scholarly journals Obesity-Associated Inflammation: Does Curcumin Exert a Beneficial Role?

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 1021
Author(s):  
Rosaria Varì ◽  
Beatrice Scazzocchio ◽  
Annalisa Silenzi ◽  
Claudio Giovannini ◽  
Roberta Masella
Keyword(s):  
Adipose Tissue ◽  
Inflammatory Response ◽  
Chronic Diseases ◽  
Immune Cells ◽  
Molecular Mechanisms ◽  
Curcuma Longa ◽  
Low Grade ◽  
Obese People ◽  
Cytokines And Chemokines ◽  
Anti Inflammatory

Curcumin is a lipophilic polyphenol, isolated from the plant turmeric of Curcuma longa. Curcuma longa has always been used in traditional medicine in Asian countries because it is believed to have numerous health benefits. Nowadays it is widely used as spice component and in emerging nutraceutical food worldwide. Numerous studies have shown that curcumin possesses, among others, potential anti-inflammatory properties. Obesity represents a main risk factor for several chronic diseases, including type 2 diabetes, cardiovascular disease, and some types of cancer. The establishment of a low-grade chronic inflammation, both systemically and locally in adipose tissue, occurring in obesity most likely represents a main factor in the pathogenesis of chronic diseases. The molecular mechanisms responsible for the onset of the obesity-associated inflammation are different from those involved in the classic inflammatory response caused by infections and involves different signaling pathways. The inflammatory process in obese people is triggered by an inadequate intake of nutrients that produces quantitative and qualitative alterations of adipose tissue lipid content, as well as of various molecules that act as endogenous ligands to activate immune cells. In particular, dysfunctional adipocytes secrete inflammatory cytokines and chemokines, the adipocytokines, able to recruit immune cells into adipose tissue, amplifying the inflammatory response also at systemic level. This review summarizes the most recent studies focused at elucidating the molecular targets of curcumin activity responsible for its anti-inflammatory properties in obesity-associated inflammation and related pathologies.

scholarly journals Modulation of the inflammatory response to LPS by the recruitment and activation of brown and brite adipocytes in mice

2020 ◽  
Vol 319 (5) ◽  
pp. E912-E922
Author(s):  
Patrick Munro ◽  
Océane Dufies ◽  
Samah Rekima ◽  
Agnès Loubat ◽  
Christophe Duranton ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Inflammatory Response ◽  
Low Grade ◽  
Inflammatory Phenotype ◽  
Anti Inflammatory ◽  
And Function

Recruitment and activation of brown and brite adipocytes in the adipose tissue of mice lead to a local low-grade anti-inflammatory phenotype in response to acute endotoxemia without alteration of adipocyte phenotype and function.

scholarly journals Mechanisms and Effect of Coptidis Rhizoma on Obesity-Induced Inflammation: In Silico and In Vivo Approaches

2021 ◽  
Vol 22 (15) ◽  
pp. 8075
Author(s):  
Oh-Jun Kwon ◽  
Ji-Won Noh ◽  
Byung-Cheol Lee
Keyword(s):  
Adipose Tissue ◽  
Inflammatory Cytokines ◽  
Tolerance Test ◽  
Control Group ◽  
Low Grade ◽  
Cytokines And Chemokines ◽  
Epididymal Fat ◽  
Coptidis Rhizoma ◽  
Anti Inflammatory

Obesity is characterized as a chronic, low-grade inflammation state accompanied by the infiltration of immune cells into adipose tissue and higher levels of inflammatory cytokines and chemokines. This study aimed to investigate the mechanisms and effects of Coptidis Rhizoma (CR) on obesity and its associated inflammation. First, we applied a network pharmacology strategy to search the target genes and pathways regulated by CR in obesity. Next, we performed in vivo experiments to confirm the antiobesity and anti-inflammatory effects of CR. Mice were assigned to five groups: normal chow (NC), control (high-fat diet (HFD)), HFD + CR 200 mg/kg, HFD + CR 400 mg/kg, and HFD + metformin 200 mg/kg. After 16 weeks of the experimental period, CR administration significantly reduced the weight of the body, epididymal fat, and liver; it also decreased insulin resistance, as well as the area under the curve of glucose in the oral glucose tolerance test and triglyceride in the oral fat tolerance test. We observed a decrease in adipose tissue macrophages (ATMs) and inflammatory M1 ATMs, as well as an increase in anti-inflammatory M2 ATMs. Gene expression levels of inflammatory cytokines and chemokines, including tumor necrosis factor-α, F4/80, and C-C motif chemokine (CCL)-2, CCL4, and CCL5, were suppressed in adipose tissue in the CR groups than levels in the control group. Additionally, histological analyses suggested decreased fat accumulation in the epididymal fat pad and liver in the CR groups than that in the control group. Taken together, these results suggest that CR has a therapeutic effect on obesity-induced inflammation, and it functions through the inhibition of macrophage-mediated inflammation in adipose tissue.

scholarly journals Polar Curcuma longa extract inhibits leptin release by adipose tissue derived from overweight and obese people

2017 ◽  
Vol 15 (3) ◽  
pp. 244-249 ◽  
Author(s):  
Sa’ad Al-Lahham ◽  
Ashraf Sawafta ◽  
Nidal Jaradat ◽  
Fouad Nafaa ◽  
Abdelkarem Barqawi ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Curcuma Longa ◽  
Inhibitory Effect ◽  
Inflammatory Factors ◽  
Enzyme Linked Immunosorbent Assay ◽  
Morbidly Obese ◽  
Low Grade ◽  
Obese People ◽  
Subcutaneous Adipose ◽  
Low Grade Inflammation

Obesity escalates at an alarming rate worldwide. It is associated with chronic low-grade inflammation, which is implicated in the pathogenesis of type 2 diabetes and cardiovascular diseases. Adipose tissue is a primary site of obesity-induced pro-inflammatory factors such as leptin. Curcuminoids are potent anti-inflammatory agents; however, evidence on the polar fraction of Curcuma longa is scarce and the effect on leptin release has never been investigated. Therefore, we will investigate the influence of aqueous C. longa extract on leptin release from human subcutaneous adipose tissue (SAT). To achieve this, SAT explants were obtained from patients who underwent abdominal surgery. Patients were both males (67%) and females (33%). Their average body mass index (BMI) and age were 33.4 kg/m2 and 43 years, respectively. Tissue explants were treated in triplicate with or without 0.1 and 1 mg/mL aqueous C. longa extracts and incubated for 24 and 48 h. Enzyme-linked immunosorbent assay (ELISA) was used to determine the concentration of leptin secreted by SAT. We have shown that 24 h treatment of SAT with 0.1 and 1 mg/mL of C. longa polar extract inhibited the release of leptin, while 48 h treatment of SAT with only 1 mg/mL of C. longa polar extract inhibited leptin release. Concentration of basal leptin released from SAT derived from females was higher than from males. However, this could be because females were morbidly obese. Our data demonstrate for the first time the inhibitory effect of aqueous C. longa extract on leptin release, shedding light on the role of leptin and adipose tissue in the mechanism of C. longa in reducing low-grade inflammation. This avoids the poor solubility and consequently the low bioavailability disadvantages of curcuminoids.

scholarly journals Adipocyte, Immune Cells, and miRNA Crosstalk: A Novel Regulator of Metabolic Dysfunction and Obesity

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1004
Author(s):  
Sonia Kiran ◽  
Vijay Kumar ◽  
Santosh Kumar ◽  
Robert L Price ◽  
Udai P. Singh
Keyword(s):  
Insulin Resistance ◽  
Immune Response ◽  
T Cells ◽  
Immune Cells ◽  
Metabolic Diseases ◽  
Liver Disorder ◽  
Low Grade ◽  
Peripheral Tissues ◽  
Nonalcoholic Fatty Liver ◽  
Cytokines And Chemokines

Obesity is characterized as a complex and multifactorial excess accretion of adipose tissue (AT) accompanied with alterations in the immune response that affects virtually all age and socioeconomic groups around the globe. The abnormal accumulation of AT leads to several metabolic diseases, including nonalcoholic fatty liver disorder (NAFLD), low-grade inflammation, type 2 diabetes mellitus (T2DM), cardiovascular disorders (CVDs), and cancer. AT is an endocrine organ composed of adipocytes and immune cells, including B-Cells, T-cells and macrophages. These immune cells secrete various cytokines and chemokines and crosstalk with adipokines to maintain metabolic homeostasis and low-grade chronic inflammation. A novel form of adipokines, microRNA (miRs), is expressed in many developing peripheral tissues, including ATs, T-cells, and macrophages, and modulates the immune response. miRs are essential for insulin resistance, maintaining the tumor microenvironment, and obesity-associated inflammation (OAI). The abnormal regulation of AT, T-cells, and macrophage miRs may change the function of different organs including the pancreas, heart, liver, and skeletal muscle. Since obesity and inflammation are closely associated, the dysregulated expression of miRs in inflammatory adipocytes, T-cells, and macrophages suggest the importance of miRs in OAI. Therefore, in this review article, we have elaborated the role of miRs as epigenetic regulators affecting adipocyte differentiation, immune response, AT browning, adipogenesis, lipid metabolism, insulin resistance (IR), glucose homeostasis, obesity, and metabolic disorders. Further, we will discuss a set of altered miRs as novel biomarkers for metabolic disease progression and therapeutic targets for obesity.

scholarly journals The α7-nicotinic receptor is upregulated in immune cells from HIV-seropositive women: consequences to the cholinergic anti-inflammatory response

2015 ◽  
Vol 4 (12) ◽  
pp. e53 ◽  
Author(s):  
Manuel Delgado-Vélez ◽  
Carlos A Báez-Pagán ◽  
Yamil Gerena ◽  
Orestes Quesada ◽  
Laura I Santiago-Pérez ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Immune Cells ◽  
Nicotinic Receptor ◽  
Anti Inflammatory ◽  
Hiv Seropositive

scholarly journals Decreased TLR3 in Hyperplastic Adipose Tissue, Blood and Inflamed Adipocytes is Related to Metabolic Inflammation

2018 ◽  
Vol 51 (3) ◽  
pp. 1051-1068 ◽  
Author(s):  
Jèssica Latorre ◽  
José M. Moreno-Navarrete ◽  
Mónica Sabater ◽  
Maria Buxo ◽  
José I. Rodriguez-Hermosa ◽  
...  
Keyword(s):  
Weight Loss ◽  
Adipose Tissue ◽  
Low Grade ◽  
Metabolic Inflammation ◽  
Fat Depots ◽  
Acute Surgery ◽  
Obese Subjects ◽  
Anti Inflammatory ◽  
The Impact

Background/Aims: Obesity is characterized by the immune activation that eventually dampens insulin sensitivity and changes metabolism. This study explores the impact of different inflammatory/ anti-inflammatory paradigms on the expression of toll-like receptors (TLR) found in adipocyte cultures, adipose tissue, and blood. Methods: We evaluated by real time PCR the impact of acute surgery stress in vivo (adipose tissue) and macrophages (MCM) in vitro (adipocytes). Weight loss was chosen as an anti-inflammatory model, so TLR were analyzed in fat samples collected before and after bariatric surgery-induced weight loss. Associations with inflammatory and metabolic parameters were analyzed in non-obese and obese subjects, in parallel with gene expression measures taken in blood and isolated adipocytes/ stromal-vascular cells (SVC). Treatments with an agonist of TLR3 were conducted in human adipocyte cultures under normal conditions and upon conditions that simulated the chronic low-grade inflammatory state of obesity. Results: Surgery stress raised TLR1 and TLR8 in subcutaneous (SAT), and TLR2 in SAT and visceral (VAT) adipose tissue, while decreasing VAT TLR3 and TLR4. MCM led to increased TLR2 and diminished TLR3, TLR4, and TLR5 expressions in human adipocytes. The anti-inflammatory impact of weight loss was concomitant with decreased TLR1, TLR3, and TLR8 in SAT. Cross-sectional associations confirmed increased V/ SAT TLR1 and TLR8, and decreased TLR3 in obese patients, as compared with non-obese subjects. As expected, TLR were predominant in SVC and adipocyte precursor cells, even though expression of all of them but TLR8 (very low levels) was also found in ex vivo isolated and in vitro differentiated adipocytes. Among SVC, CD14+ macrophages showed increased TLR1, TLR2, and TLR7, but decreased TLR3 mRNA. The opposite patterns shown for TLR2 and TLR3 in V/ SAT, SVC, and inflamed adipocytes were observed in blood as well, being TLR3 more likely linked to lymphocyte instead of neutrophil counts. On the other hand, decreased TLR3 in adipocytes challenged with MCM dampened lipogenesis and the inflammatory response to Poly(I:C). Conclusion: Functional variations in the expression of TLR found in blood and hypertrophied fat depots, namely decreased TLR3 in lymphocytes and inflamed adipocytes, are linked to metabolic inflammation.

Immunology of Eating Disorders

2018 ◽  
pp. 241-250
Author(s):  
Adaliene Versiani Matos Ferreira ◽  
Laís Bhering Martins ◽  
Nayara Mussi Monteze ◽  
Geneviève Marcelin ◽  
Karine Clément
Keyword(s):  
Eating Disorders ◽  
Body Weight ◽  
Anorexia Nervosa ◽  
Immune Cells ◽  
Eating Behaviors ◽  
Viral Infections ◽  
Low Grade ◽  
Obese People ◽  
Obese Subjects ◽  
Low Grade Inflammation

Eating disorders (EDs) are characterized by dysregulation in eating behavior leading to extreme increase or decrease in food intake that, in turn, changes body weight, adiposity, and physical health. Anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED) are the three major eating disorders. Peculiar immune abnormalities occur in these conditions. Previous studies have reported a higher number of CD4+ T lymphocytes in patients with AN, which are related to a relative resistance to viral infections, even in the presence of leukopenia. It has also been proposed that a cluster of cytokines is altered in these patients. A chronic low-grade inflammation has been observed in obese people with BED and in patients with AN, but with a different profile in each condition. In this context, antagonist drugs of specific cytokines, such as anti-TNF, showed improvement of AN-related symptoms, but increased weight gain in obese subjects. The identification of specific molecules and/or immune cells that impair neuronal circuits implicated in eating behaviors may contribute to the development of pharmacological strategies for eating disorders.

scholarly journals Adiponectin as Link Factor between Adipose Tissue and Cancer

2019 ◽  
Vol 20 (4) ◽  
pp. 839 ◽  
Author(s):  
Erika Di Zazzo ◽  
Rita Polito ◽  
Silvia Bartollino ◽  
Ersilia Nigro ◽  
Carola Porcile ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Immune Cells ◽  
Active Role ◽  
Low Grade ◽  
Poor Clinical Outcome ◽  
Different Types ◽  
Obesity And Cancer ◽  
Low Grade Inflammation ◽  
Circulating Levels ◽  
Proliferation And Invasion

Adipose tissue is a key regulator of energy balance playing an active role in lipid storage as well as in synthesizing several hormones directly involved in the pathogenesis of obesity. Obesity represents a peculiar risk factor for a growing list of cancers and is frequently associated to poor clinical outcome. The mechanism linking obesity and cancer is not completely understood, but, amongst the major players, there are both chronic low-grade inflammation and deregulation of adipokines secretion. In obesity, the adipose tissue is pervaded by an abnormal number of immune cells that create an inflammatory environment supporting tumor cell proliferation and invasion. Adiponectin (APN), the most abundant adipokine, shows anti-inflammatory, anti-proliferative and pro-apoptotic properties. Circulating levels of APN are drastically decreased in obesity, suggesting that APN may represent the link factor between obesity and cancer risk. The present review describes the recent advances on the involvement of APN and its receptors in the etiology of different types of cancer.

scholarly journals Hydroalcoholic extract from Origanum vulgare induces a combined anti-mycobacterial and anti-inflammatory response in innate immune cells

PLoS ONE ◽  
2019 ◽  
Vol 14 (3) ◽  
pp. e0213150 ◽  
Author(s):  
Federica De Santis ◽  
Noemi Poerio ◽  
Angelo Gismondi ◽  
Valentina Nanni ◽  
Gabriele Di Marco ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Immune Cells ◽  
Innate Immune ◽  
Innate Immune Cells ◽  
Origanum Vulgare ◽  
Hydroalcoholic Extract ◽  
Anti Inflammatory
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