scholarly journals Modelling the Cost-Effectiveness of Implementing a Dietary Intervention in Renal Transplant Recipients

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1175
Author(s):  
Friso B. Coerts ◽  
Judith J. Gout-Zwart ◽  
Eke G. Gruppen ◽  
Yvonne van der Veen ◽  
Maarten J. Postma ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Renal Transplant ◽  
The Netherlands ◽  
Budget Impact ◽  
Dietary Adherence ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Risk Of Death ◽  
Potassium Supplementation ◽  
The Cost

Background: The Dietary Approach to Stop Hypertension (DASH) and potassium supplementation have been shown to reduce the risk of death with a functioning graft (DWFG) and renal graft failure in renal transplant recipients (RTR). Unfortunately, a key problem for patients is the adherence to these diets. The aim of this study is to evaluate the cost-effectiveness and budget impact of higher adherence to either the DASH or potassium supplementation. Methods: A Markov model was used to simulate the life course of 1000 RTR in the Netherlands. A societal perspective with a lifetime time horizon was used. The potential effect of improvement of dietary adherence was modelled in different scenarios. The primary outcomes are the incremental cost-effectiveness ratio (ICER) and the budget impact. Results: In the base case, improved adherence to the DASH diet saved 27,934,786 and gained 1880 quality-adjusted life years (QALYs). Improved adherence to potassium supplementation saved €1,217,803 and gained 2901 QALYs. Both resulted in dominant ICERs. The budget impact over a five-year period for the entire Dutch RTR population was €8,144,693. Conclusion: Improving dietary adherence in RTR is likely to be cost-saving and highly likely to be cost-effective compared to the current standard of care in the Netherlands.

scholarly journals The Cost-Effectiveness of Hepatitis C Virus Screening Strategies among Recently Arrived Migrants in the Netherlands

2020 ◽  
Vol 17 (17) ◽  
pp. 6091
Author(s):  
Mohamed N.M.T. Al Khayat ◽  
Job F.H. Eijsink ◽  
Maarten J. Postma ◽  
Jan C. Wilschut ◽  
Marinus van Hulst
Keyword(s):  
Hepatitis C Virus ◽  
Cost Effectiveness ◽  
Hepatitis C ◽  
The Netherlands ◽  
Budget Impact ◽  
Cost Effective ◽  
Life Years ◽  
Screening Strategies ◽  
Hcv Screening ◽  
The Cost

Objective: We aimed to assess the cost-effectiveness of hepatitis C virus (HCV) screening strategies among recently arrived migrants in the Netherlands. Methods: A Markov model was used to estimate the health effects and costs of HCV screening from the healthcare perspective. A cohort of 50,000 recently arrived migrants was used. In this cohort, three HCV screening strategies were evaluated: (i) no screening, (ii) screening of migrants from HCV-endemic countries and (iii) screening of all migrants. Results: Strategy (ii) screening of migrants from HCV-endemic countries compared to strategy (i) no screening, yielded an incremental cost-effectiveness ratio (ICER) of €971 per quality-adjusted life-years (QALYs) gained. Strategy (iii) screening of all migrants compared with strategy (ii) screening of migrants from HCV-endemic countries yielded an ICER of €1005 per QALY gained. The budget impact of strategy (ii) screening of migrants from HCV-endemic countries and strategy (iii) screening of all migrants was €13,752,039 and €20,786,683, respectively. Conclusion: HCV screening is cost-effective. However, the budget impact may have a strong influence on decision making.

scholarly journals SP839CIGARETTE SMOKING STRENGTHENS THE INFLUENCE OF AGE ON THE RISK OF DEATH IN RENAL TRANSPLANT RECIPIENTS IN 2 YEARS FOLLOW-UP

2015 ◽  
Vol 30 (suppl_3) ◽  
pp. iii654-iii654
Author(s):  
Oktawia Mazanowska ◽  
Marcelina Zabinska ◽  
Katarzyna Kościelska-Kasprzak ◽  
Dorota Kaminska ◽  
Miroslaw Banasik ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Risk Of Death

scholarly journals PUK13 COST-EFFECTIVENESS OF INTRODUCING A DIETARY INTERVENTION FOR RENAL TRANSPLANT RECIPIENTS

2019 ◽  
Vol 22 ◽  
pp. S915
Author(s):  
J. Gout-Zwart ◽  
F. Coerts ◽  
E. Gruppen ◽  
A. Gomes-Neto ◽  
Y. van der Veen ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Renal Transplant ◽  
Dietary Intervention ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

Cytomegalovirus Disease, Short-Term Cardiovascular Events and Graft Survival in a Cohort of Kidney Transplant Recipients With High CMV IgG Seroprevalence

2021 ◽  
pp. 152692482110027
Author(s):  
James S. Díaz ◽  
Fabián A. Jaimes
Keyword(s):  
Renal Transplant ◽  
Kidney Transplant ◽  
Cardiovascular Events ◽  
Graft Loss ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Cytomegalovirus Disease ◽  
Risk Of Death ◽  
Cmv Disease

Introduction: Both cytomegalovirus (CMV) infection and CMV disease have been linked with several long-term indirect effects in kidney transplant recipients. Research questions: We conducted a retrospective study to assess the association between cytomegalovirus disease and risks of death, shortterm cardiovascular events and graft loss in a cohort of renal transplant recipients. Design: The associations between CMV disease and death and cardiovascular events were determined using Cox regression models, while the association between viral disease and graft loss risk was analyzed through a competing risks regression according to the Fine and Gray method. Death with a functioning graft was considered as a competing risk event. Results: A total of 865 consecutive renal transplant recipients were included. The prevalence of seropositive donor/seronegative recipient (D+/R-) group was 89.9% with the remaining patients classified as seropositive recipient (R+). After median follow-up time of 24.4 months, CMV disease was not a risk factor for all-causes mortality (HR = 1.75; 95% CI 0.94-3.25), early cardiovascular events (HR = 0.54; 95% CI 0.16-1.82) or graft loss (subhazard ratio [the HR adjusted for competing risk of death with functioning graft] = 0.99; 95% CI 0.53-1.84). Conclusions: In this cohort with high prevalence of CMV IgG antibodies, we found no association between cytomegalovirus disease and risk of death or graft loss. The relationship between CMV and cardiovascular disease remains to be unraveled and probably corresponds to a multifactorial phenomenon involving individual risk factors and the immune response to infection rather than the virus effect itself.

scholarly journals CYP3A5 GENOTYPING MAY REDUCE THE COST OF CARE AND GUIDE DOSING IN PAEDIATRIC RENAL TRANSPLANT RECIPIENTS TREATED WITH TACROLIMUS

2017 ◽  
Vol 10 (05) ◽  
Author(s):  
Stephen M. Roper ◽  
Mini Michael ◽  
Eileen D. Brewer ◽  
Ji Lee ◽  
Alvaro H. Orjuela ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Cost Of Care ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
The Cost

AFRICAN-AMERICAN RENAL TRANSPLANT RECIPIENTS EXPERIENCE DECREASED RISK OF DEATH DUE TO INFECTION: POSSIBLE IMPLICATIONS FOR IMMUNOSUPPRESSIVE STRATEGIES

2000 ◽  
Vol 70 (2) ◽  
pp. 375-379 ◽  
Author(s):  
Herwig-Ulf Meier-Kriesche ◽  
Akinlolu Ojo ◽  
John C. Magee ◽  
Diane M. Cibrik ◽  
Julie A. Hanson ◽  
...  
Keyword(s):  
African American ◽  
Renal Transplant ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Risk Of Death
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