scholarly journals Food Timing, Circadian Rhythm and Chrononutrition: A Systematic Review of Time-Restricted Eating’s Effects on Human Health

Nutrients ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3770
Author(s):  
Réda Adafer ◽  
Wassil Messaadi ◽  
Mériem Meddahi ◽  
Alexia Patey ◽  
Abdelmalik Haderbache ◽  
...  
Keyword(s):  
Weight Loss ◽  
Human Health ◽  
Caloric Intake ◽  
Metabolic Effects ◽  
Adherence Rate ◽  
Average Weight ◽  
Human Populations ◽  
Daily Food ◽  
Intrinsic Effect ◽  
Improve Health

Introduction: Recent observations have shown that lengthening the daily eating period may contribute to the onset of chronic diseases. Time-restricted eating (TRE) is a diet that especially limits this daily food window. It could represent a dietary approach that is likely to improve health markers. The aim of this study was to review how time-restricted eating affects human health. Method: Five general databases and six nutrition journals were screened to identify all studies published between January 2014 and September 2020 evaluating the effects of TRE on human populations. Results: Among 494 articles collected, 23 were finally included for analysis. The overall adherence rate to TRE was 80%, with a 20% unintentional reduction in caloric intake. TRE induced an average weight loss of 3% and a loss of fat mass. This fat loss was also observed without any caloric restriction. Interestingly, TRE produced beneficial metabolic effects independently of weight loss, suggesting an intrinsic effect based on the realignment of feeding and the circadian clock. Conclusions: TRE is a simple and well-tolerated diet that generates many beneficial health effects based on chrononutrition principles. More rigorous studies are needed, however, to confirm those effects, to understand their mechanisms and to assess their applicability to human health.

The Effects of Imagery and Language Cognitive Strategies on Dietary Intake, Weight Loss, and Perception of Food

1995 ◽  
Vol 15 (2) ◽  
pp. 145-157
Author(s):  
Constance C. Kirk ◽  
David C. Griffey
Keyword(s):  
Weight Loss ◽  
Dietary Intake ◽  
Cognitive Strategies ◽  
Caloric Intake ◽  
Control Group ◽  
Average Weight ◽  
Cassette Tape ◽  
Daily Caloric Intake ◽  
Experimental Subjects ◽  
Experimental Group

Two forms of suggestion were practiced by a randomly assigned experimental group of twenty-seven volunteers, over a six week period, to determine the effects of suggestion on dietary intake, weight loss, and perception of food. One form of suggestion entailed reading a variety of written suggestions every time before eating and/or drinking. The other form was auditory; subjects listened to a fifteen minute cassette tape which led them through a variety of imagery suggestions. ANOVA, analysis of variance, was used to determine that the experimental group ( n = 27) experienced a significant average weight loss of 4.963 pounds ( p > .001) and decreased total daily caloric intake by approximately 200 calories per day; the control group ( n = 21) gained an average of one pound with a slight increase in daily caloric intake. Experimental subjects indicated that they were less anxious, less frustrated, and less depressed before eating a favorite food. They reported a lessening of liking foods that were harmful to them and experienced a diminution of their desire for eating such foods.

scholarly journals A very low carbohydrate ketogenic diet improves glucose tolerance in ob/ob mice independently of weight loss

2009 ◽  
Vol 297 (5) ◽  
pp. E1197-E1204 ◽  
Author(s):  
Michael K. Badman ◽  
Adam R. Kennedy ◽  
Andrew C. Adams ◽  
Pavlos Pissios ◽  
Eleftheria Maratos-Flier
Keyword(s):  
Gene Expression ◽  
Weight Loss ◽  
Ketogenic Diet ◽  
Glucose Homeostasis ◽  
Energy Homeostasis ◽  
Caloric Intake ◽  
Normal Weight ◽  
Metabolic Effects ◽  
Fibroblast Growth Factor 21 ◽  
Low Carbohydrate

In mice of normal weight and with diet-induced obesity, a high-fat, low-carbohydrate ketogenic diet (KD) causes weight loss, reduced circulating glucose and lipids, and dramatic changes in hepatic gene expression. Many of the effects of KD are mediated by fibroblast growth factor 21 (FGF21). We tested the effects of KD feeding on ob/ ob mice to determine if metabolic effects would occur in obesity secondarily to leptin deficiency. We evaluated the effect of prolonged KD feeding on weight, energy homeostasis, circulating metabolites, glucose homeostasis, and gene expression. Subsequently, we evaluated the effects of leptin and fasting on FGF21 expression in ob/ ob mice. KD feeding of ob/ ob mice normalized fasting glycemia and substantially reduced insulin and lipid levels in the absence of weight loss. KD feeding was associated with significant increases in lipid oxidative genes and reduced expression of lipid synthetic genes, including stearoyl-coenzyme A desaturase 1, but no change in expression of inflammatory markers. In chow-fed ob/ ob mice, FGF21 mRNA was elevated 10-fold compared with wild-type animals, and no increase from this elevated baseline was seen with KD feeding. Administration of leptin to chow-fed ob/ ob mice led to a 24-fold induction of FGF21. Fasting also induced hepatic FGF21 in ob/ ob mice. Thus, KD feeding improved ob/ ob mouse glucose homeostasis without weight loss or altered caloric intake. These data demonstrate that manipulation of dietary macronutrient composition can lead to marked improvements in metabolic profile of leptin-deficient obese mice in the absence of weight loss.

scholarly journals Key Genes of Lipid Metabolism and WNT-Signaling Are Downregulated in Subcutaneous Adipose Tissue with Moderate Weight Loss

Nutrients ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 639
Author(s):  
Ruth Schübel ◽  
Disorn Sookthai ◽  
Judith Greimel ◽  
Theron Johnson ◽  
Mirja Grafetstätter ◽  
...  
Keyword(s):  
Weight Loss ◽  
Adipose Tissue ◽  
Lipid Metabolism ◽  
Wnt Signaling ◽  
Subcutaneous Adipose Tissue ◽  
Metabolic Effects ◽  
Average Weight ◽  
Expression Of Genes ◽  
Post Hoc ◽  
Subcutaneous Adipose

Smaller cross-sectional studies and bariatric surgery trials suggest that weight loss may change the expression of genes in adipose tissue that have been implicated in the development of metabolic diseases, but well-powered intervention trials are lacking. In post hoc analyses of data from a 12-week dietary intervention trial initially designed to compare metabolic effects of intermittent vs. continuous calorie restriction, we analyzed the effects of overall weight loss on the subcutaneous adipose tissue (SAT) transcriptome. Changes in the transcriptome were measured by microarray using SAT samples of 138 overweight or obese individuals (age range: 35–65 years, BMI range: 25–40, non-smokers, non-diabetics). Participants were grouped post hoc according to the degree of their weight loss by quartiles (average weight loss in quartiles 1 to 4: 0%, −3.2%, −5.9%, and −10.7%). Candidate genes showing differential expression with weight loss according to microarray analyses were validated by reverse transcription quantitative polymerase chain reaction (RT-qPCR), and fold changes (FCs) were calculated to quantify differences in gene expression. A comparison of individuals in the highest vs. the lowest weight loss quartile revealed 681 genes to be differentially expressed (corrected p < 0.05), with 40 showing FCs of at least 0.4. Out of these, expression changes in secreted frizzled-related protein 2 (SFRP2, FC = 0.65, p = 0.006), stearoyl-CoA desaturase (SCD, FC = −1.00, p < 0.001), and hypoxia inducible lipid droplet-associated (HILPDA, FC = −0.45, p = 0.001) with weight loss were confirmed by RT-qPCR. Dietary weight loss induces significant changes in the expression of genes implicated in lipid metabolism (SCD and HILPDA) and WNT-signaling (SFRP2) in SAT.

scholarly journals MON-LB107 Treat: A Randomized Controlled Trial Examining the Effects of Time Restricted Eating on Weight Loss and Metabolic Markers

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Dylan A Lowe ◽  
Ethan James Weiss ◽  
Jeffrey E Olgin ◽  
Eric Vittinghoff ◽  
John A Shepherd ◽  
...  
Keyword(s):  
Weight Loss ◽  
Fat Mass ◽  
Weight Change ◽  
Controlled Trial ◽  
Randomized Study ◽  
Subcutaneous Fat ◽  
Caloric Intake ◽  
Fat Free Mass ◽  
Metabolic Effects ◽  
Control Group

Abstract Background: Studies indicate that time-restricted eating (TRE) can prevent weight gain and/or lead to weight loss [1,2]. The few human studies to date are small and/or non-randomized [3,4]. This is a prospective and randomized study in humans who are overweight and obese designed to determine if TRE leads to weight loss and to characterize the metabolic effects of TRE. Methods: 140 overweight and obese males and females with a body mass index between 27-43 kg/m2 were enrolled in the study. 100 participants completed the 12-week protocol. The study was conducted on a custom mobile study app on the Eureka Research Platform. Participants were given a Bluetooth weight scale to use daily, which was connected through the study app. Subjects were randomized to one of two eating plans and received daily reminders about their eating windows through the app. The control group was instructed to eat three structured meals per day. The TRE group was instructed to eat ad libitum from 12:00 pm until 8:00 pm and completely abstain from caloric intake from 8:00 pm until 12:00 pm the following day (16h fast:8h eat). Participants who lived within 60 miles of the study site were eligible to undergo extensive in-person metabolic testing. Results: Weight change in the TRE group was -1.3 kg compared to -0.6 kg in the control group (p=0.22). 46 (TRE n=22; control=24) of 50 participants who opted into the “in-person” visits completed all 4 visits. In that cohort, weight change in the TRE group was -1.62 kg compared to -0.57 kg in control (p=0.09). There were no significant differences in the changes in total fat mass, visceral or subcutaneous fat mass, waist or hip measurements, or resting metabolic rate. However, there was a trend towards reduced fat-free mass in the TRE group (-1.10kg) compared to controls (-0.35kg) (p=0.09). There was a significant change in the appendicular fat-free mass index of the TRE subjects compared to controls (p=0.011). This change in appendicular fat-free mass index was not associated with significant differences in strength measures. No changes were observed in plasma ketones, insulin, or glucose between treatment groups. Conclusion: These results indicate that TRE may lead to reductions in body weight in individuals who are overweight or obese. However, the majority of weight loss is attributed to reductions in fat-free mass rather than fat mass. Future analyses will determine if TRE leads to changes in metabolic blood markers or the plasma metabolome. References: 1.Hatori et al. Cell Metab. 2012 Jun 6;15(6):848-60. doi: 10.1016/j.cmet.2012.04.019. Epub 2012 May 17.2. Chaix et al. Cell Metab. 2019 Feb 5;29(2):303-319.e4. doi: 10.1016/j.cmet.2018.08.004. Epub 2018 Aug 30.3.Moro et al. J Transl Med. 2016 Oct 13;14(1):290.4.Wilkinson et al.Cell Metab. 2020 Jan 7;31(1):92-104.e5. doi: 10.1016/j.cmet.2019.11.004. Epub 2019 Dec 5.

Study of the properties larch and larch wood construction materials

2016 ◽  
Author(s):  
М.А. Чубинский ◽  
К.В. Чаузов
Keyword(s):  
Weight Loss ◽  
Urea Formaldehyde ◽  
Construction Materials ◽  
Siberian Larch ◽  
Larix Sibirica ◽  
Average Weight ◽  
Biological Stability ◽  
Laminated Beam ◽  
Coniophora Puteana ◽  
Larch Wood

Несмотря на огромные запасы, древесина лиственницы до сего времени в незначительных объемах используется в строительной индустрии, других отраслях экономики, что связано как с технологическими сложностями ее переработки, так и недостаточной изученностью ее свойств. Одним из уникальных свойств древесины лиственницы сибирской (Larix sibirica) является ее повышенная естественная биостойкость, наряду с максимально высокой среди отечественных хвойных пород прочностью. Стойкость древесины лиственницы (Larix sibirica) к воздействию дереворазрушающих грибов Coniofora puteana значительно превышает стойкость сосны. В среднем потеря массы ядровой древесины лиственницы сибирской под воздействием дереворазрушающего гриба Coniophora puteana составляет 14,84%, снижаясь с увеличением возраста дерева, а контрольные образцы из ядровой древесины сосны в возрасте 90 лет имели потерю массы 57,8%. Возраст дерева является одним из наиболее значимых факторов, влияющих на степень биостойкости древесины. По мере его увеличения значительно повышается устойчивость деструктивному воздействию дереворазрушающих грибов Coniophora puteana. Положение образцов также влияет на степень биостойкости древесины, однако эта зависимость слабо выражена по сравнению с влиянием возраста и плотности древесины. Исследования кинетики разложения древесины лиственницы сибирской и роли экстрактивных веществ в развитии дереворазрушающих грибов позволяют утверждать наличие связи биостойкости и содержания в древесине экстрактивных веществ. Для изготовления клееного бруса из древесины лиственницы предложена клеевая композиция, включающая карбамидомеламиноформальдегидный клей и карбамидоформальдегидную смолу, модифицированную шунгитами. Ее применение позволяет получать клеевые соединения, не уступающие по прочности при скалывании массивной древесине, как по сухому образцу, так и после его вымачивания. Таким образом, клееный брус из древесины лиственницы сибирской характеризуется высокими показателями биостойкости, прочности и водостойкости. Despite vast reserves, larch wood so far in small volumes used in the construction industry and other sectors of the economy, which is connected as the technological difficulties of its treatment, as well as insufficient knowledge of its properties. One of the unique properties of the wood of Siberian larch (Larix sibirica) is its increased natural biological stability (decay resistant), along with the highest among the domestic softwood strength. Resistance Larch (Larix sibirica) to the effects of wood-destroying fungi Coniofora puteana is much higher than pine. The average weight loss of Siberian larch heartwood exposed wood-destroying fungi Coniophora puteana is 14.84%, decreasing with increasing age of the tree, and control samples of heartwood pine at age 90 had a weight loss of 57.8%. Age of a tree is one of the most significant factors affecting the degree of biological stability of wood. With the increase it significantly increases the stability of the destructive effects of wood-destroying fungi and Coniophora puteana. The position of the sample in tree also affects the degree of biological stability of wood, but this dependence is poorly developed in comparison with the influence of age and wood density. Studies of the kinetics of decomposition of Siberian larch wood and the role of extractives in the development of wood-destroying fungi suggest a link, and the decay resistant of the content in the wood extractives. For the manufacture of larch glued laminated beam proposed adhesive composition comprising urea and melamine-formaldehyde glue and urea-formaldehyde resins, modified shungites. Its use allows to obtain the bonds are not inferior in strength at shearing solid wood as dry sample, and after soaking. Thus, glued laminated beam from Siberian larch wood is characterized by high decay resistant, strength and water resistance.

scholarly journals Incidence and Outcomes of Home Parenteral Nutrition in Patients With Crohn Disease in Olmsted County, Minnesota

2020 ◽  
Vol 2 (4) ◽  
Author(s):  
Zeinab Bakhshi ◽  
Siddhant Yadav ◽  
Bradley R Salonen ◽  
Sara L Bonnes ◽  
Jithinraj Edakkanambeth Varayil ◽  
...  
Keyword(s):  
Weight Loss ◽  
Parenteral Nutrition ◽  
Short Bowel Syndrome ◽  
Crohn Disease ◽  
Severe Disease ◽  
Bloodstream Infections ◽  
Home Parenteral Nutrition ◽  
Average Weight ◽  
Olmsted County ◽  
Short Bowel

Abstract Background We sought to estimate the incidence of home parenteral nutrition (HPN) use in a population-based cohort of patients with Crohn disease (CD), and to assess clinical outcomes and complications associated with HPN. Methods We used the Rochester Epidemiology Project (REP) to identify residents of Olmsted County, who were diagnosed with CD between 1970 and 2011, and required HPN. Results Fourteen out of 429 patients (3.3%) with CD received HPN (86% female). Eleven patients (79%) had moderate–severe CD and 12 patients (86%) had fistulizing disease. Thirteen patients (93%) underwent surgery, primarily due to obstruction. Among CD incidence cases, the cumulative incidence of HPN from the date of CD diagnosis was 0% at 1 year, 0.5% at 5 years, 0.8% at 10 years, and 2.4% at 20 years. Indications for HPN included short bowel syndrome in 64%, malnutrition in 29%, and bowel rest in 21%. The median duration of HPN was 2.5 years. There was an average weight gain of 1.2 kg at 6 months, an average weight loss of 1.4 kg at 1 year, and a further weight loss of 2.2 kg at 2 years from the start of HPN. Patients were hospitalized a mean of 5 times after the start of HPN, mainly due to catheter-related bloodstream infections and thrombosis. Conclusions Less than 4% of patients with CD need HPN. Most have moderate to severe disease with short bowel syndrome or malnutrition. Possible reasons for the patients’ weight loss could be noncompliance, and increased metabolic needs because of active disease.

scholarly journals Patterns of Weight Change in Aging and Dying

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 491-491
Author(s):  
Stephen Thielke
Keyword(s):  
Older Adults ◽  
Weight Loss ◽  
Risk Factor ◽  
Weight Change ◽  
Population Level ◽  
Chronological Age ◽  
Average Weight ◽  
Remaining Life ◽  
Entire Cohort ◽  
History Of

Abstract Little research has characterized the natural history of weight change in older adults. Different changes may occur during aging and dying. We analyzed 18 years of weight measures from a cohort of 736,361 Veterans, all of whom had died at age 70 or older. We produced summary measures that accounted for both chronological age and number of years before death. Several clear population-level trends appeared. (1) The average weight of the sample declined across all ages at a rate of about 0.18 BMI points per year. (2) Starting about seven years before death, the amount of loss began to accelerate, reaching a decline of 0.75 BMI points in the year before death. (3) Changes in weight relative to years of remaining life were independent of chronologic age. People who died at age 70 experienced, on average, the same type and duration of terminal decline as did those who died at age 95. (4) The dying process involved a cumulative loss of about 1.3 BMI points. (5) The distribution of weights during advancing age both declined and narrowed. (6) Disproportionate deaths occurred at the lower BMI ranges (below a BMI of 24), and especially below 18, regardless of age. (7) The finding in #5 is explained by the entire cohort losing weight, with death of the thinnest members. These findings argue for examining survival time in studies of weight change. They indicate that weight loss may be a natural part of dying, rather than a risk factor for it.

scholarly journals Anti-Atherogenic Effect of 10% Supplementation of Anchovy (Engraulis encrasicolus) Waste Protein Hydrolysates in ApoE-Deficient Mice

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2137
Author(s):  
Jessica Maria Abbate ◽  
Francesco Macrì ◽  
Francesca Arfuso ◽  
Carmelo Iaria ◽  
Fabiano Capparucci ◽  
...  
Keyword(s):  
Human Health ◽  
Antioxidant Activities ◽  
Protein Hydrolysate ◽  
Protein Hydrolysates ◽  
Metabolic Effects ◽  
Lipid Lowering ◽  
High Frequency Ultrasound ◽  
Aortic Sinus ◽  
Fish Waste ◽  
Plaque Development

Fish protein consumption exerts beneficial metabolic effects on human health, also correlating with a decreased risk for cardiovascular disease. Fish waste contains high amount of proteins and utilization may offer the opportunity for generating compounds advantageous for human health. Especially, fish waste protein hydrolysates beneficially influence pathways involved in body composition, exerting anti-inflammatory and antioxidant activities, making their potential supplementation in human disorders of increased interest. This study assessed the effect of a 10% (w/w) anchovy waste protein hydrolysate (APH) diet for 12 weeks in reducing atherosclerosis in ApoE−/− mice, through histological and immunohistochemical methods. In addition, monitoring of plaque development was performed, using high-frequency ultrasound and magnetic resonance imaging. Overall, the APH diet attenuated atherosclerotic plaque development, producing a regression of arterial lesions over time (p < 0.05). Twelve weeks on an APH diet had an anti-obesity effect, improving lipid metabolism and reducing hepatic enzyme activity. A significant reduction in plaque size and lipid content was observed in the aortic sinus of APH-fed mice, compared to the control (p < 0.001), whereas no differences in the extracellular matrix and macrophage recruitment were observed. Supplementation of APH significantly attenuates atherosclerosis in ApoE−/− mice, exerting a lipid-lowering activity. The opportunity to use fish waste protein hydrolysates as a nutraceutical in atherosclerosis is worthy of future investigations, representing a low cost, sustainable, and nutritional strategy with minimal environmental impact.

Infant Obesity, Weight Reduction with Normal Increase in Linear Growth and Fat-free Body Mass

PEDIATRICS ◽  
1992 ◽  
Vol 89 (1) ◽  
pp. 143-145
Author(s):  
JOYCE M. PEIPERT ◽  
VIRGINIA A. STALLINGS ◽  
GERARD T. BERRY ◽  
JULE ANNE D. HENSTENBURG
Keyword(s):  
Weight Loss ◽  
Body Mass ◽  
Weight Maintenance ◽  
Caloric Intake ◽  
Resting Energy Expenditure ◽  
Induce Weight Loss ◽  
Infant Obesity ◽  
Normal Increase ◽  
Free Body ◽  
Treatment Of Obesity

Dietary caloric restriction, as a means to induce weight loss, is seldom used as a treatment of obesity in infancy for fear that permanent stunting of growth may result.1-4 Thus, there is little information on controlled weight loss as the treatment for infant obesity or, more importantly, its effect on growth in length, head circumference, and fat-free body mass during weight loss.5 We present a case of an obese infant who, secondary to a metabolic disorder, required nutritional support both intravenously and by nasogastric tube. During 15 months, the patient's resting energy expenditure (REE) was measured to determine an appropriate caloric intake to promote weight loss and later weight maintenance.

THE EFFECTS OF LOW-CARBOHYDRATE VERSUS LOW-FAT DIETS IN OBESE/OVERWEIGHT ADULTS: ONE-YEAR FOLLOW-UP OF A RANDOMIZED TRIAL

2021 ◽  
pp. 27-29
Author(s):  
Maitri Hathi ◽  
Sudesh Kumar
Keyword(s):  
Weight Loss ◽  
Randomized Trial ◽  
Caloric Intake ◽  
Low Fat ◽  
Obese Adults ◽  
Low Carbohydrate Diet ◽  
Low Carbohydrate ◽  
One Year ◽  
The One

Aprevious paper reported the six month comparison of weight loss in overweight and/or obese adults randomly assigned to either a VLCK-diet or LF-diet. To review the one year outcomes between these diets 1year follow-up of a randomized trial on 113 overweight/obese adults with a BMI>25 kg/m2; with no abnormalities were randomly selected. Participants who selected VLCK diet received counseling to restrict carbohydrate intake to <30 gram per day and those who selected LF diet received counseling to restrict caloric intake by 500 calories per day with <30% of calories from fat. Changes in weight, Body Mass Index, Body Fat, and Waist Circumference were measured at intervals of rst, third, sixth and twelfth month of participants who completed the one-year follow-up. Participants on the very-low-carbohydrate diet had lost more weight loss than participants on the conventional low-fat diet at 3months, 6month and but the difference at 12months were signicant. Study conclude that participants on a VLCK-diet had more favorable overall outcomes at 1year than did those on a conventional LF-diet. Weight loss was similar between groups.

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