scholarly journals β-Carotene Status Is Associated with Inflammation and Two Components of Metabolic Syndrome in Patients with and without Osteoarthritis

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2280
Author(s):  
Chi-Hua Yen ◽  
Po-Sheng Chang ◽  
Ching-Ju Chiu ◽  
Yu-Yun Huang ◽  
Ping-Ting Lin
Keyword(s):  
Metabolic Syndrome ◽  
Abdominal Obesity ◽  
Odds Ratio ◽  
Control Group ◽  
Low Grade ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Inflammatory Status ◽  
Obese Control ◽  
Β Carotene

This study was conducted to investigate the β-carotene status in osteoarthritis (OA) patients and examine its relationships with the risk of inflammation and metabolic syndrome. OA patients were stratified by obesity based on body fat percentage (obese OA, n = 44; non-obese OA, n = 56), and sixty-nine subjects without OA or obesity were assigned as a non-obese control group. β-carotene, metabolic parameters, and inflammation status were assessed. Obese OA patients exhibited a significantly higher rate of metabolic syndrome (p = 0.02), abdominal obesity (p < 0.01), and lower β-carotene status (p < 0.01) compared with non-obese OA and non-obese controls. After adjusting for potential confounders, β-carotene status (≥0.8 µM) was significantly inversely correlated with the risk of metabolic syndrome (odds ratio = 0.27, p < 0.01), abdominal obesity (odds ratio = 0.33, p < 0.01), high blood pressure (odds ratio = 0.35, p < 0.01), hyperglycemia (odds ratio = 0.45, p < 0.05), and inflammation (odds ratio = 0.30, p = 0.01). Additionally, subjects who had a high β-carotene status with a low proportion of metabolic syndrome when they had a low-grade inflammatory status (p < 0.01). Obese OA patients suffered from a higher prevalence of metabolic syndrome and lower β-carotene status compared to the non-obese controls. A better β-carotene status (≥0.8 µM) was inversely associated with the risk of metabolic syndrome and inflammation, so we suggest that β-carotene status could be a predictor of the risk of metabolic syndrome and inflammation in patients with and without OA.

scholarly journals Association between Neutrophil-to-Lymphocyte Ratio with Abdominal Obesity and Healthy Eating Index in a Representative Older Spanish Population

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 855 ◽  
Author(s):  
Elena Rodríguez-Rodríguez ◽  
Ana M. López-Sobaler ◽  
Rosa M. Ortega ◽  
M. Luisa Delgado-Losada ◽  
Ana M. López-Parra ◽  
...  
Keyword(s):  
Older Adults ◽  
Body Fat ◽  
Abdominal Obesity ◽  
Healthy Eating ◽  
Healthy Eating Index ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Lymphocyte Ratio ◽  
Inflammatory Status ◽  
Inflammatory State

Poor diet quality and obesity, especially abdominal obesity, have been associated with systemic inflammation. The neutrophil-to-lymphocyte Ratio (NLR) is an available and inexpensive inflammation biomarker. The aim of the present study was to determine the association of dietary patterns and obesity with an inflammatory state. A group of 1747 Spanish noninstitutionalized older adults individuals were included, and a food-frequency questionnaire was applied. The Global Food Score (GFS) and Healthy Eating Index for Spanish population (SHEI) were calculated. Weight, height and waist (WC) and hip circumferences were measured, and BMI, waist-to-height ratio (WHtR), and waist-to-hip ratio (WHR) determined. In addition, body-fat percentage was measured by bioimpedance. NLR was calculated (NLR ≥ p80: 2.6; 2.8 and 2.4 as inflammatory status in the entire population, men and women, respectively). The men with inflammatory status presented significative higher values of WC, WHtR, WHR, and body-fat percentage (101.82 ± 10.34 cm, 0.61 ± 0.06, 0.98 ± 0.06, and 31.68 ± 5.94%, respectively) than those with better inflammatory status (100.18 ± 10.22 cm, 0.59 ± 0.06, 0.97 ± 0.07, and 30.31 ± 6.16%, respectively). Those males with worse inflammatory state had lower scores for protein foods (OR = 0.898 (0.812–0.993); p = 0.037). The women with NLR ≥ 2.4 had higher WHtR and WHR (0.62 ± 0.09 and 0.91 ± 0.09) than those with NLR < 2.4 (0.60 ± 0.08 and 0.90 ± 0.08). In multiple linear regression analysis, NLR was positively related with WHtR and negatively related with SHEI score (β = 0.224 ± 0.094; R2 = 0.060; p < 0.05 and β = −0.218 ± 0.101; R2 = 0.061; p < 0.05), adjusting by sex, age, marital status, education level, smoking, hours of sleeping and inflammatory diseases. In women, the higher the SHEI and GFS scores were and the better meeting the aims of cereal and vegetable servings, the less the odds of inflammatory status (OR = 0.970 (0.948–0.992); p = 0.008; OR = 0.963 (0.932–0.995); p = 0.024; OR = 0.818 (0.688–0.974); p = 0.024 and OR = 0.829 (0.730–0.942); p = 0.004, respectively). WHtR and quality of diet is related to the inflammation status in older adults regardless to the sex.

scholarly journals Pengaruh pemberian minuman lidah buaya terhadap kadar antioksidan total dan persentase lemak tubuh pada sindrom metabolik

2018 ◽  
Vol 7 (1) ◽  
pp. 1-8
Author(s):  
Marisi Elizabeth R. Silitonga ◽  
K. Heri Nugroho HS ◽  
Kusmiyati Tjahjono ◽  
Nyoman Suci Widyastiti ◽  
Diana Nur Afifah
Keyword(s):  
Metabolic Syndrome ◽  
Treatment Group ◽  
Body Fat ◽  
Aloe Vera ◽  
Control Group ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Total Antioxidant ◽  
Antioxidant Concentration ◽  
And Control

Background: Metabolic syndrome is related to glucose metabolism disturbance (hyperglycemia), lipid (dyslipidemia), high blood pressure, and central obesity. Metabolic syndrome implicates to heart attack, diabetes mellitus, hypertension, and death. Aloe vera, well known rich of polyphenol and vitamin, has a pharmacological effect to improve insulin resistance, chronic inflammation, and oxidative stress.Objective: To prove the effect of Aloe vera-based drink toward total antioxidant concentration improvement and body fat percentage reduction in metabolic syndrome subjects.Methods: Thus study was pre-post randomized true experimental study with control group design. The subjects were divided by 2 groups, treatment group (n=19) and control group (n=19). Treatment group was given 165 g/d Aloe vera-based drink for 30 days. Both of groups were given nutrition education about metabolic syndrome management. Total antioxidant concentration and body fat percentage were assessed pre-post-test by ABTS and BIA respectively, while food intake and activity were assessed by 24-h recall and GPAQ respectively. Independent t-test and Mann Whitney test were used to compare before and after treatment between control and treatment group.Results: Total antioxidant concentration significantly improved (p=0.00) in treatment group from 1.2 to 2.0 mmol/L, while total antioxidant concentration decreased from 1.4 to 1.3 mmol/L (p=0.074) in this control group. Moreover, there was significant difference of total antioxidant between treatment and control groups in the end of study (p=0.00). Furthermore, body fat percentage was reduced significantly from 32.8 to 32,4 mmol/L (p=0.005) in treatment group, while the reduction of body fat percentage in control group was not significant from 33.1 to 33,4 mmol/L (p=0.100). There was no difference of body fat percentage between two groups after intervention (p=0.358).Conclusion: Aloe vera-based drink improved total antioxidant concentration in metabolic syndrome subjects.

scholarly journals INFLUENCES OF SHORT-TERM NORMOBARIC HYPOXIC TRAINING ON METABOLIC SYNDROME-RELATED MARKERS IN OVERWEIGHT AND NORMAL-WEIGHT MEN

2018 ◽  
Vol 14 (1) ◽  
pp. e44-e52
Author(s):  
Sohee Shin ◽  
Toshio Matsuoka ◽  
Wi-Young So
Keyword(s):  
Metabolic Syndrome ◽  
Heart Rate ◽  
Density Lipoprotein ◽  
Exercise Group ◽  
Normal Weight ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Short Term ◽  
Hypoxic Training ◽  
Weight Groups

Background and Objective This study examined the influence of short-term normobaric hypoxic training on metabolic syndrome-related markers in overweight and normal-weight men. Material and Methods Forty-one Japanese men were included and were divided into two groups based on their body mass indices (BMIs): BMI≥25 or BMI<25. Participants in the overweight and normal-weight groups were randomly classified into the hypoxic exercise group (hypoxic overweight, HO; hypoxic normal-weight, HN) and the normoxic exercise group (normoxic overweight, NO; normoxic normal-weight, NN). Subjects performed treadmill exercise three days per week for four weeks at an exercise intensity of 60% of maximum heart rate, under either normobaric hypoxic or normobaric normoxic conditions, for 50 min (including 5 min warm-up and cool-down periods) after a 30-min rest period. The study parameters included weight, body fat percentage, BMI, heart rate, waist circumference, ankle-brachial pulse wave velocity (PWV), blood sugar, triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), fasting insulin, Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) scores, and adiponectin levels. Repeated measures two-way analysis of variance was used to examine differences in the mean parameter values between the two groups (overweight and normal-weight) before and after training. Results Hypoxic training improved the weight, body fat percentage, BMI, waist circumference, PWV, TC, LDL-C levels, and HOMA-IR scores in the overweight and normal-weight groups (p<0.05). In addition, TG level, HDL-C level, and HOMA-IR scores showed significant interactions with hypoxic training, as these parameters improved in the hypoxic overweight group (p<0.05). Conclusion These results suggest that hypoxic training could be useful for improving arterial stiffness, circulatory system function, body composition, and energy metabolism in adult males.

scholarly journals Metaflammation: Tissue-Specific Alterations of the NLRP3 Inflammasome Platform in Metabolic Syndrome

2018 ◽  
Vol 25 (11) ◽  
pp. 1294-1310 ◽  
Author(s):  
Raffaella Mastrocola ◽  
Manuela Aragno ◽  
Giuseppe Alloatti ◽  
Massimo Collino ◽  
Claudia Penna ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Advanced Glycation Endproducts ◽  
Low Grade ◽  
Advanced Glycation ◽  
Added Sugars ◽  
Physiological Ageing ◽  
Glycation Endproducts ◽  
Inflammatory Status ◽  
Age Related

In the last decades, the extension of life expectancy and the increased consumption of foods rich in saturated fats and added sugars have exposed the general population to emerging health problems. The prevalence of metabolic syndrome (MS), composed of a cluster of factors as obesity, dyslipidemia, hyperglycemia, and hypertension, is rapidly increasing in industrialized and developing countries leading to precocious onset of age-related diseases. Indeed, oxidative stress, accumulation of advanced glycation endproducts, and a chronic low-grade inflammation are common features of MS and physiological ageing. In particular, the entire set of MS factors contributes to the development of an inflammatory status named metaflammation, which has been associated with activation of early innate immune response through the assembling of the multiprotein complex inflammasome. The most investigated family of inflammasome platforms is the NOD-like receptor pyridine containing (NLRP) 3, which is activated by several exogenous and endogenous stimuli, leading to the sequential cleavage of caspase-1 and IL-1β, followed by secretion of active IL-1β. We here collect the most recent findings on NLRP3 activation in MS providing evidence of its central role in disease progression and organ dysfunction in target tissues of metaflammation, in particular in cardiovascular, hepatic and renal complications, with a focus on oxidative stress and advanced glycation endproducts. A wide overview of the most promising strategies for the modulation of NLRP3 activation and related metabolic repercussions is also provided, since the finding of specific pharmacological tools is an urgent requirement to reduce the social and economic burden of MS- and elderly-associated diseases.

scholarly journals A Genetic Score of Predisposition to Low-Grade Inflammation Associated with Obesity May Contribute to Discern Population at Risk for Metabolic Syndrome

Nutrients ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 298 ◽  
Author(s):  
Sebastià Galmés ◽  
Margalida Cifre ◽  
Andreu Palou ◽  
Paula Oliver ◽  
Francisca Serra
Keyword(s):  
Metabolic Syndrome ◽  
At Risk ◽  
Ex Vivo ◽  
Low Grade ◽  
Omega 3 ◽  
Genetic Score ◽  
Population At Risk ◽  
Inflammatory Status ◽  
Anti Inflammatory ◽  
Low Grade Inflammation

Omega-3 rich diets have been shown to improve inflammatory status. However, in an ex vivo system of human blood cells, the efficacy of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) modulating lipid metabolism and cytokine response is attenuated in overweight subjects and shows high inter-individual variability. This suggests that obesity may be exerting a synergistic effect with genetic background disturbing the anti-inflammatory potential of omega-3 long-chain polyunsaturated fatty acids (PUFA). In the present work, a genetic score aiming to explore the risk associated to low grade inflammation and obesity (LGI-Ob) has been elaborated and assessed as a tool to contribute to discern population at risk for metabolic syndrome. Pro-inflammatory gene expression and cytokine production as a response to omega-3 were associated with LGI-Ob score; and lower anti-inflammatory effect of PUFA was observed in subjects with a high genetic score. Furthermore, overweight/obese individuals showed positive correlation of both plasma C-Reactive Protein and triglyceride/HDLc-index with LGI-Ob; and high LGI-Ob score was associated with greater hypertension (p = 0.047), Type 2 diabetes (p = 0.026), and metabolic risk (p = 0.021). The study shows that genetic variation can influence inflammation and omega-3 response, and that the LGI-Ob score could be a useful tool to classify subjects at inflammatory risk and more prone to suffer metabolic syndrome and associated metabolic disturbances.

scholarly journals Subnormal Peripheral Blood Leukocyte Counts Are Related to the Lowest Prevalence and Incidence of Metabolic Syndrome: Tianjin Chronic Low-Grade Systemic Inflammation and Health Cohort Study

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Shaomei Sun ◽  
Hongmei Wu ◽  
Qing Zhang ◽  
Chongjin Wang ◽  
Yinting Guo ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cohort Study ◽  
Peripheral Blood ◽  
Peripheral Blood Leukocyte ◽  
Cox Proportional Hazards ◽  
Low Grade ◽  
Cross Sectional ◽  
Inflammatory Status ◽  
Leukocyte Counts ◽  
Blood Leukocyte

Few studies have assessed the relationship between a subnormal inflammatory status and metabolic syndrome (MS). We therefore designed a cross-sectional and 5-year cohort study to evaluate how a subnormal peripheral blood leukocyte count is related to MS. Participants were recruited from Tianjin Medical University General Hospital-Health Management Centre. Both a baseline cross-sectional (n=46,179) and a prospective assessment (n=13,061) were performed. Participants without a history of MS were followed up for 5 years. Leukocyte counts and MS components were assessed at baseline and yearly during the follow-up. Adjusted logistic and Cox proportional hazards regression models were used to assess relationships between the categories of leukocyte counts and MS. The subnormal leukocyte counts group (1,100&#x2013;3,900&#x2009;cells/mm3) had the lowest prevalence and incidence of MS. The odds ratio and hazard ratio (95&#x25; confidence interval) of the highest leukocyte counts were 1.98 (1.57&#x2013;2.49) and 1.50 (1.22&#x2013;1.84) (bothPfor trend &#x3C;0.0001), respectively, when compared to the subnormal leukocyte counts group after adjusting for potential confounders. This study has shown that subnormal leukocyte counts are independently related to the lowest prevalence and incidence of MS. The findings suggest that it is necessary to restudy and discuss the clinical or preventive value of subnormal leukocyte counts.

The circulating level of modified ldl and c3-convertase stabilization among patients with abdominal obesity

2016 ◽  
Vol 62 (5) ◽  
pp. 44-45 ◽  
Author(s):  
Sofia O. Eliashevich ◽  
Oxana M. Drapkina ◽  
Batogab B. Shoibonov
Keyword(s):  
Abdominal Obesity ◽  
Complement System ◽  
Functional Activity ◽  
Close Association ◽  
Density Lipoprotein ◽  
Low Grade ◽  
Classical Pathway ◽  
Low Density ◽  
Cvd Risk ◽  
Inflammatory Status

Background. The abdominal obesity is associated with a low-grade chronic inflammatory status, to which the complement system is an important contributor. Recent studies documented the close association between modified low-density lipoproteins (mLDL) and the increase of C3 production in human macrophages. In several reports, C3 and the degree of C3 activation (C3a and C3a-desArg) have been linked to diabetes and cardiovascular disease (CVD). However the studies of C3-convertase functional activity haven’t been taken yet.Aim: to evaluate a potential association between mLDL level and C3-convertase stabilization of the classical pathway of complement system activation in middle-aged individuals with abdominal obesity at low cardiovascular risk.Patients and methods. A pilot study, including 45 patients without evidence of atherosclerosis at low CVD risk in the next 10 years according to SCORE, was designed. Abdominal obesity was detected according to the IDF criteria (2009). All patients underwent a comprehensive clinical evaluation with lipid profile and glucose analyzes. The level of mLDL (U) and the C3-convertase functional activity (%) - a key enzyme complex of the classical pathway complement activation, were assessed by using original techniques. Receiving data have been analyzed and compared in the total sample and separately among patients with abdominal obesity.Results. Analysis included 45 participants (mean age: 41(9) years; body mass index: 27(5) kg/m2; and 47% male). Mean lipid values were as follows: total cholesterol: 5.4 (1) mmol/l; LDL-C: 3.8 (1) mmol/l; HDL-C: 0.98 (0.3) mmol/l; triglycerides 2.5 (1.5–2.1) mmol/l. 27 (60%) participants of the sample had signs of abdominal obesity. Among them 41 % (11) with overweight, 44 % (12) with obesity. There were found significant differences in the mLDL level of patients with abdominal obesity and without it (p< 0,01). The median of mLDL level of patients with abdominal obesity was 15.25 U (12.3 – 24.6), while the median of mLDL level of patients without abdominal obesity was 9 U (5.7 – 12.4). Plasma mLDL levels were associated with smoking and triglycerides (Spearman up to 0.6, p<0.05), independently of low-density lipoprotein-cholesterol and other variables. The activity of stabilized C3-convertase was high (mean 18.5 (7.6)%) in the majority of patients (82%), independently of BMI, waist circumference, blood pressure, levels of TG, LDL-C, HDL-C and mLDL-C. No significant correlation between C3-convertase activity and lipoprotein fractions was found.Conclusion. Our findings underscore the role of mLDL in early atherosclerosis among the asymptomatic middle-age sample with abdominal obesity at low risk of CVD. The observed fact of stabilization of C3 convertase, apparently, can serve as a predictor of the autoimmune nature of abdominal obesity. One product of the enhanced C3 cleavage is C3a-desArg, which is a hormone that stimulates the acylation and triglyceride synthesis. The association between lipid homeostasis, obesity and innate immune system need to be studied in larger samples.

scholarly journals Serum IL-12 Is Increased in Mexican Obese Subjects and Associated with Low-Grade Inflammation and Obesity-Related Parameters

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
K. Suárez-Álvarez ◽  
L. Solís-Lozano ◽  
S. Leon-Cabrera ◽  
A. González-Chávez ◽  
G. Gómez-Hernández ◽  
...  
Keyword(s):  
Body Fat ◽  
Adult Population ◽  
Strong Relationship ◽  
Normal Weight ◽  
Low Grade ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Necrosis Factor Alpha ◽  
Obese Subjects ◽  
Low Grade Inflammation

Interleukin-(IL-) 12 has been recently suggested to participate during development of insulin resistance in obese mice. Nevertheless, serum IL-12 levels have not been accurately determined in overweight and obese humans. We thus studied serum concentrations of IL-12 in Mexican adult individuals, examining their relationship with low-grade inflammation and obesity-related parameters. A total of 147 healthy individuals, 43 normal weight, 61 overweight, and 43 obese subjects participated in the study. Circulating levels of IL-12, tumor necrosis factor-alpha (TNF-α), leptin, insulin, glucose, total cholesterol, and triglyceride were measured after overnight fasting in all of the study subjects. Waist circumference and body fat percentage were recorded for all the participants. Serum IL-12 was significantly higher in overweight and obese individuals than in normal weight controls. Besides being strongly related with body mass index (r=0.5154), serum IL-12 exhibited a significant relationship with abdominal obesity (r=0.4481), body fat percentage (r=0.5625), serum glucose (r=0.3158), triglyceride (r=0.3714), and TNF-α(r=0.4717). Thus, serum levels of IL-12 are increased in overweight and obese individuals and show a strong relationship with markers of low-grade inflammation and obesity in the Mexican adult population. Further research is needed to understand the role of IL-12 in developing obesity-associated alterations in humans.

Microbiota and epigenetic regulation of inflammatory mediators in type 2 diabetes and obesity

2014 ◽  
Vol 5 (1) ◽  
pp. 33-43 ◽  
Author(s):  
M. Remely ◽  
E. Aumueller ◽  
D. Jahn ◽  
B. Hippe ◽  
H. Brath ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Gut Microbiota ◽  
Epigenetic Regulation ◽  
Control Group ◽  
Low Grade ◽  
Type 2 Diabetics ◽  
Significant Difference

Metabolic syndrome is associated with alterations in the structure of the gut microbiota leading to low-grade inflammatory responses. An increased penetration of the impaired gut membrane by bacterial components is believed to induce this inflammation, possibly involving epigenetic alteration of inflammatory molecules such as Toll-like receptors (TLRs). We evaluated changes of the gut microbiota and epigenetic DNA methylation of TLR2 and TLR4 in three groups of subjects: type 2 diabetics under glucagon-like peptide-1 agonist therapy, obese individuals without established insulin resistance, and a lean control group. Clostridium cluster IV, Clostridium cluster XIVa, lactic acid bacteria, Faecalibacterium prausnitzii and Bacteroidetes abundances were analysed by PCR and 454 high-throughput sequencing. The epigenetic methylation in the regulatory region of TLR4 and TLR2 was analysed using bisulfite conversion and pyrosequencing. We observed a significantly higher ratio of Firmicutes/ Bacteroidetes in type 2 diabetics compared to lean controls and obese. Major differences were shown in lactic acid bacteria, with the highest abundance in type 2 diabetics, followed by obese and lean participants. In comparison, F. prausnitzii was least abundant in type 2 diabetics, and most abundant in lean controls. Methylation analysis of four CpGs in the first exon of TLR4 showed significantly lower methylation in obese individuals, but no significant difference between type 2 diabetics and lean controls. Methylation of seven CpGs in the promoter region of TLR2 was significantly lower in type 2 diabetics compared to obese subjects and lean controls. The methylation levels of both TLRs were significantly correlated with body mass index. Our data suggest that changes in gut microbiota and thus cell wall components are involved in the epigenetic regulation of inflammatory reactions. An improved diet targeted to induce gut microbial balance and in the following even epigenetic changes of pro-inflammatory genes may be effective in the prevention of metabolic syndrome.

scholarly journals CROSSFIT TRAININGS AS AN ALTERNATIVE APPROACH TO PREVENT THE PERFORMANCE LOSS DURING THE REST OF THE END OF SEASON IN ELITE WRESTLERS

2020 ◽  
Vol 19 (S2) ◽  
pp. 51-57
Author(s):  
S Özbay ◽  
T Akbulut ◽  
V Cinar
Keyword(s):  
Body Weight ◽  
Bench Press ◽  
Rest Period ◽  
Dynamic Strength ◽  
Control Group ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Performance Loss ◽  
Crossfit Training ◽  
Maximal Dynamic Strength

Aim. The objective of this study is to investigate the effectiveness of Crossfit training in order to minimize performance loss of elite wrestlers during 30-day rest period. Materials and Methods. Total 23 elite male wrestlers who competed at the last national championship participated in this study. The participants were divided into two groups as Crossfit and control group. The Crossfit group performed 5 pull-ups, 10 push-ups and 15 squat exercises consecutively (Crossfit-Cindy) for total 20-min, during the 30-day period, 6 days per week. The Control group did not perform any exercise programs during this period. Before and after the 30-day period, athletes were applied anthropometric measurements as well as VO2max (aerobic capacity), bench press and squat (maximal dynamic strength), leg and handgrip strength (isometric strength), pull-up and push-up (strength endurance) tests. Results. After the 30-day period in the control group, body weight and body fat percentage (BF %) increased significantly, whereas all performance variables decreased significantly. Maximal dynamic strength and aerobic capacity values decreased significantly in the Crossfit group, while body weight, body fat percentage, isometric strength and strength endurance values were maintained. Moreover, the decrease in VO2max and bench press tests was higher in the control group than in the Crossfit group. Conclusion: Consequently, the present study showed that 20-min Crossfit training was highly effective in maintaining the form of elite wrestlers during a 30-day rest period

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