scholarly journals Anti-Inflammatory and Immunomodulatory Properties of Fermented Plant Foods

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1516
Author(s):  
Roghayeh Shahbazi ◽  
Farzaneh Sharifzad ◽  
Rana Bagheri ◽  
Nawal Alsadi ◽  
Hamed Yasavoli-Sharahi ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Inflammatory Responses ◽  
Biological Activities ◽  
Large Body ◽  
Antioxidant Compounds ◽  
Antioxidant Enzyme Activities ◽  
Fermented Foods ◽  
Plant Foods ◽  
Immunomodulatory Properties ◽  
Anti Inflammatory

Fermented plant foods are gaining wide interest worldwide as healthy foods due to their unique sensory features and their health-promoting potentials, such as antiobesity, antidiabetic, antihypertensive, and anticarcinogenic activities. Many fermented foods are a rich source of nutrients, phytochemicals, bioactive compounds, and probiotic microbes. The excellent biological activities of these functional foods, such as anti-inflammatory and immunomodulatory functions, are widely attributable to their high antioxidant content and lactic acid-producing bacteria (LAB). LAB contribute to the maintenance of a healthy gut microbiota composition and improvement of local and systemic immunity. Besides, antioxidant compounds are involved in several functional properties of fermented plant products by neutralizing free radicals, regulating antioxidant enzyme activities, reducing oxidative stress, ameliorating inflammatory responses, and enhancing immune system performance. Therefore, these products may protect against chronic inflammatory diseases, which are known as the leading cause of mortality worldwide. Given that a large body of evidence supports the role of fermented plant foods in health promotion and disease prevention, we aim to discuss the potential anti-inflammatory and immunomodulatory properties of selected fermented plant foods, including berries, cabbage, and soybean products, and their effects on gut microbiota.

scholarly journals Exploiting the Anti-inflammatory Potential of White Capsicum Extract by the Nanoformulation in Phospholipid Vesicles

Antioxidants ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1683
Author(s):  
Ilaria Pappalardo ◽  
Anna Santarsiero ◽  
Maria De Luca ◽  
Maria Assunta Acquavia ◽  
Simona Todisco ◽  
...  
Keyword(s):  
Inflammatory Responses ◽  
Biological Activities ◽  
Phospholipid Vesicles ◽  
Antioxidant Compounds ◽  
Bioactive Components ◽  
Property A ◽  
Phytochemical Content ◽  
Capsicum Species ◽  
Anti Inflammatory

The peppers of the Capsicum species are exploited in many fields, as flavoring agents in food industry, or as decorative and therapeutic plants. Peppers show a diversified phytochemical content responsible for different biological activities. Synergic activity exerted by high levels of antioxidant compounds is responsible for their important anti-inflammatory property. A methanolic extract was obtained from a new pepper genotype and tested for anti-inflammatory activity. The extract was incorporated into phospholipid vesicles to increase the bioavailability of its bioactive components. Two types of phospholipid vesicles were produced, conventional liposomes and Penetration Enhancer containing Vesicles (PEVs). They were tested in human monoblastic leukemia U937 cell line, showing no cytotoxic effect. The intracellular reactive oxygen species (ROS) and nitric oxide (NO) levels were measured to value the in vitro efficacy of the vesicles in regulating inflammatory responses. Liposomal incorporation significantly reduced ROS levels in extract-treated LPS-activated cells. Furthermore, LC-MS/MS analyses demonstrated that liposomes facilitated the transport of the extract components across the cell membrane and their accumulation into the cytoplasm.

scholarly journals MiR-155/GSK-3β mediates anti-inflammatory effect of Chikusetsusaponin IVa by inhibiting NF-κB signaling pathway in LPS-induced RAW264.7 cell

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Yi Xin ◽  
Qin Yuan ◽  
Chaoqi Liu ◽  
Changcheng Zhang ◽  
Ding Yuan
Keyword(s):  
Signaling Pathway ◽  
Mouse Liver ◽  
Inflammatory Responses ◽  
Biological Activities ◽  
Raw264.7 Cells ◽  
Inflammation Model ◽  
Raw264.7 Cell ◽  
Anti Inflammatory ◽  
Gsk 3Β ◽  
Inflammatory Effect

Abstract It has been demonstrated that Chikusetsusaponin IVa (CsIVa) possesses abundant biological activities. Herein, using LPS to establish acute inflammation model of mouse liver and cell line inflammation model, we investigated whether miR-155/GSK-3β regulated NF-κB signaling pathway, and CsIVa exerted anti-inflammatory effects by regulating miR-155/GSK-3β signaling pathway. Our results showed that LPS induced high expression of miR-155 and miR-155 promoted macrophage activation through GSK-3β. In addition, CsIVa inhibited inflammatory responses in LPS-induced mouse liver and RAW264.7 cells. Furthermore, we demonstrated that CsIVa improved the inflammatory response in LPS-induced RAW264.7 cells by inhibiting miR-155, increasing GSK-3β expression, and inhibiting NF-κB signaling pathway. In conclusion, our study reveals that CsIVa suppresses LPS-triggered immune response by miR-155/GSK-3β-NF-κB signaling pathway.

scholarly journals Biological and pathophysiological role of adiponectin

2019 ◽  
Vol 10 (2) ◽  
pp. 83-87
Author(s):  
Yury V. Petrenko ◽  
Ksenia S. Gerasimova ◽  
Valeria P. Novikova
Keyword(s):  
Adipose Tissue ◽  
Inflammatory Responses ◽  
Biological Activities ◽  
Normal Weight ◽  
Blood Levels ◽  
High Concentration ◽  
Obese People ◽  
Adipoq Gene ◽  
Wide Range ◽  
Anti Inflammatory

Adipose tissue is now recognized as an important endocrine organ that secretes numerous protein hormones, including leptin, adiponectin, and resistin. Adiponectin is a hormone that is produced by white adipose tissue. Adiponectin has been isolated independently by several groups of scientists. In humans, this protein is encoded by the ADIPOQ gene. Adiponectin receptors are widely distributed in many organs and tissues including liver, heart, pancreas, kidneys, muscles and many other cell types. A serum concentration of adipocin correlates with body mass index (BMI). Decreased level of adiponectin leads to obesity, the development of gestational complications in pregnant women, as well as a high risk of diabetes mellitus development and atherosclerosis. A high concentration of this hormone has anti-inflammatory, antiatherogenic, antiproliferative and cancer-defense mechanisms. Adiponectin strongly suppresses hepatic gluconeogenesis by inhibiting genes involved in glucose production. Obese people have lower blood levels of adiponectin than normal weight individuals. Adiponectin’s anti-inflammatory and anti-apoptotic properties result in protection of the blood vessels, heart, lungs, and colon. Adiponectin, an abundant adipocyte-secreted factor with a wide-range of biological activities, improves insulin sensitivity in insulin target tissues, modulates inflammatory responses, and plays a crucial role in the regulation of energy metabolism.

scholarly journals Lignans and Gut Microbiota: An Interplay Revealing Potential Health Implications

Molecules ◽  
2020 ◽  
Vol 25 (23) ◽  
pp. 5709
Author(s):  
Alice Senizza ◽  
Gabriele Rocchetti ◽  
Juana I. Mosele ◽  
Vania Patrone ◽  
Maria Luisa Callegari ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Biological Activities ◽  
Receptor Activation ◽  
Bacterial Metabolism ◽  
Plant Polyphenols ◽  
Potential Health ◽  
Plant Foods ◽  
Apoptotic Effects ◽  
Entire Gastrointestinal Tract

Plant polyphenols are a broad group of bioactive compounds characterized by different chemical and structural properties, low bioavailability, and several in vitro biological activities. Among these compounds, lignans (a non-flavonoid polyphenolic class found in plant foods for human nutrition) have been recently studied as potential modulators of the gut–brain axis. In particular, gut bacterial metabolism is able to convert dietary lignans into therapeutically relevant polyphenols (i.e., enterolignans), such as enterolactone and enterodiol. Enterolignans are characterized by various biologic activities, including tissue-specific estrogen receptor activation, together with anti-inflammatory and apoptotic effects. However, variation in enterolignans production by the gut microbiota is strictly related to both bioaccessibility and bioavailability of lignans through the entire gastrointestinal tract. Therefore, in this review, we summarized the most important dietary source of lignans, exploring the interesting interplay between gut metabolites, gut microbiota, and the so-called gut–brain axis.

scholarly journals Human placental extract ameliorates methotrexate-induced hepatotoxicity in rats via regulating antioxidative and anti-inflammatory responses

2021 ◽  
Author(s):  
Mamdooh Ghoneum ◽  
Mohamed S. A. El-Gerbed
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Responses ◽  
Biological Effects ◽  
Cellular Damage ◽  
Male Rats ◽  
Antioxidant Enzyme Activities ◽  
Oxidative Stress Biomarkers ◽  
Tnf Α ◽  
Anti Inflammatory ◽  
Liver Tissues

Abstract Purpose Methotrexate (MTX) induces hepatotoxicity, limiting its clinical efficacy as a widely known chemotherapy drug. In the current study, we examined the protective effect of human placenta extract (HPE) against MTX-induced liver damage in rats, as well as its ability to regulate antioxidative and anti-inflammatory liver responses. Methods Male rats were orally administered MTX at a daily dose of 5 mg/kg-body-weight in the presence or absence of HPE (10.08 mg/kg) for 2 weeks. We measured the biological effects of MTX and HPE on the levels of liver enzymes, lipid profile, lipid peroxidation, oxidative stress biomarkers, and cytokines [tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), and interleukin-10 (IL-10)]. In addition, histological examination and histopathological scoring of liver tissues were performed. Results MTX-treated rats showed significantly increased (p < 0.001) liver enzyme levels for aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total bilirubin, total cholesterol, and triglyceride levels. However, HPE supplementation in MTX-treated rats significantly decreased (p < 0.001) these elevated levels. HPE supplementation also significantly reduced the oxidative stress biomarker malondialdehyde (MDA), reversed the reduction in glutathione (GSH), and markedly increased the antioxidant enzyme activities of catalase (CAT) and superoxide dismutase (SOD) in the livers of MTX-treated rats. Furthermore, HPE supplementation significantly decreased the MTX-elevated levels of the pro-inflammatory cytokines TNF-α, IL-6, and IL-10. Histopathological examinations showed that MTX produced severe cellular damage and inflammatory lesions in liver tissues, while treatment with HPE improved hepatic histologic architecture. Conclusion HPE has the ability to ameliorate methotrexate-induced liver injury in rats by mechanisms that include boosting antioxidative responses and down-regulating MDA and pro-inflammatory cytokine production.

scholarly journals Gut Microbiota Manipulation as a Tool for Colorectal Cancer Management: Recent Advances in Its Use for Therapeutic Purposes

2020 ◽  
Vol 21 (15) ◽  
pp. 5389
Author(s):  
Federica Perillo ◽  
Chiara Amoroso ◽  
Francesco Strati ◽  
Maria Rita Giuffrè ◽  
Angélica Díaz-Basabe ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Gut Microbiota ◽  
Targeted Therapies ◽  
Inflammatory Responses ◽  
Fecal Microbiota Transplantation ◽  
Large Body ◽  
Cancer Recurrence ◽  
Fecal Microbiota ◽  
Cancer Management ◽  
Host Microbe Interactions

Colorectal cancer (CRC) is a multifaceted disease influenced by both environmental and genetic factors. A large body of literature has demonstrated the role of gut microbes in promoting inflammatory responses, creating a suitable microenvironment for the development of skewed interactions between the host and the gut microbiota and cancer initiation. Even if surgery is the primary therapeutic strategy, patients with advanced disease or cancer recurrence after surgery remain difficult to cure. Therefore, the gut microbiota has been proposed as a novel therapeutic target in light of recent promising data in which it seems to modulate the response to cancer immunotherapy. The use of microbe-targeted therapies, including antibiotics, prebiotics, live biotherapeutics, and fecal microbiota transplantation, is therefore considered to support current therapies in CRC management. In this review, we will discuss the importance of host−microbe interactions in CRC and how promoting homeostatic immune responses through microbe-targeted therapies may be useful in preventing/treating CRC development.

scholarly journals Fucoidan Isolated from Saccharina japonica Inhibits LPS-Induced Inflammation in Macrophages via Blocking NF-κB, MAPK and JAK-STAT Pathways

Marine Drugs ◽  
2020 ◽  
Vol 18 (6) ◽  
pp. 328 ◽  
Author(s):  
Jing Ye ◽  
Donghui Chen ◽  
Zhicheng Ye ◽  
Yayan Huang ◽  
Na Zhang ◽  
...  
Keyword(s):  
High Performance ◽  
Molecular Mechanisms ◽  
Inflammatory Responses ◽  
Biological Activities ◽  
Saccharina Japonica ◽  
Janus Kinase ◽  
Mitogen Activated Protein Kinase ◽  
Resonance Spectroscopy ◽  
Mechanism Study ◽  
Anti Inflammatory

Fucoidan has been reported to have a variety of biological activities. However, different algae species, extraction methods, harvesting seasons, and growth regions lead to the structural variation of fucoidan, which would affect the bioactivities of fucoidan. To date, the anti-inflammatory properties and the underlying mechanism of fucoidan from brown alga Saccharina japonica (S. japonica) remain limited. The aims of the present study were to investigate the structure, the anti-inflammatory properties, and the potential molecular mechanisms of fucoidan isolated from S. japonica (SF6) against lipopolysaccharide (LPS)-activated RAW 264.7 macrophages. SF6 was characterized using high performance liquid gel permeation chromatography (HPGPC), Fourier transform infrared spectroscopy (FTIR), and nuclear magnetic resonance spectroscopy (NMR), and observed to be rich in fucose, galactose, and sulfate. Additionally, results showed that SF6 remarkably inhibited LPS-induced production of various inflammatory mediators and pro-inflammation cytokines, including nitric oxide (NO), NO synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α), interleukin-β (IL-β), and interleukin-6 (IL-6). A mechanism study showed that SF6 could effectively inhibit inflammatory responses through blocking LPS-induced inflammation pathways, including nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK), and Janus kinase (JAK)-2 and signal transducer and activator of transcription (STAT)-1/3 pathways. These results suggested that SF6 has the potential to be developed as an anti-inflammatory agent applied in functional food.

Gut Microbiota Determines Graft Survival Outcome Through Regulation of Anti-Inflammatory and Pro-Inflammatory Responses

2018 ◽  
Vol 102 ◽  
pp. S333
Author(s):  
Yanbao Xiong ◽  
C. Colin Brinkman ◽  
Lauren E. Hittle ◽  
W. Florian Fricke ◽  
Emmanuel F. Mongodin ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Graft Survival ◽  
Inflammatory Responses ◽  
Survival Outcome ◽  
Anti Inflammatory

scholarly journals Anti-Inflammatory, Antioxidant, and Microbiota-Modulating Effects of Camellia Oil from Camellia brevistyla on Acetic Acid-Induced Colitis in Rats

Antioxidants ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 58 ◽  
Author(s):  
Chun-Ching Wu ◽  
Yu-Tang Tung ◽  
Sheng-Yi Chen ◽  
Wei-Ting Lee ◽  
Hsin-Tang Lin ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Gut Microbiota ◽  
Inflammatory Responses ◽  
Control Treatment ◽  
Protective Effects ◽  
Colon Tissue ◽  
Colonic Injury ◽  
Camellia Oil ◽  
Anti Inflammatory

Altering the microbiota by the daily diet is highly associated with improved human health. Studies confirms the gastrointestinal protective and anti-inflammatory effects of camellia oil; however, the benefits in gut microbiota remain unclear. Camellia oils of Camellia oleifera (PCO) and C. brevistyla (TCCO) were used to evaluate probiotic growth in vitro. In addition, the protective effects of camellia oils in the acetic acid (AA)-induced colitis rat model were investigated. In vitro fermentation study showed the proliferation of Lactobacillus spp. and Bifidobacterium spp. from human intestinal microbiota was increased after TCCO treatment. Moreover, the rats pretreated with TCCO exhibited significantly less AA-induced colonic injury and hemorrhage, higher serum immunoglobulin G 1 (IgG 1) levels, lower malondialdehyde levels, and lower inflammatory cytokine production in the colon tissue compared with those in the PCO group. Surprising, the protective effect against acetic acid-induced colitis by TCCO was similar to sulfasalazine (positive control) treatment. Moreover, TCCO increased the richness and diversity of probiotics in gut microbiota. TCCO alleviated AA-induced colitis by modulating gut microbiota, reducing oxidative stress and suppressing inflammatory responses.

Abstract 1045: E-ntpdase-1/Cd39 Confers Anti-inflammatory And Immunomodulatory Properties To Circulating Membrane-derived Microparticles

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Yara Banz ◽  
Guido Beldi ◽  
Yan Wu ◽  
Anny Usheva ◽  
Simon C Robson
Keyword(s):  
Vascular Function ◽  
Inflammatory Responses ◽  
Purinergic Signalling ◽  
Nucleoside Triphosphate ◽  
Wild Type ◽  
Nf Kappa B ◽  
Cellular Origin ◽  
Immunomodulatory Properties ◽  
Anti Inflammatory ◽  
2D Gel

Background: Microparticles (MPs, <1.5ÂμM) are circulating, membrane-derived micro-vesicles shed from cells and platelets under physiological conditions as well as following stress, such as post-myocardial infarction. MPs have been implicated in inflammation, coagulation and vascular function. CD39, the prototype nucleoside triphosphate diphosphohydrolase (NTP-Dase1) within the vasculature modulates extracellular purinergic signalling through ATP and ADP hydrolysis, conferring anti-inflammatory, anti-thrombotic properties to the intravascular space. The aim of this study was to determine if CD39 is present on MPs and whether this impacts MP phenotype and function. Methods: The proteome, absolute numbers as well as cellular origin of circulating MPs from wild type (wt) and cd39-null C57Bl6 mice were compared by 2D-gel electrophoresis, western blot and flow cytometry. Isolated MPs were incubated with endothelial cells (EC) to analyze their intrinsic pro-inflammatory potential. Results: CD39 can be demonstrated and has ecto-enzymatic activity on circulating MPs from wt mice. 2D-gel analysis revealed that cd39-null MPs express lower levels of talin (component of focal adhesion) and ATP synthase, when compared to wild type MPs. Mutant mice have increased numbers of circulating MPs, with significantly higher fractions derived from platelets and endothelium as compared to wt mice (p<0.05). The presence of CD39 on wt MPs significantly attenuates inflammatory responses following incubation with EC as compared to cd39-null MPs (reduced IL-6 and TNF-alpha secretion, ICAM-1 and VCAM-1 expression, vWF release and NF-kappa B activation, p<0.05). Conclusions: CD39 confers anti-inflammatory and immunomodulatory properties upon circulating MPs. These results highlight the protective potential of CD39; a finding that may be exploited therapeutically, with the prospective of administering soluble CD39 (apyrase) to the site of intravascular injury to ameliorate inflammation, as occurs for instance in acute coronary syndromes.

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