scholarly journals A Systematic Review of the Dietary Choline Impact on Cognition from a Psychobiological Approach: Insights from Animal Studies

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1966
Author(s):  
Fernando Gámiz ◽  
Milagros Gallo
Keyword(s):  
Animal Studies ◽  
Dietary Intervention ◽  
Developmental Stages ◽  
Beneficial Effects ◽  
Prisma Statement ◽  
Meta Analyses ◽  
Rats And Mice ◽  
The Impact ◽  
Psychobiological Approach ◽  
Dietary Choline

The influence of dietary choline availability on cognition is currently being suggested by animal and human studies which have focused mainly on the early developmental stages. The aim of this review is to systematically search through the available rodent (rats and mice) research published during the last two decades that has assessed the effect of dietary choline interventions on cognition and related attentional and emotional processes for the entire life span. The review has been conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement guidelines covering peer-reviewed studies included in PubMed and Scopus databases. After excluding duplicates and applying the inclusion/exclusion criteria we have reviewed a total of 44 articles published in 25 journals with the contribution of 146 authors. The results are analyzed based on the timing and duration of the dietary intervention and the behavioral tests applied, amongst other variables. Overall, the available results provide compelling support for the relevance of dietary choline in cognition. The beneficial effects of choline supplementation is more evident in recognition rather than in spatial memory tasks when assessing nonpathological samples whilst these effects extend to other relational memory tasks in neuropathological models. However, the limited number of studies that have evaluated other cognitive functions suggest a wider range of potential effects. More research is needed to draw conclusions about the critical variables and the nature of the impact on specific cognitive processes. The results are discussed on the terms of the theoretical framework underlying the relationship between the brain systems and cognition.

scholarly journals Exogenous application of growth stimulators improves the condition of maize exposed to soil drought

2021 ◽  
Vol 43 (4) ◽  
Author(s):  
Agnieszka Ostrowska ◽  
Maciej T. Grzesiak ◽  
Tomasz Hura
Keyword(s):  
Plant Growth ◽  
Developmental Stages ◽  
Aminolevulinic Acid ◽  
Stem Elongation ◽  
Development Stage ◽  
Photochemical Activity ◽  
Soil Drought ◽  
Beneficial Effects ◽  
Induced Changes ◽  
The Impact

AbstractSoil drought is a major problem in plant cultivation. This is particularly true for thermophilic plants, such as maize, which grow in areas often affected by precipitation shortage. The problem may be alleviated using plant growth and development stimulators. Therefore, the aim of the study was to analyze the effects of 5-aminolevulinic acid (5-ALA), zearalenone (ZEN), triacontanol (TRIA) and silicon (Si) on water management and photosynthetic activity of maize under soil drought. The experiments covered three developmental stages: three leaves, stem elongation and heading. The impact of these substances applied during drought stress depended on the plant development stage. 5-ALA affected chlorophyll levels, gas exchange and photochemical activity of PSII. Similar effects were observed for ZEN, which additionally induced stem elongation and limited dehydration. Beneficial effects of TRIA were visible at the stage of three leaves and involved leaf hydration and plant growth. A silicon preparation applied at the same developmental stage triggered similar effects and additionally induced changes in chlorophyll levels. All the stimulators significantly affected transpiration intensity at the heading stage.

scholarly journals An Old Drug for a New Application: Potential Benefits of Sildenafil in Wound Healing

2012 ◽  
Vol 15 (4) ◽  
pp. 483 ◽  
Author(s):  
Shadi Farsaie ◽  
Hossein Khalili ◽  
Iman Karimzadeh ◽  
Simin Dashti-Khavidaki
Keyword(s):  
Wound Healing ◽  
Animal Studies ◽  
Case Reports ◽  
Experimental Studies ◽  
Phosphodiesterase Inhibitor ◽  
Cochrane Central Register ◽  
Skin Damage ◽  
Beneficial Effects ◽  
Cochrane Database ◽  
The Impact

Purpose: Several studies have evaluated the effects of sildenafil on the tissue repair and wound healing. In the present review, the impact of sildenafil on the wound healing in all available clinical and non-clinical (experimental) studies has been discussed. Methods: A literature search was performed using PubMed, Scopus, Medline, Embase, Cochrane central register of controlled trials and Cochrane database systematic reviews. Related articles indexed in Google Scholar were also included. Key words used as search terms were ‘phosphodiesterase inhibitor’, ‘sildenafil’, ‘skin’, ‘cutaneous’, ‘skin lesion’, ‘skin damage’, ‘wound’, and ‘wound healing’. No time limitation was considered in this review. Results: A total of 15 animal studies, 7 case reports, and 2 small clinical studies have reported the effects of sildenafil on the wound healing. The effects included skin flaps and grafts, anastomosis, systemic sclerosis and Raynaud's disease. Conclusions: The available data support the beneficial effects of sildenafil in improvement of tissue healing in various conditions. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

scholarly journals The Impact of Consumption of Dairy Products on Phospholipid Metabolism: A Systematic Review

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 1261-1261
Author(s):  
Emad Yuzbashian ◽  
Catherine B Chan
Keyword(s):  
Dairy Products ◽  
Animal Studies ◽  
Meta Analysis ◽  
Phospholipid Metabolism ◽  
Human Studies ◽  
Resistance Risk ◽  
Human Trials ◽  
Beneficial Effects ◽  
Funding Sources ◽  
The Impact

Abstract Objectives Metabolomics approach indicates that circulating phospholipid (PL) and some PL species are associated with a lower insulin resistance risk. Evidence suggests that dairy products' health beneficial effects may pertain to their regulatory influence on PL metabolism. Therefore, we aimed to systematically review the existing literature of animal and human trials to unravel the impact of dairy products on the concentration of PL and its metabolism. Methods Three online databases, including PubMed, Scopus, and Web of Science, were searched to find relevant studies published in peer-reviewed journals between January 2000 and July 2020. Included studies were interventional trials (animal and human) that investigated the effect of dairy or its subtypes on the circulating or liver content of PL and its species. The risk of bias (RoB) in trials in humans and animals was assessed using the revised Cochrane's and SYRCLE's RoB assessment, respectively. Since there was marked methodological heterogeneity, a meta-analysis did not perform. Results In this review, 2427 articles were identified and screened after removing duplicate articles. Following evaluation of the titles and abstracts and then full-text assessment, 17 studies were identified that met the inclusion criteria. Studies were classified according to their type, resulting in nine human trials and eight animal studies. For human studies, the RoB assessment indicated that more than 55% of studies had high RoB. None animal studies receive low RoB because of the lack of methodological information. Findings from human studies revealed that plasma/serum concentration of PL did not change after intervention with dairy products. PL concentration remained stable even after a high dosage of milk supplemented with dairy-derived PL; however, certain PC or LPC species were increased by interventions. These findings were also confirmed in animal studies. The interesting point in animal studies was that high fat diet-induced elevation of PL tends to be normalized after intervention with dairy products enriched with milk-PL. Furthermore, in mice, intervention with yogurt or cheese did not impact serum or liver content of PL or PC. Conclusions Dairy products can influence the blood concentration of PC and LPC species in both rodents and humans without alteration of total PL and PC. Funding Sources Alberta Diabetes Institute.

scholarly journals Improvement of semen parameters after coil embolization of varicoceles: a systematic review

2021 ◽  
Vol 20 ◽  
Author(s):  
Sergio Quilici Belczak ◽  
Vanessa Stefaniak ◽  
Leonardo Garcia Góes ◽  
Felipe Coelho Neto ◽  
Walter Jr. Boim de Araújo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Studies ◽  
Cost Effective ◽  
Semen Parameters ◽  
Semen Parameter ◽  
Cost Effective Method ◽  
Prisma Statement ◽  
Meta Analyses ◽  
The Impact

Abstract This systematic review was conducted in accordance with the 2009 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, including clinical studies in which one of the outcomes was semen parameter improvement after varicocele embolization using coils only. The objective of the review was to assess the evidence on the role of embolization using coils alone for semen parameter improvement in men with varicocele, since embolization using coils is the most cost-effective method of varicocele repair. Study quality was assessed using the methodological index for non-randomized studies (MINORS). Out of six retrospective and two prospective observational or comparative clinical studies involving 701 patients, semen concentration improved significantly in all five studies that assessed this parameter. Mean semen motility improved significantly in seven studies. The impact of embolization on semen density could not be analyzed.

scholarly journals A Systematic Review on Adaptation Practices in Aquaculture towards Climate Change Impacts

2021 ◽  
Vol 13 (20) ◽  
pp. 11410
Author(s):  
Asnarulkhadi Abu Samah ◽  
Hayrol Azril Mohamed Shaffril ◽  
Mohd Fauzi Fadzil ◽  
Nobaya Ahmad ◽  
Khairuddin Idris
Keyword(s):  
Climate Change ◽  
Systematic Review ◽  
Climate Change Impacts ◽  
Searching Strategy ◽  
Prisma Statement ◽  
The Many ◽  
Meta Analyses ◽  
Adaptation Practices ◽  
The Impact ◽  
Selection Of

The impact of climate change is one of the many challenges faced by aquaculture communities nowadays. Only a limited number of articles have attempted to systematically review available literature in this field, which has led to the current study, aiming to develop a systematic review related to the practice of adapting to climate change among aquaculture communities. This systematic review was guided by the PRISMA Statement (Preferred Reporting Items for Systematic reviews and Meta-Analyses) in its systematic searching strategy on Scopus, Web of Science, and Google Scholar, resulting in the selection of 20 related studies. All selected articles were assessed using the Mixed Method Appraisal Tool (MMAT). Employing thematic analysis, five main themes resulted, namely Governmental (five subthemes), Community (three subthemes), Facilities (five subthemes), Temperature (two subthemes) and Financial (three subthemes), along with 18 subthemes. Based on the pattern of previous studies, the review presented several recommendations for scholars, agencies, and communities to consider in future.

scholarly journals The Impact of Low-FODMAPs, Gluten-Free, and Ketogenic Diets on Gut Microbiota Modulation in Pathological Conditions

Nutrients ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 373 ◽  
Author(s):  
Sofia Reddel ◽  
Lorenza Putignani ◽  
Federica Del Chierico
Keyword(s):  
Gut Microbiota ◽  
Dietary Intervention ◽  
Microbiota Composition ◽  
Gluten Free ◽  
Beneficial Effects ◽  
Balanced Diet ◽  
Ketogenic Diets ◽  
Pathological Conditions ◽  
Long Time ◽  
The Impact

The gut microbiota performs several essential protective, structural, and metabolic functions for host health. The maintenance of a beneficial microbiota requires a homeostatic equilibrium within microbial communities, and between the microorganisms and the host. The gut microbiota composition may be affected by external factors, among them diet habits may be considered most important. In some pathological conditions such as irritable bowel syndrome (IBS), celiac disease (CD), or neurological disorders (ND), specific dietary regimens as low-fermentable, oligo-, di-, mono-saccharides and polyols (FODMAPs), ketogenic (KD), and gluten-free (GFD) diets are considered therapeutic. These kinds of diets are characterized by a reduction or exclusion of a specific nutrient from the entire dietary pattern. Despite these alimentary regimens showing beneficial effects on disease symptoms, they can affect microbiota composition, especially if they are protracted for a long time. To date, only a few studies have reported the effects of these diets on gut microbiota. In this review, we discuss the effects of low-FODMAPs, KD, and GFD on gut microbiota modulation in pathological conditions, advancing the possibility of depicting a balanced diet and developing personalized dietary intervention protocols.

scholarly journals Gestational Diabetes Mellitus: The Impact of Carbohydrate Quality in Diet

Nutrients ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1549 ◽  
Author(s):  
Tiziana Filardi ◽  
Francesca Panimolle ◽  
Clara Crescioli ◽  
Andrea Lenzi ◽  
Susanna Morano
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Dietary Intervention ◽  
Clinical Care ◽  
Insulin Requirement ◽  
Glycaemic Index ◽  
Current Evidence ◽  
Beneficial Effects ◽  
The Impact

Gestational diabetes mellitus (GDM) is defined as “glucose intolerance that is first diagnosed during pregnancy”. Mothers with GDM and their infants may experience both short and long term complications. Dietary intervention is the first therapeutic strategy. If good glycaemic control is not achieved, insulin therapy is recommended. There is no consensus on which nutritional approach should be used in GDM. In the last few years, there has been growing evidence of the benefits of a low glycaemic index (LGI) diet on diabetes and cardiovascular disease. The effect of a LGI diet on GDM incidence has been investigated as well. Several studies observed a lower incidence of GDM in LGI diet arms, without adverse maternal and fetal outcomes. The main positive effect of the LGI diet was the reduction of 2-h post-prandial glucose (PPG). Several studies have also evaluated the effect of the LGI diet in GDM treatment. Overall, the LGI diet might have beneficial effects on certain outcomes, such as 2-h PPG, fasting plasma glucose and lipid profile in patients with GDM. Indeed, most studies observed a significant reduction in insulin requirement. Overall, according to current evidence, the LGI nutritional approach is safe and it might therefore be considered in clinical care for GDM.

scholarly journals Molecular Transducers of Physical Activity Consortium (MoTrPAC) Progress and Study Protocol Design

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1757-1757
Author(s):  
Lyndon Joseph ◽  
Williams John
Keyword(s):  
Physical Activity ◽  
Study Protocol ◽  
Animal Studies ◽  
Molecular Mechanisms ◽  
Protocol Design ◽  
Treadmill Running ◽  
Beneficial Effects ◽  
Public Data ◽  
Response To Exercise ◽  
The Impact

Abstract Objectives Physical activity is beneficial to human health and wellbeing across the lifespan. The numerous benefits of regular physical activity (PA) have long been recognized. Despite this, most exercise studies are associational and the molecular mechanisms that are the bases for the beneficial effects remain obscure as are the mechanisms of multiorgan communications and benefits. MoTrPAC is a large NIH discovery project (19 grants; 37 Principal Investigators; 23 institutions) whose goals are to assemble a comprehensive map of the molecular changes that occur in response to exercise and provide insights into how they are altered by age, sex, body composition and fitness level and develop a user-friendly database to facilitate investigator-initiated studies and catalyze the field of PA research and explore hypotheses exploring novel mechanisms by which PA improves or preserves health. Methods This project will explore and document changes in molecules mobilized in blood, muscle and fat in humans as well as 15 additional tissues for rats in response to different aerobic and resistance exercise regimes. The human studies are a multicenter clinical trial cohort of people of both sexes from 10–80 years of age and recruitment has begun. Preclinical animal Studies (PASS) have been conducted in 6 and 18-month old F344 rats and tissues harvested from control inactive rats and rats at seven time-points following a single 30 minute acute bout of treadmill running. A separate group of rats were subjected to an intensive (70% VO2max) and progressive run training program of 5 day/week for 1,2, 4, or 8 weeks with 18 tissues collected. Multiple state of art and omics platforms including genomic, transcriptomic, epigenomic, proteomic and metabolomics are being employed to define and discover the molecules mobilized in response to exercise. Results This presentation will highlight the study protocol design and data from the initial public data release (November 15th, 2019). Data will be available to the extramural community to collaborate with the MoTrPAC investigators to explore innovative mechanisms to expand the impact of the initial studies. Conclusions The product from this consortium will begin to characterize the molecular mechanisms of molecules identified in the ‘molecular map’ that underlie the beneficial effects of PA. Funding Sources National Institutes of Health.

Bowel ischaemia after endovascular aneurysm repair

VASA ◽  
2018 ◽  
Vol 47 (4) ◽  
pp. 273-277
Author(s):  
Christopher Lowe ◽  
Oussama El Bakbachi ◽  
Damian Kelleher ◽  
Imran Asghar ◽  
Francesco Torella ◽  
...  
Keyword(s):  
Case Reports ◽  
Endovascular Aneurysm Repair ◽  
Artery Occlusion ◽  
Bibliographic Databases ◽  
Bowel Ischaemia ◽  
Prophylactic Measures ◽  
Increased Risk ◽  
Prisma Statement ◽  
Meta Analyses ◽  
Aneurysm Repair

Abstract. The aim of this review was to investigate presentation, aetiology, management, and outcomes of bowel ischaemia following EVAR. We present a case report and searched electronic bibliographic databases to identify published reports of bowel ischaemia following elective infra-renal EVAR not involving hypogastric artery coverage or iliac branch devices. We conducted our review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement standards. In total, five cohort studies and three case reports were included. These studies detailed some 6,184 infra-renal elective EVARs, without procedure-related occlusion of the hypogastric arteries, performed between 1996 and 2014. Bowel ischaemia in this setting is uncommon with an incidence ranging from 0.5 to 2.8 % and includes a spectrum of severity from mucosal to transmural ischaemia. Due to varying reporting standards, an overall proportion of patients requiring bowel resection could not be ascertained. In the larger series, mortality ranged from 35 to 80 %. Atheroembolization, hypotension, and inferior mesenteric artery occlusion were reported as potential causative factors. Elderly patients and those undergoing prolonged procedures appear at higher risk. Bowel ischaemia is a rare but potentially devastating complication following elective infra-renal EVAR and can occur in the setting of patent mesenteric vessels and hypogastric arteries. Mortality ranges from 35 to 80 %. Further research is required to identify risk factors and establish prophylactic measures in patients that have an increased risk of developing bowel ischaemia after standard infra-renal EVAR.

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