scholarly journals Caffeine Sources and Consumption among Saudi Adults Living with Diabetes and Its Potential Effect on HbA1c

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1960
Author(s):  
Salwa Ali Albar ◽  
Merfat Abdulrahman Almaghrabi ◽  
Rawabi Ahmed Bukhari ◽  
Rawan Hussein Alghanmi ◽  
Maha Ali Althaiban ◽  
...  
Keyword(s):  
Health Outcomes ◽  
Type Ii Diabetes ◽  
Statistical Significance ◽  
Caffeine Intake ◽  
P Value ◽  
Age Difference ◽  
Inverse Association ◽  
Type Ii ◽  
Cross Sectional Survey ◽  
Caffeine Consumption

Information regarding the spread and effect of coffee and caffeine intake by individuals with type II diabetes remains unclear. This study aims to identify the amount and sources of habitual caffeine intake by individuals with type II diabetes and to investigate its association with other health outcomes, especially HbA1c. This is a cross-sectional survey involving 100 people medically defined as having type II diabetes comprising both genders, recruited from a care centre. All participants completed a caffeine semi-quantitative food frequency questionnaire (C-FFQ) to estimate their caffeine consumption, a two day 24-h recall, and a detailed questionnaire. The average caffeine intake was calculated from all sources and the differences in mean by gender were tested using a regression model (adjusted to important confounders). Regression models were used to verify the association between average caffeine intake on HbA1c and other health outcomes with adjustment for important confounders. A p value < 0.05 represented statistical significance. Arabic coffee (gahwa) and tea were the most common sources of caffeine among Saudi adults living with diabetes. Average caffeine intake for the whole sample was 194 ± 165 mg/day, which is 2.3 ± 2 mg/kg. There was an inverse association between caffeine intake and age: difference in mean −3.26 mg/year (95%CI: −5.34, −1.18; p = 0.003). Males had significantly higher consumption of caffeine compared to females: difference in mean 90.7 mg/day (95%CI: 13.8, 167.6; p = 0.021). No association was found between average caffeine intake and HbA1C or any other cardiovascular risk factors. This information can help public health practitioners and policy makers when assessing the risk of caffeine consumption among this vulnerable group.

EFEKTIVITAS PERAWATAN ULKUS DIABETIKUM TERHADAP PENERIMAAN DIRI PASIEN DIABETES MELITUS TIPE II DI ASRI WOUND CARE CENTRE MEDAN

2019 ◽  
Vol 4 (2) ◽  
pp. 178
Author(s):  
Elis Anggeria ◽  
Patimah Sari Siregar
Keyword(s):  
Diabetes Mellitus ◽  
Type Ii Diabetes ◽  
Wound Care ◽  
Type Ii Diabetes Mellitus ◽  
P Value ◽  
Type Ii ◽  
Diabetic Ulcer ◽  
Diabetic Ulcers ◽  
Self Acceptance ◽  
Ulcer Treatment

<p><em>Diabetes mellitus (DM) is a group of metabolic diseases characterized by high levels of glucose in the blood (hyperglycemia) that occurs due to impaired insulin secretion, decreased insulin action, or a result of both. Self-acceptance is the ability and desire of individuals to live with all the characteristics themselves against diabetes mellitus. This study aims to determine the effectiveness of diabetic ulcer treatment on self-acceptance of Type II Diabetes Mellitus patients at Asri Wound Care Center Medan. This study uses quantitative research methods with a quasi-experimental design through the one-group pretest-posttest design approach. The population in the study as many as 20 people, with sampling techniques using saturated sampling, the research sample amounted to 20 people. This study uses a nonparametric statistical test that is paired t-test. The results of research on self-acceptance of patients with type II diabetes mellitus before treatment of diabetic ulcers showed that the majority of self-acceptance was not good, and the self-acceptance of patients after treatment of diabetic ulcers obtained the majority of good self-acceptance. The effectiveness of diabetic ulcer treatment on self-acceptance of type II diabetes mellitus patients obtained significance value p-value = 0.00 (p-value &lt;0.05) then H0 was rejected. This means that there are differences in self-acceptance of type II Diabetes mellitus patients before and after diabetic ulcer treatment at Asri Wound Care Center Medan. Future researchers are expected to discuss more deeply about the factors that affect the self-acceptance of diabetes mellitus patients who are undergoing treatment for diabetic ulcers.</em></p>

Abstract 392: The Plasma Proteome of Tangier Disease Patients Reveals Perturbations of Diabetic and Inflammatory Pathways

2016 ◽  
Vol 36 (suppl_1) ◽  
Author(s):  
James T McParland ◽  
Evanthia Pashos ◽  
Daniel J Rader ◽  
Marina Cuchel
Keyword(s):  
Inflammatory Response ◽  
Type Ii Diabetes ◽  
Enrichment Analysis ◽  
Nonparametric Test ◽  
Type Ii Diabetes Mellitus ◽  
Gene Set Enrichment Analysis ◽  
P Value ◽  
Type Ii ◽  
Tangier Disease ◽  
Inflammatory Pathways

Aim: The ATP-binding cassette transporter 1 (ABCA1) is a membrane protein well known for its role in cholesterol efflux and HDL formation. Recently, ABCA1 has been implicated as playing a key role in other processes, such as insulin secretion and inflammatory response. We sought to further investigate these potential roles through a quantitative proteomics approach. Specifically, we hypothesized that we could detect differential protein signatures in the plasma of Tangier patients that correspond to pathways involved in diabetes and inflammation. Methods: We used SOMAscan® technology (SomaLogic, Boulder, CO, USA) to analyze plasma collected from 5 Tangier disease patients (homozygotes or compound heterozygotes for functional ABCA1 mutations) and 7 normolipidemic controls. We tested for differences in the levels of approximately 1,000 plasma proteins using a nonparametric test (KS). We then performed Ingenuity Canonical Pathway analysis to examine if proteins linked to diabetes and inflammation pathways were significantly more likely to be differentially abundant in the plasma. We corroborated the results using Gene Set Enrichment Analysis (GSEA). Results: We found an enrichment in differentially abundant proteins involved in type II diabetes mellitus signaling (p-value=0.0002) and inflammatory pathways, such as granulocyte adhesion and diapedesis (p-value=2.2*10 -12 ). These results were also corroborated by GSEA, where gene sets corresponding to GO biological processes such as immune response (p-value=0.008) and inflammatory response (p-value=0.032) ranked at the top of the enrichment results. Conclusions: The results from this pilot study support the concept that ABCA1 is implicated in pathways affecting immune and inflammatory response and type II diabetes.

When Studies are in Error: Basic Statistical Vocabulary Needed to Understand Clinical Studies

1996 ◽  
Vol 1 (1) ◽  
pp. 25-28 ◽  
Author(s):  
Martin A. Weinstock
Keyword(s):  
Null Hypothesis ◽  
Statistical Power ◽  
Critical Appraisal ◽  
Type I Error ◽  
Statistical Significance ◽  
P Value ◽  
Type I ◽  
Type Ii ◽  
Type Ii Error ◽  
Error Type

Background: Accurate understanding of certain basic statistical terms and principles is key to critical appraisal of published literature. Objective: This review describes type I error, type II error, null hypothesis, p value, statistical significance, a, two-tailed and one-tailed tests, effect size, alternate hypothesis, statistical power, β, publication bias, confidence interval, standard error, and standard deviation, while including examples from reports of dermatologic studies. Conclusion: The application of the results of published studies to individual patients should be informed by an understanding of certain basic statistical concepts.

Influence of Caffeine and Caffeine Withdrawal on Headache and Cerebral Blood Flow Velocities

Cephalalgia ◽  
1997 ◽  
Vol 17 (3) ◽  
pp. 188-190 ◽  
Author(s):  
EGM Couturier ◽  
DM Laman ◽  
MAJ van Duijn ◽  
H van Duijn
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Statistical Significance ◽  
Transcranial Doppler Sonography ◽  
Caffeine Intake ◽  
Caffeine Consumption ◽  
Caffeine Withdrawal ◽  
Basilar Arteries ◽  
Blood Flow Velocities ◽  
Flow Velocities

Caffeine consumption may cause headache, particularly migraine. Its withdrawal also produces headaches and may be related to weekend migraine attacks. Transcranial Doppler sonography (TCD) has shown changes in cerebral blood flow velocities, (BFV) during and between attacks of migraine. In order to examine whether headache and changes in BFV could develop from controlled caffeine alterations, 20 healthy volunteers, without a headache history, underwent clinical evaluation, TCD and serum caffeine measurements on four occasions, comparing conditions of regular caffeine intake, caffeine withdrawal and “re-caffeination”. After 24 h of complete caffeine abstinence, 10 suffered from moderate to severe headaches with complete recovery within 1 h after caffeine intake. The BFVs in both middle cerebral, both posterior cerebral and basilar arteries were higher following the withdrawal period, reaching statistical significance in the left middle cerebral, basilar and both posterior cerebral arteries. BFVs decreased significantly within half an hour after caffeine intake in all subjects, and were similar to baseline values after 2 h. Our results emphasize the relationship between caffeine withdrawal, the development of headache and alterations in cerebral blood flow velocities. Also, these findings indicate that accurate interpretation of TCD measurements should account for the influence of caffeine on BFVs.

scholarly journals HUBUNGAN ANTARA DIABETES MELLITUS TIPE II DENGAN DERAJAT OSTEOARTHRITIS LUTUT

2021 ◽  
Vol 5 (1) ◽  
pp. 39
Author(s):  
Maruf Hari Subroto ◽  
Basuki Supartono ◽  
Ryan Herardi
Keyword(s):  
Diabetes Mellitus ◽  
Knee Osteoarthritis ◽  
Diabetic Patient ◽  
Type Ii Diabetes ◽  
Cartilage Damage ◽  
Type Ii Diabetes Mellitus ◽  
P Value ◽  
Type Ii ◽  
Keywords Knee ◽  
Diabetes Mellitus Group

Osteoarthritis is a degenerative disease that cause damage to joint cartilage damage. Osteoarthritis affects 151,4 million people in the world, including 27,4 million in Southeast Asia. Osteoarthritis is a disease that is a burden on public health and the country. The prevalence of osteoarthritis is one in four people aged 50 years and individuals aged 65 years are more at risk of developing calcification of the knee joint. Risk factors such as type II Diabetes Mellitus are observed in one of osteoarthritis research. A hispanic study explained the prevalence of osteoarthritis patient are twice as much in diabetic patient than non-diabetic patient. A score of 6.5% of HbA1c test is required to diagnose diabetes. The goal of this study is to find out the connection of type 2 diabetes mellitus and knee osteoarthritis. This research uses observational analytic with cross sectional research design with a total of 45 patient from Orthopedic clinic of Al – Fauzan General Hospital in 2016 – 2019 and analyzed with chi square test. According to the result, the most group of age is elderly about 34 people (75,6%), the most group of gender is women about 34 people (75,6%), the most group of HbA1c is non-diabetes mellitus group about 30 people (66,7%), the most group of osteoarthritis stage is severe de (4) about 28 people (62,2%), and there is no connection between type II diabetes mellitus with the stage of knee osteoarthritis with p value of 0,828 (p > 0.05). this research shows no significant correlation between type II diabetes mellitus and the stage of knee osteoarthritis. Keywords : Knee Osteoarthritis; HbA1c; Type II Diabetes Mellitus AbstrakOsteoarthritis adalah penyakit degeneratif yang disebabkan kerusakan tulang rawan sendi. Osteoarthritis dialami 151,4 juta orang di dunia dan 27,4 juta orang di Asia Tenggara. Osteoarthritis merupakan penyakit yang menjadi beban kesehatan masyarakat dan negara. Prevalensi terjadinya osteoarthritis yaitu satu dari empat orang berusia 50 tahun dan individu berusia lebih dari 65 tahun beresiko mengalami pengapuran sendi lutut. Penelitian osteoarthritis mengamati faktor risiko terjadinya osteoarthritis seperti diabetes mellitus tipe 2. Studi Hispanik menjelaskan prevalensi penderita osteoarthritis dua kali lebih banyak terjadi pada penderita dengan diabetes dibandingkan penderita tanpa diabetes. Pemeriksaan HbA1c direkomendasikan untuk mendiagnosis diabetes, dengan batas nilai 6,5 %. Tujuan penelitian ini adalah untuk mengetahui hubungan antara diabetes mellitus tipe II dengan derajat osteoarthritis lutut. Penelitian ini menggunakan analitik observasional dengan desain penelitian potong lintang dengan jumlah sampel 45 pasien di Poli Orthopedi Rumah Sakit Umum Al – Fauzan tahun 2016 – 2019 dan dianalisa menggunakan uji kai kuadrat. Berdasarkan hasil penelitian, usia terbanyak adalah lansia yaitu 34 orang (75,6 %), jenis kelamin terbanyak adalah perempuan yaitu 34 orang (75,6 %), HbA1c terbanyak adalah non diabetes mellitus yaitu 30 orang (66,7 %), derajat osteoarthritis lutut terbanyak adalah derajat berat (4) yaitu 28 orang (62,2 %), dan tidak terdapat hubungan yang bermakna antara diabetes mellitus tipe II dengan derajat osteoarthritis lutut dengan nilai p sebesar 0,828 (p > 0,05). Penelitian ini menunjukan tidak terdapat hubungan yang bermakna antara diabetes mellitus tipe II dengan derajat osteoarthritis lutut

scholarly journals Diastolic dysfunction in cases with Type II diabetes mellitus.

2019 ◽  
Vol 26 (12) ◽  
pp. 2040-2043
Author(s):  
Munir Ahmed ◽  
Abdul Hayee ◽  
Shahla Afsheen Memon ◽  
Ismail Salim Memon ◽  
Abdul Qayoom Memon
Keyword(s):  
Diabetes Mellitus ◽  
Diastolic Dysfunction ◽  
Type Ii Diabetes ◽  
Female Gender ◽  
Type Ii Diabetes Mellitus ◽  
P Value ◽  
Type I ◽  
Type Ii ◽  
Cross Sectional ◽  
Significant Difference

Objectives: To determine the frequency of diastolic dysfunction in patients presenting with type II Diabetes Mellitus. Study Design: Cross sectional study. Setting: Sheikh Zayed Hospital, Rahim Yar Khan. Period: From 01-01-2017 to 30-06-2017. Material & Methods: In this study the cases were selected via non probability consecutive sampling of both male and female gender with age more than 40 years having type II DM of at least more than 2 years were included. The cases suffering from type I DM, gestational DM and those with HTN, end stage kidney and liver failure were excluded. Trans thoracic echocardiography was done to label diastolic dysfunction and was labelled as yes when the E/A ratio was <0.8. The data was analysed using chi square test and p value less than 0.05 was taken as significant. Results: In this study, 100 cases of type II DM were included with mean age of 51.31±7.89 years at presentation. There were 61% males and 39% females. Diastolic dysfunction was observed in 53% of the cases. There was no significant difference in terms of gender where it affected 56.41% of females with p= 0.92. Diastolic dysfunction was more in cases that had duration of DM more than 3 years affecting 48 (70.58%) cases with p= 0.001 and it was also significantly high in cases that had BMI more than 30 where it was seen in 40 (70.17%) of cases with p= 0.001. Conclusion: Diastolic dysfunction seen in half of the cases suffering from type II DM and it is significantly high in cases that had duration of DM more than 3 years and BMI more than 30.

scholarly journals Serum chromium, glycosylated hemoglobin level and body mass index among control and uncontrol sudanese patients with type II diabetes mellitus: Correlation study

2021 ◽  
Vol 16 (2) ◽  
pp. 196-203
Author(s):  
Nassr Eldin M. A. shrif ◽  
Ahmed Mohamed Ahmed Dawood ◽  
Abdelmahmoud Mokhtar Bashir ◽  
Hassan Mohammed Khair Ibrahim ◽  
Abd Elgadir A Altoum
Keyword(s):  
Diabetes Mellitus ◽  
Type Ii Diabetes ◽  
Glycosylated Hemoglobin ◽  
Type Ii Diabetes Mellitus ◽  
P Value ◽  
Diabetic Patients ◽  
Type Ii ◽  
Chromium Level ◽  
Serum Chromium ◽  
R Value

Background: Chromium is an essential micronutrient which is required for the normal functioning of insulin and regulation of blood sugar levels. It acts as a vital antioxidant for maintaining insulin homeostasis. In diabetes mellitus, the free radical production is increased and levels of antioxidants like chromium, vanadium, selenium and manganese are reduced. Aim: To study the level of serum chromium level in patients with type 2 diabetes mellitus and its association with glycemic control. Materials and Methods: One hundred and twenty individuals were enrolled in this study, classified into 60 type II diabetes mellitus (type II DM) patients and 60 apparently health as control group. Serum chromium and Glycosylated Hemoglobin (HbA1c) level were measured using atomic absorption spectrometry and Ichroma. Results: The results showed significant decrease in serum chromium level in type II DM patients (0.0151±0.005) when compared with healthy group (0.122±0.691) with p-value (0.002). In addition to that there was significant decrease in mean concentration of serum chromium level in controlled diabetic patients (0.0206± 0.003) when compared with uncontrolled diabetic patients (0.0120±0.002) with P-value (0.04).Also there was significant positive correlation between chromium level and Body Mass Index (BMI) (R-value 0.450, P-value 0.014), and significant negative correlation between chromium level and age (R-value- 0.660, P-value 0.011) , a significant strong negative correlation between chromium level and HbA1c (R-value -0.843, P-value 0.0260). Conclusion: The study concluded that, serum chromium level is significantly decrease in type II DM.

scholarly journals Relationship Between Family Support and Self Care Agency with the Quality of Living Type II Diabetes Patients

2019 ◽  
Vol 3 (1) ◽  
pp. 22-32
Author(s):  
Ferawati ◽  
Mei Fitria Kurniati
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Family Support ◽  
Type Ii Diabetes ◽  
Self Care ◽  
P Value ◽  
Diabetic Patients ◽  
Type Ii ◽  
Care Agency

Background: Diabetes Mellitus is a chronic disease characterized by high blood sugar level and is caused by an increase in glucose levels due to a progressive decrease in insulin secretion caused by insulin resistance. The ability of diabetic patients to do appropriate and succesful self-care habits is closely related to morbidity and mortality and significantly affect productivity and quality of life. Purpose: The purpose of this study is to determie the correlation between family support and self care agency with quality of life of diabetes mellitus patient type II.Method: This study uses analitycal methods, namely research that explores how and why health phenomena occur with a cross-sectional approach.Result: The results of the Spearman-Rho test that the P-value in te sig (2-tailed) column 0.123 is more than the level of significance α 0,05 ( 0,000 < 0,05 ) so it can be concluded that H0 is accepted and H1 is rejected.Conclusion: There is no relationship between self care agency and the quality of life of people with type II diabetes mellitus in prolanic patients

scholarly journals Towards Sustainable Development: Exploring the Knowledge of Environmental Impact Assessment among Undergraduates in a Nigerian University

2020 ◽  
pp. 1-10
Author(s):  
Queencallista N Sidney- Nnebue ◽  
Anita O. Garba ◽  
Gbenga E. Fadiora ◽  
Felicia C. Etim ◽  
Amanda N. Ezenagu ◽  
...  
Keyword(s):  
Environmental Impact ◽  
Marital Status ◽  
Impact Assessment ◽  
Environmental Impact Assessment ◽  
Statistical Significance ◽  
P Value ◽  
Sources Of Information ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Level Of Knowledge

Background: Efficient project management suffices that decision makers are adequately informed on the impacts of their actions and inactions on the environment. Objective: To explore the knowledge of environmental impact assessment (EIA) among undergraduates of the faculty of environmental sciences in a university in Nigeria.                                                Materials and Methods: This was a cross sectional survey of 350 undergraduates selected via multistage sampling technique. Data were obtained using self- administered semi-structured questionnaires, and analysed using statistical package for social sciences software version 22. Statistical significance were done using Chi-square test at p value < 0.05. Results: Two hundred and eighteen (62.3%) respondents reported awareness of EIA and cited their sources of information on EIA as 111(50.6%) schools, 109 (50%) textbooks, etc. Only (12.6%) out of 350 respondents had good level of knowledge on EIA. Fifty one (14.6%) out of 350 respondents reported ever participated in EIA process, while 34 (9.7%) were participating in EIA process currently. The level of knowledge of EIA process among respondents significantly vary with [gender, p=0.002) and marital status, p= 0.032)] respectively. Conclusions: This study found apparently poor awareness of EIA, poor knowledge of EIA and poor participation in the EIA process. The level of knowledge on EIA vary significantly with gender and marital status. We recommend comprehensive but targeted, need- based environmental education to help create awareness, impart knowledge and equip these students with EIA strategies and skills to handle environmental challenges.

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