scholarly journals Low-Carbohydrate High-Fat Diet and Exercise: Effect of a 10-Week Intervention on Body Composition and CVD Risk Factors in Overweight and Obese Women—A Randomized Controlled Trial

Nutrients ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 110
Author(s):  
Thorhildur Ditta Valsdottir ◽  
Bente Øvrebø ◽  
Thea Martine Falck ◽  
Sigbjørn Litleskare ◽  
Egil Ivar Johansen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Weight Loss ◽  
Body Composition ◽  
High Fat Diet ◽  
Normal Diet ◽  
Obese Women ◽  
High Fat ◽  
Post Intervention ◽  
Diet And Exercise ◽  
Low Carbohydrate

We assessed the effect of weight-loss induced with a low-carbohydrate-high-fat diet with and without exercise, on body-composition, cardiorespiratory fitness and cardiovascular risk factors. A total of 57 overweight and obese women (age 40 ± 3.5 years, body mass index 31.1 ± 2.6 kg∙m−2) completed a 10-week intervention using a low-carbohydrate-high-fat diet, with or without interval exercise. An equal deficit of 700 kcal∙day−1 was prescribed, restricting diet only, or moderately restricting diet and adding exercise, producing four groups; normal diet (NORM); low-carbohydrate-high-fat diet (LCHF); normal diet and exercise (NORM-EX); and low-carbohydrate-high-fat diet and exercise (LCHF-EX). Linear Mixed Models were used to assess between-group differences. The intervention resulted in an average 6.7 ± 2.5% weight-loss (p < 0.001). Post-intervention % fat was lower in NORM-EX than NORM (40.0 ± 4.2 vs. 43.5 ± 3.5%, p = 0.024). NORM-EX reached lower values in total cholesterol than NORM (3.9 ± 0.6 vs. 4.7 ± 0.7 mmol/L, p = 0.003), and LCHF-EX (3.9 ± 0.6 vs. 4.9 ± 1.1 mmol/L, p = 0.004). Post intervention triglycerides levels were lower in NORM-EX than NORM (0.87 ± 0.21 vs. 1.11 ± 0.34 mmol/L, p = 0.030). The low-carbohydrate-high-fat diet had no superior effect on body composition, V˙O2peak or cardiovascular risk factors compared to a normal diet, with or without exercise. In conclusion, the intervention decreased fat mass, but exercise improved body composition and caused the most favorable changes in total cholesterol and triglycerides in the NORM-EX. Exercise increased cardiorespiratory fitness, regardless of diet.

Multimodal measurement of body composition change with diet- and exercise-induced weight loss in obese women

2011 ◽  
Vol 35 (2) ◽  
pp. 204-205
Author(s):  
A.R. Josse ◽  
S.A. Atkinson ◽  
M.A. Tarnopolsky ◽  
H. Azizian ◽  
J.K.G. Kramer ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Composition ◽  
Obese Women ◽  
Composition Change ◽  
Body Composition Change ◽  
Diet And Exercise ◽  
Exercise Induced

scholarly journals α-Methyl-L-Tryptophan as a Weight-Loss Agent in Multiple Models of Obesity in Mice

2021 ◽  
Author(s):  
Sathish Sivaprakasam ◽  
Sabarish Ramachandran ◽  
Mohd Omar Faruk Sikder ◽  
Yangzom Doma Bhutia ◽  
Mitchell Wachtel ◽  
...  
Keyword(s):  
Weight Loss ◽  
High Fat Diet ◽  
Amino Acid Profile ◽  
Normal Diet ◽  
The Body ◽  
Multiple Models ◽  
High Fat ◽  
Liver And Kidney ◽  
Obesity In Mice ◽  
Treatment Of Obesity

a-Methyl-L-tryptophan (a-MLT) is currently in use as a tracer in its 11C-labeled form to monitor the health of serotonergic neurons in humans. In the present study, we found this compound to function as an effective weight-loss agent at pharmacological doses in multiple models of obesity in mice. The drug was able to reduce the body weight when given orally in drinking water (1 mg/ml) in three different models of obesity: normal mice on high-fat diet, Slc6a14-null mice on high-fat diet, and ob/ob mice on normal diet. Only the L-enantiomer (a-MLT) was active while the D-enantiomer (a-MDT) had negligible activity. The weight-loss effect was freely reversible, with the weight gain resuming soon after the withdrawal of the drug. All three models of obesity were associated with hyperglycemia, insulin resistance, and hepatic steatosis; a-MLT reversed these features. There was a decrease in food intake in the treatment group. Mice on a high-fat diet showed decreased cholesterol and protein in the serum when treated with a-MLT; there was however no evidence of liver and kidney dysfunction. Plasma amino acid profile indicated a significant decrease in the levels of specific amino acids, including tryptophan; but the levels of arginine were increased. We conclude that a-MLT is an effective, reversible, and orally active drug for the treatment of obesity and metabolic syndrome.

scholarly journals Influence of sex, high-fat diet, and exercise training on potassium currents of swine coronary smooth muscle

2007 ◽  
Vol 293 (3) ◽  
pp. H1553-H1563 ◽  
Author(s):  
Yan Yang ◽  
Allan W. Jones ◽  
Tom R. Thomas ◽  
Leona J. Rubin
Keyword(s):  
Smooth Muscle ◽  
Exercise Training ◽  
High Fat Diet ◽  
Normal Diet ◽  
High Fat ◽  
Coronary Smooth Muscle ◽  
Endothelin 1 ◽  
Beneficial Effects ◽  
Diet And Exercise ◽  
Males And Females

Potassium channels in vascular smooth muscle (VSM) control vasodilation and are potential regulatory targets. This study evaluated effects of sex differences, exercise training (EX), and high-fat diet (HF) on K+ currents ( IK) of coronary VSM cells. Yucatan male and female swine were assigned to either sedentary confinement (SED), 16 wk of EX, 20 wk of HF, or 20 wk of HF with 16 wk of EX (HF-EX). VSM cells of normal-diet SED animals exhibited three components of IK: 4-aminopyridine-sensitive IK(KV), TEA-sensitive IK(BK), and 4-aminopyridine + TEA-insensitive IK. Females exhibited significantly higher basal IK than males in the same group. EX increased basal IK in males and females. HF reduced IK in males and females and nullified effects of EX. Endothelin-1 increased IK significantly in males but not in females. In the presence of endothelin-1, 1) IK(KV) was similar in SED males and females and EX increased IK(KV) to a greater extent in males than in females and 2) IK(BK) was greater in SED females than in males and EX increased IK(BK) to a greater extent in males, resulting in IK(BK) similar to EX females. Importantly, HF nullified effects of EX on IK(KV) and IK(BK). These data indicate that basal IK of SED female swine is inherently greater than that shown in SED males and that males require EX to achieve comparable levels of IK. Importantly, HF reduced IK in males and females and nullified effects of EX, suggesting HF abrogates beneficial effects of EX on coronary smooth muscle.

Sequential Diets and Weight loss: Including a Low Carbohydrate High Fat Diet With and Without Time Restricted Feeding

Nutrition ◽  
2021 ◽  
pp. 111393
Author(s):  
Rebecca A.G. Christensen ◽  
Sasha High ◽  
Sean Wharton ◽  
Elham Kamran ◽  
Maral Dehlehhosseinzadeh ◽  
...  
Keyword(s):  
Weight Loss ◽  
High Fat Diet ◽  
Restricted Feeding ◽  
High Fat ◽  
Low Carbohydrate

scholarly journals High-Intensity Interval Training Does Not Change Vaspin and Omentin and Does Not Reduce Visceral Adipose Tissue in Obese Rats

2021 ◽  
Vol 12 ◽  
Author(s):  
Leandro Ribeiro Costa ◽  
Cynthia Aparecida de Castro ◽  
Diego Adorna Marine ◽  
Fernando Fabrizzi ◽  
Vanessa de Oliveira Furino ◽  
...  
Keyword(s):  
Body Composition ◽  
Adipose Tissue ◽  
High Fat Diet ◽  
Interval Training ◽  
Normal Diet ◽  
High Intensity Interval Training ◽  
High Fat ◽  
Obese Rats ◽  
High Intensity Interval ◽  
Visceral Adipose

This study aimed to determine the expression of omentin and vaspin, inflammatory markers, body composition, and lipid profile in diet-induced obese rats and high-intensity interval training (HIIT). Forty Wistar rats were divided into four groups: untrained normal diet, trained normal diet (T-ND), untrained high-fat diet (Unt-HFD), and trained high-fat diet (T-HFD). For the animals of the Unt-HFD and T-HFD groups, a high-fat diet was offered for 4 weeks. After that, all the animals in the T-ND and T-HFD groups were submitted to HITT, three times per week, for 10 weeks (2 weeks of adaptation and 8 weeks of HIIT). Muscle (gastrocnemius), liver, epididymal adipose tissue, retroperitoneal adipose tissue, visceral adipose tissue (VAT), and serum were collected to analyze TNF-α, IL-6, PCR, IL-8, IL-10, IL-4, vaspin, and omentin. A body composition analysis was performed before adaptation to HIIT protocol and after the last exercise session using dual-energy X-ray absorptiometry. Omentin and vaspin in the VAT were quantified using Western blotting. The results showed that, when fed a high-fat diet, the animals obtained significant gains in body fat and elevated serum concentrations of vaspin and blood triglycerides. The HIIT was able to minimize body fat gain but did not reduce visceral fat despite the increase in maximum exercise capacity. Moreover, there was a reduction in the serum levels of adiponectin, IL-6, and IL-10. Finally, we concluded that, although the training protocol was able to slow down the weight gain of the animals, there was no reduction in visceral fat or an improvement in the inflammatory profile, including no changes in omentin and vaspin.

scholarly journals Daily physical activity and macronutrient distribution of low-calorie diets jointly affect body fat reduction in obese women

2009 ◽  
Vol 34 (4) ◽  
pp. 595-602 ◽  
Author(s):  
Constanza Matilde López-Fontana ◽  
Almudena Sánchez-Villegas ◽  
Miguel Angel Martínez-Gonzalez ◽  
José Alfredo Martinez
Keyword(s):  
Physical Activity ◽  
Body Composition ◽  
Body Fat ◽  
High Fat Diet ◽  
Fat Distribution ◽  
Obese Women ◽  
High Fat ◽  
Low Fat ◽  
Low Fat Diet ◽  
Composition Changes

Inadequate dietary patterns and sedentary lifestyles are believed to be important factors in predisposing people to obesity. This study analyzed the potential interaction between habitual physical activity and the carbohydrate (CHO)-fat distribution in 2 hypocaloric diets and the impact of such interplay on body composition changes. Forty healthy obese women, 20–50 years old, were randomly assigned to a high- or low-CHO energy-restricted diet, which was low or high in fat, respectively, during 10 weeks. Baseline and final measurements were performed to assess dietary habits, resting metabolic rate, and body composition changes. Physical activity was measured with a triaxial accelerometer and with a questionnaire. There were no significant differences in anthropometric and metabolic variables between both dietary groups at baseline. However, there was a positive correlation between total free-living physical activity and arm muscle preservation after 10 weeks (r = 0.371; p = 0.024). Interestingly, an interaction between macronutrient (CHO–fat distribution) intake and physical activity was found, since less-active subjects with a high-CHO–low-fat diet showed a greater fat loss than those more active with a lower-CHO–high-fat diet, whereas more-active subjects with a high-CHO–low-fat diet showed a smaller fat loss than those receiving a low-CHO–high-fat diet. Physical activity and the macronutrient content of energy-restricted diets, when designed to promote body fat mass reduction, should be considered together to better predict the outcome.

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