Author(s):  
Anna Knyszyńska ◽  
Aleksandra Radecka ◽  
Paulina Zabielska ◽  
Joanna Łuczak ◽  
Beata Karakiewicz ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Depressive Symptoms ◽  
Iron Metabolism ◽  
Depressive Disorders ◽  
Binding Capacity ◽  
Iron Binding ◽  
Multiple Sclerosis Patients ◽  
Iron Binding Capacity

Multiple sclerosis (MS) is a chronic inflammatory disease of autoimmune origin for which there is currently no available cure. In the course of MS, next to neurological disorders, patients often present with chronic fatigue syndrome and depressive disorders, which impact on their daily function and quality of life. The aim of study was to analyse the relationship between serum parameters of iron metabolism and the severity of fatigue, depressive symptoms, and quality of life in MS patients. Methods: The study sample consisted of 90 people with a diagnosis of multiple sclerosis, age range 19–67 years, whose functional status evaluated using the Expanded Disability Status Scale in 90% of the participants did not exceed 3.5 points. Venous blood samples were collected for blood cell count determination and for the purposes of obtaining serum analysed for the concentrations of iron, ferritin, transferrin, transferrin saturation, unsaturated iron binding capacity (UIBC), and total iron binding capacity (TIBC). The participants were also evaluated according to the Fatigue Severity Scale, Beck Depression Inventory, and Functional Assessment of Multiple Sclerosis. Results: Ferritin levels were significantly correlated with the severity of depressive symptoms (r = −0.22; p = 0.04) and quality of life assessment (r = 0.22; p = 0.04) in the MS patients. Moreover, the severity of fatigue and depressive symptoms was significantly linked to a deterioration in quality of life. Conclusions: Ferritin deficiency in MS patients is associated with an exacerbation of depressive disorders and a decline in quality of life. Symptoms of fatigue in MS patients are inversely proportional to mood and quality of life.

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