scholarly journals Early-Life Metabolic and Hormonal Markers in Blood and Growth until Age 2 Years: Results from a Randomized Controlled Trial in Healthy Infants Fed a Modified Low-Protein Infant Formula

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1159
Author(s):  
Stefanie M. P. Kouwenhoven ◽  
Manja Fleddermann ◽  
Martijn J. J. Finken ◽  
Jos W. R. Twisk ◽  
Eline M. van der Beek ◽  
...  
Keyword(s):  
Body Composition ◽  
G Protein ◽  
Early Life ◽  
Protein Intake ◽  
Blood Parameters ◽  
Anthropometric Parameters ◽  
Low Protein ◽  
Significant Difference ◽  
The Impact ◽  
Breast Fed

Background: High protein intake in early life is associated with an increased risk of childhood obesity. Dietary protein intake may be a key mechanistic modulator through alterations in endocrine and metabolic responses. Objective: We aimed to determine the impact of different protein intake of infants on blood metabolic and hormonal markers at the age of four months. We further aimed to investigate the association between these markers and anthropometric parameters and body composition until the age of two years. Design: Term infants received a modified low-protein formula (mLP) (1.7 g protein/100 kcal) or a specifically designed control formula (CTRL) (2.1 g protein/100 kcal) until 6 months of age in a double blinded RCT. The outcomes were compared with a breast-fed (BF) group. Glucose, insulin, leptin, IGF-1, IGF-BP1, -BP2, and -BP3 levels were measured at the age of 4 months. Anthropometric parameters and body composition were assessed until the age of 2 years. Groups were compared using linear regression analysis. Results: No significant differences were observed in any of the blood parameters between the formula groups (n = 53 mLP; n = 44 CTRL) despite a significant difference in protein intake. Insulin and HOMA-IR were higher in both formula groups compared to the BF group (n = 36) (p < 0.001). IGF-BP1 was lower in both formula groups compared to the BF group (p < 0.01). We found a lower IGF-BP2 level in the CTRL group compared to the BF group (p < 0.01) and a higher IGF-BP3 level in the mLP group compared to the BF group (p = 0.03). There were no significant differences in glucose, leptin, and IGF-1 between the three feeding groups. We found specific associations of all early-life metabolic and hormonal blood parameters with long-term growth and body composition except for IGF-1. Conclusions: Reducing protein intake by 20% did not result in a different metabolic profile in formula-fed infants at 4 months of age. Formula-fed infants had a lower insulin sensitivity compared to breast-fed infants. We found associations between all metabolic and hormonal markers (except for IGF-1) determined at age 4 months and growth and body composition up to two years of age.

scholarly journals The influence of protein nutrition in early life on growth and development of the pig

1983 ◽  
Vol 50 (3) ◽  
pp. 605-617 ◽  
Author(s):  
R. G. Campbell ◽  
A. C. Dunkin
Keyword(s):  
Body Composition ◽  
Growth Performance ◽  
Early Life ◽  
Protein Intake ◽  
Subsequent Development ◽  
Live Weight ◽  
High Energy ◽  
Protein Retention ◽  
Protein Nutrition ◽  
Low Protein

1. The effects of feeding either a high-protein (HP) diet or a low-protein (LP) diet between 1·8 and 15 kg live weight (LW) and a low-energy (LE) or a high-energy (HE) intake but at the same protein intake subsequent to 15 kg LW on the performance and body composition of pigs growing to 75 kg LW were investigated.2. During the LW period 1·8–15 kg, pigs given the LP diet exhibited poorer growth performance (P < 0·01) and at 15 kg contained more fat (P < 0·01) in their empty bodies than pigs given the HP diet.3. On the LE treatment subsequent to 15 kg LW, pigs previously given the LP diet deposited protein at a faster rate and exhibited more rapid and efficient growth to 60 kg LW than those given the HP diet before 15 kg. However, on the HE treatment, pigs previously given the LP diet deposited protein at a slower rate and exhibited poorer growth performance (P < 0·05) between 15 and 45 kg LW but grew at a faster rate between 45 and 60 kg LW than pigs previously given the HP diet.4. On the LE treatment subsequent to 15 kg LW the differences in body composition between the two protein groups were no longer significant at 45 kg. However, on the HE treatment, pigs previously given the LP diet remained fatter (P < 0·05) to 60 kg LW than those previously given the HP diet.5. The results suggested that restricting protein intake between 1.8 and 15 kg LW reduced, temporarily, the upper limit of protein retention and growth performance during subsequent development. This finding is discussed in relation to the effects of protein nutrition in early life on the hyperplasic development of muscle tissue.

scholarly journals Effects of a Meal Replacement on Body Composition and Metabolic Parameters among Subjects with Overweight or Obesity

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Xiaohui Guo ◽  
Yifan Xu ◽  
Hairong He ◽  
Hao Cai ◽  
Jianfen Zhang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Composition ◽  
Total Energy ◽  
Intervention Group ◽  
Overweight And Obesity ◽  
Metabolic Parameters ◽  
Control Group ◽  
Meal Replacement ◽  
Significant Difference ◽  
The Impact

Meal replacement plans are effective tools for weight loss and improvement of various clinical characteristics but not sustainable due to the severe energy restriction. The aim of the study was to evaluate the impact of meal replacement, specifically 388 kcal in total energy, on body composition and metabolic parameters in individuals with overweight and obesity from a Chinese population. A parallel, randomized controlled trial was performed with 174 participants (ChiCTR-OOC-17012000). The intervention group (N=86) was provided with a dinner meal replacement, and the control group (N=88) continued their routine diet as before. Body composition and blood parameters were assessed at 0, 4, 8, and 12 weeks. A post hoc analysis (least significant difference (LSD) test), repeated measurements, and pairedT-test were used to compare each variable within and between groups. Significant (p<0.001) improvements in body composition components were observed among the intervention group, including body weight (−4.3 ± 3.3%), body mass index (−4.3 ± 3.3%), waist circumference (−4.3 ± 4.4%), fat-free mass (−1.8 ± 2.9%), and body fat mass (−5.3 ± 8.8%). Body composition improvements corresponded with significant metabolic improvements of blood glucose (−4.7 ± 9.8%). Further improvements in visceral fat area (−7.7 ± 10.1%), accompanying with improvements in systolic (−3.7 ± 6.9%) and diastolic (−5.3 ± 7.7%) blood pressure, were only found in male subjects. To conclude, meal replacement intake with 388 kcal in total energy at dinner time for 12 weeks contributed to improvement in body composition and clinically significant metabolic parameters in both male and female participants with overweight/obesity. Additionally, glucose and blood pressure reduction were gender-specific highlighting the importance of gender stratification for design of nutritional intervention studies for improvement of health.

scholarly journals Dietary Protein, Exercise, and Frailty Domains

Nutrients ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 2399 ◽  
Author(s):  
Josje D. Schoufour ◽  
Elvera Overdevest ◽  
Peter J. M. Weijs ◽  
Michael Tieland
Keyword(s):  
Physical Activity ◽  
Beneficial Effect ◽  
Dietary Protein ◽  
Protein Intake ◽  
Social Health ◽  
Physical Domain ◽  
Physical Frailty ◽  
Future Studies ◽  
Low Protein ◽  
The Impact

Increasing awareness of the impact of frailty on elderly people resulted in research focusing on factors that contribute to the development and persistence of frailty including nutrition and physical activity. Most effort so far has been spent on understanding the association between protein intake and the physical domain of frailty. Far less is known for other domains of frailty: cognition, mood, social health and comorbidity. Therefore, in the present narrative review, we elaborate on the evidence currently known on the association between protein and exercise as well as the broader concept of frailty. Most, but not all, identified studies concluded that low protein intake is associated with a higher prevalence and incidence of physical frailty. Far less is known on the broader concept of frailty. The few studies that do look into this association find a clear beneficial effect of physical activity but no conclusions regarding protein intake can be made yet. Similar, for other important aspects of frailty including mood, cognition, and comorbidity, the number of studies are limited and results are inconclusive. Future studies need to focus on the relation between dietary protein and the broader concept of frailty and should also consider the protein source, amount and timing.

scholarly journals Low Protein Intake: The Impact on Calcium and Bone Homeostasis in Humans

2003 ◽  
Vol 133 (3) ◽  
pp. 855S-861S ◽  
Author(s):  
Jane E. Kerstetter ◽  
Kimberly O. O'Brien ◽  
Karl L. Insogna
Keyword(s):  
Protein Intake ◽  
Bone Homeostasis ◽  
Low Protein ◽  
The Impact

scholarly journals Effect of dietary protein intake on the body composition and metabolic parameters of neutered dogs

2017 ◽  
Vol 6 ◽  
Author(s):  
Iris Mayumi Kawauchi ◽  
Juliana Toloi Jeremias ◽  
Paula Takeara ◽  
Danilo Ferreira de Souza ◽  
Júlio Cesar de Carvalho Balieiro ◽  
...  
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
G Protein ◽  
Protein Intake ◽  
Biochemical Parameters ◽  
Mixed Model ◽  
Energy Requirement ◽  
The Body ◽  
Serum Concentrations ◽  
Time Interaction

AbstractNeutering is a common veterinary recommendation and is often associated with obesity development. Thus, the aim of the present study was to evaluate the effects of two different amounts of protein intake by neutered dogs regarding maintenance energy requirement (MER), body composition, and biochemical and hormonal parameters. A total of fourteen healthy adult dogs were fed either a diet containing 59·7 g protein/1000 kcal (4184 kJ) (P60) or a diet with 94·0 g protein/1000 kcal (4184 kJ) (P94) for 26 weeks after neutering to maintain their body weight prior to neutering. A mixed model was fitted to verify diet, time and diet × time interaction effects on biochemical parameters, serum concentrations of insulin, glucagon, leptin and insulin-like growth factor-1 (IGF-1). MER and the body composition data were evaluated within diets (paired t test) and within times (unpaired t test). A time effect was found for fructosamine, TAG, total lipids and IGF-1 serum concentrations. The diet × time interaction was significant for glucagon (P < 0·05). No differences between diets in the MER within each time were found. However, there was a reduction in the MER of dogs fed the P60 diet 26 weeks after neutering (P = 0·042). The fat body mass of dogs fed the P60 diet increased (P < 0·05) after neutering, even without a body-weight change. Some of the biochemical parameters changed over time, but all remained within the normal range. For the period evaluated in the present study, a diet with 94·0 g of protein/1000 kcal (4184 kJ) metabolisable energy seems to be a beneficial nutritional strategy to maintain the MER and the body composition of dogs after neutering.

scholarly journals Effect of dietary protein on plasma insulin-like growth factor-1, growth, and body composition in healthy term infants: a randomised, double-blind, controlled trial (Early Protein and Obesity in Childhood (EPOCH) study)

2015 ◽  
Vol 115 (2) ◽  
pp. 271-284 ◽  
Author(s):  
Guy Putet ◽  
Jean-Marc Labaune ◽  
Katherine Mace ◽  
Philippe Steenhout ◽  
Dominik Grathwohl ◽  
...  
Keyword(s):  
Body Composition ◽  
Growth Factor ◽  
Growth Velocity ◽  
Head Circumference ◽  
Protein Intake ◽  
Controlled Trial ◽  
Insulin Like Growth Factor ◽  
Term Infants ◽  
Early Protein ◽  
Breast Fed

AbstractThe effect of protein intake on growth velocity in infancy may be mediated by insulin-like growth factor-1 (IGF-1). This study aimed to determine the effects of formulae containing 1·8 (F1·8) or 2·7 g (F2·7) protein/418·4 kJ (100 kcal) on IGF-1 concentrations and growth. Healthy term infants were randomly assigned to receive F1·8 (n74) or F2·7 (n80) exclusively for the first 4 months of life. A group of breast-fed infants (n84) was followed-up simultaneously (reference). Growth and body composition were measured at 0·5, 4, 6, 12, 36, 48 and 60 months of life. The IGF-1 concentrations at 4 months (primary outcome) were similar in the F1·8 (67·1 (sd20·8) ng/l;n70) and F2·7 (71·2 (sd27·5) ng/l;n73) groups (P=0·52). Both formula groups had higher IGF-1 concentrations than the breast-fed group at 4 and 9 months of age (P≤0·0001). During the first 60 months of life, anthropometric parameters in the F1·8 group were lower compared with the F2·7 group, and the differences were significant for head circumference from 2 to 60 months, body weight at 4 and 6 months and length at 9, 12 and 36 months of age. There were no significant differences in body composition between these two groups at any age. We conclude that, in formula-fed infants, although increased protein intake did not affect the IGF-1 concentration during the first 12 months of life, it did affect length and head circumference growth, suggesting that factors other than IGF-1 could play roles in determining growth velocity.

scholarly journals Effectiveness of a Per-Meal Protein Prescription and Nutrition Education with versus without Diet Coaching on Dietary Protein Intake and Muscle Health in Middle-Aged Women

Nutrients ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 375
Author(s):  
Kelley L. Jackson ◽  
Sareen S. Gropper ◽  
Dennis Hunt ◽  
Deborah D’Avolio ◽  
David Newman
Keyword(s):  
Nutrition Education ◽  
Dietary Protein ◽  
Protein Intake ◽  
Dietary Protein Intake ◽  
Speed Test ◽  
Significant Difference ◽  
Meal Protein ◽  
Muscle Health ◽  
Chair Rise ◽  
The Impact

Sufficient dietary protein intake is vital to maintaining muscle health with aging. Yet protein intake among adults is often inadequate. This study’s main objective was to examine the impact of nutrition education (NE) and a per-meal protein prescription (PRx) with versus without diet coaching on protein intake. A secondary objective examined its effects on muscle health. Participants included 53 women, age 45–64 years. All participants received NE and PRx; those randomized to coached-group received 10-weeks of diet coaching. Assessments included: protein intake at baseline, weeks 4 and 12 and muscle health (muscle mass, grip strength, five-chair rise test, 4 mgait speed test). The Chi-square test examined percentages of participants meeting PRx between groups. Repeated measures analysis of variance assessed within group and intervention effects on protein intake and muscle health parameters. Protein intake (g/kg body weight) increased (p < 0.001): not-coached (n = 28) 0.8 ± 0.2 to 1.2 ± 0.3 and coached (n = 25) 1.0 ± 0.2 to 1.4 ± 0.3 with no significant difference between groups. A greater percentage of coached-group participants met (p = 0.04) breakfast (72%) and met (p < 0.001) three-meal (76%) PRx versus not-coached participants (25% and 53%, respectively). Participants in both groups exhibited significantly (p < 0.001) improved times for the five-chair rise test and 4 mgait speed test. Diet coaching in conjunction with a PRx and NE should be considered to assist individuals in improving protein intake through self-selection of protein-rich foods.

P7 THE IMPACT OF PREHABILITATION ON PARAMETERS OF BODY COMPOSITION IN PATIENTS UNDERGOING MULTIMODAL THERAPY FOR OESOPHAGO-GASTRIC (OG) CANCER

2019 ◽  
Vol 32 (Supplement_2) ◽  
Author(s):  
Doganay Emre ◽  
R Boshier Piers ◽  
J Halliday Laura ◽  
Thomas Rob ◽  
E Low Donald ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Body Composition ◽  
Neoadjuvant Therapy ◽  
Physical Performance ◽  
Skeletal Muscle Index ◽  
Significant Difference ◽  
Axial Ct ◽  
Gastric Cancer Patients ◽  
Subcutaneous Adipose ◽  
The Impact

Abstract Aims This study characterises changes in body composition and physical performance during neoadjuvant therapy in the context of prehabilitation before oesophago-gastric resection. Background & Methods Neoadjuvant therapy has deleterious effects on functional capacity and may lead to a decline in physical fitness and skeletal muscle mass. This is a retrospective review of oesophago-gastric cancer patients undergoing prehabilitation. Assessment of body composition (skeletal muscle, visceral and subcutaneous adipose tissue) was performed from L3 axial CT images acquired at the time of diagnosis and after neoadjuvant therapy. Results 42 patients (33M, 65.7±11.1) met the inclusion criteria. Patients body weight (81.8±21.3 kg vs. 81.3±21 kg, p=0.668) and BMI (27.9±7.2 kg/m2 vs. 27.8±7.0 kg/m2, p=0.648) did not change significantly between the study time points. There was no significant difference between estimated lean body mass (39.2±13.2 vs. 38.3±10.1; 95%CI -2.5 to 4.3 p=0.592) and fat mass (30.6±15.4 vs. 28.6±14.0; 95%CI -1.7 to 5.7, p=0.284). Skeletal muscle index significantly decreased (46.5±9.9 to 43.1±9.8; 95%CI 2.1 to 4.6, p<0.001). Patients who were adherent to the prehabilitation programme had a significantly higher skeletal muscle index compared to noncompliant patients (47.4±10.4 vs. 40.2±8.9; 95%CI 1.5 to 13.5, p=0.016). Patients who achieved a higher MET-minutes were less likely to be sarcopenic (F(1,40 = 6.1, p = 0.018)).There was no decline in physical performance (Median IQR; VO2max ml kg−1min−1) during neoadjuvant therapy (17.5 [14-19.3] vs. 17.5 [13.3-19.3]; p=0.164). Conclusion this is the first study to report variations in parameters of body composition in patients undergoing a prehabilitation programme. Findings suggest that prehabilitation may be a useful adjunct in limiting the extent of sarcopenia and patient deconditioning during neoadjuvant therapy.

Impact of physical activity, protein intake and social network and their combination on the development of frailty

2019 ◽  
Vol 30 (2) ◽  
pp. 340-346
Author(s):  
Sandra Haider ◽  
Igor Grabovac ◽  
Deborah Drgac ◽  
Christine Mogg ◽  
Moritz Oberndorfer ◽  
...  
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Social Network ◽  
Protein Intake ◽  
Community Dwelling ◽  
Adverse Health Outcomes ◽  
Low Protein ◽  
Geriatric Condition ◽  
The Impact

Abstract Background Frailty is a geriatric condition associated with adverse health outcomes. As physical inactivity, low protein intake and poor social network are known risk factors, we aimed to assess the influence of these parameters and their interaction in an 11-year follow-up study on a Europe-wide level. Methods Data from the Study on Health, Ageing and Retirement in Europe were used, including 22 226 community-dwelling robust and prefrail persons aged ≥50 years, from 11 countries. Frailty was assessed with the ‘Frailty Instrument for Primary care of the Survey of Health, Ageing and Retirement in Europe’. Additionally, self-reported physical activity (PA), protein intake and satisfaction with social network were assessed. The impact of these parameters on the development of frailty was calculated using multivariate cox regressions. Results Performing no regular PA, was associated with higher hazards ratio (HRs) for frailty compared with performing regular PA [men: 1.90 (95%CI: 1.50–2.42); women: 1.65 (95%CI: 1.25–2.18)]; HRs for low protein intake were 1.16 (95%CI: 0.93–1.46) for men and 1.05 (95%CI: 0.80–1.37) for women. And HR for poor social network were 0.92 (95%CI: 0.74–1.15) for men and 1.72 (95%CI: 1.31–2.27)] for women. In general, persons with a combination of two of the assessed risk factors had a higher risk for frailty compared with those with no or only one of the risk factors. However, no significant synergy index could be found. Conclusion The results illustrate the importance of PA, but also of nutritional and social network to prevent frailty.

scholarly journals A modified low-protein infant formula supports adequate growth in healthy, term infants: a randomized, double-blind, equivalence trial

2019 ◽  
Vol 111 (5) ◽  
pp. 962-974 ◽  
Author(s):  
Stefanie M P Kouwenhoven ◽  
Nadja Antl ◽  
Martijn J J Finken ◽  
Jos W R Twisk ◽  
Eline M van der Beek ◽  
...  
Keyword(s):  
Body Composition ◽  
Weight Gain ◽  
Amino Acid ◽  
Infant Formula ◽  
Protein Intake ◽  
Amino Acid Profile ◽  
Double Blind ◽  
Equivalence Trial ◽  
Low Protein ◽  
Formula Group

ABSTRACT Background A high protein intake in early life is associated with a risk of obesity later in life. The essential amino acid requirements of formula-fed infants have been reassessed recently, enabling a reduction in total protein content and thus in protein intake. Objectives We aimed to assess the safety of an infant formula with a modified amino acid profile and a modified low-protein (mLP) content in healthy term-born infants. Outcomes were compared with a specifically designed control (CTRL) infant formula. Methods In this double-blind, randomized controlled equivalence trial, infants received either mLP (1.7 g protein/100 kcal; n = 90) or CTRL formula (2.1 g protein/100 kcal; n = 88) from enrollment (age ≤ 45 d) to 6 mo of age. A breastfed group served as a reference (n = 67). Anthropometry and body composition were determined at baseline, 17 wk (including safety blood parameters), and 6 mo of age. The primary outcome was daily weight gain from enrollment up until the age of 17 wk (at an equivalence margin of ±3.0 g/d). Results Weight gain from baseline (mean ± SD age: 31 ± 9 d) up to the age of 17 wk was equivalent between the mLP and CTRL formula groups (27.9 and 28.8 g/d, respectively; difference: −0.86 g/d; 90% CI: −2.36, 0.63 g/d). No differences in other growth parameters, body composition, or in adverse events were observed. Urea was significantly lower in the mLP formula group than in the CTRL formula group (−0.74 mmol/L; 95% CI: −0.97, −0.51 mmol/L; P &lt; 0.001). Growth rates, fat mass, fat-free mass, and several essential amino acids were significantly higher in both formula groups than in the breastfed reference group. Conclusions Feeding an infant formula with a modified amino acid profile and a lower protein content from an average age of 1 mo until the age of 6 mo is safe and supports an adequate growth, similar to that of infants consuming CTRL formula. This trial was registered at www.trialregister.nl as Trial NL4677.

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