scholarly journals Optimizing Inpatient Nutrition Care of Adult Patients with Inflammatory Bowel Disease in the 21st Century

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1581
Author(s):  
Elaine Chiu ◽  
Chris Oleynick ◽  
Maitreyi Raman ◽  
Barbara Bielawska
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Assessment Tools ◽  
Nutrition Intervention ◽  
Early Screening ◽  
Hospital Malnutrition ◽  
Nutrition Care ◽  
Inflammatory Bowel ◽  
Active Inflammation ◽  
Complications And Mortality

Malnutrition is highly prevalent in inflammatory bowel disease (IBD) patients and disproportionately affects those admitted to hospital. Malnutrition is a risk factor for many complications in IBD, including prolonged hospitalization, infection, greater need for surgery, development of venous thromboembolism, post-operative complications, and mortality. Early screening for malnutrition and prompt nutrition intervention if indicated has been shown to prevent or mitigate many of these outlined risk factors. There are many causes of malnutrition in IBD including reduced oral food intake, medications, active inflammation, and prior surgical resections. Hospitalization can further compound pre-existing malnutrition through inappropriate diet restrictions, nil per os (NPO) for endoscopy and imaging, or partial bowel obstruction, resulting in “post-hospital syndrome” after discharge and readmission. The aim of this article is to inform clinicians of the prevalence and consequences of malnutrition in IBD, as well as available screening and assessment tools for diagnosis, and to offer an organized approach to the nutritional care of hospitalized adult IBD patients.

scholarly journals Caspase recruitment domain (CARD) family (CARD9, CARD10, CARD11, CARD14 and CARD15) are increased during active inflammation in patients with inflammatory bowel disease

2018 ◽  
Vol 15 (1) ◽  
Author(s):  
Jesús K. Yamamoto-Furusho ◽  
Gabriela Fonseca-Camarillo ◽  
Janette Furuzawa-Carballeda ◽  
Andrea Sarmiento-Aguilar ◽  
Rafael Barreto-Zuñiga ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Caspase Recruitment Domain ◽  
Inflammatory Bowel ◽  
Active Inflammation

scholarly journals Nutritional Assessment in Inflammatory Bowel Disease (IBD)—Development of the Groningen IBD Nutritional Questionnaires (GINQ)

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2739 ◽  
Author(s):  
Vera Peters ◽  
Behrooz Z Alizadeh ◽  
Jeanne HM de Vries ◽  
Gerard Dijkstra ◽  
Marjo JE Campmans-Kuijpers
Keyword(s):  
Inflammatory Bowel Disease ◽  
Dietary Intake ◽  
Bowel Disease ◽  
Dietary Habits ◽  
Nutritional Assessment ◽  
Dietary Assessment ◽  
Dietary Guidelines ◽  
Assessment Tools ◽  
Dietary Assessment Methods ◽  
Inflammatory Bowel

Diet plays a key role in the complex etiology and treatment of inflammatory bowel disease (IBD). Most existing nutritional assessment tools neglect intake of important foods consumed or omitted specifically by IBD patients or incorporate non-Western dietary habits, making the development of appropriate dietary guidelines for (Western) IBD patients difficult. Hence, we developed a food frequency questionnaire (FFQ), the Groningen IBD Nutritional Questionnaires (GINQ-FFQ); suitable to assess dietary intake in IBD patients. To develop the GINQ-FFQ, multiple steps were taken, including: identification of IBD specific foods, a literature search, and evaluation of current dietary assessment methods. Expert views were collected and in collaboration with Wageningen University, division of Human Nutrition and Health, this semi-quantitative FFQ was developed using standard methods to obtain a valid questionnaire. Next, the GINQ-FFQ was digitized into a secure web-based environment which also embeds additional nutritional and IBD related questions. The GINQ-FFQ is an online self-administered FFQ evaluating dietary intake, taking the previous month as a reference period. It consists of 121 questions on 218 food items. This paper describes the design process of the GINQ-FFQ which assesses dietary intake especially (but not exclusively) in IBD patients. Validation of the GINQ-FFQ is needed and planned in the near future.

scholarly journals P794 Nutritional assessment in inflammatory bowel disease (IBD): development of the Groningen IBD Nutritional Questionnaires (GINQ)

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S624-S625
Author(s):  
V Peters ◽  
B Alizadeh ◽  
J de Vries ◽  
G Dijkstra ◽  
M Campmans-Kuijpers
Keyword(s):  
Inflammatory Bowel Disease ◽  
Dietary Intake ◽  
Bowel Disease ◽  
Dietary Habits ◽  
Nutritional Assessment ◽  
Dietary Assessment ◽  
Dietary Guidelines ◽  
Assessment Tools ◽  
Dietary Intakes ◽  
Inflammatory Bowel

Abstract Background Diet plays a key role in the complex aetiology and treatment of inflammatory bowel disease (IBD). Most existing nutritional assessment tools neglect intakes of important foods consumed or omitted specifically by IBD patients or incorporate non-Western dietary habits, making development of appropriate dietary guidelines for (Western) IBD patients difficult. Hence, we developed a food frequency questionnaire (FFQ), the Groningen IBD Nutritional Questionnaires (GINQ-FFQ); suitable to assess dietary intake in IBD patients. Methods To develop the GINQ-FFQ multiple steps (Figure 1) were taken; identification of IBD specific foods, literature search and evaluation of current dietary assessment methods. Expert views were collected and in collaboration with Wageningen University, division of Human Nutrition and Health, this semi-quantitative FFQ was developed using standard methods to obtain a validate questionnaire. Next, the GINQ-FFQ was digitalised into a secure web-based environment which also embeds additional nutritional and IBD-related questions. Results The GINQ-FFQ is an online self-administered FFQ evaluating dietary intake over the past month as a proxy of habitual intake of the previous six months. The GINQ-FFQ consists of 121 questions on 218 food items. It takes about 45 min to fill out the GINQ-FFQ. Conclusion This paper describes the design process of the GINQ-FFQ which is newly developed to assess dietary intakes especially (but not exclusively) in IBD patients.

scholarly journals Intestinal CD103+CD4+ and CD103+CD8+ T-Cell Subsets in the Gut of Inflammatory Bowel Disease Patients at Diagnosis and During Follow-up

2019 ◽  
Vol 25 (9) ◽  
pp. 1497-1509 ◽  
Author(s):  
Britt Roosenboom ◽  
Peter J Wahab ◽  
Carolijn Smids ◽  
Marcel J M Groenen ◽  
Elly van Koolwijk ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
T Cells ◽  
T Cell ◽  
Bowel Disease ◽  
Cd8 T Cell ◽  
T Cell Subsets ◽  
Healthy Controls ◽  
Inflammatory Bowel ◽  
Active Inflammation

Abstract Background The integrin CD103 is proposed to be a potential therapeutical target in inflammatory bowel disease (IBD), as it can form a heterodimeric integrin with β7 (Etrolizumab, anti-β7 integrin) on epithelial T cells. Therefore, we aimed to study the frequencies of different intestinal CD103+T-cell subsets, both CD4+ and CD8+, in newly diagnosed, untreated IBD patients at baseline and during follow-up, compared with healthy controls. Methods Intestinal biopsies from inflamed segments during colonoscopy and peripheral blood samples were prospectively taken from IBD patients at diagnosis and during follow-up. Blood and single cell suspensions from biopsies were analyzed for CD103+ T-cell subpopulations by flow cytometry and expressed as median percentages of the total T-cell population. Results In total, 75 Crohn’s disease (CD) patients, 49 ulcerative colitis (UC) patients, and 16 healthy controls were included. At presentation, IBD patients displayed lower percentages of CD103+T-cell subsets in inflamed biopsies: 3% (1 to 5) CD103+CD4+ in IBD vs 5% (5 to 7) in healthy controls (P = 0.007) and 9% (4 to 15) CD103+CD8+ compared with 42% (23 to 57) in healthy controls (P = 0.001). The majority of intestinal T cells was composed of CD103-CD4+ T cells (65% [52 to 74]) in IBD compared with 30% (21 to 50) in healthy controls (P = 0.001). In patients with endoscopic remission during follow-up (n = 27), frequencies of CD103+ and CD103-T-cell subsets were comparable with healthy controls. Conclusion At diagnosis, active inflammation in IBD was associated with decreased percentages of both CD103+CD4+ and CD103+CD8+T-cell subsets in colon and ileum biopsies. In active disease during follow-up, these T-cell populations remained low but increased in remission to values comparable with healthy controls. A shift toward more CD103-T cells was observed during active inflammation.

scholarly journals Systematic Review of Self-Management Assessment Tools for Children With Inflammatory Bowel Disease

JPGN Reports ◽  
2021 ◽  
Vol 2 (3) ◽  
pp. e075
Author(s):  
Angharad Vernon-Roberts ◽  
Emma Rouse ◽  
Richard B. Gearry ◽  
Andrew S. Day
Keyword(s):  
Systematic Review ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Assessment Tools ◽  
Self Management ◽  
Inflammatory Bowel

scholarly journals Modulation of the microbiota-gut-brain axis by probiotics in a murine model of inflammatory bowel disease

2016 ◽  
Vol 310 (11) ◽  
pp. G989-G998 ◽  
Author(s):  
Jacob R. Emge ◽  
Kevin Huynh ◽  
Elaine N. Miller ◽  
Manvir Kaur ◽  
Colin Reardon ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Drinking Water ◽  
Recognition Memory ◽  
Gut Microbiota ◽  
Bowel Disease ◽  
Recognition Task ◽  
Gastrointestinal Diseases ◽  
Inflammatory Bowel ◽  
Novel Object Recognition Task ◽  
Active Inflammation

Anxiety, depression, and altered memory are associated with intestinal diseases, including inflammatory bowel disease (IBD). Understanding the link between these behavioral changes and IBD is important clinically since concomitant mood disorders often increase a patient's risk of requiring surgery and developing secondary functional gastrointestinal diseases. Anxiety-like behavior (light/dark box test) and recognition memory (novel object recognition task) were determined at the peak and during resolution of inflammation in the dextran sodium sulfate (DSS) mouse model of acute colitis. DSS (5 days) was administered via drinking water followed by 3 or 9 days of normal drinking water to assess behavior during active or resolving inflammation, respectively. Disease (weight, colon length, and histology) was assessed and the composition of the gut microbiota was characterized by using qPCR on fecal pellet DNA. In a subset of mice, pretreatment with probiotics was started 1 wk prior to commencing DSS. During active inflammation (8 days), mice demonstrated impaired recognition memory and exhibited anxiety-like behavior vs. controls. These behavioral defects were normalized by 14 days post-DSS. Shifts in the composition of the gut microbiota were evident during active inflammation, notably as decreases in lactobacilli and segmented filamentous bacteria, which were also reversed once the disease had resolved. Administration of probiotics could prevent the behavioral defects seen in acute DSS. Taken together, our findings indicate that changes in mood and behavior are present during acute inflammation in murine IBD and associated with dysbiosis and that these outcomes can be prevented by the administration of probiotics.

Development and Pilot Testing of the Inflammatory Bowel Disease Nutrition Care Pathway

2020 ◽  
Vol 18 (12) ◽  
pp. 2645-2649.e4 ◽  
Author(s):  
Caroline Hwang ◽  
Kelly Issokson ◽  
Catherine Giguere-Rich ◽  
Swapna Reddy ◽  
Andrew Tinsley ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Care Pathway ◽  
Pilot Testing ◽  
Nutrition Care ◽  
Inflammatory Bowel

scholarly journals Low FODMAP Diet for Functional Gastrointestinal Symptoms in Quiescent Inflammatory Bowel Disease: A Systematic Review of Randomized Controlled Trials

Nutrients ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3648
Author(s):  
Maria G. Grammatikopoulou ◽  
Dimitrios G. Goulis ◽  
Konstantinos Gkiouras ◽  
Meletios P. Nigdelis ◽  
Stefanos T. Papageorgiou ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Randomized Controlled Trials ◽  
Bowel Disease ◽  
Functional Gastrointestinal Disorders ◽  
Assessment Tools ◽  
Cell Phenotype ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Inflammatory Bowel ◽  
Fodmap Diet

A low FODMAP diet (LFD) has been hypothesized to relieve symptoms of functional gastrointestinal disorders (FGD) in patients with inflammatory bowel disease (IBD). The aim of the study was to systematically review the literature for randomized controlled trials (RCTs) assessing the effectiveness of the LFD in patients with IBD and FGD. Four databases were searched, but a meta-analysis was not performed due to methodological and outcomes heterogeneity. Four RCTs fulfilled the criteria, with three having some concerns in their risk of bias assessment. All interventions compared the LFDs against a “typical” or sham diet, spanning in duration from 21 days to 6 weeks. Quality of life was improved in two RCTs, while revealing inconsistent findings in the third trial, based on different assessment tools. The fecal assays revealed non-significant findings for most variables (fecal weight, pH, water content, gene count, and gut transit time) and inconsistent findings concerning stool frequency and short-chain fatty acids concentration. Levels of fecal calprotectin, CRP, or T-cell phenotype did not differ between intervention and comparator arms. Two RCTs reported a reduction in abdominal pain, while results concerning pain duration and bloating were inconsistent. In one trial, energy intake was considerably reduced among LFD participants. Regarding gut microbiota, no differences were noted. A considerable degree of methodological and outcome heterogeneity was observed, paired with results inconsistency. The available data are not sufficient to justify the claim that an LFD induces relief of FGD symptoms, although it may pave the way to a placebo response.

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