scholarly journals Hypocalcemia and Vitamin D Deficiency in Children with Inflammatory Bowel Diseases and Lactose Intolerance

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2583
Author(s):  
Martyna Jasielska ◽  
Urszula Grzybowska-Chlebowczyk
Keyword(s):  
Vitamin D ◽  
Calcium Phosphate ◽  
Vitamin D Deficiency ◽  
Inflammatory Bowel Diseases ◽  
Lactose Intolerance ◽  
Mineral Density ◽  
Functional Abdominal Pain ◽  
Hydrogen Breath Test ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Background: A diet restricted in dairy products can cause calcium and vitamin D deficiency and, secondarily, lead to malnutrition and low bone mass. The aim of the study was to determine the incidence hypocalcemia and vitamin D deficiency in children with inflammatory bowel diseases and lactose intolerance (LI). Material and Methods: A total of 107 patients were enrolled to the study (mean age 14.07 ± 3.58 years; 46.7% boys): 43 with Crohn’s disease (CD), 31 with ulcerative colitis (UC), and 33 with functional abdominal pain (AP-FGID). Hydrogen breath test with lactose and laboratory tests to assess the calcium-phosphate metabolism were performed in all patients. The results of densitometry were interpreted in 37 IBD patients. Results: LI was diagnosed in 23.2% patients with CD, 22.6% with UC, and 21.2% children with AP-FGID, (p = 0.9). Moreover, 9.5% patients with CD, in 21.4% with UC, and in 51.5% with AP-FGID had optimal concentration of 25(OH)D (p = 0.0002). Hypocalcemia was diagnosed in 21% of patients with CD, 16.1% with UC patients, AP-FGID patients had normal calcium levels (p = 0.02). There was no difference in concentrations of total calcium, phosphorus, and 25(OH)D between patients on low-lactose diet and normal diet (p > 0.05). BMD Z-score ≤ −1 SD was obtained by 12 CD patients (48%), and 6 with UC (50%). Conclusion: The use of a low-lactose diet in the course of lactose intolerance in children with inflammatory bowel diseases has no effect on the incidence of calcium-phosphate disorders and reduced bone mineral density.

Factors affecting vitamin D deficiency in active inflammatory bowel diseases

2019 ◽  
Vol 51 (5) ◽  
pp. 657-662 ◽  
Author(s):  
Giorgia Burrelli Scotti ◽  
Maria Teresa Afferri ◽  
Aurora De Carolis ◽  
Valentina Vaiarello ◽  
Valeria Fassino ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Inflammatory Bowel Diseases ◽  
Factors Affecting ◽  
Bowel Diseases ◽  
Inflammatory Bowel

scholarly journals Vitamin D level in Hungarian patients with inflammatory bowel diseases

2013 ◽  
Vol 154 (46) ◽  
pp. 1821-1828 ◽  
Author(s):  
Katalin Lőrinczy ◽  
Péter László Lakatos ◽  
Miklós Tóth ◽  
Ágnes Salamon ◽  
Adrienn Nemes ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Inflammatory Bowel Diseases ◽  
Bowel Disease ◽  
Activity Index ◽  
Disease Activity Index ◽  
Clinical Activity ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Introduction: Vitamin D has an important role in the immune regulation. Vitamin D is essential for innate and adaptive immune systems and it plays a significant role in the formation of immune tolerance, as well. Aim: Vitamin D deficiency has been observed in patients with inflammatory bowel diseases in Western Europe, but there is no data available from Eastern Europe. Method: The study included 169 patients with inflammatory bowel disease. Results: The median vitamin D level was 22.7±10.6 ng/ml. Only 20% of the patients had adequate vitamin D level (>30 ng/ml), 52% had vitamin D insufficiency (15–30 ng/ml), and 28% of them had severe vitamin D deficiency (<15 ng/ml). Vitamin D concentration failed to correlate with clinical activity indexes (partial Mayo score: r = –0.143; Crohn’s disease activity index: r = –0.253) and with inflammatory parameters (C-reactive protein: r = 0.008; erythrocyte sedimentation rate: r = 0.012). Conclusions: Since vitamin D deficiency can be frequently observed in Hungarian patients with inflammatory bowel disease, its level should be tested in these patients. Orv. Hetil., 154(46), 1821–1828.

scholarly journals Advances in the understanding of mineral and bone metabolism in inflammatory bowel diseases

2011 ◽  
Vol 300 (2) ◽  
pp. G191-G201 ◽  
Author(s):  
Fayez K. Ghishan ◽  
Pawel R. Kiela
Keyword(s):  
Vitamin D ◽  
Bone Metabolism ◽  
Inflammatory Mediators ◽  
Inflammatory Bowel Diseases ◽  
Experimental Models ◽  
Mineral Density ◽  
Anabolic Hormone ◽  
Increased Risk ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Chronic inflammatory disorders such as inflammatory bowel diseases (IBDs) affect bone metabolism and are frequently associated with the presence of osteopenia, osteoporosis, and increased risk of fractures. Although several mechanisms may contribute to skeletal abnormalities in IBD patients, inflammation and inflammatory mediators such as TNF, IL-1β, and IL-6 may be the most critical. It is not clear whether the changes in bone metabolism leading to decreased mineral density are the result of decreased bone formation, increased bone resorption, or both, with varying results reported in experimental models of IBD and in pediatric and adult IBD patients. New data, including our own, challenge the conventional views, and contributes to the unraveling of an increasingly complex network of interactions leading to the inflammation-associated bone loss. Since nutritional interventions (dietary calcium and vitamin D supplementation) are of limited efficacy in IBD patients, understanding the pathophysiology of osteopenia and osteoporosis in Crohn's disease and ulcerative colitis is critical for the correct choice of available treatments or the development of new targeted therapies. In this review, we discuss current concepts explaining the effects of inflammation, inflammatory mediators and their signaling effectors on calcium and phosphate homeostasis, osteoblast and osteoclast function, and the potential limitations of vitamin D used as an immunomodulator and anabolic hormone in IBD.

Vitamin D Deficiency Associated with Disease Activity in Patients with Inflammatory Bowel Diseases

2015 ◽  
Vol 60 (10) ◽  
pp. 3085-3091 ◽  
Author(s):  
Mehdi Torki ◽  
Ali Gholamrezaei ◽  
Leila Mirbagher ◽  
Manijeh Danesh ◽  
Sara Kheiri ◽  
...  
Keyword(s):  
Vitamin D ◽  
Disease Activity ◽  
Vitamin D Deficiency ◽  
Inflammatory Bowel Diseases ◽  
Bowel Diseases ◽  
Inflammatory Bowel

scholarly journals Do Only Calcium and Vitamin D Matter? Micronutrients in the Diet of Inflammatory Bowel Diseases Patients and the Risk of Osteoporosis

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 525
Author(s):  
Alicja Ewa Ratajczak ◽  
Anna Maria Rychter ◽  
Agnieszka Zawada ◽  
Agnieszka Dobrowolska ◽  
Iwona Krela-Kaźmierczak
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Inflammatory Bowel Diseases ◽  
Bone Mineralization ◽  
Mineral Density ◽  
Bowel Diseases ◽  
Prevention Of Osteoporosis ◽  
Inflammatory Bowel ◽  
Extraintestinal Complications

Osteoporosis is one of the most common extraintestinal complications among patients suffering from inflammatory bowel diseases. The role of vitamin D and calcium in the prevention of a decreased bone mineral density is well known, although other nutrients, including micronutrients, are also of extreme importance. Despite the fact that zinc, copper, selenium, iron, cadmium, silicon and fluorine have not been frequently discussed with regard to the prevention of osteoporosis, it is possible that a deficiency or excess of the abovementioned elements may affect bone mineralization. Additionally, the risk of malnutrition, which is common in patients with ulcerative colitis or Crohn’s disease, as well as the composition of gut microbiota, may be associated with micronutrients status.

Vitamin D deficiency in patients with either rheumatic diseases or inflammatory bowel diseases on biologic therapy

2016 ◽  
Vol 11 (6) ◽  
pp. 803-807 ◽  
Author(s):  
Vincenzo Bruzzese ◽  
Angelo Zullo ◽  
Andrea Piacchianti Diamanti ◽  
Lorenzo Ridola ◽  
Roberto Lorenzetti ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Rheumatic Diseases ◽  
Inflammatory Bowel Diseases ◽  
Biologic Therapy ◽  
Bowel Diseases ◽  
Inflammatory Bowel

scholarly journals Erratum to: Vitamin D deficiency in patients with either rheumatic diseases or inflammatory bowel diseases on biologic therapy

2016 ◽  
Vol 12 (1) ◽  
pp. 141-141
Author(s):  
Vincenzo Bruzzese ◽  
Angelo Zullo ◽  
Andrea Picchianti Diamanti ◽  
Lorenzo Ridola ◽  
Roberto Lorenzetti ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Rheumatic Diseases ◽  
Inflammatory Bowel Diseases ◽  
Biologic Therapy ◽  
Bowel Diseases ◽  
Inflammatory Bowel
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