scholarly journals Dietary Methyl-Group Donor Intake and Breast Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1843
Author(s):  
Heleen Van Puyvelde ◽  
Nikos Papadimitriou ◽  
Joanna Clasen ◽  
David Muller ◽  
Carine Biessy ◽  
...  
Keyword(s):  
Alcohol Intake ◽  
Menopausal Status ◽  
Hormone Receptor Status ◽  
Folate Intake ◽  
Dietary Intakes ◽  
Dietary Folate ◽  
Methyl Group ◽  
Dietary Folate Intake ◽  
One Carbon Metabolism ◽  
Prospective Investigation

(1) Background: Methyl-group donors (MGDs), including folate, choline, betaine, and methionine, may influence breast cancer (BC) risk through their role in one-carbon metabolism; (2) Methods: We studied the relationship between dietary intakes of MGDs and BC risk, adopting data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort; (3) Results: 318,686 pre- and postmenopausal women were followed between enrolment in 1992–2000 and December 2013–December 2015. Dietary MGD intakes were estimated at baseline through food-frequency questionnaires. Multivariable Cox proportional hazards regression models were used to quantify the association between dietary intake of MGDs, measured both as a calculated score based on their sum and individually, and BC risk. Subgroup analyses were performed by hormone receptor status, menopausal status, and level of alcohol intake. During a mean follow-up time of 14.1 years, 13,320 women with malignant BC were identified. No associations were found between dietary intakes of the MGD score or individual MGDs and BC risk. However, a potential U-shaped relationship was observed between dietary folate intake and overall BC risk, suggesting an inverse association for intakes up to 350 µg/day compared to a reference intake of 205 µg/day. No statistically significant differences in the associations were observed by hormone receptor status, menopausal status, or level of alcohol intake; (4) Conclusions: There was no strong evidence for an association between MGDs involved in one-carbon metabolism and BC risk. However, a potential U-shaped trend was suggested for dietary folate intake and BC risk. Further research is needed to clarify this association.

scholarly journals Comparison of standardised dietary folate intake across ten countries participating in the European Prospective Investigation into Cancer and Nutrition

2011 ◽  
Vol 108 (3) ◽  
pp. 552-569 ◽  
Author(s):  
Jin Young Park ◽  
Genevieve Nicolas ◽  
Heinz Freisling ◽  
Carine Biessy ◽  
Augustin Scalbert ◽  
...  
Keyword(s):  
Educational Level ◽  
Food Sources ◽  
Folate Intake ◽  
International Agency ◽  
Cross Sectional ◽  
Dietary Folate ◽  
Supplement Use ◽  
Methylation Of Dna ◽  
Dietary Folate Intake ◽  
Prospective Investigation

Folate plays an important role in the synthesis and methylation of DNA as a cofactor in one-carbon metabolism. Inadequate folate intake has been linked to adverse health events. However, comparable information on dietary folate intake across European countries has never been reported. The objective of the present study was to describe the dietary folate intake and its food sources in ten countries in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. A cross-sectional analysis was conducted in 36 034 participants (aged 35–74 years) who completed a single 24 h dietary recall using a computerised interview software program, EPIC-Soft® (International Agency for Research on Cancer, Lyon). Dietary folate intake was estimated using the standardised EPIC Nutrient DataBase, adjusted for age, energy intake, weight and height and weighted by season and day of recall. Adjusted mean dietary folate intake in most centres ranged from 250 to 350 μg/d in men and 200 to 300 μg/d in women. Folate intake tended to be lower among current smokers and heavier alcohol drinkers and to increase with educational level, especially in women. Supplement users (any types) were likely to report higher dietary folate intake in most centres. Vegetables, cereals and fruits, nuts and seeds were the main contributors to folate intake. Nonetheless, the type and pattern of consumption of these main food items varied across the centres. These first comparisons of standardised dietary folate intakes across different European populations show moderate regional differences (except the UK health conscious group), and variation by sex, educational level, smoking and alcohol-drinking status, and supplement use.

Dietary Folate Intake and Breast Cancer Risk: European Prospective Investigation Into Cancer and Nutrition

2014 ◽  
Vol 107 (1) ◽  
pp. dju367-dju367 ◽  
Author(s):  
J. de Batlle ◽  
P. Ferrari ◽  
V. Chajes ◽  
J. Y. Park ◽  
N. Slimani ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Folate Intake ◽  
Dietary Folate ◽  
Dietary Folate Intake ◽  
Prospective Investigation

scholarly journals Preconception Dietary Folate Intake and Risk of Spontaneous Abortion

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 771-771
Author(s):  
Anne Sofie Laursen ◽  
Elizabeth E Hatch ◽  
Lauren A Wise ◽  
Kenneth J Rothman ◽  
Henrik T Sørensen ◽  
...  
Keyword(s):  
Folic Acid ◽  
Alcohol Intake ◽  
Fetal Loss ◽  
Study Entry ◽  
Folate Intake ◽  
Folic Acid Supplement ◽  
Dietary Folate ◽  
Supplement Use ◽  
Acid Supplement ◽  
Dietary Folate Intake

Abstract Objectives Previous studies suggest a beneficial effect of supplemental folic acid use and dietary folate intake on fertility, while results for fetal loss are conflicting. Most previous research on fetal loss focused on folic acid supplement use. We therefore, investigated the association between dietary folate intake and spontaneous abortion (SAB) in a Danish preconception cohort of couples trying to conceive. Methods We recruited couples who were trying to conceive and did not receive fertility treatment. Pregnancies were ascertained through bimonthly follow-up questionnaires completed up to 12 months after study entry. SABs were identified by self-report on the follow-up questionnaires and through the Danish National Patient Registry. Dietary folate intake at study entry was estimated using a validated food frequency questionnaire (FFQ). Folate intake was adjusted for total energy intake using the residual method and categorized as < 250,250–399 and > = 400µg/day. We used Cox proportional hazards regression models with gestational weeks as time scale to compute hazard ratios (HRs) and 95% confidence intervals (CIs) for SAB, adjusting for age, partner's age, educational attainment, smoking status, anthropometry, physical activity, alcohol intake, folic acid supplement use, time-to-pregnancy, gravidity and parity. In sensitivity analyses, we stratified by folic acid supplement use, body mass index (BMI) and alcohol intake. Results Of the 2,957 women who became pregnant within 12 months of study entry and completed the FFQ, we identified 432 SABs. HRs for an SAB among women who consumed 250–399 and >= 400 µg/day of dietary folate compared with <250 µg/day were 0.83 (95% CI: 0.53; 1.29) and 0.87 (95% CI: 0.54; 1.39), respectively. Comparing intake > = 400 with <250 µg/day, the association was stronger when the analysis was restricted to folic acid supplement users, 0.74 (95% CI: 0.39; 1.40), to women with a BMI >= 25, 0.67 (95% CI: 0.31; 1.43), and to a reported alcohol intake >4 drinks/week, 0.66 (95% CI: 0.16; 2.66). Conclusions Our study may suggest that high dietary folate intake among folic acid supplement users is associated with a lower risk of SAB, although our estimates are imprecise. Funding Sources National Institute of Child Health and Human Development.

scholarly journals Dietary folate intake and pancreatic cancer risk: Results from the European prospective investigation into cancer and nutrition

2018 ◽  
Vol 144 (7) ◽  
pp. 1511-1521 ◽  
Author(s):  
Jin Young Park ◽  
H. Bas Bueno‐de‐Mesquita ◽  
Pietro Ferrari ◽  
Elisabete Weiderpass ◽  
Jordi Batlle ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Risk ◽  
Folate Intake ◽  
Dietary Folate ◽  
Pancreatic Cancer Risk ◽  
Dietary Folate Intake ◽  
Prospective Investigation

Folic acid supplementation, dietary folate intake and risk of small for gestational age in China

2019 ◽  
Vol 23 (11) ◽  
pp. 1965-1973
Author(s):  
Huaqi Guo ◽  
Baohong Mao ◽  
Meng Wang ◽  
Qing Liu ◽  
Liping Yang ◽  
...  
Keyword(s):  
Folic Acid ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Folic Acid Supplementation ◽  
Folate Intake ◽  
Care Hospital ◽  
Dietary Folate ◽  
Acid Supplementation ◽  
Dietary Folate Intake ◽  
Reduced Risk

AbstractObjective:To investigate the hypothesis that folic acid supplementation and dietary folate intake before conception and during pregnancy reduce the risk of small for gestational age (SGA) and to examine the joint effect of folic acid supplementation and dietary folate intake on the risk of SGA.Design:Participants were interviewed by trained study interviewers using a standardized and structured questionnaire. Information on birth outcomes and maternal complications was abstracted from medical records and dietary information was collected via a semi-quantitative FFQ before conception and during pregnancy.Setting:A birth cohort data analysis using the 2010–2012 Gansu Provincial Maternity and Child Care Hospital.Participants:Women (n 8758) and their children enrolled in the study.Results:Folic acid supplementation was associated with a reduced risk of SGA (OR = 0·72, 95 % CI 0·60, 0·86), with the reduced risk seen mainly for SGA at ≥37 weeks of gestational age (OR = 0·70, 95 % CI 0·58, 0·85) and nulliparous SGA (OR = 0·67, 95 % CI 0·54, 0·84). There was no significant association between dietary folate intake and SGA risk.Conclusions:Our study suggested that folic acid supplementation was associated with a reduced risk of SGA and the risk varied by preterm status and parity.

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