scholarly journals Subnormal Peripheral Blood Leukocyte Counts Are Related to the Lowest Prevalence and Incidence of Metabolic Syndrome: Tianjin Chronic Low-Grade Systemic Inflammation and Health Cohort Study

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Shaomei Sun ◽  
Hongmei Wu ◽  
Qing Zhang ◽  
Chongjin Wang ◽  
Yinting Guo ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cohort Study ◽  
Peripheral Blood ◽  
Peripheral Blood Leukocyte ◽  
Cox Proportional Hazards ◽  
Low Grade ◽  
Cross Sectional ◽  
Inflammatory Status ◽  
Leukocyte Counts ◽  
Blood Leukocyte

Few studies have assessed the relationship between a subnormal inflammatory status and metabolic syndrome (MS). We therefore designed a cross-sectional and 5-year cohort study to evaluate how a subnormal peripheral blood leukocyte count is related to MS. Participants were recruited from Tianjin Medical University General Hospital-Health Management Centre. Both a baseline cross-sectional (n=46,179) and a prospective assessment (n=13,061) were performed. Participants without a history of MS were followed up for 5 years. Leukocyte counts and MS components were assessed at baseline and yearly during the follow-up. Adjusted logistic and Cox proportional hazards regression models were used to assess relationships between the categories of leukocyte counts and MS. The subnormal leukocyte counts group (1,100–3,900 cells/mm3) had the lowest prevalence and incidence of MS. The odds ratio and hazard ratio (95% confidence interval) of the highest leukocyte counts were 1.98 (1.57–2.49) and 1.50 (1.22–1.84) (bothPfor trend <0.0001), respectively, when compared to the subnormal leukocyte counts group after adjusting for potential confounders. This study has shown that subnormal leukocyte counts are independently related to the lowest prevalence and incidence of MS. The findings suggest that it is necessary to restudy and discuss the clinical or preventive value of subnormal leukocyte counts.

scholarly journals Neutrophil:lymphocyte ratio is positively related to type 2 diabetes in a large-scale adult population: a Tianjin Chronic Low-Grade Systemic Inflammation and Health cohort study

2015 ◽  
Vol 173 (2) ◽  
pp. 217-225 ◽  
Author(s):  
Xiaoyan Guo ◽  
Shu Zhang ◽  
Qing Zhang ◽  
Li Liu ◽  
Hongmei Wu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cohort Study ◽  
Large Scale ◽  
Smoking Status ◽  
Adult Population ◽  
Cox Proportional Hazards ◽  
Low Grade ◽  
Cross Sectional ◽  
History Of

AimIt is widely known that inflammation is related to type 2 diabetes (T2D), but few studies have shown a direct relationship between the immune system and T2D using a reliable biomarker. Neutrophil:lymphocyte ratio (NLR) is an easy-to-analyze inflammation biomarker, but few studies have assessed the relationship between NLR and T2D. In order to evaluate how NLR is related to T2D, we designed a large-scale cross-sectional and prospective cohort study in an adult population.Subjects and methodsParticipants were recruited from the Tianjin Medical University General Hospital-Health Management Centre. Both a baseline cross-sectional (n=87 686) and a prospective (n=38 074) assessment were performed. Participants without a history of T2D were followed up for ∼6 years (with a median follow-up of 2.7 years). Adjusted logistic and Cox proportional hazards regression models were used to assess relationships between the quintiles of NLR and T2D (covariates: age, sex, BMI, smoking status, drinking status, hypertension, hyperlipidemia, and family history of cardiovascular disease, hypertension, hyperlipidemia, or diabetes).ResultsThe prevalence and incidence of T2D were 4.9% and 6.8/1000 person-years respectively. The adjusted odds ratio and hazard ratio (95% CI) of the highest NLR quintile were 1.34 (1.21, 1.49) and 1.39 (1.09, 1.78) (both P for trend <0.01) respectively as compared to the lowest quintile of NLR. Leukocyte, neutrophil, and lymphocyte counts do not significantly predict the eventual development of T2D.ConclusionThe present study demonstrates that NLR is related to the prevalence and incidence of T2D, and it suggests that NLR may be an efficient and accurate prognostic biomarker for T2D.

COMPARATIVE EFFECTS OF NITROGEN MUSTARD (HN2), CHLORAMBUCIL (CB 1348), AND BUSULPHAN (MYLERAN) ON THE PERIPHERAL BLOOD AND THE FERROKINETIC PATTERNS IN DOGS

1962 ◽  
Vol 40 (5) ◽  
pp. 667-677 ◽  
Author(s):  
L. G. Israels ◽  
C. Sinclair ◽  
J. Graf ◽  
A. Zipursky
Keyword(s):  
Peripheral Blood ◽  
Alkylating Agents ◽  
Peripheral Blood Leukocyte ◽  
Red Cell ◽  
Inhibitory Effects ◽  
Cell Production ◽  
Plasma Iron ◽  
Leukocyte Counts ◽  
Blood Leukocyte ◽  
Phenylbutyric Acid

Three alkylating agents, HN2 (methyl-bis(betachlorethyl)amine), chlorambucil (p-(di-2-chlorethylamino)-phenylbutyric acid), and busulphan (1,4-dimethanesulphonoxybutane) were studied with regard to their effects on leukocyte and red cell production in dogs. This was assessed by estimation of the peripheral blood leukocyte and reticulocyte changes as well as alterations in the plasma iron, Fe59 disappearance rate, plasma iron turnover, and red cell incorporation of radioactive iron. The two chlorethylamines had a similar effect on both leukocyte and red cell production. The effect on peripheral leukocyte counts was evident in 24 hours and the reticulocyte response indicated maximum interference with erythropoiesis on the third to seventh day following the drug. The effect of busulphan on both granulocytes and lymphocytes was slower to appear and slowly progressive. A difference in ferrokinetic pattern between the chlorethylamines and busulphan was also noted. The dissimilarity in ferrokinetic patterns may indicate a difference not only in mechanism of these agents on proliferating normoblasts but also in the inhibitory effects on the acceptance of iron by the red cell precursors and other body iron pools.

The Relation Between Peripheral Blood Leukocyte Counts and Respiratory Symptoms, Atopy, Lung Function, and Airway Responsiveness in Adults

CHEST Journal ◽  
2001 ◽  
Vol 119 (1) ◽  
pp. 105-114 ◽  
Author(s):  
Sarah A. Lewis ◽  
Ian D. Pavord ◽  
John R. Stringer ◽  
Alan J. Knox ◽  
Scott T. Weiss ◽  
...  
Keyword(s):  
Lung Function ◽  
Peripheral Blood ◽  
Respiratory Symptoms ◽  
Peripheral Blood Leukocyte ◽  
Airway Responsiveness ◽  
Leukocyte Counts ◽  
Blood Leukocyte
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