scholarly journals Plasma B Vitamers: Population Epidemiology and Parent-Child Concordance in Children and Adults

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 821
Author(s):  
Stephanie Andraos ◽  
Beatrix Jones ◽  
Clare Wall ◽  
Eric Thorstensen ◽  
Martin Kussmann ◽  
...  

Scope: B vitamers are co-enzymes involved in key physiological processes including energy production, one-carbon, and macronutrient metabolism. Studies profiling B vitamers simultaneously in parent–child dyads are scarce. Profiling B vitamers in parent–child dyads enables an insightful determination of gene–environment contributions to their circulating concentrations. We aimed to characterise: (a) parent–child dyad concordance, (b) generation (children versus adults), (c) age (within the adult subgroup (age range 28–71 years)) and (d) sex differences in plasma B vitamer concentrations in the CheckPoint study of Australian children. Methods and Results: 1166 children (11 ± 0.5 years, 51% female) and 1324 parents (44 ± 5.1 years, 87% female) took part in a biomedical assessment of a population-derived longitudinal cohort study: The Growing Up in Australia’s Child Health CheckPoint. B vitamer levels were quantified by UHPLC/MS-MS. B vitamer levels were weakly concordant between parent–child pairs (10–31% of variability explained). All B vitamer concentrations exhibited generation-specificity, except for flavin mononucleotide (FMN). The levels of thiamine, pantothenic acid, and 4-pyridoxic acid were higher in male children, and those of pantothenic acid were higher in male adults compared to their female counterparts. Conclusion: Family, age, and sex contribute to variations in the concentrations of plasma B vitamers in Australian children and adults.

1997 ◽  
Vol 78 (01) ◽  
pp. 457-461 ◽  
Author(s):  
S E Humphries ◽  
A Panahloo ◽  
H E Montgomery ◽  
F Green ◽  
J Yudkin

1970 ◽  
Vol 6 (1) ◽  
pp. 184-193
Author(s):  
Ольга Віговська

У статті теоретично обґрунтовано феномен конструктивного самозбереження особистості як ознаки самоактуалізації, розкриття власного потенціалу і побудови перспективи розвитку особистості та емпірично виявлено ознаки психологічної детермінації домінуючого інстинкту у конструктивній самореалізації жінок з різним соціальним статусом. Зазначено, що проблема самозбереження асоціюється з особливостями прояву інстинкту самозбереження людини, але потреби вищого порядку зумовлюють соціальну природу її поведінки, яка локалізована у найвищій точці самореалізації. Теоретично обгрунтовано, що самореалізація визначає тенденцію раціональної організації життя людини та проявляється у її почутті задоволеністю життям. З’ясовано, що психологічну основу конструктивного самозбереження становлять індивідуально-типологічні характеристики людини, які відображають психофізіологічні та психосоціальні резерви самореалізації особистості. Розроблена програма емпіричного дослідження, а також комплекс використаних методів математичної обробки результатів дослідження дає змогу конкретизувати психологічний зміст детермінації домінуючого інстинкту у конструктивній самореалізації жінок вікового діапазону 35-45 років та з різним соціальним статусом. У жінок, які виховують проблемну (хвору) дитину, домінує інстинкт "егофільного типу", що виражається у їх надмірному егоцентризмі і супроводжується низькими показниками самоактуалізації, на відміну від досліджуваних жінок, які виховують здорових дітей і у яких на фоні вираженої тенденції до самоактуалізації домінує базовий інстинкт "дослідницького типу" та "лібертофільного типу". This article theoretically proves constructive phenomenon of self identity as signs of self-disclosure own potential and prospects of development of individual construction. In addition, it empirically showes signs of psychological determination of the dominant instinct in a constructive self-determination of women with different social statuses. It was noted that the issue of self-preservation is associated with the peculiarities of manifestation of self-preservation instinct of man, but it needs higher-order cause social nature of the behavior that is localized at the highest point of self-realization. It theorized that self-realization determines the trend of rational organization of human life and manifests itself in its sense of life satisfaction. It was found that the psychological basis of constructive self-preservation of the individual make individually-typological characteristics of a person that reflect physiological and psychosocial reserves of self-realization. The developed program of empirical research, as well as the methods used complex mathematical processing of results of research allows to specify the content of the psychological determination of the dominant instinct of constructive self-realization а women age range of 35-45 years and with different social status. Women who bring up the problem child dominates the instinct of self-preservation, which is reflected in their excessive self-centeredness, and is accompanied by low levels of self-actualization, as opposed to the study of women who are raising healthy children and that against the backdrop of a pronounced tendency to self-actualization, dominated by basic instinct "research type" and "independent type."


Author(s):  
Paul H. Yi ◽  
Jinchi Wei ◽  
Tae Kyung Kim ◽  
Jiwon Shin ◽  
Haris I. Sair ◽  
...  

1990 ◽  
Vol 10 (4) ◽  
pp. 439-448 ◽  
Author(s):  
Won O. Song ◽  
Allen Smith ◽  
Carl Wittwer ◽  
Bonita Wyse ◽  
Gaurth Hansen

1998 ◽  
Vol 80 (08) ◽  
pp. 298-301 ◽  
Author(s):  
Andreas Ruf ◽  
Axel Vogt ◽  
Christoph Lichy ◽  
Florian Buggle ◽  
Heinrich Patscheke ◽  
...  

SummaryDetermination of circulating activated platelets may be helpful to estimate the prognosis and to stratify therapies in arterial vascular disorders including stroke. We used flow cytometry and phase contrast microscopy to study whether the fraction of platelets expressing p-selectin and CD63 and the fraction of platelets with shape change are increased in patients with acute and previous cerebrovascular ischemia.The proportion of platelets expressing activation dependent antigens was higher in patients with acute (n = 24; p-selectin: 8.23 ± 4.21%; CD63: 3.53 ± 2.53%) and with previous cerebrovascular ischemia (n = 46; 3.86 ± 1.98%; 2.80 ± 1.79%) as compared to age- and sex-matched control subjects (n = 35; 2.17 ± 0.96%; 1.79 ± 0.75%; p ≤0.005, respectively). In patients with previous ischemia, there was no difference between treatment with aspirin (n = 25) or phenprocoumon (n = 21). Hypertension, diabetes mellitus and smoking were not associated with increased antigen expression (analysis of variance). The fraction of discoid platelets and platelet counts were not significantly different between groups.Our results indicate increased expression of platelet neoantigens in acute and to a less degree in previous cerebrovascular ischemia. Ongoing platelet activation after cerebrovascular ischemia despite therapy with aspirin or phenprocoumon indicates that new anti-platelet drugs may be of benefit for these patients. Flow cytometry appears to be a useful tool to assess platelet function in cerebrovascular ischemia.


2017 ◽  
Vol 205 ◽  
pp. 781-789 ◽  
Author(s):  
Ahmad Sedaghat ◽  
Arash Hassanzadeh ◽  
Jamaloddin Jamali ◽  
Ali Mostafaeipour ◽  
Wei-Hsin Chen

2000 ◽  
Vol 9 (2) ◽  
pp. 124-130 ◽  
Author(s):  
Candace Bourland Hicks ◽  
Anne Marie Tharpe ◽  
Daniel H. Ashmead

The determination of auditory thresholds by means of behavioral techniques in young infants can be difficult. This could be the result of limitations in methodology, a lack of observable auditory responsiveness, or both. In the current study, 2- and 4-month old infants were tested under enhanced conditions for obtaining behavioral responses (i.e., salient auditory stimuli, reduced visual distractions, reinforced correct responses). A two-interval, forced-choice task with four intensity levels was used. Although a behavioral threshold was obtained for the 4-month-olds, threshold determination for the 2-month-olds remained elusive. In light of the current findings and previous studies of visual acuity of infants, these results suggest a lack of behavioral responsiveness to auditory stimuli for the younger infants rather than methodological limitations. With infants in the 2-month-old age range, clinical audiologists should expect few behavioral responses to auditory stimuli at intensity levels below those that elicit startle responses.


Parasitology ◽  
1987 ◽  
Vol 94 (2) ◽  
pp. 399-404 ◽  
Author(s):  
P. Vogel ◽  
D. A. P. Bundy

SUMMARYThe Jamaican iguanid lizard Anolis lineatopus is the host of 4 species of helminth parasite: an acanthocephalan (Centrorhynchus spinosus), a digenean (Mesocoelium danforthi), and 2 nematodes (Cyrtosumum scelopori and Thelandros (?cubensis). Prevalance of C. spinosus was unrelated to host age but was considerably higher in males (43%) than in females (10%). The intensity increased with host age: (range: 1–23, median: 3). Prevalence of C. scelopori increased with host age in both sexes: juveniles (<3 months) were uninfected while infection occurred in almost all lizards older than 9 months. Intensity was higher in males (range: 1–403, median: 158) than in females (range: 1–297, median: 86). The infection patterns of C. spinosus and C. scelopori differed significantly from each other and were not consistent with a simplistic direct relationship between time of exposure and infection prevalence. Acanthocephalan and digenean infections occurred at low prevalence and intensity although prevalence in older, larger lizards tended to be higher than in younger, smaller ones.


2007 ◽  
Vol 121 (6) ◽  
pp. 745-757 ◽  
Author(s):  
Yuan-De Tan ◽  
Myriam Fornage ◽  
Varghese George ◽  
Hongyan Xu

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